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Hoganson, US
David M. Hoganson, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100234678 | BIOMIMETIC VASCULAR NETWORK AND DEVICES USING THE SAME - The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits. | 09-16-2010 |
| 20100274353 | BIOMIMETIC VASCULAR NETWORK AND DEVICES USING THE SAME - The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits. | 10-28-2010 |
| 20110053207 | SYSTEM AND METHOD FOR IN VITRO BLOOD VESSEL MODELING - The present invention provides an in vitro blood vessel model for investigation of drug induced vascular injury and other vascular pathologies. The in vitro blood vessel model provides two channels separated by a porous membrane that is coated on one side by an endothelial cell layer and is coated on the other side by a smooth muscle cell layer, wherein said model is susceptible to the extravasation of red blood cells across said porous membrane due to drug induced vascular injury. | 03-03-2011 |
David M. Hoganson, St. Louis, MO US
| Patent application number | Description | Published |
|---|---|---|
| 20110035026 | Anti-adhesion device - The construct described herein allows opposing tissues to form adhesions with either side of the construct, as part of the natural healing process. The construct however is multi-layered, wherein the space between the layers provides the protection from unwanted adhesions forming between and bonding separate tissues. In one embodiment, this space between layers of the construct may be developed spontaneously, that is the multiple layers are released by design after a finite time and the opposing tissues are free to move independent of each other, free of adhesions. | 02-10-2011 |
David M. Hoganson, West Chester, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100094196 | Systems and methods for delivering agents into targeted tissue of a living being - The systems basically comprise a delivery system for accessing the targeted tissue within the living being and introduction of at least one agent at select locations in the into the myocardium and other select tissues. The delivery systems are arranged to access the tissues of the heart. One or more of the systems can be utilized during transluminal, transthoracic and direct surgical access procedures. Where appropriate, for example in the case of intraventricular access, portions of the system are steerable to properly orient the device. The instruments may pierce the heart tissue and create channels extending from the endocardium, the epicardium, or the cardiac vessels. When tissue penetration is utilized, the device may include a feature to control the depth of penetration. To minimize bleeding through the channels the device can dilate small initial punctures that later contract down after device removal. When the formation of channels is required, this can be achieved, by way of example, with a rotary-tipped device, pressurized fluid jet devices, vibratory instruments and piercing needle-like tip devices. The system may utilize some form of mechanical action or application of energy (e.g. electrical, sonic, thermal, optical, pressurized fluid, radio frequency (RF), nuclear) in the process. The mechanical action or energy application may affect the surroundings tissues at a distance from the device. The agent delivered to the tissue may include one or more of pharmaceuticals, biologically active agents, radiopaque materials, etc. | 04-15-2010 |
| 20100217290 | Surgical connector systems and methods of use - A system and method of use for effecting the bypass or other anastomosis, connection, or port in a portion of a native blood vessel, duct, lumen or other tubular organ within the body of a living being. The system includes a connector assembly and a deployment instrument for carrying the device to the desired position within the vessel, duct, lumen or tubular organ. The system includes a piercer-dilator instrument to form an opening in the wall of the vessel, duct, lumen or tubular organ into which a connector assembly may be deployed by the deployment instrument. The connector assembly may be at least partially formed of a resorbable material and includes movable members for securing it to the tissue of the vessel, duct, lumen or tubular organ contiguous with the opening. Other components may be included in the device for expediting the procedure, with or without the use of sutures. | 08-26-2010 |
Eugene M. Hoganson, West End, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20090143160 | GOLFER'S HEAD MOVEMENT MONITOR DEVICE AND METHOD - A system and method for determining an amount and direction of a golfer's head movement as the golfer executes a golf swing. The system may include at least two light baffles for monitoring the golfer's head movement along a path generally parallel to a target line. The baffles may reflect light into the golfer's eyes when the golfer's head is either outside and to the left of a preset range, or outside and to the right of the preset range. The system may further include at least two additional light baffles for monitoring lunging and bobbing head motion. The additional light baffles may reflect light into the golfer's eyes when the golfer's head lunges or bobs beyond a further preset range. The system includes the additional advantage of repositionable elements to facilitate progression of precise movement control. | 06-04-2009 |
Kenneth Michael Hoganson, Aurora, CO US
| Patent application number | Description | Published |
|---|---|---|
| 20090311054 | VARIABLE SPEED DRIVE FOR PNEUMATIC TRANSPORT SYSTEM - Provided herein are systems and methods for use in controlling a translocation process of a pneumatic tube system in order to reduce the amount of energy transferred from the tube system to a pneumatic carrier and, hence, its contents. Generally, these utilities entail identifying and/or reducing forces applied to a pneumatic carrier traveling through a travel path within a pneumatic tube system. The systems and method disposed herein allow for varying the velocity of a pneumatic carrier as it passes through a travel path of the pneumatic system. Such varying of the velocity allows for reducing the total forces applied to the pneumatic carrier during passage through the system. In one arrangement, the power output of a power source connected to a compressor device is altered to vary the velocity of pneumatic carries in the system. | 12-17-2009 |
| 20100094451 | PNEUMATIC TRANSPORT DELIVERY CONTROL - The presented inventions seek to create a verifiable and closed loop chain-of-custody for a specific transaction in a pneumatic tube transport system while allowing a sender and recipient to perform asynchronous activity. That is, one aspect the presented inventions allows a sender to securely send a carrier to a desired recipient while allowing the desired recipient to receive the secured carrier at a convenient time and/or location without tying up system resources. Another aspect improves the physical barriers between high value payloads and the unintended recipients. This is done in part by introducing randomness into the carrier delivery process such that no member of the general public or facility staff knows the location and/or delivery time of a secured carrier without having access to specific database records indicating the current location and/or delivery status of the secured carrier. | 04-15-2010 |
| 20100111617 | AIR VALVE PNEUMATIC TUBE CARRIER SYSTEM - A valve device and method are provided that are operative to selectively divert the flow of air within a pneumatic carrier within a pneumatic carrier system. Generally, the device includes a pneumatic tube that is sized to permit the passage of pneumatic carriers. The pneumatic tube includes at least aperture in a sidewall of the pneumatic tube, an outer sleeve, and an actuator. The actuator acts on the outer sleeve to block and open the aperture to fluid flow in order to divert air in the pneumatic system. In one embodiment, the valve is disposed in a pneumatic system in conjunction with a pneumatic carrier handling device. | 05-06-2010 |
| 20100221074 | VARIABLE DIAMETER PNEUMATIC TUBE BRAKE - A braking device and method is provided that is operative to selectively slow and/or stop a pneumatic carrier within a pneumatic carrier system. Generally, the device includes a pneumatic tube that is sized to permit the passage of pneumatic carriers. The pneumatic tube includes at least one braking element that may be disposed into the bore of the pneumatic tube to at least partially impede the passage of a pneumatic carrier through the bore. In one embodiment, the braking element is formed as a variable diameter section of the pneumatic tube that may be selectively constricted to change the diameter of the bore of the pneumatic tube. Such constriction may slow and/or stop the passage of a pneumatic carrier through the bore of the pneumatic tube. | 09-02-2010 |