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Hong Shen

Hong Shen, West Windsor, NJ US

Patent application numberDescriptionPublished
20090042926Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment - The present invention encompasses compounds of Formula (I): as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.02-12-2009
20090170891Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment - The present invention encompasses compounds of Formula I:07-02-2009
20090258862Niacin receptor agonists, compositions containing such compounds and methods of treatment - Compounds of the formula (I): as well as pharmaceutically acceptable salts and solvates are disclosed. The compounds are useful for treating dyslipidemias, and in particular, reducing serum LDL, VLDL and triglycerides, and raising HDL levels. Pharmaceutical compositions and methods of treatment are also included.10-15-2009
20100144778Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment - The present invention encompasses compounds of Formula (I): as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.06-10-2010
20100197691SOLUBLE EPOXIDE HYDROLASE INHIBITORS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT - Compounds of the Formula: (I) as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating hypertension, diabetes, inflammation, atherosclerosis, pain, and the like are disclosed. Pharmaceutical compositions and methods of use are also included.08-05-2010
20110003849SOLUBLE EPOXIDE HYDROLASE INHIBITORS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT - Compounds of the formula: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating diabetes, inflammation, atherosclerosis, hypertension, pain and the like are disclosed. Pharmaceutical compositions and methods of use are also included.01-06-2011

Patent applications by Hong Shen, West Windsor, NJ US

Hong Shen, San Diego, CA US

Patent application numberDescriptionPublished
20090088560Process for Nucleic Acid Purification - This invention provides a method of isolating and purifying nucleic acid using a binding buffer comprising a sodium- or potassium-ion-containing solution with the final concentrations of either sodium- or potassium-ion concentration of at least about 500 mM, preferably greater than about 1 M to saturate, and the pH of such solution of being adjusted in the range of about 2.0 to 5.0, for reversible binding of the nucleic acid to a silicon-containing matrix. The invention further provides a method of increasing reversible binding of the nucleic acid to a silicon-containing matrix using the binding buffer of the invention in addition to 20% to 50% (v/v) of a water-soluble organic solvent, e.g., ethanol. Nucleic acid obtained thereof that is free of chaotropes and other toxic chemicals, and nucleic acid purification kits comprising the binding buffer of the invention are also provided.04-02-2009
20100105656TRIAZOLOPYRAZINE DERIVATIVES - The invention relates to compounds of the formula I04-29-2010
20100324061ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS - Enantiomerically pure compound of formula 112-23-2010

