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Hostetler, US
Brandon Hostetler, Walkerton, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20090042209 | Neoplasia-Specific tNOX Isoforms and Methods - All neoplastic cells express one or more members of a unique family of cell surface ubiquinone (NADH) oxidase proteins with protein disulfide-thiol interchange activity (ECTO-NOX proteins) that are characteristically inhibited by quinone site inhibitors with anti-cancer activity. Cancers of different cellular or tissue origins express different tNOX cancer isoforms or combinations of isoforms and shed these proteins into the circulation. Herein are disclosed methods both for cancer detection and diagnosis of particular origin, based on the patterns and molecular weights of the isoforms which allow the identification of the cell type and or tissue of origin of the neoplasm. Relative tNOX amounts are proportional to tumor burden and provide a reliable measure of response to therapy and disease progression. | 02-12-2009 |
Brian Hostetler, Chesterfield, MO US
| Patent application number | Description | Published |
|---|---|---|
| 20080294488 | SUPPLY CHAIN MANAGEMENT SYSTEM - A method of transporting commodities in a supply chain management system including a supply chain. The method includes providing a database and a network in communication with the database, which is accessible by at least one member of the supply chain via the network. The method also includes providing a container and supporting one or more commodities using the container, assigning at least one sensor to the commodities, sensing a condition of the commodities and generating a signal indicative of the commodity condition, identifying information related to the commodities, acquiring data related to identifying the commodity information, distributing the signal and the acquired data over the network, storing the signal and the acquired data in the database, monitoring the commodities via the network, and managing at least one of storage and transport of the commodities through the supply chain based on the signal and the acquired data. | 11-27-2008 |
Eric Hostetler, Collegeville, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20120064005 | RADIOLABELED PDE10 INHIBITORS - The present invention is directed to radiolabeled pyrimidinone compounds of general structural formula I which are useful as radiotracers for quantitative imaging of PDE10 in mammals. | 03-15-2012 |
| 20120121508 | RADIOLABELED CGRP ANTAGONISTS - The present invention is directed to radiolabeled CGRP receptor antagonists which are useful for the quantitative imaging of CGRP receptors in mammals. | 05-17-2012 |
Eric J. Hostetler, Silverado, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20130069380 | Multi-configuration grappling hook system - A retractable and fast-deploying grappling hook has a plurality of tines foldable around a central shaft that can quickly be individually set into a deployed position or a retracted position with no more than two turns of a capping head. The speed and ease of operation of the deploying and locking mechanism are due in part to the concavely machined undersurface of the head which mirrors the path end of the tines hinged to the side of the shaft. The same locking maneuver and adjustment of the head apply coincidentally to the deployed and retracted tines. A belt-attachable caddy houses a slotted receptacle for a removable plate mounting a take-up reel around which a cable secured to an eyelet at the proximal end of the shaft can be wound. | 03-21-2013 |
Greg Hostetler, Newark, DE US
| Patent application number | Description | Published |
|---|---|---|
| 20110053920 | SUBSTITUTED BICYCLIC PYRIMIDINES - The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted heterobicyclic pyrimidines of Formula (I): | 03-03-2011 |
Greg A. Hostetler, Newark, DE US
| Patent application number | Description | Published |
|---|---|---|
| 20090062284 | Thio-Substituted Biarylmethanesulfinyl Derivatives - The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted biaryl-methanesulfinyl acetamides of Formula (I): | 03-05-2009 |
| 20100273779 | Pyridazinone Derivatives - The present invention is directed to novel pyridizinone derivatives that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition. | 10-28-2010 |
| 20100280007 | Pyridazinone Derivatives - The present invention is directed to novel pyridizinone derivatives that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition. | 11-04-2010 |
| 20110288075 | Pyridazinone Derivatives - The present invention is directed to novel pyridazinone derivatives that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition/cognitive disorders. | 11-24-2011 |
| 20120028919 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS - The present invention provides a compound of formula I | 02-02-2012 |
| 20120238551 | Substituted Phenoxypropylcycloamine Derivatives as Histamine-3 (H3) Receptor Ligands - The present invention provides compounds of formula I: | 09-20-2012 |
| 20120295882 | Tricyclic Derivatives and Their Pharmaceutical Use and Compositions - This application relates to tricyclic compounds of Formula I: | 11-22-2012 |
