Patent application number | Description | Published |
20090191219 | METHODS FOR DIAGNOSING AND TREATING OBESITY BY MODULATING THE ACTIVITY OF AUTO-ANTIBODIES AGAINST THE MELANOCORTIN-4 RECEPTOR - Disclosed are biological markers for obesity and methods for diagnosing and treating obesity and related conditions by detecting and modulating the activity of auto-antibodies against the melanocortin-4 receptor or a portion of the melanocortin-4 receptor. Also disclosed are methods for discovering new therapeutics which modulate the activity of auto-antibodies against the melanocortin-4 receptor or a portion of the melanocortin-4 receptor, in particular which prevent the binding of auto-antibodies against the melanocortin-4 receptor or a portion of the melanocortin-4 receptor. | 07-30-2009 |
20110044987 | MONOCLONAL ANTIBODIES AND BINDING FRAGMENTS THEREOF DIRECTED TO THE MELANOCORTIN-4 RECEPTOR AND THEIR USE IN THE TREATMENT OF CACHEXIA AND RELATED CONDITIONS AND DISEASES - Disclosed are monoclonal antibodies, binding fragments, and derivatives thereof directed to the human melanocortin-4 receptor, as well as pharmaceutical compositions including the same, and therapeutic uses, including methods for treating cachexia and related conditions and diseases, using such monoclonal antibodies, binding fragments, derivatives, and pharmaceutical compositions. | 02-24-2011 |
20140112928 | ANTIBODIES AGAINST TROPOMYOSIN-RELATED KINASE B RECEPTORS - The invention relates to monoclonal antibodies directed to a particular part of tropomyosin-related kinase B receptor (TrkB) and hybridoma cell lines producing these. Fragments of these antibodies, in particular fragments representing complementarity determining regions (CDRs), and proteins comprising these, are useful in a method of treating cancer, pain, anorexia, anorexia nervosa and/or cachexia. | 04-24-2014 |
Patent application number | Description | Published |
20140211842 | Adapting Robustness in Video Coding - An input receives a video signal comprising a plurality of frames, each comprising a plurality of image portions. Each of the image portions is encoded by an encoder, to generate an encoded signal. An adaptation module selects a respective encoding mode used to encode each of the image portions. The selection is based on a process that balances an estimate of distortion for the image portion if encoded using the respective encoding mode and a bitrate that would be incurred by encoding the image portion using the respective encoding mode. The adaptation module is also configured to determine, within each of one or more frames of the video signal, at least two different regions having different perceptual significance, and to adapt the above-mentioned process in dependence on which of the regions the image portion being encoded is in. | 07-31-2014 |
20140211858 | SPATIALLY ADAPTIVE VIDEO CODING - A video signal comprises a sequence of source frames to be encoded. A pre-processing stage determines a region of interest for a plurality of the source frames, and spatially adapts each of the plurality of the source frames to produce a respective warped frame. In the respective warped frame, the region of interest comprises a higher spatial proportion of the warped frame than in the source frame. The pre-processing stage supplies the warped frames to an encoder to be encoded into an encoded version of the video signal. | 07-31-2014 |
20140211860 | CONDITIONAL CONCEALMENT OF LOST VIDEO DATA - A receiving apparatus comprises a receiver for receiving a video signal, an output for outputting the video signal to a screen, storage device or further terminal; and a concealment module for applying a concealment algorithm to a lost area of the video signal. The concealment module is configured to determine an estimate of concealment quality selectively directed toward a region of interest within the area in question, and based on this estimate to determine whether or not to apply the concealment algorithm. | 07-31-2014 |
20140307771 | RESOURCE FOR ENCODING A VIDEO SIGNAL - An apparatus for encoding video data, the apparatus comprising a compliance module configured to compare a resource requirement associated with encoding video data to form at least part of an encoded frame using a standard encoding mode with an acceptable resource level and an encoder configured to, responsive to a determination that the resource requirement will exceed the acceptable resource level, form the at least part of an encoded frame by encoding some of the video data using the standard encoding mode and filling a remainder of the at least part of the encoded frame with data that is associated with a lower resource usage than data generated using the standard encoding mode. | 10-16-2014 |
