Hommes
Daan Hommes, Los Angeles, CA US
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20150126553 | BICYCLIC HETEROCYCLES CAPABLE OF MODULATING T-CELL RESPONSES, AND METHODS OF USING SAME - The present disclosure is directed in part to bicyclic heterocycles, such as a compound represented by formula (I) or (II) as disclosed herein, and their use in treating medical disorders, such as immune inflammatory disorders such as Crohn's disease, ulcerative colitis, rheumatic disorders, psoriasis, and allergies. The compounds are contemplated to modulate T-Cell responses. | 05-07-2015 |
Daniel J. Hommes, Shelby Township, MI US
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20080223347 | ENGINE PCV SYSTEM WITH HYDROPHOBIC, OLEOPHOBIC MEMBRANE FOR AIR/OIL SEPARATION - An engine crankcase emission control system for an internal combustion engine includes a cylinder air intake system connected to associated engine cylinders. The system also includes an engine crankcase. A crankcase air outlet connects the crankcase to the cylinder air intake system at a location subject to variable intake vacuum pressures to allow crankcase vapors to be drawn into inlet air passing to the cylinders. A hydrophobic, oleophobic membrane covers the crankcase air outlet. The membrane inhibits the passage of oil and water out of the crankcase through the crankcase air outlet. | 09-18-2008 |
20080314572 | LUBRICATION SYSTEM AND OIL COOLER WITH BYPASS - An oil cooler for an engine or other lubricated mechanism includes a connector through which the oil cooler is connected to an oil supply passage and a return oil passage in an engine crankcase or other supply source. The connector includes a seal face to which inlet and outlet passages from the cooler are connected with oil supply and return passages in a connected mechanism. A continually open oil bypass is provided by forming a groove or slot in the seal face of the oil cooler extending between the inlet and outlet passages of the oil cooler and forming the cooler oil bypass. Alternatively, a bypass may be formed by a slot in a mating engine or mechanism connector connecting with the supply and return oil passages. Using a perimeter gasket between mating connectors can increase the bypass oil flow by the area of the clearance within the gasket opening created by the thickness of the gasket. | 12-25-2008 |
Daniel J. Hommes, Eden, NY US
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20090242331 | Reserve dry sump oil tank assembly for a motor vehicle - A dry sump oil tank assembly is provided for a vehicle. The dry sump oil tank assembly includes a main oil tank that defines a main outlet aperture. A reserve oil tank defines a reserve outlet aperture. An oil transfer tube connects the main oil tank at the main outlet aperture to the reserve oil tank at the reserve outlet aperture. The reserve oil tank is shaped to fit between a frame rail and a fender of the vehicle. | 10-01-2009 |
Daniel J. Hommes, Metamora, MI US
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20120124994 | Composite Centrifugal Compressor Wheel - A centrifugal compressor wheel for a turbocharger is disclosed. The wheel includes an axially extending hub having an inlet end, an outlet end, an arcuate outer surface and a shaft bore. The wheel also includes a blade array disposed on the outer surface of the hub, the blade array comprising a plurality of circumferentially-spaced, radially and axially extending, arcuate centrifugal impeller blades disposed thereon; the hub and the blade array comprising a non-woven, discontinuous-fiber-filled, polymer matrix composite material. | 05-24-2012 |
20130319380 | INTEGRATED INTAKE MANIFOLD AND COMPRESSOR - An induction system for an internal combustion engine having at least one cylinder includes a centrifugal compressor configured to pressurize an airflow being received from the ambient. The induction system also includes an intake manifold configured to channel the pressurized airflow to the at least one cylinder. The centrifugal compressor is disposed within and integral to the intake manifold. An internal combustion engine employing such an induction system is also disclosed. | 12-05-2013 |
20140290629 | ENGINE ASSEMBLY - An engine assembly generally includes an engine and an intake manifold. The engine includes a plurality of cylinders. The plurality of cylinders includes a pair of cylinders. The engine is configured to sequentially fire the pair of cylinders. The intake manifold defines a plurality of ports. Each port is in fluid communication with one of the plurality of cylinders. The plurality of ports includes a pair of ports. Each of the pair of ports is disposed in fluid communication with one of the pair of cylinders. The intake manifold further includes a baffle disposed between the pair of ports to restrict fluid flow within the intake manifold between the pair of ports. | 10-02-2014 |
Daniel W. Hommes, Los Angeles, CA US
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20160140303 | VALUE-BASED HEALTH CARE MANAGEMENT SYSTEMS AND METHODS - A system and method are disclosed for management of patient care and research using a combination of value-based methodology and translational research methodology. The system includes software to generate a single outcome measurement, or “Value-Quotient (VQ)” expressing a delivered health value and the associated costs. The software may also include a user interface to generate and manage coordinated care pathways (i.e. tight control scenarios) aimed at complication prevention and disease control. The software also may include functionality for direct task differentiation for provider teams, shifting work load from physicians to trained nurses and administration. | 05-19-2016 |
