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Hoffman, WA
Adam Paul Hoffman, Bellevue, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20110137941 | SEGMENTATION AND PROFILING OF USERS - The formulation of a profile group of users by defining segments using a function as applied to a single attribute, and combining them with set operations. The segments may be populated by applying the selected function against the selected attribute against multiple users. Then, the profile groups build upon the segments and are populated by applying the selected operations against the selected combination of segments. This represents an efficient mechanism for formulating profile groups based on user attributes. | 06-09-2011 |
| 20110138401 | LIVE UPDATE OF USER SEGMENTS - The real-time updating of segments of users defined by applying a function to at least one user attribute. In response to an event, the segment may be updated in real-time to either or both of removing the user from a segment, or adding a user to a segment. In one embodiment, user profile groups are populated by performing combinatory operations upon multiple segments. In that case, any profile group that depends on the updated segment may also be updated. Thus, operations that rely upon segment and/or profile group membership need not wait until the next calculation of the segment and profile group membership before correctly reflecting the newly discovered user attributes. | 06-09-2011 |
Allan S. Hoffman, Seattle, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20080199957 | ENHANCED TRANSPORT USING MEMBRANE DISRUPTIVE AGENTS - Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontophoresis, and/or electrophoresis can also be used with the disrupting agents. | 08-21-2008 |
| 20080220531 | STIMULI-RESPONSIVE MAGNETIC NANOPARTICLES AND RELATED METHODS - Stimuli-responsive magnetic nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles. | 09-11-2008 |
| 20100150952 | pH-RESPONSIVE POLYMER CARRIER COMPOSITIONS FOR CYTOSOLIC PROTEIN DELIVERY - pH-Responsive polymer-based protein delivery carriers and compositions, methods for making the carriers and compositions, and methods for using the carriers and compositions for intracellular protein antigen delivery, inducing a cytotoxic T-lymphocyte response, introducing a tumor-specific protein antigen to an antigen presenting cell to induce an immune response, and providing tumor protection to a subject. | 06-17-2010 |
| 20100160216 | ENHANCED TRANSPORT USING MEMBRANE DISRUPTIVE AGENTS - Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes (at physiologic pH, but can become active toward cell membranes if the environment is acidified below ca. pH 6.8), coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophereis can also be used with the disrupting agents. | 06-24-2010 |
| 20100210504 | ENHANCED TRANSPORT USING MEMBRANE DISRUPTIVE AGENTS - Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes (at physiologic pH, but can become active toward cell membranes if the environment is acidified below ca. pH 6.8), coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophereis can also be used with the disrupting agents. | 08-19-2010 |
| 20100215749 | TEMPERATURE- AND pH-RESPONSIVE POLYMER COMPOSITIONS - Temperature- and pH-responsive copolymer compositions, and drug delivery devices, conjugates, nanoparticles, and micelles that include the compositions. | 08-26-2010 |
| 20110123636 | MICELLIC ASSEMBLIES - Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles. | 05-26-2011 |
| 20110129921 | TARGETED POLYMER BIOCONJUGATES - Polymer bioconjugate having a RNAi agent covalently coupled to the alpha or omega end of a pH-dependent membrane-destabilizing polymer. | 06-02-2011 |
| 20110142951 | MICELLES FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS - Composition comprising a polymeric micelle and an associated polynucleotide. | 06-16-2011 |
| 20110143434 | DIBLOCK COPOLYMERS AND POLYNUCLEOTIDE COMPLEXES THEREOF FOR DELIVERY INTO CELLS - Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic. | 06-16-2011 |
| 20110143435 | POLYMERIC CARRIER - Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g. oligonucleotides) and/or other therapeutic agents into a living cell. | 06-16-2011 |
Benjamin Todd Hoffman, Seattle, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20100250216 | SYSTEM AND METHOD FOR CHARACTERIZING FRACTURES IN A SUBSURFACE RESERVOIR - The disclosed methods, systems, and software are described to optimize fracture characteristics and simulate fluid flow rates in a well model. The well model, which includes at least one fracture intersecting a production well, is generated with static and dynamic data. Fluid flow in the well model is simulated to obtain simulated fluid flow rates between fractures and the well. Fracture properties, such as length, height and aperture, are then updated responsive to measured and simulated fluid flow rates. Multiple simulation runs and updating of the fracture properties can be performed until the simulated fluid flow rates converge with the measured fluid flow rates. Pressure data can be used to determine gridblock permeability, which in turn helps constrain the model, thus providing more reliable fracture properties. Uncertainty ranges of the fracture properties can also be calculated. | 09-30-2010 |
