Hongtao Zhang
Hongtao Zhang, Paoli, PA US
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20100061984 | COMPOSITIONS AND METHODS FOR MODULATION OF SUPPRESSOR T CELL ACTIVATION - Methods of treating autoimmune disorders, coronary artery disease, allergy symptoms, allograft rejection sepsis/toxic shock are disclosed. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3 in combination with a T suppressor stimulus and/or an antigen. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3. Some methods comprise administering soluble GITR or antibodies that bind to GITR ligand. Methods of treating cancer, infectious diseases, and immune deficiency are also disclosed as are vaccination methods. The methods comprise administering one or more regulatory compositions to inactivate the T suppressor cells by reducing the acetylation level and/or protein level of FOXP3. Improved vaccines and vaccination methods are disclosed. Methods of identifying compounds that are useful to modulate acetylation level and/or protein level of FOXP3 and treat diseases are disclosed. | 03-11-2010 |
20100076174 | ErbB Interface Peptidomimetics And Methods Of Use Thereof - Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed. | 03-25-2010 |
20100120688 | ErbB Interface Peptidomimetics And Methods Of Use Thereof - Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed. | 05-13-2010 |
20100189649 | MONOCLONAL ANTIBODIES TO ACTIVATED ERBB FAMILY MEMBERS AND METHODS OF USE - Antibodies which bind to activated members of the erbB, TNF, and IgSF family of receptors and pharmaceutical compositions comprising the same are disclosed. Peptides and mimetics of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are also described. Methods of using such antibodies, peptides, and mimetics in tumor therapeutic, prophylactic, imaging and diagnostic applications are disclosed. | 07-29-2010 |
20100239587 | ErbB Interface Peptidomimetics And Methods Of Use Thereof - Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed. | 09-23-2010 |
20120164066 | ANTIGEN-BINDING PROTEINS COMPRISING RECOMBINANT PROTEIN SCAFFOLDS - Disclosed herein are recombinant protein scaffolds and recombinant multifunctional protein scaffolds for use in producing antigen-binding proteins In addition, nucleic acids encoding such recombinant protein scaffolds, recombinant multifunctional protein scaffolds, and antigen-binding proteins are provided Vectors and cells useful for expression of the described proteins are also provided, as are methods of use. | 06-28-2012 |
20130137774 | METHODS AND USE OF COMPOUNDS THAT BIND TO HER2/NEU RECEPTOR COMPLEX - This application describes pharmaceutical compositions, commercial packages, and methods for inhibiting cell proliferative disorders, especially those disorders, including Her2 related cancers, characterized by overactivity and/or inappropriate activity of a receptor tyrosine kinase, and methods for imaging an HER-2 expressing tumor. | 05-30-2013 |
20130190405 | METHODS AND USE OF COMPOUNDS THAT BIND TO HER2/NEU RECEPTOR COMPLEX - This application describes pharmaceutical compositions, kits, and methods for inhibiting cell proliferative disorders, especially those disorders characterized by overactivity and/or inappropriate activity of a receptor tyrosine kinase, including Her2 related cancers, and methods for imaging an Her-2 expressing tumor. | 07-25-2013 |
20130217857 | ERBB INTERFACE PEPTIDOMIMETICS AND METHODS OF USE THEREOF - Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed. | 08-22-2013 |
20140135298 | MUTATION MIMICKING COMPOUNDS THAT BIND TO THE KINASE DOMAIN OF EGFR - This invention is in the fields of cancer therapy. More particularly it concerns compounds which are useful agents for treating cell proliferative disorders, especially those disorders characterized by over activity and/or inappropriate activity of a EGFR, including EGFR-related cancers, particularly for expanding the efficacy of drugs previously developed for this purpose, and for methods of treatments using the compounds for this purpose. | 05-15-2014 |
20140178375 | ANTIBODY-LIKE PROTEINS FOR THERAPEUTIC AND DIAGNOSTIC USE - Disclosed herein are recombinant protein scaffolds for use in producing antigen-binding proteins. Related antigen-binding proteins are also provided herein. In addition, nucleic acids encoding such recombinant protein scaffolds and antigen-binding proteins are also described. Vectors and cells useful for expression of the described proteins are also provided, as are methods of use. | 06-26-2014 |
20140187579 | TIP60 INHIBITORS - This invention is in the fields of immunology and autoimmunity. More particularly it concerns pharmaceutical compositions comprising compounds which are useful agents for inhibiting the functions of TIP60 and the use of such compounds in the treatment of an individual suffering, for example, from ulcerative colitis and other irritable bowel diseases. | 07-03-2014 |
