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Hildebrand, US

Atsuko Hildebrand, Winchester, KY US

Patent application numberDescriptionPublished
20100224468Switch and welding method of same - A switch comprises a switch housing including a cover, a terminal block welded to the cover and a fixed contact point therein, a moving block provided with a boss for fitting a manual shaft of an automatic transmission and a movable contact point corresponding to the fixed contact point and movable to the switch housing and elastic seal rings interposed between inner and outer peripheral surfaces of each of the terminal block and the cover, and the operation portion. One of the cover or the terminal block is formed of a colored, laser transmissive material and the other is formed of a laser non-transmissive material. The terminal block and the cover are automatically aligned with the moving block by an elastic force of the seal ring and a thermal welding part is circularly formed by means of a laser beam on the side of the outer periphery in each of the terminal block and the cover to be aligned for coupling the terminal block with the cover to fix the alignment.09-09-2010

Barret W. Hildebrand, Arlington, VA US

Patent application numberDescriptionPublished
20100063395Telemedicine platform for standardized interpretation of vascular data using vascular analysis - A system and method, for obtaining and analyzing vascular data and generating results, that uses vascular test data to determine the state of the vessel. The data and the determinations can be used to generate reports, render diagnoses or identifying ailments, and may do so remotely. The system includes a telemedicine server and may include a number of other modules such as work stations, review tools, data storage modules, etc. The invention allows rapid and efficient analysis of the data, and provides mechanisms for comparing patient data to know or measured normative data sets, remotely if desired, and provides more accurate and less invasive diagnoses based on vascular conditions. The invention permits remote receipt, processing and distribution of the data and diagnoses.03-11-2010

Bryan Hildebrand, Carlsbad, CA US

Patent application numberDescriptionPublished
20100249937FLANGED INTERBODY FUSION DEVICE - Methods and devices are disclosed for treating the vertebral column. An implant for treating the spine is provided comprising at least two articulations between the spacer and the bone facing surface of the fixation plate. Another implant for treating the spine is also provided, comprising two or more fixation plates attached to a spacer with two or more articulations, wherein the fixation plates are independently movable.09-30-2010

Calvin Hildebrand, Santa Fe, NM US

Patent application numberDescriptionPublished
20100261918Novel Process for Separating Lipids From a Biomass - A novel low cost separation process for separating lipid oil from an algal biomass for biofuel production is described herein. The process of the present invention comprises of two steps: (i) breaking the algae cells and (ii) separation of the lipid oils from the broken cells. The separated lipids are extracted by conventional techniques followed by conversion to a biofuel.10-14-2010

Curt Hildebrand, Murray, UT US

Patent application numberDescriptionPublished
20100327548STRUCTURES, ASSEMBLIES, AND METHODS FOR CONTROLLING VEHICLE SUSPENSION - A suspension system for a land vehicle has at least one rear suspension device and at least one front suspension device. The rear suspension device includes a first biasing member disposed within a first housing and is configured for mounting on a rear axle housing of the land vehicle. The front suspension device includes a second biasing member disposed in a second housing and is configured to be at least partially received within a bump stop support of the land vehicle.12-30-2010

