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Hong Zhu
Hong Zhu, Shanghai CN
| Patent application number | Description | Published |
|---|---|---|
| 20080234287 | SULFUR-CONTAINING NAPHTHALIMIDE DERIVATIVES - The invention discloses novel sulfur-containing naphthalimide derivatives, and the preparation and uses thereof. The conjugated plane of naphthalimide derivatives of the invention is enlarged by incorporating 5- or 6-membered heteroaromatic ring and/or introducing S heteroatom, thus increasing the anti-tumor activity of naphthalimide. The compounds of the invention displays significant inhibiting activities to the proliferation of various tumor cells such as human lung cancer, gastric cancer, liver cancer, leucocythemia and the like. The inhibition of cell proliferation is dose-dependent. | 09-25-2008 |
| 20100165165 | METHOD AND DEVICE FOR A CMOS IMAGE SENSOR - A method for determining photocurrents corresponding to a plurality of wavelength ranges. The method includes receiving at least a light by a photodiode within a first wavelength range. The first wavelength range includes a second wavelength range and a third wavelength range. The method provides a first bias voltage to the photodiode and determines a first photocurrent within the first wavelength range, the first photocurrent being associated with the photodiode and the first bias voltage. The method also provides a second bias voltage to the photodiode, different from the first bias voltage, and determines a second photocurrent within the first wavelength range, the second photocurrent being associated with the photodiode and the second bias voltage. The method further includes processing information associated with the first and second photocurrents, and determining at least a third photocurrent corresponding to the second wavelength range and a fourth photocurrent corresponding to the third wavelength range. | 07-01-2010 |
| 20100197066 | METHOD OF INTERCONNECT FOR IMAGE SENSOR - A method for fabricating CMOS image sensor device, the method includes providing a semiconductor substrate having a P type impurity characteristic. The semiconductor substrate includes a surface region. The method forms a first dielectric layer having a first thickness overlying a first region of the semiconductor substrate. The method includes providing a N type impurity region in a portion of the semiconductor substrate underneath the first dielectric layer to cause formation of a photodiode device region characterized by at least the N type impurity region and the P type substrate. A second dielectric layer having a second thickness is formed in a second region of the surface region. The second dielectric layer is formed within a portion of the first region within the first thickness of the first dielectric layer. The method forms a polysilicon gate layer overlying at least the second region to form a contact member coupled to the second region. | 08-05-2010 |
| 20110069197 | SYSTEM AND METHOD FOR CMOS IMAGE SENSING - A system is provided for determining a color using a CMOS image sensor. The system includes an input port for receiving a user command. The system further includes an image sensor, an optical device that forms an image on the image sensor, and a processor. The image sensor includes an n-type substrate and a p-type epitaxy layer overlying the n-type substrate. The image sensor includes a control circuit that applies a first voltage on the n-type substrate to obtain a first output. The control circuit applies a second voltage on the n-type substrate to obtain a second output. The control circuit also applies a third voltage on the n-type substrate to obtain a third output. The p-type epitaxy layer includes a silicon germanium material. The image sensor additionally includes an epitaxy layer interposed between the n-type substrate and the p-type epitaxy layer. | 03-24-2011 |
| 20110070677 | SYSTEM AND METHOD FOR CMOS IMAGE SENSING - A method for forming a CMOS image sensing pixel, which is configured to determine a color, includes providing an n-type substrate that includes a first thickness and a first width. The method also includes forming a p-type layer, the p-type layer overlaying the n-type substrate. The p-type layer includes a second thickness and a second width. The second thickness and the second width are associated with a light characteristic. The method additionally includes forming an n-type layer, the n-type layer overlaying the p-type layer. The n-type layer includes a third thickness and a third width. In addition, the method includes forming a pn junction between the p-type layer and the n-type layer. The pn junction includes a fourth width. The method also includes providing a control circuit. The control circuit is electrically coupled to the n-type substrate. | 03-24-2011 |
| 20110149085 | SYSTEM AND METHOD FOR CMOS IMAGE SENSING - A method is provided for determining a color using a CMOS image sensor. The CMOS image sensor includes an n-type substrate and a p-type epitaxy layer overlying the n-type substrate. The method includes applying a first voltage on the n-type substrate and obtaining a first output, which is associated with the first voltage. The method further includes applying a second voltage on the n-type substrate and obtaining a second output, which is associated with the second voltage. The method additionally includes applying a third voltage on the n-type substrate and obtaining a third output, which is associated with the third voltage. The method also includes providing a plurality of weighting factors and determining the color based on the plurality of weighting factors, the first output, the second output, and the third output. | 06-23-2011 |