Carll Bennett Hoffman, Mercer Island, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20100250625 | OBJECT-RELATIONAL MAPPING WITH DYNAMIC RELATIONAL SCHEMAS - In an embodiment, a generic database application of a computer system receives a portion of input data from a database. The generic database application can communicate with the database using a variety of different database schemas. The generic database application of the computer system infers a portion of ORM metadata associated with the received input data. The computer system accesses a generic ORM query where the ORM query is configured to provide mapping information to map the input data into a graph of objects according to the database object properties included in the ORM metadata. The computer system maps the input data into a graph of objects using the database object properties included in the ORM metadata and displays an ORM object view which includes the graph of objects. | 09-30-2010 |
David W. Hoffman, Kent, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20100295927 | SYSTEM AND METHOD FOR STEREOSCOPIC IMAGING - A method is disclosed for performing stereoscopic imaging. The method may involve obtaining a first image of a scene, at a first time, using a camera disposed on a platform, where the distance between the camera and the scene is changing. The camera may be used to obtain a second image of the scene, at a second time, with one of the first and second images being larger than the other. One of the images that is larger than the other may be resized so that the sizes of the two images are substantially similar. Both of the images may be rotated a predetermined degree so that the images form a stereo pair that may be viewed with a stereoscope viewing component or made into an anaglyph for viewing with an anaglyph viewing component. | 11-25-2010 |
Herbert L. Hoffman, Seattle, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20090078820 | WING-TO-BODY FAIRING - In one embodiment, a wing-to-body fairing for reducing noise due to wing-to-body fairing vibrations in at least one of an aircraft and a spacecraft comprises a honeycomb center comprising a cavity which is substantially filled with foam material. | 03-26-2009 |
| 20090184200 | VIBRATION DAMPING FOR WING-TO-BODY AIRCRAFT FAIRING - A wing-to-body fairing for aircraft is formed from a sandwich structure having integrated vibration damping. | 07-23-2009 |
| 20090184206 | PARTICLE-FILLED WING-TO-BODY FAIRING - A wing-to-body fairing for reducing noise due to wing-to-body fairing vibrations in an aircraft, spacecraft, or vehicle may include a honeycomb center having a cavity which is at least partially filled with particle material. | 07-23-2009 |
John Hoffman, Seattle, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20080220531 | STIMULI-RESPONSIVE MAGNETIC NANOPARTICLES AND RELATED METHODS - Stimuli-responsive magnetic nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles. | 09-11-2008 |
Jon Hoffman, Vancouver, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20090023333 | COMPLIANT COAXIAL CONNECTOR - A connector includes a connector body, a plurality of compression coaxial contacts disposed in the connector body, and a plurality of coaxial cables connected to corresponding ones of the plurality of compression coaxial contacts. The connector body includes a conductive elastomeric ground plane. | 01-22-2009 |
Keith Hoffman, Lake Stevens, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20090262355 | SURFACE PLASMON RESONANCE SYSTEM AND APPARATUS FOR INTERROGATING A MICROARRAY - According to an embodiment, an SPR analysis system includes a housing enclosing with a fluid supply volume substantially enclosed within the housing, a flow cell module configured to receive reagents and analyte from the fluid supply volume, and an enclosed optics assembly configured to interrogate a microarray portion of the flow cell module. | 10-22-2009 |
| 20090262356 | USER INTERFACE AND METHOD FOR USING AN SPR SYSTEM - According to an embodiment, an SPR analysis system includes an SPR analysis system control computer program having a graphical user interface and configured to control the operation of an SPR analysis apparatus. According to an embodiment, an SPR data analysis computer program includes an SPR microarray video viewer and a sensorgram generator responsive to the SPR video. | 10-22-2009 |
Kristofer D. Hoffman, Sammamish, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20100199357 | SECURE HOSTING FOR UNTRUSTED CODE - Various technologies and techniques are disclosed for increasing security in execution environments. A system is described for handling DLL calls made from untrusted code. An execution environment instantiates a lower trust process when a high trust process determines a need to call untrusted code. When the untrusted code calls a method in an original DLL, the execution environment loads a shim DLL into the lower trust process. The shim DLL has a clone of the method from the original DLL. A method for increasing security when processing calls from untrusted code is described. A shim DLL is created from an original DLL, and is deployed so an execution environment will load the shim DLL instead of the original DLL. When an execution environment receives a call from a caller DLL to the original DLL, the call is routed through the shim DLL. A pluggable validation system is also described. | 08-05-2010 |