Daniel Hildebrand, Menlo Park, CA US

Patent application numberDescriptionPublished
20100219092Two-Part Package for Medical Implant - The invention provides a two-part package and method of use for a pre-attached medical implant and delivery tool system. The package includes a wet compartment and a dry compartment and allows a pre-attached implant and delivery tool system to be at least partially stored immersed in a fluid in the wet compartment and at least partially stored in the dry compartment. In one embodiment the implant comprises a replacement heart valve, and the heart valve is stored inside the wet compartment while the heart valve delivery tool remains dry in the dry compartment.09-02-2010
20110257735SYSTEMS AND METHODS FOR DELIVERING A MEDICAL IMPLANT - The present invention relates to apparatus and methods for endovascularly delivering and releasing a prosthesis, e.g., an aortic prosthesis, within and/or across a patient's native heart valve, referred to hereinafter as replacing the patient's heart valve. In some embodiments the delivery system comprises a plurality of first actuatable element adapted to engage a plurality of second elements in a first configuration to capture the implant within the delivery system, and wherein the plurality of first actuatable element are adapted to engage the plurality of second elements in a second configuration and to release the implant from the delivery system.10-20-2011
20120016469Methods and Apparatus for Endovascularly Replacing a Heart Valve - The invention includes methods of and apparatus for endovascularly replacing a heart valve of a patient. One aspect of the invention provides a method including the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve in an unexpanded configuration; and applying an external non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to change the shape of the anchor, such as by applying proximally and/or distally directed force on the anchor using a releasable deployment tool to expand and contract the anchor or parts of the anchor. Another aspect of the invention provides an apparatus including a replacement valve; an anchor; and a deployment tool comprising a plurality of anchor actuation elements adapted to apply a non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to reshape the anchor.01-19-2012
20120029627Methods and Apparatus for Endovascular Heart Valve Replacement Comprising Tissue Grasping Elements - The present invention provides an apparatus for endovascularly replacing a patient's heart valve. In some embodiments, the apparatus includes an expandable anchor supporting a replacement valve, the anchor and replacement valve being adapted for percutaneous delivery and deployment to replace the patient's heart valve, the anchor having a braid having atraumatic grasping elements adapted to grasp tissue in a vicinity of the patient's heart valve.02-02-2012
20120041550Methods and Apparatus for Endovascular Heart Valve Replacement Comprising Tissue Grasping Elements - A method for endovascularly replacing a patient's heart valve including the following steps: endovascularly delivering an anchor and a replacement valve supported within the anchor to a vicinity of the heart valve in a collapsed delivery configuration, the anchor having grasping elements adapted to grasp tissue in a vicinity of the heart valve; expanding the anchor, thereby rotating the grasping elements; and grasping the tissue with the rotating grasping elements.02-16-2012
20120132547TWO-PART PACKAGE FOR MEDICAL IMPLANT - The invention provides a two-part package and method of use for a pre-attached medical implant and delivery tool system. The package includes a wet compartment and a dry compartment and allows a pre-attached implant and delivery tool system to be at least partially stored immersed in a fluid in the wet compartment and at least partially stored in the dry compartment. In one embodiment the implant comprises a replacement heart valve, and the heart valve is stored inside the wet compartment while the heart valve delivery tool remains dry in the dry compartment.05-31-2012

Patent applications by Daniel Hildebrand, Menlo Park, CA US

Daniel Hildebrand, San Francisco, CA US

Patent application numberDescriptionPublished
20100121434Medical Devices and Delivery Systems for Delivering Medical Devices - Medical devices and delivery systems for delivering medical devices to a target location within a subject. In some embodiments the medical devices can be locked in a fully deployed and locked configuration. In some embodiments the delivery systems are configured with a single actuator to control the movement of multiple components of the delivery system. In some embodiments the actuator controls the independent and dependent movement of multiple components of the delivery system.05-13-2010
20100280495Medical Devices and Delivery Systems for Delivering Medical Devices - Medical devices and delivery systems for delivering medical devices to a target location within a subject. In some embodiments the medical devices can be locked in a fully deployed and locked configuration. In some embodiments the delivery systems are configured with a single actuator to control the movement of multiple components of the delivery system. In some embodiments the actuator controls the independent and dependent movement of multiple components of the delivery system.11-04-2010
20110052020Lens Capsule Size Estimation - Methods of estimating the size of an ocular lens capsule.03-03-2011
20120022547Intraocular Lens Delivery Devices and Methods of Use - Intraocular lens delivery devices and methods of use.01-26-2012
20120046740MEDICAL DEVICES AND DELIVERY SYSTEMS FOR DELIVERING MEDICAL DEVICES - Medical devices and delivery systems for delivering medical devices to a target location within a subject. In some embodiments the medical devices can be locked in a fully deployed and locked configuration. In some embodiments the delivery systems are configured with a single actuator to control the movement of multiple components of the delivery system. In some embodiments the actuator controls the independent and dependent movement of multiple components of the delivery system.02-23-2012