20140234221 | ANTIGEN-BINDING PROTEINS COMPRISING RECOMBINANT PROTEIN SCAFFOLDS - Disclosed herein are recombinant protein scaffolds and recombinant multifunctional protein scaffolds for use in producing antigen-binding proteins In addition, nucleic acids encoding such recombinant protein scaffolds, recombinant multifunctional protein scaffolds, and antigen-binding proteins are provided Vectors and cells useful for expression of the described proteins are also provided, as are methods of use. | 08-21-2014 |
20140309246 | METHODS AND USE OF BIFUNCTIONAL ENZYME-BUILDING CLAMP-SHAPED MOLECULES - This invention is in the fields of cancer therapy. More particularly it concerns compounds which are useful agents for inhibiting cell proliferative disorders, especially those disorders characterized by over activity and/or inappropriate activity of a EGFR, including EGFR-related cancers, and methods for treating these disorders. | 10-16-2014 |
20140348831 | ANTI-PROSTATE CANCER ANTIBODIES AND METHODS OF DETECTION AND TREATMENT OF PROSTATE CANCER USING THE SAME - Disclosed herein are antibodies that detect a lipid-like antigen on prostate cancer cells and methods of detecting and treating prostate cancer using the same. | 11-27-2014 |
Hongtao Zhang, Mount Vernon, NY US
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20100130430 | STABILIZED THERAPEUTIC SMALL HELICAL ANTIVIRAL PEPTIDES - Provided are constrained peptides that inhibit HIV assembly. Pharmaceutical compositions comprising the above peptides are also provided. Additionally provided are methods of inhibiting replication of a capsid-containing virus in a cell. Also provided are methods of treating a mammal infected with a capsid-containing virus. Further provided are methods of treating a mammal at risk for infection with a capsid-containing virus. Methods of making the above peptides are additionally provided, as are uses of the above peptides and pharmaceutical compositions. | 05-27-2010 |
20120165249 | Stabilized Therapeutic Small Helical Antiviral Peptides - Provided are constrained peptides that inhibit HIV assembly. Pharmaceutical compositions comprising the above peptides are also provided. Additionally provided are methods of inhibiting replication of a capsid-containing virus. | 06-28-2012 |
Hongtao Zhang, Oakland Gardens, NY US
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20100035912 | Small Molecule Inhibitors of Retroviral Assembly and Maturation - Chemical compounds that disrupt retroviral assembly and maturation are presented herein. More particularly, this disclosure provides small molecule compounds that disrupt the formation and maturation of virus particles and methods of using such small molecules to treat HIV-1 infection. | 02-11-2010 |
Hongtao Zhang, Beijing CN
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20100015619 | METHOD OF DETECTING GENOMIC ABERRATIONS FOR PRENATAL DIAGNOSIS - This invention relates to assays used to detect and confirm genomic aberrations, such as chromosomes 13, 18, 21, X and Y aneuploidy as well as 22q11.2 deletions, for prenatal diagnosis. For the detection, combined STR markers (all tetra-nucleotide repeats) are employed to cover different chromosome regions. For the confirmation step, individual chromosome specific STR markers (tetra-nucleotide repeats) are utilized. This invention particularly relates to multiplex analysis for the presence or absence of STR markers in genomic DNA isolated from peripheral blood, amniotic fluid, cultured amniocytes, chorionic villi, or fetal cells existing in maternal blood. This invention offers an efficient approach to identify chromosomal abnormalities by using STR markers. | 01-21-2010 |
20110257024 | APPLICATION OF SURFACE PLASMON RESONANCE TECHNOLOGY FOR DETECTING AND GENOTYPING HPV - The present invention discloses using SPR technology to simultaneously and qualitatively detect different HPV genotypes. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of HPV specific DNA probes used for the detection of different HPV genotypes. | 10-20-2011 |
Hongtao Zhang, Mt.vernon, NY US
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20090281041 | ANTIVIRAL CELL-PENETRATING PEPTIDES - Disclosed herein are cell penetrating peptides useful as treatment for Human Immunodeficiency Virus. | 11-12-2009 |
Hongtao Zhang, Mason, OH US