Kristofer D. Hoffman, Redmond, WA US
Kristofer Duncan Hoffman, Sammamish, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20080244444 | CONTEXTUAL COMPUTER WORKSPACE - A contextual computer workspace feature provides users with a mechanism to capture and output a state of a contextual computer workspace so that the user may continue working on a computer-based task as though no interruptions occurred. A state of a contextual computer workspace, including the window views and content thereof, is captured. Upon capturing a state of a contextual computer workspace, an indication to access the contextual computer workspace is received. The state of the contextual computer workspace is restored and the restored state is then output to communicate the contextual computer workspace to the user. | 10-02-2008 |
Nell H. Hoffman, Seattle, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20100107100 | Mobile Device Style Abstraction - Style abstraction techniques are described for use in customizing elements included in a user interface. In an implementation, a structural attribute is obtained that defines a structural component of an element that is to be included in a user interface. A style attribute is also obtained that is operable to define a visual aspect of the structural component. The user interface is generated by combining the style attribute and the structural attribute at run-time to form the element. The element, that includes the visual aspect applied to the structural component, is presented on a display device of a mobile device. | 04-29-2010 |
| 20100159966 | Mobile Communications Device User Interface - A mobile communications device user interface is described. In an implementation, a method is implemented by a mobile communications device that includes outputting a user interface having a portion that is configured to accept content. When an option is selected in relation to the portion to initiate a communication and the content includes one or more contacts, the communication is formed that includes the content and is automatically addressed to the one or more contacts. | 06-24-2010 |
Phil Hoffman, Walla Walla, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20080210525 | Manufacturing device for use with a vibratory conveyor, and method for manufacturing a product - A manufacturing device for use with a vibratory conveyor having a product transporting bed, and a method for manufacturing a product is described and which includes a flexible substrate having a first upper course, and a second lower course which rests upon a product transporting bed of a vibratory conveyor, and wherein a product which is being manufactured and transported by the vibratory conveyor travels between the upper and lower courses of the flexible substrate as the product moves along the vibratory conveyor. | 09-04-2008 |
Philip L. Hoffman, Walla Walla, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20100236994 | Sorting apparatus and mehtod utilizing a mechanical diverter - The present invention is an apparatus and method for sorting foreign material and undesirable articles from a product stream. A mechanical diverter having a concave shape is responsive to an inspection station coupled to the product stream. The mechanical diverter is employed to effectively launch or otherwise redirect undesirable articles in an alternate path. In addition, an air ejector is responsive to the inspection station and is employed to dislodge foreign material from the product stream. | 09-23-2010 |
Timothy J. Hoffman, Redmond, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20090017427 | Intelligent Math Problem Generation - A problem generator that takes an input as a math problem, analyzes the math problem, and intelligently spawns similar example problem types. The output is a set of math problems based on the conditions set during analysis and customization. For example, if the original problem deals with linear equations, this will be detected during analysis and used to spawn other linear equations as problems. Moreover, if the answer to the original problem is in integer format, so will the answers to the spawned problems. A customizable UI is designed to allow further customization of problem conditions to generate an accurate set of problems based on the initial input. Problem generator templates can be created, shared and modified for distribution and/or future use. Additionally, problem generation APIs can be extended for external code to automate and consume generated math problems. | 01-15-2009 |
William Dale Hoffman, Renton, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20090064428 | CABANA TAILGATE RAMP - A method and apparatus for a ramp system for use with standardized cargo containers. In one advantageous embodiment, a container system comprises a container, a hinge, and a movable ramp. The container may have an opening and the hinge may be connected to the container at the opening of the container. The moveable ramp may be connected to the hinge. | 03-12-2009 |