Patent applications by Daniel Hildebrand, San Francisco, CA US

Daniel K. Hildebrand, San Francisco, CA US

Patent application numberDescriptionPublished
20090319023Stents and Stent Grafts - The subjected devices include a stent, a graft and a means for attaching the graft to the stent. One or more members are received in a permanent or temporary receptacle within the stent attach the graft to the stent. In one variation, an interference fit is employed; in another, the graft is bonded to a stent-captured member(s).12-24-2009

David Hildebrand, Austin, TX US

Patent application numberDescriptionPublished
20080288330SYSTEM AND METHOD FOR USER ACCESS RISK SCORING - Systems and methods for measuring access risk associated with an enterprise having at least one resource accessible by at least one user with at least one entitlement to access the resource. Some embodiments implement a method of identifying the resources, users, and entitlements and associating access risk scores with the entitlements. The method can include combining the access risk scores associated with each user to form composite access risks scores and outputting the composite access risk scores. In some embodiments, the user with the highest composite access risk score can be identified and remedial action taken. The highest access risk user of some embodiments may be a department, a division, a subsidiary, or an organization. The method can occur in real time and an administrator can be alerted to changes in entitlements. Access risk scores can be adjusted for compensating controls and personal factors and attributes of the users.11-20-2008

David B. Hildebrand, Coppell, TX US

Patent application numberDescriptionPublished
20090285045Area Efficient First-In First-Out circuit - A FIFO memory having an available capacity of no more than N words deep by M bits wide. A write port receives data to store in the FIFO memory, and a read port provides the data stored in the FIFO memory. X memories store the data, where each of the X memories has a size of N/X by M. Control logic receives the data from the write port, writes the data into at least one of the X memories in a serial write manner, reads the data from at least one of the X memories in a serial read manner, and provides the data to the read port. The control logic also disables power to selected ones of the X memories when they are not being written to or read from. The FIFO memory is configured to both read and write the data at a given time to a given one of the X memories.11-19-2009

