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Hongtao Zhang
Hongtao Zhang, Paoli, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100061984 | COMPOSITIONS AND METHODS FOR MODULATION OF SUPPRESSOR T CELL ACTIVATION - Methods of treating autoimmune disorders, coronary artery disease, allergy symptoms, allograft rejection sepsis/toxic shock are disclosed. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3 in combination with a T suppressor stimulus and/or an antigen. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3. Some methods comprise administering soluble GITR or antibodies that bind to GITR ligand. Methods of treating cancer, infectious diseases, and immune deficiency are also disclosed as are vaccination methods. The methods comprise administering one or more regulatory compositions to inactivate the T suppressor cells by reducing the acetylation level and/or protein level of FOXP3. Improved vaccines and vaccination methods are disclosed. Methods of identifying compounds that are useful to modulate acetylation level and/or protein level of FOXP3 and treat diseases are disclosed. | 03-11-2010 |
| 20100076174 | ErbB Interface Peptidomimetics And Methods Of Use Thereof - Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed. | 03-25-2010 |
| 20100120688 | ErbB Interface Peptidomimetics And Methods Of Use Thereof - Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed. | 05-13-2010 |
| 20100189649 | MONOCLONAL ANTIBODIES TO ACTIVATED ERBB FAMILY MEMBERS AND METHODS OF USE - Antibodies which bind to activated members of the erbB, TNF, and IgSF family of receptors and pharmaceutical compositions comprising the same are disclosed. Peptides and mimetics of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are also described. Methods of using such antibodies, peptides, and mimetics in tumor therapeutic, prophylactic, imaging and diagnostic applications are disclosed. | 07-29-2010 |
| 20100239587 | ErbB Interface Peptidomimetics And Methods Of Use Thereof - Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed. | 09-23-2010 |
Hongtao Zhang, Mount Vernon, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20100130430 | STABILIZED THERAPEUTIC SMALL HELICAL ANTIVIRAL PEPTIDES - Provided are constrained peptides that inhibit HIV assembly. Pharmaceutical compositions comprising the above peptides are also provided. Additionally provided are methods of inhibiting replication of a capsid-containing virus in a cell. Also provided are methods of treating a mammal infected with a capsid-containing virus. Further provided are methods of treating a mammal at risk for infection with a capsid-containing virus. Methods of making the above peptides are additionally provided, as are uses of the above peptides and pharmaceutical compositions. | 05-27-2010 |
Hongtao Zhang, Oakland Gardens, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20100035912 | Small Molecule Inhibitors of Retroviral Assembly and Maturation - Chemical compounds that disrupt retroviral assembly and maturation are presented herein. More particularly, this disclosure provides small molecule compounds that disrupt the formation and maturation of virus particles and methods of using such small molecules to treat HIV-1 infection. | 02-11-2010 |
Hongtao Zhang, Beijing CN
| Patent application number | Description | Published |
|---|---|---|
| 20100015619 | METHOD OF DETECTING GENOMIC ABERRATIONS FOR PRENATAL DIAGNOSIS - This invention relates to assays used to detect and confirm genomic aberrations, such as chromosomes 13, 18, 21, X and Y aneuploidy as well as 22q11.2 deletions, for prenatal diagnosis. For the detection, combined STR markers (all tetra-nucleotide repeats) are employed to cover different chromosome regions. For the confirmation step, individual chromosome specific STR markers (tetra-nucleotide repeats) are utilized. This invention particularly relates to multiplex analysis for the presence or absence of STR markers in genomic DNA isolated from peripheral blood, amniotic fluid, cultured amniocytes, chorionic villi, or fetal cells existing in maternal blood. This invention offers an efficient approach to identify chromosomal abnormalities by using STR markers. | 01-21-2010 |
Hongtao Zhang, Mt.vernon, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090281041 | ANTIVIRAL CELL-PENETRATING PEPTIDES - Disclosed herein are cell penetrating peptides useful as treatment for Human Immunodeficiency Virus. | 11-12-2009 |
Hongtao Zhang, Mason, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20080271457 | Cooling Holes For Gas Turbine Combustor Having A Non-Uniform Diameter Therethrough - A gas turbine combustor liner, including a shell having a first end adjacent to an upstream end of the combustor and a second end adjacent to a downstream end of the combustor, where the shell also has a hot side, a cold side, and a centerline axis therethrough. A plurality of small, closely-spaced film cooling holes are formed in the shell through which air flows for providing a cooling film along the hot side of the shell. Each cooling hole has a non-uniform diameter as it extends through the shell. In particular, each cooling hole includes a first opening located at the cold side of the shell having a first diameter and a second opening located at the hot side of the shell having a second diameter, wherein the second diameter of the second opening is larger than the first diameter of the first opening. It is preferred that the shape of each cooling hole be substantially frusto-conical. | 11-06-2008 |
Hongtao Zhang, Devon, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20080206136 | Binding Peptidomimetics and Uses of the Same - A multimeric peptidomimetic that comprises two or more monomers is disclosed. The monomers comprise an exocyclic peptide comprising a ring structure, a flexible linker sequence and a multimeric motif. Use of the monomers, a nucleic acid molecule encoding monomers, recombinant expression vectors comprising the nucleic acid molecule and host cells comprising a recombinant expression vector are disclosed. Methods of delivering a drug, a toxin, a nucleic acid molecule, a radionuclide or a detectable compound to a cell are disclosed. | 08-28-2008 |