Patent application number | Description | Published |
20100086444 | BIOCHIP MANUFACTURING METHOD AND BIOCHIP MANUFACTURING DEVICE - Provided is a method of manufacturing a biochip using a droplet discharging device including a droplet discharging head having a cavity and a nozzle hole provided in communication with the cavity, and a liquid housing unit connected to the cavity via a passage, having the steps of filling a retention liquid which separates without getting mixed with the sample liquid into the liquid housing unit, the passage, and the cavity; injecting the sample liquid into the liquid housing unit; moving the sample liquid from the liquid housing unit to the cavity by discharging the retention liquid from the nozzle hole; stopping the discharge of the retention liquid at the moving step upon detecting with a sensor that the sample liquid reached a position adjacent to the nozzle hole; and delivering the sample liquid as droplets onto the object by discharging the sample liquid from the nozzle hole. | 04-08-2010 |
20110183378 | NUCLEIC ACID AMPLIFICATION METHOD, NUCLEIC ACID AMPLIFICATION APPARATUS, AND CHIP USED IN NUCLEIC ACID AMPLIFICATION - A nucleic acid amplification method includes introducing a liquid sample into a first chamber of a chip for use in nucleic acid amplification, the chip including a second chamber containing liquid that has a smaller specific gravity than the liquid sample and is immiscible with the liquid sample, injecting the liquid sample into the second chamber from the first chamber by a centrifugal force, regulating a temperature of an end of the chip, and rotating the chip about a rotation axis at a predetermined speed. | 07-28-2011 |
20110189660 | BIOCHIP, SAMPLE REACTION APPARATUS, AND SAMPLE REACTION METHOD - A biochip includes: a first chamber; a second chamber filled with a wax, a melting point of the wax being 25° C. or more and 63° C. or less; an injection path between the first chamber and the second chamber; and a sub-chamber that includes a wall at least partially made of the wax, the sub-chamber is formed inside the second chamber and communicates with the first chamber via the injection path. | 08-04-2011 |
20110256590 | BIOCHIP, REACTOR, AND REACTION METHOD - A biochip includes: a chamber that has a longitudinal direction; a holding unit that holds a liquid sample within a predetermined area of the chamber provided along the longitudinal direction, and releases the liquid sample from the predetermined area to an area inside the chamber by using a predetermined pressing force; and a pressed member that applies the predetermined pressing force to the liquid sample. | 10-20-2011 |
20120145260 | BIOTIP - A biotip according to an embodiment of the invention moves a reaction mixture along a longitudinal direction under the force of gravity. The biotip includes a chamber formed of a transparent material and filled with a liquid having a smaller specific gravity than the reaction mixture and immiscible with the reaction mixture, and a seal that seals the chamber. The liquid has a volume resistivity of greater than 0 Ω·cm and 5×10 | 06-14-2012 |
20120225001 | THERMAL CYCLER - A thermal cycler includes a holder receiving a reaction chamber including a channel filled with reaction mixture and an immiscible liquid having different specific gravities and allowing the reaction mixture to move along an opposed inner wall, a temperature gradient forming unit forming a temperature gradient in the movement direction of the reaction mixture relative to the channel during loading into the holder, and a driving unit rotating the holder and temperature gradient forming unit about a rotation axis having a component perpendicular to the gravitational direction and a component perpendicular to the movement direction of the reaction mixture, and a maximum distance from the rotation axis to a point in the channel is smaller than a maximum distance connecting two points in the channel when projected on a plane perpendicular to the rotation axis. | 09-06-2012 |
20120301367 | REACTION VESSEL - A reaction vessel which satisfies a relationship A11-29-2012 | |
20130210081 | THERMAL CYCLER AND THERMAL CYCLE METHOD - A thermal cycler ( | 08-15-2013 |
20130260383 | THERMAL CYCLER AND CONTROL METHOD OF THERMAL CYCLER - An attachment unit for attachment of a reaction container including a channel filled with a reaction solution containing a fluorescent probe and a liquid having a specific gravity different from that of the reaction solution and being immiscible with the reaction solution, the reaction solution moving close to opposed inner walls, a first heating unit heating a first region of the channel and a second heating unit heating a second region of the channel when the reaction container is attached to the attachment unit, a drive mechanism switching arrangement of the attachment unit, the first heating unit, and the second heating unit between a first arrangement and a second arrangement in which a lowermost position of the channel is located within a first region and a second region, respectively, a measurement unit measuring light intensity, and a control unit controlling the portions described above. | 10-03-2013 |
