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Hildinger
Markus Hildinger, Zurich CH
| Patent application number | Description | Published |
|---|---|---|
| 20100311116 | FAST GENERATION OF HIGH EXPRESSION STABLE CELL LINES EXPRESSING RECOMBINANT PROTEINS UNDER MINIMAL AND SHORT-TERM SELECTIVE PRESSURE - The present invention provides a novel method for the fast generation of high expression stable cell lines for the production of recombinant proteins with high efficacy of stable integration while using low selective pressure for only a short period of time. The method uses transiently expressed piggybac transposase to mediate stable integration of a transgene of interest flanked by the PB transposon termini. | 12-09-2010 |
Markus Hildinger, Pforzheim DE
| Patent application number | Description | Published |
|---|---|---|
| 20090023186 | USE OF VALPROIC ACID FOR ENHANCING PRODUCTION OF RECOMBINANT PROTEINS IN MAMMALIAN CELLS - Culturing cells for the commercial production of proteins for diagnosis and therapy is a costly and time consuming process. The equipment required is expensive, and production cost are high. In order to provide commercially viable processes it is desirable to use cell lines which produce large quantities of product with each production run. However, most cells do not produce large quantities of desired product per se either because they do not produce a large quantity of product per unit of time (specific productivity) or because they do not survive long enough in the culture medium (time). Here, we identified that addition of a valproic acid compound to the culture medium increases overall (batch) yield and titer. More importantly, compared to the widely used sodium butyrate, batch yields using a valproic acid compound as a medium additive are significantly higher. | 01-22-2009 |
| 20090233334 | CELL CULTIVATION AND PRODUCTION OF RECOMBINANT PROTEINS BY MEANS OF AN ORBITAL SHAKE BIOREACTOR SYSTEM WITH DISPOSABLE BAGS AT THE 1,500 LITER SCALE - The present invention provides a novel method for culturing cells as well as a novel method for producing a recombinant protein by culturing cells at large scale (up to 1,500 L nominal volume and 750 L working volume), whereby an inflated bag provides a sterile, disposable cultivation chamber. The inflated bag is partially filled with liquid cultivation media and cells, and placed into a containment vessel. The containment vessel is positioned onto an orbitally shaken platform. The orbital shaking moves the containment vessel and thus the bag and induces thereby motion to the liquid contained therein (“shake mixing”). This motion (caused by orbital shaking) induces a dynamic force field that ensures cell suspension, bulk mixing, and oxygen transfer from the liquid surface to the respiring cells without damaging shear or foam generation. | 09-17-2009 |
Markus Hildinger, Naples IT
| Patent application number | Description | Published |
|---|---|---|
| 20090192115 | USE OF COMPOUNDS THAT INTERFERE WITH THE HEDGEHOG SIGNALING PATHWAY FOR THE MANUFACTURE OF A MEDICAMENT FOR PREVENTING, INHIBITING, AND/OR REVERSING OCULAR DISEASES RELATED WITH OCULAR NEOVASCULARIZATION - The use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization. Particularly, the above-mentioned diseases are (wet) age-related macular degeneration, (proliferative) diabetic retinopathy, neovascular glaucoma, retinal vein occlusion, or retinopathy of prematurity (ROP). | 07-30-2009 |
Rainer Hildinger, Erlangen DE
| Patent application number | Description | Published |
|---|---|---|
| 20110289391 | INTERLEAVER DEVICE AND RECEIVER FOR A SIGNAL GENERATED BY THE INTERLEAVER DEVICE - The inventive concept enables backward-compatible extension of existing interleaver-based transmission systems to the effect that in addition to an existing logical transport channel, which is interleaved using a standardized interleaver profile, further logical transport channels may be transmitted via the same physical transmission channel. In this context, the first transport channel obviously is reduced in terms of data rate, so that the additional transport channels may actually obtain a transmission capacity that is needed accordingly. Interleaver profiles of the further logical transport channels are derived, to this end, from the interleaver profile of the first transport channel. | 11-24-2011 |
Stefan Hildinger, Stuttgart - Vaihingen DE
| Patent application number | Description | Published |
|---|---|---|
| 20100192569 | EXHAUST GAS SYSTEM AND METHOD FOR RECOVERING ENERGY - A system and method for recovering energy from gases of an internal combustion engine in conjunction with exhaust gas recirculation is described and illustrated, and in some embodiments includes an exhaust gas recirculation valve and an exhaust gas recirculation heat exchanger, with a working medium which undergoes a cyclic process being evaporated in the exhaust gas recirculation heat exchanger by hot exhaust gases, and with resulting steam being converted into mechanical or electrical energy which is available as additional energy. To improve heat recovery with little technical expenditure, an exhaust gas control valve can interact with the exhaust gas recirculation heat exchanger, and can control the mass flow of exhaust gases flowing through the exhaust gas recirculation heat exchanger constantly in all operating phases of the internal combustion engine, approximately in the vicinity of the performance limit of energy recovery. | 08-05-2010 |
Thomas Hildinger, Heidenheim DE
| Patent application number | Description | Published |
|---|---|---|
| 20120068569 | Dynamoelectric machine - The invention relates to a dynamoelectric machine, comprising the following components or features: | 03-22-2012 |