Dean Hildebrand, San Jose, CA US

Patent application numberDescriptionPublished
20110078467REDUCING ENERGY CONSUMPTION IN A COMPUTING CLUSTER - Embodiments of the invention relate to reducing energy consumption in a computing cluster. An aspect of the invention includes a method for reducing energy consumption in a computing cluster. The method includes monitoring requests to server. The method further includes activating a server, if at least one request is to be routed to the server in a reduced power consumption state. The method further includes routing the requests to at least one server. The method further includes reducing power consumption on the server, if the server does not have at least one active request.03-31-2011
20110145307DIRECTORY TRAVERSAL IN A SCALABLE MULTI-NODE FILE SYSTEM CACHE FOR A REMOTE CLUSTER FILE SYSTEM - Directory traversal in a scalable multi-node file system cache for a remote cluster file system, is provided. One implementation involves maintaining a scalable multi-node file system cache in a local cluster file system, and caching local file data in the cache by fetching file data on demand from a remote cluster file system into the cache over the network. The local file data corresponds to file data in the remote cluster file system. The local namespace emulates the remote namespace and is created on demand. Access to data further involves performing directory traversal for the cache for the remote cluster file system by creating a directory structure on demand.06-16-2011
20110145363DISCONNECTED FILE OPERATIONS IN A SCALABLE MULTI-NODE FILE SYSTEM CACHE FOR A REMOTE CLUSTER FILE SYSTEM - Facilitating access to data in a network, is provided. One implementation involves maintaining a scalable multi-node file system cache in a local cluster file system, and caching file data in a cache by fetching file data on demand from a remote cluster file system into the local cached file system over the network. The local file data corresponds to file data in the remote cluster file system. Upon disconnection from the remote cluster file system, all file operations are supported at the cache. Then, upon reconnection to the remote cluster file system over the network, the remote cluster file system is synchronized with the information cached in the cache during the disconnection even in the presence of failures.06-16-2011
20110145367SCALABLE CACHING OF REMOTE FILE DATA IN A CLUSTER FILE SYSTEM - Scalable caching of remote file data in cluster file systems is provided. One implementation involves maintaining a cache in a local cluster file system and caching local file data in the cache by fetching file data on demand from the remote cluster file system into the local cached file system over the network. The local file data and metadata corresponds to the remote file data and metadata in the remote cluster file system. Updates made to the local file data and metadata are pushed back to the remote cluster file system asynchronously.06-16-2011
20110145499ASYNCHRONOUS FILE OPERATIONS IN A SCALABLE MULTI-NODE FILE SYSTEM CACHE FOR A REMOTE CLUSTER FILE SYSTEM - Asynchronous file operations in a scalable multi-node file system cache for a remote cluster file system, is provided. One implementation involves maintaining a scalable multi-node file system cache in a local cluster file system, and caching local file data in the cache by fetching file data on demand from the remote cluster file system into the cache over the network. The local file data corresponds to file data in the remote cluster file system. Local file information is asynchronously committed from the cache to the remote cluster file system over the network.06-16-2011
20110296422Switch-Aware Parallel File System - Embodiments of the invention related to a switch-aware parallel file system. A computing cluster is partitioned into a plurality of computing cluster building blocks comprising a parallel file system. Each computing cluster building block comprises a file system client, a storage module, a building block metadata module, and a building block network switch. The building block metadata module tracks a storage location of data allocated by the storage module within the computing cluster building block. The computing cluster further comprises a file system metadata module that tracks which of the plurality of computing cluster building blocks data is allocated among within the parallel file system. The computing cluster further comprises a file system network switch to provide the parallel file system with access to each of the plurality of computing cluster building blocks and the file system metadata module. At least one additional computing cluster building block is added to the computing cluster, if resource utilization of the computing cluster exceeds a pre-determined threshold.12-01-2011

George R. Hildebrand, Independence, MO US

Patent application numberDescriptionPublished
20100140299Trigger Sprayer - A trigger sprayer having six parts: (i) a dip tube, (ii) a valve, (iii) a flexible pump diaphragm having a circumferential valve lip, (iv) a shroud having a trigger, an element which engages the diaphragm, and front and rear mating elements, (v) a body having a closure for a container, an inlet coupled to the dip tube, a valve seat for the valve, an element which engages the valve lip, a discharge barrel having a proximal opening into which the valve lip seats, a vent chamber, a vent barrel coupled to the vent chamber, a rear mating structure coupling to the rear mating element of the shroud so that the shroud can pivot, and a forward mating element, and (vi) a combination nozzle and door assembly with a nozzle which couples to the fluid discharge barrel of the molded body, and has a trigger locking element.06-10-2010
20100276454ROTATING SPRAYER AND METHODS FOR USING THE SAME - A trigger sprayer may include a rotatable nozzle to facilitate the discharge of liquid from the nozzle in any desired direction and may also include a locking mechanism for preventing activation of the trigger sprayer. The trigger sprayer may also fit within the footprint of a container to which the trigger sprayer is attached.11-04-2010

Greg A. Hildebrand, Keizer, OR US

Patent application numberDescriptionPublished
20110053459SLOW SPEED SPINDLE FOR MICROPUNCH GRINDING - An apparatus has a motor, a shaft attached to the motor arranged to be turned by the motor when the motor operates, an attachment at an end of the shaft opposite the motor arranged to allow mounting of components to be ground, a loading block arranged under the end of the shaft having the attachment to support the components to be ground, and an interface to a grinding tool arranged adjacent to the loading block. An apparatus has a motor mounted on a slide, a shaft attached to the motor arranged to spin when the motor operates. an attachment on the end of the shaft to allow attachment of a component, a loading block at least partially supporting the shaft. an interface to a manufacturing tool, the motor and shaft arranged to insert the shaft into the interface when moved along the slide to an engaged position.03-03-2011