Gregor Hommes, Weil Am Rhein DE
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20150361416 | METHOD OF PRODUCING NANOBIOCATALYSTS - A method of producing nanobiocatalysts includes: suspending a support material in a liquid medium; functionalizing a surface of the support material by mixing the suspended support material with a functionalizer for a first predefined time at a first predefined temperature, wherein a first broth results; applying a protein directly in the first broth after the first predefined time; mixing the protein with the first broth and incubating the protein for a second predefined time at a second predefined temperature, wherein a second broth results; immobilizing the incubated protein onto the functionalized surface of the support material, wherein a third broth results; filtering the third broth; and gathering a retentate of the filtering. By directly processing the first and second broths allows for providing a continuous process and production of the nanobiocatalysts, which can be optimized regarding time, water, chemical and energy consumption. Also, problems related to thixotrophy can be minimized. | 12-17-2015 |
Martin Hommes, Drachten NL
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20090218011 | METHOD FOR MANUFACTURING A STAINLESS STEEL PRODUCT - The invention relates to a method for making a thin finished product to be formed by deformation that combines strength with resistance to a highly corrosive environment. The method comprises forming a sheet of stainless steel with a microstructure consisting predominantly of ferrite, austenite, martensite or a mixture thereof, with a thickness of less than 3 mm, to a three dimensional semi finished product, treating said semi finished product with a nitrogen-containing atmosphere at a temperature of between 1000° C. and 1200° C. during a time and under a nitrogen pressure, sufficient to saturate the product through the thickness with a nitrogen content between a lower limit of 0.3 wt % and an upper limit that is provided by the beginning of nitride separation, cooling down said product at such a rate and nitrogen pressure that nitride separation is avoided, and subsequently machining the nitrogen saturated semi- finished product to the finished product. The invention further relates to a rotary shaving assembly prepared by the method of the invention. | 09-03-2009 |
Martin Hommes, Eindhoven NL
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20100011629 | DEVICE FOR SUPPLYING SUPERHEATED WATER | 01-21-2010 |
Ronaldus Hommes, Haarlem NL
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20130143301 | BETA-GLUCOSIDASE I VARIANTS WITH IMPROVED PROPERTIES - The present disclosure is generally directed to enzymes and in particular beta-glucosidase variants. Also described are nucleic acids encoding beta-glucosidase variants, compositions comprising beta-glucosidase variants, methods of using beta-glucosidase variants, and methods of identifying additional useful beta-glucosidase variants. | 06-06-2013 |
Ronaldus Wilhelmus Hommes, Haarlem NL
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20140302585 | CELLULASE VARIANTS WITH IMPROVED EXPRESSION, ACTIVITY AND STABILITY, AND USE THEREOF - The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof. | 10-09-2014 |
20150315560 | VARIANTS OF CELLOBIOHYDROLASES - Disclosed are a number of homologs and variants of | 11-05-2015 |
20160122734 | VARIANTS OF CELLOBIOHYDROLASES - Disclosed are a number of homologs and variants of | 05-05-2016 |
20160122735 | VARIANTS OF CELLOBIOHYDROLASES - Disclosed are a number of homologs and variants of | 05-05-2016 |
Ronaldus W.j. Hommes, Leiden NL
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20110251116 | MULTIPLE MUTATION VARIANTS OF SERINE PROTEASE - The present invention provides novel | 10-13-2011 |
20140005094 | MULTIPLE MUTATION VARIANTS OF SERINE PROTEASE | 01-02-2014 |
Ronaldus W.j. Hommes, Haarlem NL
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20080293610 | Use and production of storage-stable neutral metalloprotease - The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved storage stability. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions comprising neutral metalloprotease(s) obtained from | 11-27-2008 |
20120009651 | Production of Thermolysin and Variants Thereof and Use In Liquid Detergents - The present invention provides methods and compositions comprising at least one thermolysin-like neutral protease enzyme with improved storage stability and/or catalytic activity. In some embodiments, the thermolysin finds use in cleaning and other applications comprising detergent. In some particularly preferred embodiments, the present invention provides methods and compositions comprising thermolysin formulated and/or engineered to resist detergent-induced inactivation. | 01-12-2012 |
20120135500 | CELLULASE VARIANTS WITH IMPROVED EXPRESSION, ACTIVITY AND STABILITY, AND USE THEREOF - The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof. | 05-31-2012 |
