Holgate
Ben Calvin Holgate, Pearland, TX US
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20150267505 | Selector Valve for High Pressure Hydrocarbon Production Operations - An apparatus for directing a fluid from an inlet to one of a plurality of outlets that are associated with a wellhead assembly includes a block body having a block inlet and a plurality of block outlets. A selector plug is located within the block body, the selector plug having a plug inlet aligned with the block inlet along a central axis, a plug outlet at an angle relative to the central axis, and a plug bore extending from the plug inlet to the plug outlet. A stem member is moveable to selectively rotate the selector plug within the block body so that the plug outlet aligns with one of the plurality of block outlets, providing a fluid flow path from the block inlet to such one of the plurality of block outlets, and impeding fluid communication from the block inlet to the others of the plurality of block outlets. | 09-24-2015 |
Ben Calvin Holgate, Houston, TX US
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20150076377 | POWER BOOST ASSIST CLOSED DEVICE FOR ACTUATORS - An apparatus for assisting an actuator to close a valve has a cylindrical booster housing with a central axis. The booster housing includes an upward facing piston cavity and a downward facing lower cavity with internal threads for selectively coupling with external threads of a piston head of a valve actuator. A bulkhead is formed between the piston cavity and the lower cavity. The bulkhead has an opening for selectively accepting an actuator stem of the valve actuator therethrough. A booster piston is located within the piston cavity. The booster piston has a piston mounting means located on its bottom side for selectively securing a top end of the actuator stem of the valve actuator to the booster piston. The booster piston is moveable upwards in an axial direction to move the valve from a lower open position to an upper closed position. | 03-19-2015 |
20150204448 | Non-Welded Hardface Gate and Seats - A gate valve includes a valve body with a flow passage intersected by a gate cavity. The gate valve also includes a gate with a gate body. The gate body has a downstream gate body face, and an upstream gate body face on an opposite side of the gate body. A seat ring is located between each gate body face and the valve body, at the intersection of the flow passage and the gate cavity. Each seat ring has a seat ring face proximate to the gate. At least one removable insert is located between one of the seat ring faces and one of the gate body faces. The insert is removably coupled to one of the faces and formed of a material harder and more wear resistant as compared to the gate body and the seat ring. | 07-23-2015 |
20160097251 | Non-Parallel Multi-Bore Sealing Device - An apparatus for sealing at least one hub bore of a multi-bore fluid hub associated with a wellhead assembly includes a plug body having a plug bore opening on an outer mating surface. A plug bore extends from a first end of the plug body to the plug bore opening. The plug body is selectively insertable into a hub housing of the multi-bore fluid hub. An insert is in engagement with the outer mating surface and is moveable relative to the plug body between an unengaged position, and an engaged position where the insert seals across one of the hub bores. A stem member is coupled to the plug body and is moveable to selectively rotate the plug body within the multi-bore fluid hub so that the plug bore opening aligns with one of the hub bores and the insert aligns with another of the hub bores. | 04-07-2016 |
Carson L. Holgate, Palo Alto, CA US
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20150058787 | SWIPE TOOLBAR TO SWITCH TABS - Aspects of the subject technology relate to switching tabs in an application. A system is configured to provide for the display an application interface. The application interface includes a toolbar and content associated with a first tab from a plurality of tabs open in the application. The system is further configured to receive, via an input device, a swipe gesture on the toolbar in the application interface and switch, in response to the receiving of the swipe gesture, from displaying in the application interface the content associated with the first tab to displaying content associated with a second tab in the plurality of tabs. | 02-26-2015 |
Eric Holgate, North Augusta, SC US
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20100226968 | Topical agent for muscle treatment - A topical liposomal base delivery agent for physiologically enhancing muscle efficiency and relaxation, which combines the physiological effects of guaifenesin, magnesium, and methylsulfonylmethane. The resulting physiological reaction reduces muscle and joint soreness in the host. The present invention is an improvement over existing methods that deliver magnesium to muscle tissue. | 09-09-2010 |