Hal Hildebrand, Moss Beach, CA US

Patent application numberDescriptionPublished
20120137130System and Method for Providing Multi-Location Access Management to Secured Items - A system and method for providing access management to secured items through use of a plurality of server machines associated with different locations are disclosed. According to one embodiment, a local server can be dynamically reconfigured depending on a user's current location. Upon detecting that a user has moved to a new location, the local server for the new location can be reconfigured to add support for the user, while simultaneously, the local server for the previous location is reconfigured to remove support for the user. As a result, security is enhanced while the access management can be efficiently carried out to ensure that only one access from the user is permitted at any time across an entire organization, regardless of how many locations the organization has or what access privileges the user may be granted.05-31-2012

Hal S. Hildebrand, Moss Beach, CA US

Patent application numberDescriptionPublished
20110258438System and Method for Providing Different Levels of Key Security for Controlling Access to Secured Items - With files secured by encryption techniques, keys are often required to gain access to the secured files. Techniques for providing and using multiple levels of keystores for securing the keys are disclosed. The keystores store keys that are needed by users in order to access secured files. The different levels of keystores offer compromises between security and flexibility/ease of use.10-20-2011
20110307937SECURITY SYSTEM FOR GENERATING KEYS FROM ACCESS RULES IN A DECENTRALIZED MANNER AND METHODS THEREFOR - Improved system and approaches for decentralized key generation are disclosed. The keys that can be generated include both public keys and private keys. The public keys are arbitrary strings that embed or encode access restrictions. The access restrictions are used to enforce access control policies. The public keys are used to encrypt some or all portions of files. The private keys can be generated to decrypt the portions of the files that have been encrypted with the public keys. By generating keys in a decentralized manner, not only are key distribution burdens substantially eliminated but also off-line access to encrypted files is facilitated.12-15-2011

Jens Hildebrand, Midlothian, VA US

Patent application numberDescriptionPublished
20110245138Fabric Softener Active Composition - A fabric softener active composition, comprising at least 50% by weight of a bis-(2-hydroxypropyl)-dimethylammonium methylsulphate fatty acid ester having a molar ratio of fatty acid moieties to amine moieties of from 1.5 to 1.99, wherein the average chain length of the fatty acid moieties is from 16 to 18 carbon atoms and the iodine value of the fatty acid moieties, calculated for the free fatty acid, is from 0.5 to 50, and from 0.5 to 5% by weight fatty acid provides high softening performance and good storage stability in aqueous dispersion and can be handled and processed in a liquid state without addition of a flammable solvent.10-06-2011

John G. Hildebrand, Lawrenceville, GA US

Patent application numberDescriptionPublished
20080256584Method and System of Transporting Multimedia Signals - A method and system of transporting multimedia signals from a source 10-16-2008
20080263623Method and System of Providing Signals - A method and system of supporting operation of customer equipment in systems having at least a portion of their signals being transported according to standards which are not supported by the customer equipment.10-23-2008

Joseph J. Hildebrand, Littleton, CO US

Patent application numberDescriptionPublished
20090240829TRANSLATING BETWEEN IMPLICIT AND EXPLICIT PUBLISH-SUBSCRIBE PROTOCOLS - In one embodiment, a translating publish-subscribe (pub-sub) server may be configured to receive a subscribe request from a subscriber device according to an original pub-sub model. The server may then convert the received subscribe request into a pub-sub subscribe request of a second pub-sub model, and may transmit the converted received subscribe request to publisher servers operating according to the second pub-sub model.09-24-2009

