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Horan, US
Ann C. Horan, Summit, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20090004649 | EVERNINOMICIN BIOSYNTHETIC GENES - This invention is directed to nucleic acids which encode the proteins that direct the synthesis of the orthosomycin everninomicin and to use of the nucleic acids and proteins to produce compounds exhibiting antibiotic activity based on the everninomycin structure. The DNA sequence for the gene clusters responsible for encoding everninomicin biosynthetic genes, which provide the machinery for producing everninomicin, are provided. Thus, this invention provides the nucleic acid sequences needed to synthesize novel everninomicin-related compounds based on everninomicin, arising from modifications of the DNA sequence designed to change glycosyl and modified orsellinic acid groups contained in everninomicin. A | 01-01-2009 |
| 20110027865 | EVERNINOMICIN BIOSYNTHETIC GENES - This invention is directed to nucleic acids which encode the proteins that direct the synthesis of the orthosomycin everninomicin and to use of the nucleic acids and proteins to produce compounds exhibiting antibiotic activity based on the everninomycin structure. The DNA sequence for the gene clusters responsible for encoding everninomicin biosynthetic genes, which provide the machinery for producing everninomicin, are provided. Thus, this invention provides the nucleic acid sequences needed to synthesize novel eveminomicin-related compounds based on eveminomicin, arising from modifications of the DNA sequence designed to change glycosyl and modified orsellinic acid groups contained in everninomicin. A | 02-03-2011 |
Dale Horan, Indianapolis, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20090242625 | Automated transaction machine system - An automated banking machine ( | 10-01-2009 |
David J. Horan, Westfield, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080300683 | PROSTHETIC DEVICE AND METHOD OF MANUFACTURING THE SAME - A knitted prosthetic device has at least two knitted sections, where each knitted section has at least one row of fiber. The knitted prosthetic device also has at least one intra-articular section disposed between the at least two knitted sections. In addition, the at least one intra-articular section has at least one single continuous fiber traversing the at least one intra-articular section and the at least two knitted sections, where the at least one single continuous fiber forms a plurality of traverses extending between the at least two knitted sections. In particular, embodiments may be used as ligament prostheses by anchoring each of the at least two knitted sections to a bone section of a patient. Such embodiments may be constructed from a strong polymer, preferably, but not limited to, silk, where the polymer provides ligament support but bioresorbs as load bearing responsibilities are transferred to tissue resulting from in-growth. | 12-04-2008 |
| 20100209405 | SERICIN EXTRACTED SILKWORM FIBROIN FIBERS - The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form the ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed. | 08-19-2010 |
| 20110009960 | PROSTHETIC FABRIC STRUCTURE - Disclosed herein is an implantable prosthesis for breast augmentation or reconstruction procedures. The prosthesis comprises a biocompatible and biodegradable fabric structure comprising one or more individual yarns comprised of sericin-extracted native fibroin fibers, wherein the yarns are intertwined to produce the fabric structure. The fabric structure extends in at least a first dimension and has at least a first surface that is adapted to engage and support natural breast tissue and/or a prosthetic breast implant in a patient. Also disclosed are methods of supporting breast tissue or a breast implant in a patient by inserting the prosthesis between the skin of the patient and the breast tissue and/or implant within the patient. | 01-13-2011 |
| 20110167602 | IMMUNONEUTRAL SILK-FIBER-BASED MEDICAL DEVICES - Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties. | 07-14-2011 |
| 20110171453 | IMMUNONEUTRAL SILK-FIBER-BASED MEDICAL DEVICES - Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties. | 07-14-2011 |
David J. Horan, Arlington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110189773 | SILK FIBROIN FIBER BUNDLES FOR MATRICES IN TISSUE ENGINEERING - The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form the ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed. | 08-04-2011 |
James L. Horan, Golden, CO US
| Patent application number | Description | Published |
|---|---|---|
| 20090208809 | POLYMER ELECTROLYTES INCLUDING HETEROPOLYACIDS - This disclosure provides polymer electrolytes, polymer electrolyte membranes (PEM's) and membrane electrode assemblies (MEA's) such as may be useful in fuel cells which contain or comprise polyoxometalates (POM's) or heteropolyacids (HPA's). In some embodiments the polyoxometalate, it's counterions or both may comprise Mn and/or Ce. In some embodiments the polymer electrolyte is fluorinated. In some embodiments the polymer electrolyte comprises a second acidic functional group other than a polyoxometalate. In another aspect, the present disclosure provides methods of making polymer electrolytes including methods which comprising a step of copolymerizing monomers comprising a covalently bound polyoxometalates and methods which comprise a step of covalently attaching a polyoxometalate to the polymer. | 08-20-2009 |
Jeff Horan, Mt. Vernon, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20090263195 | TRENCHING AND DRAIN INSTALLATION SYSTEM AND METHOD - A system for trench and drain installation. The system utilizes an implement driven trenching assembly and a backfill pipe installation assembly. The implement driven trencher assembly digs a trench utilizing a circular trenching blade which is hydraulically operated and is mounted onto the front loader plate. The backfill pipe installation assembly uses a backfill hopper to simultaneously install drainage pipe above the trench floor and envelope the drainage pipe in backfill material to maintain the drainage pipe that a constant height above the trench floor. | 10-22-2009 |
| 20110002762 | Site Dumping Moving Floor Hopper Method and Apparatus - A site dumper elevation, rotation, and moving floor hopper implement. The implement includes a material bed for conveying material from one site location to another. The material bed has a bed side wall and a first bed gate. The bed side wall defines an upper bed wall edge and a lower bed wall edge. The material bed further has an open top, a bed tilt hinge arranged near said first bed gate and a moving floor for transferring the material towards or away from the first bed gate. The moving floor defines the bottom wall of the material bed. A first lift arm is configured to tilt the material bed and the moving floor about the bed tilt hinge at an angular distance. An undercarriage is configured to support the material bed, the moving floor, and the lift arm. The undercarriage further is configured to rotate a rotational distance about a vertically aligned axis. | 01-06-2011 |
