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Hirschberger
Michael Hirschberger, Witten DE
| Patent application number | Description | Published |
|---|---|---|
| 20100014963 | CENTRIFUGAL PUMP - A centrifugal pump having a casing axially divided into two casing halves; an intake and a discharge; as well as an at least one-stage flow channel between the intake and the discharge for a medium to be pressurized; and a shaft mounted for rotation within the casing and being driven by motor; at least one impeller attached thereon and arranged in a stage channel of the flow channel; and at least one guide device on a partition wall arranged within the stage channel in the region of the intake of the associated impeller. There is provided, for influencing the pre-rotation within the flow in the intake of the stage channel of the impeller, that the radial angular position of the guide device arranged on the partition wall is adapted to be adjusted with reference to the plane of partition of the casing as zero position; a positioning device is mounted on the partition wall at a selectable angular distance from the guide device; and said positioning device is received by the casing in the region of the plane of partition of the latter. | 01-21-2010 |
Thomas Hirschberger, Munchen DE
| Patent application number | Description | Published |
|---|---|---|
| 20100029773 | Systematic identification of new anti-prion drugs by high-throughput screening based on scanning for intensely fluorescent targets (sift) - The present invention relates to a method of identifying a compound for inhibiting aggregation of proteins involved in diseases linked to protein aggregation and/or neurodegenerative diseases, comprising the steps of: (a) bringing into contact a labeled monomeric protein and a differently labeled aggregate of said protein in the (1) presence and (2) absence of a candidate inhibitor of aggregation, (b) determining the amount of co-localized labels, representing the extent of binding of the monomeric proteins to the aggregates of said protein; and (c) comparing the result obtained in the presence and absence of said compound, wherein a decrease of co-localized labels in the presence of said compound is indicative of the compound's ability to inhibit aggregation of said protein. Moreover, the present invention relates to a pharmaceutical composition containing said inhibitor of aggregation as well as to a kit. | 02-04-2010 |
Thomas Hirschberger, Stuttgart DE
| Patent application number | Description | Published |
|---|---|---|
| 20110293520 | NEW DRUG FOR INHIBITING AGGREGATION OF PROTEINS INVOLVED IN DISEASES LINKED TO PROTEIN AGGREGATION AND/OR NEURODEGENERATIVE DISEASES - The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of diseases linked to protein aggregation and/or neurodegenerative diseases. Moreover, the present invention relates to pharmaceutical and diagnostic compositions comprising the compound of the invention as well as to a kit. Furthermore, the present invention relates to a method of imaging deposits of aggregated protein. A kit for preparing a detectably labelled compound of the present invention is also disclosed. Formula (E) wherein X, Y and L are independently nondirectionally selected from —C(R | 12-01-2011 |