Keith Hildebrand, Houlton, WI US

Patent application numberDescriptionPublished
20100030196APHERESIS OF A TARGET MOLECULE FROM CEREBROSPINAL FLUID - A system includes (i) a medium having a solid support to which an antibody directed to target molecule is bound, (ii) a reservoir for containing the medium, (iii) a first catheter, and (iv) a second catheter. The first catheter has a proximal end portion, an opening for removal of cerebrospinal fluid from a subject, and a lumen extending from the proximal end portion to the opening. The first catheter is operably couplable to the reservoir such that fluid is capable of flowing from the lumen to the reservoir. The second catheter has a proximal end portion, a delivery region for returning cerebrospinal fluid to the subject, and a lumen extending from the proximal end portion to the delivery region. The second catheter is operably couplable to the reservoir such that fluid is capable of flowing from the reservoir to the lumen.02-04-2010

Robert E. Hildebrand, Macedon, NY US

Patent application numberDescriptionPublished
20090148183METHOD AND APPARATUS FOR SHIFTING IMAGE FORMING APPARATUS PHOTORECEPTOR TO REDUCE GHOST FORMATION - A method and apparatus for shifting a photoreceptor in a cross-process direction to reduce the formation of a paper edge ghost on the photoreceptor. The shifting can occur continuously or in steps.06-11-2009

Patent applications by Robert E. Hildebrand, Macedon, NY US

Stephen Hildebrand, Apex, NC US

Patent application numberDescriptionPublished
20090035137Helicopter vibration control system and rotary force generator for canceling vibrations - Helicopter rotating hub mounted vibration control system for a rotary wing hub having periodic vibrations while rotating at an operational rotation frequency. The vibration control system includes a housing attachable to the rotary wing hub and rotating with the hub at the operational frequency. The housing is centered about the rotary wing hub axis of rotation and has an electronics housing cavity subsystem and an adjacent rotor housing cavity subsystem. The rotor housing cavity contains a first coaxial ring motor with a first rotor and imbalance mass and a second coaxial ring motor with a second rotor and imbalance mass. The electronics housing cavity contains an electronics control system which receives sensor outputs and electrically controls and drives the first motor and the second motor such that the first imbalance mass and the second imbalance mass are driven at a vibration canceling rotation frequency greater than the operational rotation frequency wherein the helicopter rotary wing hub periodic vibrations are reduced.02-05-2009

Stephen F. Hildebrand, Apex, NC US

Patent application numberDescriptionPublished
20100096818MAGNETO-RHEOLOGICAL DAMPERS FOR SEMI-ACTIVE SUSPENSION SYSTEMS - A magneto-rheological fluid damper includes a damper body having a reservoir for a magneto-rheological fluid, a piston rod, a piston rod guide disposed within the damper body, where the piston rod guide has a passage therein for receiving the piston rod. The magneto-rheological fluid damper further includes at least a first piston rod seal and at least a second piston rod seal arranged to seal between the piston rod guide and the piston rod. The magneto-rheological fluid damper further includes a fluid chamber defined between the piston rod guide and the piston rod, the fluid chamber being in communication with the reservoir. The magneto-rheological fluid damper further includes a piston rod guide filter arranged in a communication path between the fluid chamber and the reservoir to filter particulates out of the magneto-rheological fluid entering the fluid chamber. The magneto-rheological fluid damper further includes an accumulator arranged between the piston rod guide and the damper body.04-22-2010
20100109276CONTROLLABLE VEHICLE SUSPENSION SYSTEM WITH MAGNETO-RHEOLOGICAL FLUID DEVICE - A controllable suspension system for controlling the relative motion between a first body and a second body includes at least one strut including a magneto-rheological fluid damper. The fluid damper includes a piston rod guide disposed within a damper body. The piston rod guide has a passage therein for receiving a piston rod. A piston rod bearing assembly is disposed in the piston rod guide to engage with and support reciprocal motion of the piston rod. At least a first piston rod seal and at least a second piston rod seal are arranged to seal between the piston rod guide and the piston rod. A fluid chamber is defined between the piston rod guide and the piston rod. A piston rod guide gas charged accumulator is arranged between the piston rod and the damper body.05-06-2010
20110208361MOTION CONTROL SYSTEM WITH DIGITAL PROCESSING LINK - A digital processing link for a vibration control system collects sensor signals at a transfer station and combines the sensor signals into a collective signal that is transmitted under a digital communications protocol to a base station. The sensor signals are separated at the base station and individually processed to produce one or more output control signals to actuators for counteracting the measured vibration.08-25-2011

