Hogsett
Dave Hogsett, Grantham, NH US
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20140370561 | GENETICALLY MODIFIED CLOSTRIDIUM THERMOCELLUM ENGINEERED TO FERMENT XYLOSE - One aspect of the invention relates to industrial bioconversion of the xylose portion of biomass materials into fuels and chemicals. Another aspect of the invention relates to industrial bioconversion of the xylan portion of biomass materials into fuels and chemicals. In one embodiment, the invention is directed to the bacterium | 12-18-2014 |
Dave A. Hogsett, Longmount, CO US
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20160060663 | PRODUCTION OF FATTY ACIDS ESTERS - A microbial cell is used for producing at least one fatty acid ester, wherein the cell is genetically modified to contain (i) at least one first genetic mutation that enables the cell to produce at least one fatty acid and/or acyl coenzyme A (CoA) thereof by increased enzymatic activity in the cell relative to the wild type cell of malonyl-CoA dependent and malonyl-ACP independent fatty acyl-CoA metabolic pathway, wherein the fatty acid contains at least 5 carbon atoms; and (ii) a second genetic mutation that increases the activity of at least one wax ester synthase in the cell relative to the wild type cell and the wax ester synthase has sequence identity of at least 50% to a polypeptide of SEQ ID NO: 1-8 and combinations thereof or to a functional fragment of any of the polypeptides for catalyzing the conversion of fatty acid and/or acyl coenzyme A thereof to the fatty acid ester. | 03-03-2016 |
David A. Hogsett, Lebanon, NH US
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20130273555 | Detoxification of Biomass Derived Acetate Via Metabolic Conversion to Ethanol, Acetone, Isopropanol, or Ethyl Acetate - One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce lactate or acetate as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non-native gene encodes a first non-native enzyme involved in the metabolic production of lactate or acetate. Another aspect of the invention relates to a process for converting lignocellulosic biomass to lactate or acetate, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism. | 10-17-2013 |
David A. Hogsett, Grantham, NH US
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20110256601 | MODIFICATION OF HYDROGENASE ACTIVITIES IN THERMOPHILIC BACTERIA TO ENHANCE ETHANOL PRODUCTION - Bacteria consume a variety of biomass-derived substrates and produce ethanol. Hydrogenase genes have been inactivated m | 10-20-2011 |
20120094343 | Gene Knockout Mesophilic and Thermophilic Organisms, and Methods of Use Thereof - One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce lactate or acetate as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non-native gene encodes a first non-native enzyme involved in the metabolic production of lactate or acetate. Another aspect of the invention relates to a process for converting lignocellulosic biomass to lactate or acetate, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism. | 04-19-2012 |
20120108798 | Production Of Pure Lignin From Lignocellulosic Biomass - The present invention is directed to a process of producing substantially pure lignin from lignocellulosic biomass, which comprises: pre-treating a lignocellulosic feedstock to produce a reactive lignin-carbohydrate mixture; biologically-reacting the carbohydrates in the mixture, separating remaining solids from the liquid fermentation products, and drying the resulting solids to yield a substantially pure lignin product. Optionally, the lignin product may be washed and subjected to a second hydrolysis step. Optionally, the lignin product may be further processed by hydrotreating and/or pyrolysis in order to yield desirable products such as fuel additives. | 05-03-2012 |
20120142046 | Yeast Cells Expressing An Exogenous Cellulosome And Methods of Using The Same - The present invention relates to the engineering and expression of heterologous cellulosomes in microorganisms in order to facilitate the conversion of biomass to useful products. In some embodiments, the invention relates to the expression of scaffoldin proteins which form the nucleus of a cellulosome. Cellulases or other biomass-degrading enzymes can be non-covalently linked to the scaffoldin protein by virtue of a dockerin domain-cohesin domain interaction. | 06-07-2012 |
20130302870 | Flowthrough Pretreatment Of Lignocellulosic Biomass And Selective Separation Of Components Using High-Temperature Nanoporous Membranes - A new and improved biomass conversion system is disclosed using high-temperature flow-though pretreatment and a nanoporous membrane to provide more digestible biomass for subsequent conversion to biofuels. | 11-14-2013 |
20130323766 | Production of Malonyl-CoA Derived Products Via Anaerobic Pathways - The present invention provides for novel metabolic pathways to convert biomass and other carbohydrate sources to malonyl-CoA derived products, such as hydrocarbons and other bioproducts, under anaerobic conditions and with the net production of ATP. More specifically, the invention provides for a recombinant microorganism comprising one or more native and/or heterologous enzymes that function in one or more engineered metabolic pathways to achieve conversion of a carbohydrate source to, e.g., long-chain hydrocarbons and hydrocarbon derivatives, wherein the one or more native and/or heterologous enzymes is activated, upregulated, downregulated, or deleted. The invention also provides for processes to convert biomass to malonyl-CoA derived products which comprise contacting a carbohydrate source with a recombinant microorganism of the invention. | 12-05-2013 |
David Anthony Hogsett, Grantham, NH US
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20090221049 | Thermophilic Organisms For Conversion Of Lignocellulosic Biomass To Ethanol - Mutant thermophilic organisms that consume a variety of biomass derived substrates are disclosed herein. Strains of | 09-03-2009 |
