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Holgate
Eric Holgate, North Augusta, SC US
| Patent application number | Description | Published |
|---|---|---|
| 20100226968 | Topical agent for muscle treatment - A topical liposomal base delivery agent for physiologically enhancing muscle efficiency and relaxation, which combines the physiological effects of guaifenesin, magnesium, and methylsulfonylmethane. The resulting physiological reaction reduces muscle and joint soreness in the host. The present invention is an improvement over existing methods that deliver magnesium to muscle tissue. | 09-09-2010 |
Michael S. Holgate, Asheville, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20120123736 | SYSTEM FOR RAPID ASSESSMENT OF GRADE VARIATIONS AND METHOD FOR USING A SYSTEM - A system for estimating or calculating grade variations of a ground surface is provided that is convenient to use and provides data of sufficient precision for the estimating or calculating process. The system can be deployed for estimating or calculating grade variations in connection with the placement and installation of fences, gates, pools, drainage, steps, decks, patios, contour features, ponds, driveways, and other site improvements. In addition to a deployment of the system to quickly establish and/or verify elevations of outdoor features, the system can be deployed to quickly establish and/or verify elevations in a building structure for installing cabinets, countertops, or alternating current outlets. | 05-17-2012 |
Mike Holgate, Asheville, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20120083181 | FLYING DISC WITH PRINTABLE LAMINATE SURFACING - A flying disc for use in recreational activities and sports, such as for catch and throw, disc golf, and the like, is provided. The flying disc includes a disc body, the disc body including a circular central flight deck section and an annular rim connected thereto, and a laminate layer having a printable outer surface, the laminate layer bonded to and extending over at least a portion of the central flight deck section, wherein the central flight deck section optionally includes non-planar surfaces. The printable outer surface of the laminate layer has a predetermined roughness, and the disc body has a predetermined roughness greater than the predetermined roughness of the printable outer surface of the laminate layer, thereby providing improved aerodynamic features such as disc speed and lift. | 04-05-2012 |
Robert G. Holgate, Royston GB
| Patent application number | Description | Published |
|---|---|---|
| 20110008364 | ANTIBODIES TO TGF-BETA - The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGFβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb). | 01-13-2011 |
Robert George Edward Holgate, Cambridge GB
| Patent application number | Description | Published |
|---|---|---|
| 20100184959 | Polypeptide Variants - The present invention relates to methods for selecting, obtaining or producing Fc variant polypeptides which show altered recognition for an Fc ligand (e.g., FcγR, CIq). Additionally, the Fc variant polypeptides may have altered antibody-dependent cell-mediated cytotoxicity (ADCC) and/or complement dependent cytotoxicity (CDC) activity. The invention further provides methods and protocols for the application of said Fc variant polypeptides particularly for therapeutic purposes. | 07-22-2010 |
Stephen Holgate, Romsey GB
| Patent application number | Description | Published |
|---|---|---|
| 20090257980 | ANTI-VIRUS THERAPY FOR RESPIRATORY DISEASES - The present invention provides the use of IFN-β, an agent that increases the expression of IFN-β, or a polynucleotide which is capable of expressing IFN-β or said agent for the manufacture of a medicament for the treatment of rhinovirus-induced exacerbation of a respiratory disease selected from asthma and chronic obstructive pulmonary disease, wherein said treatment is by airway delivery of said medicament, e.g. by use of an aerosol nebuliser. Also provided is IFN-λ for the same purpose. | 10-15-2009 |