20130260421 | THERMAL CYCLER AND CONTROL METHOD OF THERMAL CYCLER - An attachment unit for attachment of a reaction container including a channel filled with a reaction solution and a liquid having a specific gravity different from that of the reaction solution and being immiscible with the reaction solution, the reaction solution moving close to opposed inner walls, a first heating unit that heats a first region of the channel and a second heating unit that heats a second region of the channel when the reaction container is attached to the attachment unit, a drive mechanism that switches arrangement of the attachment unit, the first heating unit, and the second heating unit between a first arrangement and a second arrangement in which a lowermost position of the channel is located within a first region and a second region, respectively, and a control unit that controls the drive mechanism, the first heating unit, and the second heating unit are provided. | 10-03-2013 |
20130330250 | DEVICE - A device includes: a tube having a first portion and a second portion; and a plunger insertable from the first portion side of the tube and having a tubular portion that can fit an inner surface of the first portion and a rod-like portion that can fit an inner surface of the second portion and is supported by the tubular portion, wherein when the tubular portion fits the inner surface of the first portion, a first state where the inner surface of the second portion and the rod-like portion are spaced apart from each other and a second state where the inner surface of the second portion and the rod-like portion fit together are formed, and in the first state, a communication path communicating the inside of the second portion with the inside of the tubular portion is formed, while in the second state, the communication path is blocked. | 12-12-2013 |
20130330811 | THERMAL CYCLER - A thermal cycler includes: a fitting section for fitting a biochip; a first temperature setting section that sets the temperature of a first region of the biochip; a second temperature setting section that sets the temperature of a second region different from the first region to a temperature different from the first temperature setting section; a driving mechanism that changes a positional relationship between the first region and the second region with respect to the gravitational direction; and a control section that controls the driving mechanism, wherein the control section performs: a process of controlling the driving mechanism such that a first arrangement in which the first region is on the lower side of the second region with respect to the gravitational direction is kept for a first predetermined period. | 12-12-2013 |
20130330818 | THERMAL CYCLER - A thermal cycler includes: a first mounting unit and a second mounting unit which are cylindrical; a temperature gradient forming unit which forms a temperature gradient along mounting directions of the first mounting unit and the second mounting unit; and a driving mechanism which rotates the first mounting unit, the second mounting unit, and the temperature gradient forming unit around a rotating shaft having a component perpendicular to a direction in which gravity is applied and a component intersecting the mounting directions of the first mounting unit and the second mounting unit, wherein the first mounting unit and the second mounting unit are disposed on opposite sides to each other with the rotating shaft interposed therebetween, the mounting direction of the first mounting unit and the mounting direction of the second mounting unit are in the same direction. | 12-12-2013 |
20140147914 | BIOTIP - A biotip according to an embodiment of the invention moves a reaction mixture along a longitudinal direction under the force of gravity. The biotip includes a chamber formed of a transparent material and filled with a liquid having a smaller specific gravity than the reaction mixture and immiscible with the reaction mixture, and a seal that seals the chamber. The liquid has a volume resistivity of greater than 0 Ω·cm and 5×10 | 05-29-2014 |
20140273101 | NUCLEIC ACID AMPLIFICATION REACTION DEVICE AND NUCLEIC ACID AMPLIFICATION METHOD - A nucleic acid amplification reaction device includes a rotary body having a mounting portion on which a cartridge, which includes a tube that has a plug containing an eluate in which a nucleic acid having bound to nucleic acid-binding solid-phase carriers is eluted from the carriers and a nucleic acid amplification reaction container that is in communication with the tube and contains oil undergoing phase separation from the eluate, is mounted; and a heater forming a temperature gradient inside the nucleic acid amplification reaction container, in which when the posture of the cartridge is changed due to the rotation of the rotary body, a droplet of the eluate introduced from the tube moves inside the nucleic acid amplification reaction container. | 09-18-2014 |
20150087026 | THERMAL CYCLER AND CONTROL METHOD OF THERMAL CYCLER - An attachment unit for attachment of a reaction container including a channel filled with a reaction solution and a liquid having a specific gravity different from that of the reaction solution and being immiscible with the reaction solution, the reaction solution moving close to opposed inner walls, a first heating unit that heats a first region of the channel and a second heating unit that heats a second region of the channel when the reaction container is attached to the attachment unit, a drive mechanism that switches arrangement of the attachment unit, the first heating unit, and the second heating unit between a first arrangement and a second arrangement in which a lowermost position of the channel is located within a first region and a second region, respectively, and a control unit that controls the drive mechanism, the first heating unit, and the second heating unit are provided. | 03-26-2015 |