Hong Zhu, Lansdale, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100197688 | EPHA4 RTK INHIBITORS FOR TREATMENT OF NEUROLOGICAL AND NEURODEGENERATIVE DISORDERS AND CANCER - The present invention is directed to compounds of generic formula (I) | 08-05-2010 |
| 20110034483 | 2-AMINOIMIDAZOLE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE - The present invention is directed to 2-aminoimidazole compounds of formula (I) | 02-10-2011 |
Hong Zhu, Tianjin CN
| Patent application number | Description | Published |
|---|---|---|
| 20080283980 | LEAD FRAME FOR SEMICONDUCTOR PACKAGE - A lead frame ( | 11-20-2008 |
| 20100283135 | LEAD FRAME FOR SEMICONDUCTOR DEVICE - A lead frame including a lead frame structure having a die support area and a plurality of electrical contact areas has shallow recesses formed on a surface of the lead frame structure. | 11-11-2010 |
Hong Zhu, Blacksburg, VA US
| Patent application number | Description | Published |
|---|---|---|
| 20100261783 | CRUCIFEROUS 3H-1,2-DITHIOLE-3-THIONE (D3T) AND METHODS OF PROTECTING AGAINST CELL INJURY - Astrocytes possess important roles in maintaining normal brain function and providing trophic support to the neurons. They also suffer a range of toxic insults, being a chief target of prooxidants such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 1-methyl-4-phenylpyridinium (MPP+), 6-hydroxydopamine (6-OHDA), 4-hydroxy-2-nonenal (HNE), and acrolein. Recently, we have observed that the cellular antioxidants and phase 2 enzymes can be upregulated by 3H-1,2-dithiole-3-thione (D3T), a nutraceutical found in cruciferous vegetables, against many prooxidants in human neuroblastoma cell lines (SH-SY5Y). However, the regulation of the above cellular factors by D3T in astrocytes and their role in ameliorating the neurotoxic effects of the above neurotoxins have not been investigated. In this study, we show that incubation of human primary astrocytes with micromolar concentrations (5-100 IM) of D3T for 24 h resulted in significant increases in the levels of reduced glutathione (GSH), glutathione reductase (GR), and the phase 2 enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1). D3T treatment also caused time-dependent increases in mRNA expression of the gamma-glutamylcysteine ligase catalytic subunit (GCLC), GR, and of NQO1 in these cells. Pretreatment of astrocytes with D3T was found to afford remarkable protection against the neurocytotoxicity elicited by MPTP, MPP+, 6-OHDA, HNE and acrolein. Taken together, this study demonstrates for the first time that in human astrocytes, the cruciferous nutraceutical D3T potently induces the cellular GSH system and the phase 2 enzyme NQO1, which is accompanied by dramatically increased resistance of these cells to the damage induced by various neurotoxicants. The results of this study may have important implications for the development of novel neuroprotective strategies. | 10-14-2010 |
Hong Zhu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100233741 | IMMUNO-BASED RETARGETED ENDOPEPTIDASE ACTIVITY ASSAYS - The present specification discloses SNAP-25 immune response inducing compositions, methods of making α-SNAP-25 antibodies that selectively binds to an epitope comprising a SNAP-25 having a carboxyl-terminus at the P | 09-16-2010 |
| 20100233802 | CELLS USEFUL FOR IMMUNO-BASED BOTULINUM TOXIN SEROTYPE A ACTIVITY ASSAYS - The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines. | 09-16-2010 |
Hong Zhu, Bloomington, MN US
| Patent application number | Description | Published |
|---|---|---|
| 20100027400 | MOTION LIMITING COVER FOR DATA STORAGE DEVICE - Disclosed herein are embodiments of motion limiting cover features that improve coil/VCM coupled resonance. The features are flexible in that their position and configuration can be customized to specifically target a certain type of undesirable motion, such as undesirable twisting (i.e., torsion) and/or bending. | 02-04-2010 |
| 20100142095 | HEAD SUSPENSION ASSEMBLY INTERCONNECT FOR A DATA STORAGE DEVICE - Interconnections for attaching a suspension assembly to an arm of an actuator or positioning device are disclosed. In illustrated embodiments, the interconnection includes one or more weld connections formed along opposed side seams of overlapping portions of the arm and head suspension assembly. In illustrated embodiments, the weld connections are formed along side surfaces generally transverse to upper and lower surfaces of the arm. In another embodiment, a groove pattern is formed, for example via a laser etching process, in an overlapping portion of the head suspension assembly or arm and an epoxy is inlayed in the groove to connect the head suspension assembly and arm. Illustrated embodiments also include multiple connections including, for example, a swage connection and a weld or other connection. | 06-10-2010 |
| 20100195243 | Variable Spindle Speed Control for Data Storage Devices - In a particular embodiment, a system is disclosed that includes a solid-state data storage medium, a disc data storage medium, and a controller adapted to selectively adjust a spindle speed associated with the disc data storage medium and a buffer size associated with the solid-state data storage medium responsive to a trigger. | 08-05-2010 |