20150016510 | Region-of-Interest Aware Video Coding - An encoder comprising an encoding module and an adaptation module. The encoding module is configured to encode video in at least one region-of-interest and outside the region-of-interest. The encoding comprises quantization, and the encoding module is operable to apply a difference in quantization granularity between the encoding inside and outside the region-of-interest. The adaptation module is configured to determine at least one metric representative of a difference in benefit of the quantization inside and outside the region-of-interest, and to adapt the difference in quantization granularity in dependence on this metric. | 01-15-2015 |
Patent application number | Description | Published |
20120076772 | STABILIZATION OF IMMUNOGLOBULINS THROUGH AQUEOUS FORMULATION WITH HISTIDINE AT WEAK ACIDIC TO NEUTRAL PH - The present invention provides, among other aspects, storage stabile aqueous formulations of immunoglobulins with histidine at a mildly acidic to neutral pH. The present invention also provides methods for stabilizing immunoglobulin compositions by formulating with histidine at a mildly acidic to neutral pH. Advantageously, the methods and formulations provided herein allow stabile aqueous compositions of immunoglobulins at mildly acidic to neutral pH useful for parenteral administration. | 03-29-2012 |
20120076779 | STABILIZATION OF IMMUNOGLOBULINS AND OTHER PROTEINS THROUGH AQUEOUS FORMULATIONS WITH SODIUM CHLORIDE AT WEAK ACIDIC TO NEUTRAL ph - The present invention provides, among other aspects, storage stabile aqueous formulations of labile proteins at a mildly acidic to neutral pH. The present invention also provides methods for stabilizing a labile therapeutic protein composition at a mildly acidic to neutral pH. Advantageously, the methods and formulations provided herein allow stabile aqueous compositions of labile proteins at mildly acidic to neutral pH useful for parenteral administration. | 03-29-2012 |
20130058961 | METHOD FOR REDUCING THE THROMBOEMBOLIC POTENTIAL OF A PLASMA-DERIVED IMMUNOGLOBULIN COMPOSITION - The present invention provides methods for reducing the amidolytic and anti-complement activity (ACA) content of an immunoglobulin composition through the use of cation exchange chromatography. In a specific embodiment, the invention provides methods for reducing the Factor XI and/or Factor XIa and/or ACA content of an immunoglobulin composition by collecting the leading portion of a cation exchange eluate. The present invention also provides immunoglobulin composition having reduced levels of amidolytic activity, Factor XI, and/or Factor XIa, and/or ACA content. | 03-07-2013 |
20140271669 | METHODS TO PRODUCE A HUMAN PLASMA-DERIVED IGG PREPARATION ENRICHED IN BRAIN DISEASE-RELATED NATURAL IGGS - The present invention provides, among other aspects, methods for the manufacture of plasma-derived immunoglobulin G compositions highly enriched for anti-brain disease related protein antibodies (e.g., anti-Aβ, anti-RAGE, and anti-α-synuclein antibodies). Advantageously, the methods provided do not affect the manufacturing processes or capabilities for producing plasma-derived IgG therapeutics. Plasma-derived IgG compositions that are highly enriched for anti-brain disease related protein antibodies (e.g., anti-Aβ, anti-RAGE, and anti-α-synuclein antibodies), as also provided here. Methods for the treatment of brain diseases and disorders by administration of plasma-derived IgG compositions highly enriched for anti-brain disease related protein antibodies (e.g., anti-Aβ, anti-RAGE, and anti-α-synuclein antibodies), are also provided. | 09-18-2014 |
20140271679 | METHODS TO PRODUCE A HUMAN PLASMA-DERIVED IGG PREPARATION ENRICHED IN BRAIN DISEASE-RELATED NATURAL IGGS - The present invention provides, among other aspects, methods for the manufacture of plasma-derived immunoglobulin G compositions highly enriched for anti-brain disease related protein antibodies (e.g., anti-β, anti-RAGE, and anti-α-synuclein antibodies). Advantageously, the methods provided do not affect the manufacturing processes or capabilities for producing plasma-derived IgG therapeutics. Plasma-derived IgG compositions that are highly enriched for anti-brain disease related protein antibodies (e.g., anti-β, anti-RAGE, and anti-α-synuclein antibodies), as also provided here. Methods for the treatment of brain diseases and disorders by administration of plasma-derived IgG compositions highly enriched for anti-brain disease related protein antibodies (e.g., anti-β, anti-RAGE, and anti-α-synuclein antibodies), are also provided. | 09-18-2014 |
20140370000 | STABILIZATION OF IMMUNOGLOBULINS THROUGH AQUEOUS FORMULATION WITH HISTIDINE AT WEAK ACIDIC TO NEUTRAL PH - The present invention provides, among other aspects, storage stabile aqueous formulations of immunoglobulins with histidine at a mildly acidic to neutral pH. The present invention also provides methods for stabilizing immunoglobulin compositions by formulating with histidine at a mildly acidic to neutral pH. Advantageously, the methods and formulations provided herein allow stabile aqueous compositions of immunoglobulins at mildly acidic to neutral pH useful for parenteral administration. | 12-18-2014 |
Patent application number | Description | Published |