Marc Holgate, Cambridgeshire GB
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20150269160 | METHOD FOR ORGANISING CONTENT - A content manager is described which offers a facility to a user to display, review and rate content items. Content items are assigned prioritization scores, influencing the manner in which those content items are organised. Prioritization scores are themselves determined on the basis of information inherent to a content item, such as the specification of the content item or associated descriptive data, and information provided by a user, such as by gestures or other input techniques, indicative of interest in that content item by that user. These prioritization scores are in turn used to rank content and reduce the memory, bandwidth, processing power and screen real estate used to present content to users. | 09-24-2015 |
Matthew A. Holgate, Chandler, AZ US
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20140074243 | Robotic Device and Method of Using a Parallel Mechanism - A parallel kinematically redundant device includes a base body portion and a movable portion. The movable portion includes first, second, and third joints. A first actuator is coupled to the first joint of the movable portion and to the base body portion. A second actuator is coupled in parallel with the first actuator between the second joint of the movable portion and the base body portion. A linking member is rotationally coupled to the third joint of the movable portion to provide an output for the first and second actuators. A housing is coupled to the base body portion and fits onto a user. A prosthetic joint device includes a base portion and a movable portion. An actuator is rotationally coupled to the movable portion and base portion. A compliant element is coupled in parallel with the actuator between the movable portion and base portion. | 03-13-2014 |
20140200680 | Control Systems and Methods for Gait Devices - A method of controlling a gait device includes a first sensor disposed on a first mobile body. A physical state of the first mobile body is measured using the first sensor to obtain a first physical state measurement. A second sensor is disposed on a second mobile body. A physical state of the second mobile body is measured using the second sensor to obtain a second physical state measurement. The first and second physical state measurements are conditioned by pseudo integration. A reference function is based on a gait activity. A reference function is determined by measuring a physical state of an able-bodied human and correlating an output position of the actuator to the physical state of the able-bodied human. A command is generated by inputting the first and second physical state measurements into the reference function to control an actuator of the gait device to match the output position. | 07-17-2014 |
20140200715 | Systems and Methods for Adding or Subtracting Energy to Body Motion - A phase oscillating device for affecting movement of a limb or a primary body includes a sensor coupled to the primary body. A physical state of the primary body is measured using the sensor. A phase angle of the primary body is determined based on the physical state measurement. The physical state measurement includes position, velocity, or acceleration. The phase angle of the primary body is filtered using a sine function. An actuator is coupled to the primary body. The actuator is triggered based on the phase angle of the primary body to provide a force or torque to assist or resist movement of the primary body. A secondary body is coupled to the primary body. The secondary body is oscillated using the actuator, which is triggered in phase with a gait step. Alternatively, a fan is coupled to the primary body and actuator to provide the oscillating force. | 07-17-2014 |
20160023350 | Gravitational Load Support System - A load support device has a first link assembly coupled to a load and a first foot of a user. A first damping element is coupled to the first link assembly. The first damping element includes a double acting piston configured to provide uni-directional damping. A first sensor is disposed on a first limb of the user. A physical characteristic of the first limb is measured with the first sensor. A damping constant of the first damping element is selected based on the physical characteristic of the first limb. A second link assembly is coupled to the load and to a second foot of the user. A second damping element is coupled to the second link assembly between the load and the second foot. The load is alternately supported by the first link assembly and damping element and the second link assembly and damping element throughout a gait cycle. | 01-28-2016 |
Matthew Aaron Holgate, Chandler, AZ US
Patent application number | Description | Published |