Steve F. Hildebrand, Apex, NC US

Patent application numberDescriptionPublished
20090306829AIRCRAFT WITH TRANSIENT-DISCRIMINATING PROPELLER BALANCING SYSTEM - A system for balancing an aircraft propeller system receives a vibration signal from the aircraft propeller system and determines whether the vibration signal indicates a transient vibration condition. If it is determined that the vibration signal does not indicate a transient condition, the system enables a balance correction controller. The controller generates a balance correction signal based on the vibration signal, and balances the aircraft propeller system in response to the balance correction signal if the balance correction controller is enabled.12-10-2009

William H. Hildebrand, Edmond, OK US

Patent application numberDescriptionPublished
20090062512Comparative ligand mapping from MHC class I positive cells - The present invention relates generally to a methodology for the isolation, purification and identification of peptide ligands presented by MHC positive cells. In particular, the methodology of the present invention relates to the isolation, purification and identification of these peptide ligands from soluble class I and class II MHC molecules which may be from uninfected, infected, or tumorigenic cells. The methodology of the present invention broadly allows for these peptide ligands and their cognate source proteins thereof to be identified and used as markers for infected versus uninfected cells and/or tumorigenic versus nontumorigenic cells, with said identification being useful for marking or targeting a cell for therapeutic treatment or priming the immune response against infected/tumorigenic cells.03-05-2009
20090182131Methods for removing anti-MHC antibodies from a sample - The present invention relates generally to anti-MHC assay methodologies utilizing functionally active, recombinantly produced, and truncated individual soluble MHC trimolecular complexes that are linked to a substrate. The methods include reacting a sample with the substrate having the MHC trimolecular complex linked thereto, whereby antibodies specific for the at least one MHC trimolecular complex linked to the substrate are removed from the biological sample.07-16-2009
20100003718METHOD AND APPARATUS FOR THE PRODUCTION OF SOLUBLE MHC ANTIGENS AND USES THEREOF - The field of the invention relates in general to at least one method and apparatus for the production of soluble MHC antigens and more particularly, but not by way of limitation, to at least one method and apparatus for the production of soluble Class I and II HLA molecules. The field of the invention also includes such produced soluble Class I and II HLA molecules and their use. According to the methodology of the present invention, the soluble Class I and II HLA molecules can be produced from either gDNA or cDNA starting material.01-07-2010
20100105107PURIFICATION AND CHARACTERIZATION OF SOLUBLE MHC PROTEINS - The present invention relates generally to the production and use of functionally active soluble HLA molecules that are isolated and purified substantially away from other proteins, and methods of purifying same.04-29-2010
20110065587EPITOPE TESTING USING SOLUBLE HLA - The present invention relates generally to a methodology for assaying the binding of a peptide to an individual, specific, soluble HLA molecule.03-17-2011
20110288270COMPARATIVE LIGAND MAPPING FROM MHC CLASS I POSITIVE CELLS - The present invention relates generally to a methodology for the isolation, purification and identification of peptide ligands presented by MHC positive cells. In particular, the methodology of the present invention relates to the isolation, purification and identification of these peptide ligands from soluble class I and class II MHC molecules which may be from uninfected, infected, or tumorigenic cells. The methodology of the present invention broadly allows for these peptide ligands and their cognate source proteins thereof to be identified and used as markers for infected versus uninfected cells and/or tumorigenic versus nontumorigenic cells, with said identification being useful for marking or targeting a cell for therapeutic treatment or priming the immune response against infected/tumorigenic cells.11-24-2011

Patent applications by William H. Hildebrand, Edmond, OK US