Patent applications by Hong Shen, San Diego, CA US

Hong Shen, Plainsboro, NJ US

Patent application numberDescriptionPublished
20080285830Computer Aided Lesion Assessment in Dynamic Contrast Enhanced Breast MRI Images - A method for performing computer-assisted lesion assessment includes acquiring contrast enhanced MRI data. A region of interest is identified. Kinetic properties, morphological properties and pattern of enhancement are determined for the identified region of interest. A score is calculated for each of the kinetic properties, morphological properties, pattern of enhancement. A cumulative score is calculated for the identified region of interest. The scores are provided to a medical practitioner to assist in diagnosing the identified region of interest.11-20-2008
20080287796Method and system for spine visualization in 3D medical images - A method and system for visualizing the spine in 3D medical images is disclosed. A spinal cord centerline is automatically determined in a 3D medical image volume, such as a CT volume. A reformatted image volume is then generated based on the spinal cord centerline. The reformatted image volume can be a straightened spine volume or a Multi-planar Reconstruction (MPR) based volume that follows the natural curve of the spine. The reconstructed volume can be displayed as 2D slices or 3D volume renderings.11-20-2008
20090041328Feature Processing For Lung Nodules In Computer Assisted Diagnosis - Feature processing is provided for lung nodules in computer-assisted diagnosis. A feature that may better distinguish nodules from background is extracted using a Hough transform. Rather than relying on a specific boundary shape, the Hough transform accumulates evidence associated with a region, such as a ring region. The accumulated evidence provides a feature score without requiring a nodule to fit a specific shape. In another approach, a background level is determined from extracted features. Rather than attempting to normalize an image prior to extraction, the features are normalized. The feature normalization and generalized Hough transform extraction may be used together or alone.02-12-2009
20090087072Method and system for diaphragm segmentation in chest X-ray radiographs - A method and system for segmenting diaphragm regions in a chest X-ray radiograph is disclosed. The diaphragm regions are segmented based on left and right lung lobe regions and a heart region in the chest X-ray radiograph. A right diaphragm region is segmented in the chest X-ray radiograph based a boundary of the right lung lobe. A left diaphragm region is segmented in the chest X-ray radiograph based on the heart region and a boundary of the left lung lobe.04-02-2009
20090103797Method and system for nodule feature extraction using background contextual information in chest x-ray images - A method and system for nodule feature extract using background contextual information in chest x-ray images is disclosed. In order to detect false positives in nodule candidates for a chest x-ray image, background contextual information, such as contextual vessel tree information, is defined in the chest x-ray image. Features are extracted for each nodule candidate based on the background contextual information, and the extracted features are used to detect whether each nodule candidate is a false positive or a genuine nodule.04-23-2009
20090116737Machine Learning For Tissue Labeling Segmentation - A method for directed machine learning includes receiving features including intensity data and location data of an image, condensing the intensity data and the location data into a feature vector, processing the feature vector by a plurality of classifiers, each classifier trained for a respective trained class among a plurality of classes, outputting, from each classifier, a probability of the feature vector belong to the respective trained class, and assigning the feature vector a label according to the probabilities of the classifiers, wherein the assignment produces a segmentation of the image.05-07-2009

Patent applications by Hong Shen, Plainsboro, NJ US

Hong Shen, Belle Mead, NJ US

Patent application numberDescriptionPublished
20110112155METHODS FOR TREATING CANCER IN PATIENTS HAVING BREAST CANCER RESISTANCE PROTEIN OVEREXPRESSION - A method for treating cancer comprising identifying a mammal that overexpresses breast cancer resistance protein; and administering to said mammal a pharmaceutical composition comprising a therapeutically effective amount of ixabepilone. In one aspect, the mammal is not administered an agent that is susceptible to breast cancer resistance protein overexpression resistance. In another aspect, the cancer is breast and/or lung cancer.05-12-2011

Hong Shen, Camarillo, CA US

Patent application numberDescriptionPublished
20110186966GAAS INTEGRATED CIRCUIT DEVICE AND METHOD OF ATTACHING SAME - A gallium arsenide (GaAs) integrated circuit device is provided. The GaAs circuit device has a GaAs substrate with a copper contact layer for making electrical ground contact with a pad of a target device. Although copper is known to detrimentally affect GaAs devices, the copper contact layer is isolated from the GaAs substrate using a barrier layer. The barrier layer may be, for example, a layer of nickel vanadium (NiV). This nickel vanadium (NiV) barrier protects the gallium arsenide substrate from the diffusion effects of the copper contact layer. An organic solder preservative may coat the exposed copper to reduce oxidation effects. In some cases, a gold or copper seed layer may be deposited on the GaAs substrate prior to depositing the copper contact layer.08-04-2011

Hong Shen, Shangai CN

Patent application numberDescriptionPublished
20120008199Structure of the Waterproof Tabletop for the Touch Panel - The present invention discloses a structure of the waterproof tabletop for the touch panel, which includes: a tempered glass which is formed together containing an imaging part and a non-imaging part which are formed integrally; a film configured under the tempered glass corresponding to the imaging part and adhered to the tempered glass to form a projection screen; and a bracket configured under the tempered glass and adhered to the tempered glass to support the tempered glass.01-12-2012

Hong Shen, Troyes Cedex FR

Patent application numberDescriptionPublished
20120121870Multilayer structure comprising a precious metal stuck onto a dielectric substrate, and an associated method and use - The invention provides a multilayer structure comprising a dielectric substrate; a sticking layer that extends over a first face of the dielectric substrate; at least one layer of precious metal placed on the sticking layer, said sticking layer comprising a derivative of an alkylsilane, the layer of precious metal being applied by evaporation or by sputtering said precious metal.05-17-2012