| Patent application number | Description | Published |
|---|
| 20080204753 | FLUORESCENCE SENSOR - A fluorescence sensor comprises a sensor section for collecting a fluorescent substance, which acts to represent presence of a substance to be detected in a sample, and an exciting light source, which produces exciting light for exciting the fluorescent substance to produce fluorescence. Besides the exciting light source, at least one different non-exciting light source is located for irradiating different non-exciting light, which varies in wavelength from the exciting light and which is substantially free from capability of exciting the fluorescent substance, to the sensor section. | 08-28-2008 |
| 20080219893 | LOCAL PLASMON ENHANCED FLUORESCENCE SENSOR - A first substance capable of undergoing binding with a substance to be detected in a sample is fixed to a detecting section. A plurality of pieces of a second substance capable of undergoing the binding with the substance to be detected are mixed in the sample. Each of fine metal particles has been bound with one of the pieces of the second substance. A fluorescent substance has been combined with each pair of the fine metal particle and the piece of the second substance into an integral body. Exciting light capable of exciting the fluorescent substance is irradiated to the detecting section, and fluorescence produced by the fluorescent substance is detected. | 09-11-2008 |
| 20090101815 | CANTILEVER FOR NEAR FIELD OPTICAL MICROSCOPES, PLASMON ENHANCED FLUORESCENCE MICROSCOPE EMPLOYING THE CANTILEVER, AND FLUORESCENCE DETECTING METHOD - A cantilever for near field optical microscopes is equipped with a probe in the vicinity of a free end thereof. The probe includes a thin film portion constituted by at least one layer of thin film that serves as the surface of the probe, and an inner bulk portion which is covered by the thin film portion. The outermost layer of the thin film portion is a thin dielectric film, and a metal portion is provided toward the interior of the probe from the thin dielectric film. | 04-23-2009 |
| 20090101836 | FLUORESCENCE SENSOR AND METHOD FOR PRODUCING THIN METAL FILM WITH APERTURES TO BE USED BY THE FLUORESCENCE SENSOR - An excitation light beam is emitted from a light source. The excitation light beam propagates through a substrate and enters an interface between the substrate and a thin metal film having fine apertures with diameters less than or equal to the wavelength of the excitation light beam, provided on the surface of the substrate opposite that on which the excitation light beam is incident. Near field light is generated at the fine apertures. Fluorescent labels, included in a sample which is supplied to contact the thin metal film, are excited by the near field light and/or surface plasmon on the thin metal film induced by the near field light. The fluorescence emitted from the fluorescent labels is detected by a photodetector. | 04-23-2009 |
| 20090258439 | IMMUNOCHROMATOASSAY METHOD AND IMMUNOCHROMATOASSAY KIT - An immunochromatoassay method that allows high detection sensitivity measurement. The method including the steps of: permeating an analyte solution that includes a visibly labeled second binding substance that specifically binds to a detection target substance into a test area of a chromatography medium provided with a first binding substance that specifically binds to the detection target substance, simultaneously with or after the permeation of the analyte solution into the test area, permeating a visual recognition aid solution into the chromatograph medium, the solution having a refractive index whose refractive index difference Δn from that of the chromatograph medium is −0.1=Δn=0.1, and visually observing the test area while the visual recognition aid solution is permeated in the test area. | 10-15-2009 |
| 20090283700 | FLUORESCENCE DETECTING METHOD - A fluorescence detecting method utilizes surface plasmon enhancement. An electric field enhancing field is caused to be generated at a detecting portion that includes a metal film provided on a surface of a dielectric prism. Fluorescence emitted by fluorescent labels, which are attached to a detection target substance, due to the excitation effect of the electric field enhancing field is detected by a photodetector. During the detection, a plurality of fine metal particles are dispersed on the detecting portion. | 11-19-2009 |
| 20090321661 | DETECTING METHOD, DETECTION SAMPLE CELL, AND DETECTING KIT - A fluorescent substance having fluorescent pigment molecules, which are enveloped in a light transmitting material that transmits fluorescence generated by the fluorescent pigment molecules, is employed as fluorescent labels in a detecting method the detects the amount of a detection target substance based on the amount of light which is generated due to excitation of the fluorescent labels. The fluorescent substance is excited by evanescent waves which are generated due to leakage from an optical waveguide mode. | 12-31-2009 |
| 20090321662 | DETECTION METHOD, DETECTION APPARATUS, AND SAMPLE CELL AND KIT FOR DETECTION - A sensor chip includes a sensor-portion having at least a metal-layer deposited on a surface of a dielectric-plate. A fluorescent-label binding-substance in an amount corresponding to the amount of a detection target substance in a sample binds to the sensor-portion when the sample is placed in contact with the sensor-portion. The sensor-portion is irradiated with excitation-light to generate an enhanced electric-field on the sensor-portion. The amount of the detection target substance is detected based on the amount of light generated by excitation of a fluorescent-label in the fluorescent-label binding-substance in the enhanced electric-field. A magnetic-particle is added to the fluorescent-label binding-substance, and the amount of the detection target substance is detected while the fluorescent-label binding-substance modified with the magnetic-particle is attracted to the vicinity of the sensor-portion by a magnetic-field application means arranged on an opposite-surface side of the dielectric-plate, opposite to the metal-layer-deposited surface thereof. | 12-31-2009 |
