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Higuchi, CA
Robert Higuchi, Solana Beach, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090105292 | Glucocorticoid Receptor Modulator Compounds and Methods - Disclosed herein are compounds of Formula I: | 04-23-2009 |
| 20100069379 | Bicyclic androgen and progesterone receptor modulator compounds and methods - The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agonists, partial agonists (i.e., partial activators and/or tissue-specific activators) and antagonists for AR and PR. Also provided are methods of making such compounds and pharmaceutical compositions, as well as critical intermediates used in their synthesis. | 03-18-2010 |
| 20110112084 | Bicyclic androgen and progesterone receptor modulator compounds and methods - The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agonists, partial agonists (i.e., partial activators and/or tissue-specific activators) and antagonists for AR and PR. Also provided are methods of making such compounds and pharmaceutical compositions, as well as critical intermediates used in their synthesis. | 05-12-2011 |
Robert I. Higuchi, Solana Beach, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080300241 | Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods - Non-steroidal tricyclic quinolinone and tricyclic quinoline compounds and compositions that are agonists, partial agonists and/or antagonists for androgen receptors (AR), their preparation and their uses are described. | 12-04-2008 |
| 20100152098 | POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF - Disclosed are compounds having polybasic functionalities. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism. | 06-17-2010 |
| 20100210678 | Tricyclic androgen receptor modulator compounds and methods - Provided are non-steroidal tricyclic compounds that are modulators of androgen receptors and methods for making and using such compounds. | 08-19-2010 |
Russell Higuchi, Alameda, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090162846 | SENP1 as a marker for cancer - The present invention provides methods of detecting cancer cells by detecting the quantity of SENP1 and/or telomerase in a sample. | 06-25-2009 |
| 20100086913 | Methods of Identification Using Methylation of CPG - The present invention relates to the materials and methods for the identification of methylated nucleotides in samples of genomic DNA. The present invention also relates to methods of diagnosis of specific conditions by identification of specific methylated nucleotides. | 04-08-2010 |
| 20100086914 | HIGH RESOLUTION, HIGH THROUGHPUT HLA GENOTYPING BY CLONAL SEQUENCING - The invention provides methods and reagent for performing full, multi-locus HLA genotyping for multiple individuals in a single sequencing run using clonal sequencing. | 04-08-2010 |
| 20100233686 | Multiplex Quantitative Nucleic Acid Amplification and Melting Assay - The invention is a single-tube multiplex assay, capable of simultaneously amplifying, detecting and quantifying multiple nucleic acid targets, using multiple hybridization probes, labeled with the same fluorescent reporter label, but each having a distinct melting temperature. The assay can be further multiplexed with the use of multiple sets of hybridization probes, each set labeled with a separate fluorescent reporter label. | 09-16-2010 |
| 20110136120 | Methods of Identification of Methylation of CPG - The present invention relates to the materials and methods for the identification of methylated nucleotides in samples of genomic DNA. The present invention also relates to methods of diagnosis of specific conditions by identification of specific methylated nucleotides. | 06-09-2011 |
Russell Gene Higuchi, Alameda, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100261189 | System and method for detection of HLA Variants - A method for detecting one or more HLA sequence types is described that comprises the steps of: amplifying a plurality of first amplicons from a double stranded nucleic acid sample, wherein the first amplicons are amplified with a plurality of pairs of nucleic acid primers that define exons 2 and 3 of both strands of HLA loci from the group consisting of HLA-A, HLA-B, and HLA-C; amplifying the first amplicons to produce a plurality of populations of second amplicons, wherein each population of second amplicons is clonally amplified from one of the first amplicons; sequencing the plurality of populations of second amplicons to generate a nucleic acid sequence composition for each of the plurality of second amplicons; and detecting variation in the sequence composition from one or more of the second amplicons for one or more of the HLA loci. | 10-14-2010 |
Terence Higuchi, Redondo Beach, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110097969 | PECTORAL SHOULDER JOINT TOY FIGURE - A torso assembly that enables forward and backward shoulder movement for a toy action figure is disclosed. The torso assembly includes a central section and shoulder sections disposed at either side. The central section includes front and back shells. Each shoulder section includes a side shell that partially overlaps the front and back shell portions, and a hinge assembly. Hinge assemblies couple the first and second shoulder sections to each other within the central section, and allow each shoulder section to pivot forward and backward relative to the central section. In some embodiments, the torso assembly may be incorporated into an action figure or doll by movable joints that connect the torso assembly to a lower abdomen and/or pelvis. | 04-28-2011 |