20140099698 | THERMOLYSIN VARIANTS AND DETERGENT COMPOSITIONS THEREWITH - The present invention provides methods and compositions comprising at least one thermolysin-like neutral protease enzyme with improved storage stability and/or catalytic activity. In some embodiments, the thermolysin finds use in cleaning and other applications comprising detergent. In some particularly preferred embodiments, the present invention provides methods and compositions comprising thermolysin formulated and/or engineered to resist detergent-induced inactivation. | 04-10-2014 |
20140134708 | USE AND PRODUCTION OF STORAGE-STABLE NEUTRAL METALLOPROTEASE - The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved storage stability. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions comprising neutral metalloprotease(s) obtained from | 05-15-2014 |
20140315775 | USE AND PRODUCTION OF CITRATE-STABLE NEUTRAL METALLOPROTEASES - The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved stability in the presence of a metal chelator. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications comprising citrate. In some particularly preferred embodiments, the present invention provides methods and compositions comprising variant neutral metalloprotease(s) engineered to resist citrate-induced autolysis. | 10-23-2014 |
20150072913 | Multiple Mutation Variants of Serine Protease - The present invention provides novel Micrococcineae spp serine proteases having multiple substitutions. In particular, the present invention provides serine proteases having multiple substitutions, DNA encoding these proteases, vectors comprising the DNA encoding the proteases, host cells transformed with the vector DNA, and enzymes produced by the host cells. The present invention also provides cleaning compositions (e.g., detergent compositions), animal feed compositions, and textile and leather processing compositions comprising these serine protease variants. In particularly preferred embodiments, the present invention provides mutant (i.e., variant) proteases derived from the wild-type proteases described herein. These variant proteases also find use in numerous applications. | 03-12-2015 |
20160032266 | PRODUCTION OF THERMOLYSIN AND VARIANTS THEREOF AND USE IN LIQUID DETERGENTS - The present invention provides methods and compositions comprising at least one thermolysin-like neutral protease enzyme with improved storage stability and/or catalytic activity. In some embodiments, the thermolysin finds use in cleaning and other applications comprising detergent. In some particularly preferred embodiments, the present invention provides methods and compositions comprising thermolysin formulated and/or engineered to resist detergent-induced inactivation. | 02-04-2016 |
Ronaldus W. J. Hommes, Haarlem NL
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20090263882 | Thermostable Neutral Metalloproteases - The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved storage stability. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions comprising neutral metalloprotease(s) obtained from | 10-22-2009 |
20110081454 | USE AND PRODUCTION OF CITRATE-STABLE NEUTRAL METALLOPROTEASES - The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved stability in the presence of a metal chelator. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications comprising citrate. In some particularly preferred embodiments, the present invention provides methods and compositions comprising variant neutral metalloprotease(s) engineered to resist citrate-induced autolysis. | 04-07-2011 |
Ronald W. J. Hommes, Haarlem NL
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20120107907 | THERMOSTABLE NEUTRAL METALLOPROTEASES - The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved storage stability. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions comprising neutral metalloprotease(s) obtained from | 05-03-2012 |
Vanja Hommes, Assen NL
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20120095534 | ILLUMINATION DEVICE AND METHOD FOR REDUCING SLEEP INERTIA OR CONTROLLING ALERTNESS - The invention relates to a method and an illumination device arranged for reducing sleep inertia and/or for controlling alertness of a human being. The illumination device is arranged for reducing sleep inertia and/or controlling alertness by light radiation. The illumination device comprises one or more light sources for generating a first illumination output and a second illumination output. The first illumination output comprises light with a dominant wavelength in the range of 590-770 nm. The second illumination output comprises light with a dominant wavelength in the range of 400-560 nm Thus, colored light is used. Alternatively, the first illumination output comprises white light with a color temperature below 4100 K, i.e. warm white light. The second color temperature then comprises white light with a color temperature above 4900 K. The illumination device comprises a controller configured for controlling the one or more light sources to expose said eye of said human being to the first illumination output during a first time interval and to the second illumination output during a second time interval. The second time interval terminates at a later point in time than the first time interval. The time intervals are selected such that at least one of the first and second time interval is less than 60 seconds. | 04-19-2012 |
20140036642 | WAKE-UP APPLIANCE WITH SNOOZE FUNCTION - A wake-up appliance ( | 02-06-2014 |
20140354189 | DIMMABLE LUMINARY FEATURING COLOUR CHANGE DURING DIMMING - A wake-up lamp system ( | 12-04-2014 |
Vanja Hommes, Eindhoven NL
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20100277316 | LIGHTING DEVICE - The invention provides a lighting device ( | 11-04-2010 |