| 20100006774 | DETECTION METHOD, DETECTION APPARATUS, AND SAMPLE CELL AND KIT FOR DETECTION - A sensor chip including a sensor portion that has at least a metal layer deposited on a surface of a dielectric plate is used. A fluorescent-label binding-substance in an amount corresponding to the amount of a detection target substance in a liquid sample binds onto the sensor-portion. The amount of the detection target substance is detected based on the amount of light generated by excitation of a fluorescent label in the fluorescent-label binding substance. An electrified fluorescent substance containing a plurality of fluorescent dye molecules enclosed by a material that transmits fluorescence output from the plurality of fluorescent dye molecules is used as the fluorescent label. The electrified fluorescent substance is attracted to the sensor portion by applying voltage to the liquid sample in a state in which the fluorescent-label binding substance has bound to the sensor portion. In this state, the amount of the detection target substance is detected. | 01-14-2010 |
| 20100009458 | DETECTION METHOD, DETECTION APPARATUS, AND SAMPLE CELL AND KIT FOR DETECTION - A sensor-chip includes a sensor-portion having at least a metal-layer deposited on a surface of a dielectric-plate. A fluorescent-label binding-substance in an amount corresponding to the amount of a detection-target-substance in a liquid-sample binds onto the sensor-portion. The amount of the detection-target-substance is detected based on the amount of light generated by excitation of a fluorescent-label in the fluorescent-label binding-substance. A fluorescent-substance the charge state of which changes in the liquid-sample according to the pH of the liquid-sample, and which contains a plurality of fluorescent-dye-molecules enclosed by a material that transmits fluorescence output from the fluorescent-dye-molecules, is used as the fluorescent-label. With the fluorescent-label binding-substance bound to the sensor-portion, the fluorescent-label is attracted to the sensor-portion by adjusting the pH of the sample-liquid to neutralize the charge state of the fluorescent-substance, thereby attracting the fluorescent-label onto the sensor-portion. In this state, the amount of the detection-target-substance is detected. | 01-14-2010 |
| 20100047820 | DETECTING METHOD, DETECTING APPARATUS, DETECTION SAMPLE CELL, AND DETECTING KIT - A sample is supplied onto the sensor portion of a sensor chip. An excitation light beam is irradiated to generate an enhanced optical field to be generated on the sensor portion. Fluorescent labels are excited, and the amount of a detection target substance is detected, based on the amount of light which is generated due to excitation of the fluorescent labels. A first electric charge is present on the surface of the sensor portion. A fluorescent substance having fluorescent pigment molecules which are enveloped in a light transmitting material that transmits fluorescence generated by the fluorescent pigment molecules, the surfaces of which are charged with second electric charges opposite the first electric charge on the surface are employed as the fluorescent labels. The fluorescent substance is attracted to the sensor portion by static electric interactions between the two charges. | 02-25-2010 |
| 20100065735 | DEVICE FOR MASS SPECTROMETRY, AND MASS SPECTROMETRY APPARATUS AND METHOD - In a device for mass spectrometry, an analyte contained in a sample is desorbed from a surface of the device by irradiating the sample in contact with the surface with measurement light. The device includes a micro-structure having a plurality of metal bodies on a surface of a substrate, and the plurality of metal bodies have sizes that can excite localized plasmons by irradiation with the measurement light. Further, the device includes an initiator fixed at least to a part of a surface of the micro-structure. | 03-18-2010 |
| 20110025315 | DETECTING METHOD AND DIELECTRIC PARTICLES CONTAINING MAGNETIC MATERIAL EMPLOYED IN THE DETECTING METHOD - A magnetic binding substance, which is a first binding substance that specifically binds with a target substance, having magnet enveloping dielectric particles, which have magnetic particles enveloped therein and surfaces modified with functional groups that exhibit polarity within a liquid sample, attached thereto, and a labeling binding substance, which is a second binding substance that specifically binds with the target substance having photoresponsive labels attached thereto, are mixed with the liquid sample such that binding reactions occur. A magnetic field is generated within a sample cell, to draw the magnetic binding substance to a local region. Excitation light is irradiated only onto a predetermined region including the local region while the magnetic binding substance is drawn to the local region, causing the photoresponsive labels present therein to generate optical signals. The optical signals are detected. | 02-03-2011 |
| 20110129942 | FLUORESCENCE DETECTING METHOD - An amount of fluorescent labels corresponding to an amount of a detection target substance are caused to bind on a detecting portion. The fluorescent labels are excited, and the amount of the detection target substance is detected based on the intensity of fluorescence emitted due to the excitation. Fine inorganic fluorescent particles which do not become discolored are employed as the fluorescent labels. | 06-02-2011 |