Joshua Courtney Horan, Danbury, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20110224188 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-alpha]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES - Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease. | 09-15-2011 |
Kevin Horan, Raynham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110139638 | Use of Polyoxyalkylene Nonionic Surfactants with Magnesium Ion Selective Electrodes - Methods are disclosed for reducing the shift in EMF bias in a magnesium ion selective electrode, comprising the step of: contacting the electrode with a composition comprising a polyoxyalkylene nonionic surfactant; wherein the polyoxyalkylene nonionic surfactant has an HLB greater than about 18. Additional aspects of the present invention are directed to methods, comprising the steps of: contacting a magnesium ion selective electrode with a composition comprising a polyoxyalkylene nonionic surfactant, wherein the polyoxyalkylene nonionic surfactant has an HLB greater than about 18; and measuring a biologically relevant level of a blood electrolyte in a blood composition with the electrode. In certain embodiments, the polyoxyalkylene nonionic surfactant is polyoxy ethylene (100) stearyl ether and the blood electrolyte is magnesium ion. | 06-16-2011 |
Michael J. Horan, Scottsdale, AZ US
| Patent application number | Description | Published |
|---|---|---|
| 20090206818 | AC VOLTAGE REGULATION SYSTEM AND METHOD - Control of the RMS AC voltage applied to the load (Motor) utilizes a switching device (SCR) such as a SCR in series between the load and a power source. A controller (lPController) including a processor and an analog to digital converter is connected to the line voltage and floats at line voltage and detects line voltage cross-over ad the voltage drop across the SCR. Abrupt voltage increases in the voltage across the SCR are used to replace the prior art zero current cross-over to permit the calculation of corrective timing to switch the SCR on at the succeeding voltage wave. | 08-20-2009 |
Paul Karl Horan, Kennett Square, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090053709 | ENHANCED SENSITIVITY OF A CANTILEVER SENSOR VIA SPECIFIC BINDINGS - Detection of miniscule amounts of an analyte is accomplished via multiple bindings of specific materials on a sensor configured to sense mass. The sensor is prepared by immobilizing an antibody to a surface of the sensor, wherein the antibody is known to bind to the analyte. The prepared sensor is exposed to the analyte. The analyte binds to the antibody. The sensor then is exposed to additional antibody, which binds to the analyte. The sensor then can be sequentially exposed to additional antibodies that are known to bind to previously bound antibodies. Each additional binding further increases the effective mass of accumulated material on the sensor. The total effective mass is greater than the mass of the accumulated analyte, thus providing means for detecting extremely minute amounts of analyte. Applications include detection of pathogens and DNA. | 02-26-2009 |
Rebecca Horan, Arlington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100209405 | SERICIN EXTRACTED SILKWORM FIBROIN FIBERS - The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form the ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed. | 08-19-2010 |
| 20110167602 | IMMUNONEUTRAL SILK-FIBER-BASED MEDICAL DEVICES - Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties. | 07-14-2011 |
| 20110171453 | IMMUNONEUTRAL SILK-FIBER-BASED MEDICAL DEVICES - Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties. | 07-14-2011 |
Stephen R. Horan, Hickory, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20080247711 | Attachment structure allowing movement and protection of a tether of a cable assembly - A cable assembly comprising a fiber optic cable and one or more attachment points to allow one or more tethers to optically connect to optical fibers within the cable. The cable assembly may be used as a drop cable for extending optical connections to a plurality of points. An attachment structure is provided for maintaining the tether to the cable to prevent damage to the tether. The attachment structure provides a loose attachment to allow the tether to move relative to the distribution cable, so the tether can move in a generally translational movement, is able to slightly twist, and to have limited lateral movement during coiling, installation, and removal of the cable assembly. This loose attachment structure may prevent damage to the tether due to forces being placed on the cable, such as during coiling or uncoiling of the cable. In one exemplary embodiment, the attachment structure is attached to the cable and receives the tether. In another exemplary embodiment, the attachment structure include a protective covering. In another embodiment, both are employed in combination. | 10-09-2008 |
Timothy J. Horan, Royersford, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100191243 | JIG AND SAW GUIDES FOR USE IN OSTEOTOMIES - An apparatus for locating a curvilinear cut in a bone comprises a jig body and a first arm, a top end of which is rotatably coupleable to a first portion of the jig body in combination with a second arm, a top end of which is rotatably coupleable to a second portion of the jig body separated from the first portion and a saw guide rotatably coupleable to the first arm, the saw guide including a bottom surface extending along a curve corresponding to a desired path through which a bone is to be cut, the saw guide including a locking feature receiving a bone fixation element which, in an operative configuration, is mounted in the bone to align the saw guide relative to the arm so that an operator may precisely align a desired axis of the saw guide with a longitudinal axis of the first arm. | 07-29-2010 |
William Horan, Springfield, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20110217114 | ARRESTING SYSTEMS AND METHODS - Systems and methods for arresting vehicles or other moving objects are detailed. The systems may be bi-directional, so as to arrest vehicles on either side of a barrier. They additionally may be reset for reuse relatively rapidly following deployment and comprise mechanical controllers for facilitating suitable deformation of the barriers. Modular slotted beams also may be employed to accommodating differing widths and crowns of roadways. | 09-08-2011 |