20100297721 | GENE KNOCKOUT MESOPHILIC AND THERMOPHILIC ORGANISMS, AND METHODS OF USE THEREOF - One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce ethanol as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non-native gene encodes a first non-native enzyme involved in the metabolic production of ethanol. Another aspect of the invention relates to a process for converting lignocellulosic biomass to ethanol, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism. | 11-25-2010 |
20110177573 | Microbial Treatment of Lignocellulosic Biomass - Aspects of the present invention relate to methods of microbially treating lignocellulosic biomass using cellulose- and/or hemicellulose-degrading bacteria. In certain embodiments, the microbially treated material is then subjected to thermal and/or chemical pretreatment. In tandem with the microbial treatment the thermal and/or chemical pretreatment may result in the production of fewer degradation products, thereby allowing for higher overall yields of ethanol per ton of starting biomass. | 07-21-2011 |
20120077239 | Thermophilic Organisms For Conversion Of Lignocellulosic Biomass To Ethanol - Mutant thermophilic organisms that consume a variety of biomass derived substrates are disclosed herein. Strains of | 03-29-2012 |
20150024450 | Gene Knockout Mesophilic and Thermophilic Organisms, and Methods of Use Thereof - One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce ethanol as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non-native gene encodes a first non-native enzyme involved in the metabolic production of ethanol. Another aspect of the invention relates to a process for converting lignocellulosic biomass to ethanol, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism. | 01-22-2015 |
Frank Hogsett, Golden, CO US
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20160002541 | COMMERCIAL FISCHER-TROPSCH REACTOR - A method for converting synthesis gas into liquid hydrocarbons by introducing a synthesis gas feed into a Fischer-Tropsch system that includes a catalytic reactor fluidly connected with at least two slurry loops, the reactor comprising at least as many reactor product outlets and slurry return inlets as slurry loops; each slurry loop comprising a separation system comprising at least one separator, an inlet of each separator fluidly connected to a reactor product outlet via a slurry offtake, and an outlet of each separator fluidly connected to a slurry return inlet via a slurry return; separating concentrated catalyst slurry from the reaction product via the slurry loops; removing liquid hydrocarbon product from each separator; and returning concentrated catalyst slurry to the catalytic reactor via the slurry returns and slurry return inlets. A system for converting synthesis gas into liquid hydrocarbons via the method is also disclosed. | 01-07-2016 |
Frank Hogsett, Arvada, CO US
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20090069450 | COMMERCIAL FISCHER-TROPSCH REACTOR - A catalytic reaction system comprising: a catalytic reactor fluidly connected with at least two slurry loops, wherein the reactor comprises at least as many reactor product outlets and at least as many slurry return inlets as slurry loops; wherein each slurry loop comprises a separation system comprising a separation system inlet, a separation system product outlet, and a concentrated catalyst slurry outlet; a slurry offtake fluidly connecting the separation system inlet with one of the reactor product outlets; and a slurry return fluidly connecting the separation system outlet with one of the slurry return inlets. The system may comprise at least three slurry loops. The system may comprise at least four slurry loops. A method for converting synthesis gas into liquid hydrocarbons via the catalytic reaction system in also disclosed. | 03-12-2009 |
Mark E. Hogsett, Tiburon, CA US
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20140184253 | In-tool ESD Events Monitoring Method And Apparatus - In one embodiment of the invention, an apparatus for electrostatic discharges (ESD) events monitoring incorporating a charged device model event simulator (CDMES) unit comprises: at least one antenna positioned in a process area; an ESD detector coupled to said at least one antenna; said ESD detector wirelessly coupled to said CDMES unit; and said ESD detector calibrated for different discharge energies generated by said CDMES unit. | 07-03-2014 |
Robert F. Hogsett, Arvada, CO US
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20100125107 | MULTIPLE GASIFIERS MANIFOLDED TO MULTIPLE FISCHER-TROPSCH REACTORS WITH OPTIONAL RECYCLE TO THE REACTORS - A method of producing synthesis gas via gasification in a Fischer-Tropsch plant, the method including providing a number of gasifiers, the number of gasifiers provided being at least one more than the base number required to provide 100% plant capacity of synthesis gas when each gasifier is operated at 100% gasifier capacity. A method of continually producing synthesis gas via gasification of a carbonaceous feed in a Fischer-Tropsch plant by providing a number of gasifiers, the number of gasifiers provided being at least one more than the base number required to provide 100% plant capacity of synthesis gas when each gasifier is operated at 100% gasifier capacity; and adjusting the amount of synthesis gas produced by adjusting the number of online gasifiers, the flow rate of carbonaceous feed to each gasifier, or a combination thereof. A system for carrying out the method is also provided. | 05-20-2010 |
Robert F. Hogsett, Lakewood, CO US
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20100037516 | METHOD FOR THERMALLY UPGRADING CARBONACEOUS MATERIALS - Carbonaceous materials are thermally upgraded in a pressurized steam environment to remove moisture and other byproducts. A variety of water/solid separation devices may be employed in a process vessel to maximize moisture removal from the upgraded charge. Heating media inlet nozzles and process chamber vents are strategically positioned at the process vessel wall to minimize short circuiting of heating media to vessel outlet vents and to continuously separate hot water removed from the charge and condensed steam, such that the upgraded material removed from the process vessel is not discharged with accompanying free moisture. After upgrading, the charge may be rehydrated to improve its stability during shipping and storage. | 02-18-2010 |