20110241473 | Electric Motor Rotor - A rotor of an electric machine is disclosed that resists expansion of the rotor components even at high rotational speed. The rotor includes first and second pluralities of laminations having slots to accept rotor bars. A support disk, also having slots, is placed between the laminations. The support disk, into which the rotor bars are slid, restrains the rotor bars from bending outwardly at high rotational speeds of the rotor. The rotor bars are further restrained at the ends by end rings, which have apertures into which ends of the rotor bars are placed. In some embodiments, containment rings are placed over axial extension of the end rings to prevent outward bowing at high speeds. In some embodiments, the rotor includes a stiffener sleeve to provide additional resistance to expansion during high rotational speeds. | 10-06-2011 |
20120073538 | Frictionless Rocking Joint - Reciprocating motion can be converted to rotary motion through a crankshaft and a connecting rod. In a joint between a connecting rod and a piston, the connecting rod rocks with respect to the piston. In some situations, the connecting rod is a pullrod always in tension or a pushrod always in compression making it difficult to lubricate the bearing surfaces. A joint is disclosed in which the bearing surfaces rock with respect to each other with no sliding between the surfaces. The connecting rod has a bearing surface that is part of a cylinder having a radius equal to a distance between a central axis of the journal to which the connecting rod is coupled and the bearing surface. The pin has a convexly- or concavely-curved bearing surface and the local radius is based on material properties and the local peak force that the rocking joint is designed to transmit. | 03-29-2012 |
20120192559 | Exhaust System for an Internal Combustion Engine - A combustion chamber of an internal combustion engine has at least a first and a second exhaust port, which are decoupled downstream of the combustion chamber. The first exhaust port is opened before the second exhaust port during an expansion stroke of the piston. The first exhaust port is coupled to a high-pressure turbine and the second exhaust port is coupled to a low-pressure turbine. By directing exhaust gases at higher pressure to the high-pressure turbine and gases at lower pressure to the low-pressure turbine, the overall energy recovery from the exhaust gases is greater than a system with one or more exhaust turbines coupled in series with all of the exhaust ports. | 08-02-2012 |
Patent application number | Description | Published |
20080216728 | Apparatus and method to optimize sailing efficiency - This invention provides improvements in the efficiency of a sailing vessel through the use of flaps, hydrofoils, or members on the keel of a sailing vessel. One or more are positioned at the top, or root of the keel of the vessel, which primarily generate a force in the windward direction to provide a counter-leeward drift force. One or more are located at the bottom, or tip of the keel of the vessel, which primarily generate a force in the leeward direction to provide a counter-heeling moment. Among other benefits, operation of these flaps, hydrofoils, or members during sailing increases the vessel's efficiency, in particular its velocity made good. Further, since they are mounted on one appendage, sailing vessels of a rudder and keel design can be equipped with counter leeward-drift and counter-heeling attributes without the need for additional appendages. | 09-11-2008 |
20090165692 | Apparatus and Method to Optimize Sailing Efficiency - This invention provides improvements in the efficiency of a sailing vessel through the use of flaps, hydrofoils, or members on the keel of a sailing vessel. One or more are positioned at the top, or root of the keel of the vessel, which primarily generate a force in the windward direction to provide a counter-leeward drift force. One or more are located at the bottom, or tip of the keel of the vessel, which primarily generate a force in the leeward direction to provide a counter-heeling moment. Among other benefits, operation of these flaps, hydrofoils, or members during sailing increases the vessel's efficiency, in particular its velocity made good. Further, since they are mounted on one appendage, sailing vessels of a rudder and keel design can be equipped with counter leeward-drift and counter-heeling attributes without the need for additional appendages. | 07-02-2009 |
20120060390 | FOOTWEAR - Improved footwear is disclosed, including an improved foot gripping member and footwear having a resilient and angled or curved sole. The improvements are particularly well adapted for footwear made for beach, street, home, sports, or general casual wear. The various features of the disclosed footwear may be utilized alone, or in combination with each other, in order to improve the comfort and improve the attachment to the footwear to the foot. | 03-15-2012 |