Jeff Hostetler, Troy, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20100094766 | INSURANCE CONFIGURATION MANAGEMENT SYSTEM AND METHOD - A method, system, and computer program product to provide a single platform to unify benefits, claims, membership, billing, and servicing. One embodiment provides a computer program-assisted system to provide a single point source for host benefits management having a centralized benefit data manager (BDM); a selector communicatively connected to said BDM to allow a user to view, select, and assemble benefit components from BDM; an editor communicatively connected to the BDM allows the ability to define and update benefit components and variables for benefit and payment policies; a read-only explainer communicatively connected to the BDM provides understandable “read-only” descriptions of benefits available; and a connector communicatively connected to the BDM as an interface layer to exchange electronic benefit data with all system processes, including external claims systems. The connector can translate rules from a user's natural language to computer code language. | 04-15-2010 |
Jeffrey K. Hostetler, Fort Worth, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20090198392 | APPARATUS, PROGRAM PRODUCT, AND METHODS FOR UPDATING DATA ON EMBEDDED CONTROL SYSTEMS - Embodiments of the present invention provide an augmentation apparatus, program product, and methods for providing updated mission control data to an embedded control system of an aircraft or other vehicle. This augmentation can include a mission system interface unit, a user interface unit, and a display unit. The mission system interface unit can interface with the embedded control system and can exchange data and control signals with the embedded control system. The user interface unit can couple to the mission system interface unit and the display unit to provide a user a direct interface with embedded control system and to supplement the displays of the embedded control system. | 08-06-2009 |
John D. Hostetler, Reno, NV US
| Patent application number | Description | Published |
|---|---|---|
| 20090017891 | GAMING DEVICE HAVING A WHEEL WITH MULTIPLE INDICATORS - A wagering game including a wheel and multiple section indicators. The wheel includes a plurality of sections having awards associated with each of the sections. The section indicators associated with the wheel simultaneously indicate sections on the wheel. The awards associated with the sections indicated by the activated section indicators are summed and provided to a player. The number of activated section indicators is predetermined, randomly determined, determined by the player's wager in the primary or base game, determined in a primary game or determined by a sub-game or a set. | 01-15-2009 |
Karl Y. Hostetler, Del Mar, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080221061 | Lung-Targeted Drugs - Methods and compositions are provided for treating lung diseases, including but not limited to infections and small cell and non-small cell lung cancer, by conjugating a drug of interest to glycerol ethers or glycerol phosphate ethers. | 09-11-2008 |
| 20090156545 | Substituted Phosphate Esters of Nucleoside Phosphonates - Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections and/or cell proliferation. The compounds provided herein are obtained by attaching the phosphonate nucleoside of interest to alkyloxyalkyl-phosphate or alkyl-phosphate in a phosphate-phosphono anhydride linkage to provide a modified nucleoside phosphonate drug. | 06-18-2009 |
| 20100173870 | Phosphonate Compounds - The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like. | 07-08-2010 |
| 20100273742 | Pharmacologically Active Agents Containing Esterified Phosphonates and Methods for Use Thereof - Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections, cell proliferation and bone metabolism. The compounds provided herein are alkyl esters of phosphonates. | 10-28-2010 |
| 20120058975 | Phosphonate Compounds - The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like. | 03-08-2012 |
| 20120122818 | LUNG-TARGETED DRUGS - Methods and compositions are provided for treating lung diseases, including but not limited to infections and small cell and non-small cell lung cancer, by conjugating a drug of interest to glycerol ethers or glycerol phosphate ethers. | 05-17-2012 |
Lester Hostetler, Kansas City, MO US
| Patent application number | Description | Published |
|---|---|---|
| 20100060008 | Wind and Water Turbine - A power generation system that provides means for a wind or water powered wheel having pairs of radially positioned arms each having a shaft with a pair of fins pivotally attached thereto and where the independently rotating fins or paddles allow for increased power generation and reduced drag. | 03-11-2010 |
Michael Hostetler, Cardiff, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20120317203 | Method and System for Business Peer Group Networking - A business social network is provided employing a relational database associating members by their job and industry and individual research areas of interest determined topic deemed of interest by member input into provided graphical interfaced questions. Answers to posed questions regarding interest level and expertise level of respective members of each cluster are employed for grouping of members for webcasts, member searches for like-minded members, and for sending topic related polls to members most likely to answer based on their expertise and level interest in the topic. | 12-13-2012 |