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20130118287 | ACTIVE COMPLIANT PARALLEL MECHANISM - An active compliant parallel device includes a movable body; a base body; and a plurality of linking members. The plurality of linking members are coupled to the movable body and the base body by a plurality of joints and include at least one compliant linking member, having a compliant element, and at least one actuating linking member, having an actuating element. The device may further include at least one damping linking member having a damping element and/or at least one passive linking member. The actuating, compliant, passive, and/or damping linking members are arranged in a parallel arrangement or structure such that each linking member makes a connection, using a connection element, such as a joint, with the base body and the movable body. The potential configurations of the device allow for movement and positioning of one or more unrestricted and externally loaded elements in space. | 05-16-2013 |
20130218295 | CONTROL SYSTEMS AND METHODS FOR GAIT DEVICES - Methods for controlling gait devices include measuring kinematic and/or loading states of limb or robotic segments; conditioning the resulting state measurement by any combination or order of integration, differentiation, filtering, and amplification; transforming conditioned state measurements by coordinate transformation; optionally conditioning the transformed state measurements a second time in a manner similar to the first conditioning step; and using the transformed or conditioned transformed state measurements as independent variables in a predetermined reference function to calculate a desired reference command for any number of actuators. | 08-22-2013 |
Michael S. Holgate, Asheville, NC US
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20120123736 | SYSTEM FOR RAPID ASSESSMENT OF GRADE VARIATIONS AND METHOD FOR USING A SYSTEM - A system for estimating or calculating grade variations of a ground surface is provided that is convenient to use and provides data of sufficient precision for the estimating or calculating process. The system can be deployed for estimating or calculating grade variations in connection with the placement and installation of fences, gates, pools, drainage, steps, decks, patios, contour features, ponds, driveways, and other site improvements. In addition to a deployment of the system to quickly establish and/or verify elevations of outdoor features, the system can be deployed to quickly establish and/or verify elevations in a building structure for installing cabinets, countertops, or alternating current outlets. | 05-17-2012 |
Mike Holgate, Asheville, NC US
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20120083181 | FLYING DISC WITH PRINTABLE LAMINATE SURFACING - A flying disc for use in recreational activities and sports, such as for catch and throw, disc golf, and the like, is provided. The flying disc includes a disc body, the disc body including a circular central flight deck section and an annular rim connected thereto, and a laminate layer having a printable outer surface, the laminate layer bonded to and extending over at least a portion of the central flight deck section, wherein the central flight deck section optionally includes non-planar surfaces. The printable outer surface of the laminate layer has a predetermined roughness, and the disc body has a predetermined roughness greater than the predetermined roughness of the printable outer surface of the laminate layer, thereby providing improved aerodynamic features such as disc speed and lift. | 04-05-2012 |
Robert Holgate, Flagstaff, AZ US
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20140330393 | Quasi-Active Prosthetic Joint System - A prosthetic joint device includes a foot portion and a main body pivotally coupled to the foot portion at a first joint. A first compliant member is coupled to the main body and foot portion. A first clutch is coupled to the first compliant member. An actuator is coupled to the first clutch to lock and unlock the first clutch and engage and disengage the first compliant member. A control system is coupled to the actuator to control the actuator based on a gait activity. | 11-06-2014 |
20140330431 | Joint Torque Augmentation System and Method for Gait Assistance - A joint torque augmentation system includes linkage assembly configured to couple to a user. Linkage assembly includes a unidirectional link and a device joint. The linkage assembly is worn by a user or is configured to couple to footwear. An actuator is coupled to the linkage assembly to provide a torque at a joint of the user. A sensor is coupled to the user to measure a position of the user. A control system is coupled to the sensor and actuator. A phase of gait for the user is determined by the control system based on the position measured by the sensor. The actuator produces a tension force on the linkage assembly during a first phase of gait. A compliant element is coupled between the actuator and linkage assembly. The compliant element is tuned based on a load carried by the user. | 11-06-2014 |