Hong Zhu, San Jose, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100198813 | SYSTEMS AND METHODS FOR A SEARCH ENGINE RESULTS PAGE RESEARCH ASSISTANT - The present invention is directed towards systems and methods for performing search engine research. The method according to one embodiment of the present invention comprises receiving a search query from a user and determining if a user is performing research. The method then generates a research set associated with the research and stores at least one query with the research. The method then provides a search engine results page in response to the query, monitors the search engine results page for user interactions and stores at least one user interact with said search engine results page. | 08-05-2010 |
Hong Zhu, Katy, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20090296270 | THERMAL FLYHEIGHT CONTROL HEATER PRECONDITIONING - Systems and methods for magnetic head preconditioning using a thermal flyheight control heater are discussed. The method of manufacturing the magnetic head comprises measuring a bit error performance of the magnetic head, heating the magnetic head with the thermal flyheight control heater, measuring another bit error rate performance, and determining a performance increase based on comparing the bit error rate performances. The heating of the magnetic head is performed while the magnetic head is unloaded from a disk. An element within the magnetic head is deformed plastically. | 12-03-2009 |
Hong Zhu, Mountain View, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090029188 | METHOD FOR EARLY DETECTION OF MAGNETIC HEAD DEGRADATION DUE TO CARBON OVERCOAT WEAR - A method for detecting an impending failure of a disk drive system. The method includes monitoring a signal from a magnetoresistive sensor for the presence of a negative signal spike. A negative signal spike can indicate that the carbon overcoat of the magnetic medium has been locally worn off. The resulting localized absence of carbon overcoat causes the magnetoresistive sensor to short to the magnetic medium. This causes a short, abrupt drop in voltage, which can be used as evidence of the localized absence of the carbon overcoat. If such a negative signal spike is detected, the user can be notified of an impending system failure. In addition to, or in lieu of, notifying the user of the impending system failure, the system can be automatically de-activated to prevent data loss and/or further damage to the recording system. | 01-29-2009 |
| 20090168262 | Magnetic head design having reduced susceptibility to electrostatic discharge from media surfaces - Methods and structures for the fabrication of a thin film, longitudinal and perpendicular recording heads are disclosed. The heads comprise a plurality of embedded static dissipative layers that extend a few nanometers from the air bearing surface. These extended layers are first to contact the magnetic media surface and drain any electric charge buildup before a damaging discharge occurs with read or write head components. The embedded static dissipative layers are particularly useful for use in heads utilizing thermal fly height control systems, which tend to increase the probability of damaging electrical discharge through critical head components. | 07-02-2009 |
Hong Zhu, Shanghaishanghai CN
| Patent application number | Description | Published |
|---|---|---|
| 20090152604 | System and method for sensing image on CMOS - A system and method for sensing image on CMOS. According to an embodiment, the present invention provide a CMOS image sensing pixel. The pixel includes an n-type substrate, which includes a first width and a first thickness. The pixel also includes a p-type epitaxy layer overlying the n-type substrate. The p-type epitaxy layer includes a second width and a second thickness. The second width is associated with one or more characteristics of a colored light. The pixel additionally includes an n-type layer overlying the p-type epitaxy layer. The n-type layer is associated with a third width and a third thickness. Additionally, the pixel includes an pn junction formed between the p-type epitaxy layer and the n-type layer. Moreover, the pixel includes a control circuit being coupled to the CMOS image sensing pixel. | 06-18-2009 |
Hong Zhu, West Sacramento, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110112185 | INSECTICIDAL FERMENTATION BROTH FROM ACTINOMYCETES - Methods and compositions are provided for the preparation of insecticidal compositions. | 05-12-2011 |
Hong Zhu, Nanjing City CN
| Patent application number | Description | Published |
|---|---|---|
| 20110177153 | TARGETED NANOPARTICLE DRUG FOR MAGNETIC HYPERTHERMIA TREATMENT ON MALIGNANT TUMORS - The present invention relates to a targeted magnetic nanoparticle drug and the preparation method thereof. The targeted magnetic nanoparticle drug comprises an effector molecule and a guidance molecule in a weight ratio of 1:0.0001-0.20. The aforesaid effector molecule is a magnetic particle, with a particle size of not more than 1000 nm and a specific adsorption rate (SAR) of 10-7000 W/gFe. The aforesaid guidance molecule comprises an antibody, a ligand or a magnetic particle. The particle size of the aforesaid targeted drug is 2-1000 nm. The targeted magnetic nanoparticle drug is prepared by coupling a magnetic particle and a guidance molecule in a weight ratio of 1:0.0001-0.20 in water, organic or inorganic substance or the mixed solution thereof. The resultant targeted magnetic nanoparticle drug can realize targeted magnetic hyperthermia treatment and targeted magnetic thermoablation treatment and prevention on the tumors, and effectively kill the cancer cells, and cure the malignant tumors. | 07-21-2011 |