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20080271457 | Cooling Holes For Gas Turbine Combustor Having A Non-Uniform Diameter Therethrough - A gas turbine combustor liner, including a shell having a first end adjacent to an upstream end of the combustor and a second end adjacent to a downstream end of the combustor, where the shell also has a hot side, a cold side, and a centerline axis therethrough. A plurality of small, closely-spaced film cooling holes are formed in the shell through which air flows for providing a cooling film along the hot side of the shell. Each cooling hole has a non-uniform diameter as it extends through the shell. In particular, each cooling hole includes a first opening located at the cold side of the shell having a first diameter and a second opening located at the hot side of the shell having a second diameter, wherein the second diameter of the second opening is larger than the first diameter of the first opening. It is preferred that the shape of each cooling hole be substantially frusto-conical. | 11-06-2008 |
Hongtao Zhang, Devon, PA US
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20080206136 | Binding Peptidomimetics and Uses of the Same - A multimeric peptidomimetic that comprises two or more monomers is disclosed. The monomers comprise an exocyclic peptide comprising a ring structure, a flexible linker sequence and a multimeric motif. Use of the monomers, a nucleic acid molecule encoding monomers, recombinant expression vectors comprising the nucleic acid molecule and host cells comprising a recombinant expression vector are disclosed. Methods of delivering a drug, a toxin, a nucleic acid molecule, a radionuclide or a detectable compound to a cell are disclosed. | 08-28-2008 |
Hongtao Zhang, Mt. Vernon, NY US
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20130004458 | Small Molecule Inhibitors of Retroviral Assembly and Maturation - Chemical compounds that disrupt retroviral assembly and maturation are presented herein. More particularly, this disclosure provides small molecule compounds that disrupt the formation and maturation of virus particles and methods of using such small molecules to treat HIV-1 infection. | 01-03-2013 |
20130059776 | Antiviral Cell-Penetrating Peptides - Disclosed herein are cell penetrating peptides useful as treatment for Human Immunodeficiency Virus. | 03-07-2013 |
Hongtao Zhang, Sunnyvale, CA US
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20130077723 | CLOCK-DATA RECOVERY WITH NON-ZERO h(-1) TARGET - In a receiver circuit, a node receives a signal that carries data from a transmitter circuit. Moreover, a clock-data-recovery (CDR) circuit in the receiver circuit recovers an at-rate clock signal from the received signal. The CDR circuit recovers the clock signal without converging a first pulse-response precursor of the signal relative to a pulse-response cursor of the signal to approximately zero (e.g., with the first pulse-response precursor h(−1) converged to a non-zero value). Furthermore, the first pulse-response precursor corresponds to at least one precurosor or postcursor of the pulse-response other than the current sample. | 03-28-2013 |
20140215245 | SERDES FAST RETRAIN METHOD UPON EXITING POWER SAVING MODE - Systems and methods for reducing power consumption of systems using serialized data transmission. In a multi-node system, the reiterative steps for the setup of the lanes within links between the nodes produces both a time invariant set of parameters associated with the channel properties of the lanes and a time variant set of parameters associated with receiver clock alignment. The time invariant set is stored in persistent storage. Links may be turned on and turned off. When a link is turned on again, the stored time invariant set may be used as initial values to reconfigure both the time invariant and the time variant sets, thereby greatly reducing the delay to begin using the link again. The reduced delay may significantly speed up the wakening process for the links, thereby encouraging the use of low-power techniques that include tuning off lanes. | 07-31-2014 |
Hongtao Zhang, Santa Clara, CA US
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20150188696 | AT-RATE SERDES CLOCK DATA RECOVERY WITH CONTROLLABLE OFFSET - Embodiments include systems and methods for applying a controllable early/late offset to an at-rate clock data recovery (CDR) system. Some embodiments operate in context of a CDR circuit of a serializer/deserializer (SERDES). For example, slope asymmetry around the first precursor of the channel pulse response for the SERDES can tend to skew at-rate CDR determinations of whether to advance or retard clocking. Accordingly, embodiments use asymmetric voting thresholds for generating each of the advance and retard signals in an attempt to de-skew the voting results and effectively tune the CDR to a position either earlier or later than the first precursor zero crossing (i.e., h(−1)=0) position. This can improve link margin and data recovery, particularly for long data channels and/or at higher data rates. | 07-02-2015 |