Robert G. Holgate, Royston GB
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20110008364 | ANTIBODIES TO TGF-BETA - The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGFβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb). | 01-13-2011 |
20130243788 | ANTIBODIES TO TGF-BETA - The present invention relates to antibody molecules, in particular antibody molecules that bind. Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb). | 09-19-2013 |
20140127230 | ANTIBODIES TO TGF-BETA - The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGFβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb). | 05-08-2014 |
Robert G. Holgate, Hertfordshire GB
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20150284456 | ANTIBODIES TO TGF-BETA - The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGFβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb). | 10-08-2015 |
Robert George Edward Holgate, Royston Hertforshire GB
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20140105914 | HUMANISED ANTI CTLA-4 ANTIBODIES - The invention provides an anti-CTLA4 antibody which inhibits the binding of CTLA4 to human B7, in particular, it inhibits binding of CTLA4 to human B7.1 and/or human B7.2. Specific antibodies are provided with specific variable region sequences as well as compositions comprising such antibodies for use in treating disease. | 04-17-2014 |
Robert George Edward Holgate, Cambridge GB
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20100184959 | Polypeptide Variants - The present invention relates to methods for selecting, obtaining or producing Fc variant polypeptides which show altered recognition for an Fc ligand (e.g., FcγR, CIq). Additionally, the Fc variant polypeptides may have altered antibody-dependent cell-mediated cytotoxicity (ADCC) and/or complement dependent cytotoxicity (CDC) activity. The invention further provides methods and protocols for the application of said Fc variant polypeptides particularly for therapeutic purposes. | 07-22-2010 |
Robert George Edward Holgate, Royston GB
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20140127236 | HUMANISED ANTI-CD52 ANTIBODIES - The present invention relates to novel humanised antibodies against human CD52 and their use in methods of treating or preventing human diseases. | 05-08-2014 |
20140161870 | Antibody Specific for CD22 and Methods of Use Thereof - The present disclosure provides antibodies specific for an epitope present on CD22. The antibodies are useful in various treatment, diagnostic, and monitoring applications, which are also provided. | 06-12-2014 |
Robert George, Edward Holgate, Hertfordshire GB
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20160115223 | POLYPEPTIDES COMPRISING A MODIFIED BACTERIOPHAGE G3P AMINO ACID SEQUENCE WITH REDUCED IMMUNOGENICITY - The invention relates to polypeptides that comprise a portion of filamentous bacteriophage gene 3 protein (g3p) sufficient to bind to and/or disaggregate amyloid, e.g., the N1-N2 portion of g3p and mutants and fragments thereof wherein that g3p amino acid sequence has been modified through amino acid substitution to be substantially less immunogenic than the corresponding wild-type g3p amino acid sequence when used in vivo. The polypeptides of the invention retain their ability bind to and/or disaggregate amyloid. The invention relates furthermore to the use of these variant g3p-polypeptides in the treatment and/or prevention of diseases associated with misfolding or aggregation of amyloid. | 04-28-2016 |
Stephen Holgate, Romsey GB
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20090257980 | ANTI-VIRUS THERAPY FOR RESPIRATORY DISEASES - The present invention provides the use of IFN-β, an agent that increases the expression of IFN-β, or a polynucleotide which is capable of expressing IFN-β or said agent for the manufacture of a medicament for the treatment of rhinovirus-induced exacerbation of a respiratory disease selected from asthma and chronic obstructive pulmonary disease, wherein said treatment is by airway delivery of said medicament, e.g. by use of an aerosol nebuliser. Also provided is IFN-λ for the same purpose. | 10-15-2009 |
20130209399 | ANTI-VIRUS THERAPY FOR RESPIRATORY DISEASES - The present invention provides the use of IFN-β, an agent that increases the expression of IFN-β, or a polynucleotide which is capable of expressing IFN-β or said agent for the manufacture of a medicament for the treatment of rhinovirus-induced exacerbation of a respiratory disease selected from asthma and chronic obstructive pulmonary disease, wherein said treatment is by airway delivery of said medicament, e.g. by use of an aerosol nebuliser. Also provided is IFN-λ for the same purpose. | 08-15-2013 |