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Hongxiang Zhang, Chadds Ford US

Hongxiang Zhang, Chadds Ford, PA US

Patent application numberDescriptionPublished
20090104674Diacylglycerol Acyltransferases for Alteration of Polyunsaturated Fatty Acids and Oil Content in Oleaginous Organisms - Acyltransferases are provided, suitable for use in the manufacture of microbial oils enriched in omega fatty acids in oleaginous yeast (e.g., 04-23-2009
20090186362FUNGAL DELTA-12 DESATURASE AND DELTA-15 DESATURASE MOTIFS - The present invention relates to fungal Δ12 desaturases (responsible for conversion of oleic acid to linoleic acid (18:2, LA)) and Δ15 fatty acid desaturases (responsible for conversion of LA to α-linolenic acid (18:3, ALA)). Amino acid motifs diagnostic of Δ12 desaturases and Δ15 desaturases are also provided. Methods of altering enzyme specificity towards Δ12 desaturation or towards Δ15 desaturation and/or increasing production of specific ω-3 and ω-6 fatty acids by over-expression of the fungal desaturases are also described.07-23-2009
20090269828ACYLTRANSFERASES FOR ALTERATION OF POLYUNSATURATED FATTY ACIDS AND OIL CONTENT IN OLEAGINOUS YEASTS - Two acyltransferases are provided, suitable for use in the manufacture of microbial oils enriched in omega fatty acids in oleaginous yeast (e.g., 10-29-2009
20090311380DOCOSAHEXAENOIC ACID PRODUCING STRAINS OF YARROWIA LIPOLYTICA - An engineered strain of the oleaginous yeast 12-17-2009
20100022647HIGH ARACHIDONIC ACID PRODUCING STRAINS OF YARROWIA LIPOLYTICA - Engineered strains of the oleaginous yeast 01-28-2010
20100041113DELTA 6 DESATURASES AND THEIR USE IN MAKING POLYUNSATURATED FATTY ACIDS - The present invention relates to Δ6 desaturases, which have the ability to convert linoleic acid [“LA”; 18:2 ω-6] to γ-linolenic acid [“GLA”; 18:3 ω-6] and/or α-linolenic acid [“ALA”; 18:3 ω-3] to stearidonic acid [“STA”; 18:4 ω-3]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ6 desaturases, along with methods of making long-chain polyunsaturated fatty acids [“PUFAs”] using these Δ6 desaturases in oleaginous yeast, are disclosed.02-18-2010
20100113811DELTA-15 DESATURASES GENES SUITABLE FOR INCREASING LEVELS OF OMEGA-3 FATTY ACIDS - The present invention relates to fungal Δ-15 fatty acid desaturases that are able to catalyze the conversion of linoleic acid (18:2, LA) to alpha-linolenic acid (18:3, ALA). Nucleic acid sequences encoding the desaturases, nucleic acid sequences which hybridize thereto, DNA constructs comprising the desaturase genes, and recombinant host plants and microorganisms expressing increased levels of the desaturases are described. Methods of increasing production of specific omega-3 and omega-6 fatty acids by over-expression of the Δ-15 fatty acid desaturases are also described herein.05-06-2010
20100317882LONG CHAIN OMEGA-3 AND OMEGA-6 POLYUNSATURATED FATTY ACID BIOSYNTHESIS BY EXPRESSION OF ACYL-CoA LYSOPHOSPHOLIPID ACYLTRANSFERASES - Methods for increasing C12-16-2010
20110086919HIGH EICOSAPENTAENOIC ACID PRODUCING STRAINS OF YARROWIA LIPOLYTICA - Engineered strains of the oleaginous yeast 04-14-2011

Patent applications by Hongxiang Zhang, Chadds Ford, PA US