Patent application number | Description | Published |
20090176255 | IMMUNOMAGNETIC CAPTURE AND IMAGING OF BIOLOGICAL TARGETS - The present invention relates to methods and systems for labeling, isolating, detecting, and/or enumerating a statistically significant number of biological cells, or other biological analytes of interest, present in a complex matrix sample. The isolation of a biological target of interest from a sample mixture is done by immunomagnetic separation. Upon introduction of the sample within an imaging chamber, the capture complex (biological target-magnetic capture agent) will be attracted by the magnetic field and will lay on the surface of the chamber in the focal plane of the imaging system. | 07-09-2009 |
20110086431 | Methods for Altering Surface Characteristics of Microspheres - Various methods for altering surface characteristics of a microsphere are provided. One method includes coupling an enolic acid to the microsphere to modify the surface characteristics of the microsphere. The surface characteristics may include charge density and/or pKa. A reagent can be coupled to the microsphere via the enolic acid. The reagent may include a biomolecule. The modified surface characteristics may increase a stability of the reagent when the reagent is coupled to the microsphere. The modified surface characteristics may also improve performance of an assay carried out with the microsphere. Another embodiment relates to a microsphere that includes an enolic acid coupled to a polymer core of the microsphere such that the enolic acid modifies surface characteristics of the microsphere. A reagent can be coupled to the microsphere via the enolic acid. | 04-14-2011 |
20120035328 | METHODS FOR FORMING DYED MICROSPHERES AND POPULATIONS OF DYED MICROSPHERES - Various methods for forming dyed microspheres are provided. One method includes activating a chemical structure coupled to a dye using heat or light to form a reaction intermediate in the presence of a microsphere. The reaction intermediate covalently attaches to a polymer of the microsphere thereby coupling the dye to the polymer and forming the dyed microsphere. Additional methods are provided for forming a dyed microsphere coupled to a molecule. These methods include dyeing the microspheres as described above in addition to synthesizing the molecule on an outer surface of the dyed microspheres. A population of dyed microspheres is also provided. Each of the dyed microspheres of the population includes a dye attached to a polymer of each of the dyed microspheres by a chemical structure. A coefficient of variation in dye characteristics of the population of dyed microspheres attributable to the dye is less than about 10%. | 02-09-2012 |
20120123026 | FUNCTIONALIZED COMPOSITIONS FOR IMPROVED IMMOBILIZATION - The present invention relates to improved covalent coupling of two or more entities such as biomolecules, polymer compositions, organic/inorganic molecules/materials, and the like, including their combinations, through one or more novel reactive groups attached to linker groups of 2-1000 atoms length. The present invention also contemplates the use of bifunctional bridge molecules to link two or more entities, wherein the functional groups of the bridge molecules are the novel reactive groups of the present invention. | 05-17-2012 |
Patent application number | Description | Published |
20100226767 | DIFFUSER ARRANGEMENT - A diffuser arrangement through which a fluid may flow is provided. The diffuser includes an outer diffuser comprising an inner surface, and a flow-guiding device, which is configured such that at least part of the boundary layer flow forming on the inner surface of the outer diffuser can be accelerated in the main flow direction, so that a flow separation is prevented on the inner surface of the outer diffuser. Also provided are an exhaust steam plenum of a steam turbine and an exhaust gas plenum of a gas turbine, both including a diffuser arrangement. | 09-09-2010 |
20110100008 | Method and Device for Operating a Steam Power Station Comprising a Steam Turbine and a Process Steam Consumer - A method for operating a steam power station is provided. The steam turbine power station includes at least one steam turbine and a process steam consumer, wherein a steam mass flow is subdivided into a first partial mass flow and a second partial mass. In a first operating state, the first partial mass flow is supplied to the steam turbine and the second partial mass flow is supplied to the process steam consumer. In a second operating state, at least part of the second partial mass flow is supplied to the steam turbine at least after the first turbine stages. A steam power station is also provided. | 05-05-2011 |
20130294907 | TUBULAR HOUSING FOR A TURBOMACHINE - A tubular housing for a turbomachine is provided. The tubular housing includes two half-tube shells which, lying against one another in two connecting regions overlap partially in each case in the tangential direction of the tubular housing. In order to specify a particularly reliable and permanent connection of the two half-tube shells which additionally develop a particularly satisfactory sealing action, it is proposed that, in order to interlock the half-tube shells in the tangential direction, in relation to the tube axis of the housing, at least one eccentric pin is provided in one or both connecting regions. | 11-07-2013 |