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| 20120045433 | COMBINATION THERAPY - The present invention relates to a combination therapy of propane-1-sulfonic acid {3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide, or a pharmaceutically acceptable salt thereof, and an topoisomerase inhibitor for treating a patient suffering from a proliferative disorder, in particular a solid tumor, for example, colorectal cancer, melanoma, and thyroid cancer. In particular, the present invention relates to such a therapy wherein the topoisomerase inhibitor is irinotecan, or a pharmaceutically acceptable salt thereof, and the disorder is colorectal cancer involving a tumor comprising b-Raf having the V600E mutation. | 02-23-2012 |
| 20120045434 | COMBINATION THERAPY - The present invention relates to a combination therapy of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide, or a pharmaceutically acceptable salt thereof, and an EGFR inhibitor for treating a patient suffering from a proliferative disorder, in particular a solid tumor, for example, colorectal cancer, melanoma, and thyroid cancer. | 02-23-2012 |
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| 20100190047 | VARIABLE VOLUME CONTAINMENT FOR ENERGY STORAGE DEVICES - A stacked energy storage device (ESD) has at least two cell segments arranged in a stack. Each cell segment may have a first electrode unit having a first active material electrode, a second electrode unit having a second active material electrode, and an electrolyte layer between the active material electrodes. Variable volume containment may be used to control the inter-electrode spacing within each cell segment. In some embodiments, one or more dynamic flexible gaskets may be included in each cell segment to seal the electrolyte within the cell segment and to deform in preferred directions. In some embodiments, hard stops may set the inter-electrode spacing of the ESD. | 07-29-2010 |
| 20100203384 | ELECTRODE FOLDS FOR ENERGY STORAGE DEVICES - A stacked energy storage device (ESD) has at least two conductive substrates arranged in a stack. Each cell segment may have a first electrode unit having a first active material electrode, a second electrode unit having a second active material electrode, and an electrolyte layer between the active material electrodes. Each active material electrode may have a plurality of folded sections and planar sections to increase the ESD capacity, for example, by increasing number of interfaces within each cell segment. | 08-12-2010 |
| 20100310923 | BI-POLAR RECHARGEABLE ELECTROCHEMICAL BATTERY - A bi-polar battery has a positive electrode unit, a negative electrode unit, at least one bi-polar electrode unit stacked therebetween, an electrolyte layer separating each adjacent electrode unit, and a gasket positioned about each electrolyte layer for creating a seal about the electrolyte layer in conjunction with the electrode units adjacent thereto. The bi-polar battery also includes a wrapper for maintaining the seals created by the gaskets. | 12-09-2010 |
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| 20090023061 | Stacked constructions for electrochemical batteries - A stacked battery has at least two cell segments arranged in a stack. Each cell segment may have a first electrode unit having a first active material electrode, a second electrode unit having a second active material electrode, and an electrolyte layer between the active material electrodes. One or more gaskets may be included in each cell segment to seal the electrolyte within the cell segment. | 01-22-2009 |
| 20090142655 | DISH SHAPED AND PRESSURE EQUALIZING ELECTRODES FOR ELECTROCHEMICAL BATTERIES - A stacked battery has at least two cell segments arranged in a stack. Each cell segment may have a first electrode unit having a first active material electrode, a second electrode unit having a second active material electrode, and an electrolyte layer between the active material electrodes. One or more gaskets may be included in each cell segment to seal the electrolyte within the cell segment. The electrode units may be “dish shaped” and may contain a pressure equalization valve to reduce electrode unit deflection and improve pressure equalization between cell segments. The pressure equalization valve may allow a gas to diffuse through adjacent cell segments and may substantially prevent electrolyte from diffusing through. | 06-04-2009 |
| 20100190047 | VARIABLE VOLUME CONTAINMENT FOR ENERGY STORAGE DEVICES - A stacked energy storage device (ESD) has at least two cell segments arranged in a stack. Each cell segment may have a first electrode unit having a first active material electrode, a second electrode unit having a second active material electrode, and an electrolyte layer between the active material electrodes. Variable volume containment may be used to control the inter-electrode spacing within each cell segment. In some embodiments, one or more dynamic flexible gaskets may be included in each cell segment to seal the electrolyte within the cell segment and to deform in preferred directions. In some embodiments, hard stops may set the inter-electrode spacing of the ESD. | 07-29-2010 |
| 20100203384 | ELECTRODE FOLDS FOR ENERGY STORAGE DEVICES - A stacked energy storage device (ESD) has at least two conductive substrates arranged in a stack. Each cell segment may have a first electrode unit having a first active material electrode, a second electrode unit having a second active material electrode, and an electrolyte layer between the active material electrodes. Each active material electrode may have a plurality of folded sections and planar sections to increase the ESD capacity, for example, by increasing number of interfaces within each cell segment. | 08-12-2010 |
| 20100310923 | BI-POLAR RECHARGEABLE ELECTROCHEMICAL BATTERY - A bi-polar battery has a positive electrode unit, a negative electrode unit, at least one bi-polar electrode unit stacked therebetween, an electrolyte layer separating each adjacent electrode unit, and a gasket positioned about each electrolyte layer for creating a seal about the electrolyte layer in conjunction with the electrode units adjacent thereto. The bi-polar battery also includes a wrapper for maintaining the seals created by the gaskets. | 12-09-2010 |
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| 20090223411 | ORGANOSILANE-NONIONIC-WATER STABLE QUATERNARY AMMONIUM COMPOSITIONS AND METHODS - Methods of applications of organosilanes optionally having a nonhydrolyzable organic group, but having one or more hydrolyzable groups, with a polyol containing at least three hydroxy groups, where any two of the hydroxy groups are separated by at least three intervening atoms by aerosolization of droplets between 0.5-8 microns are disclosed and an improved formulation comprising adding a nonionic wetting agent are disclosed. An improved aerosolization application technique and the improved formulation provide for smaller droplet size and better coverage of substrates to which the organosilanes are applied. The improved formulation has increased affinity, reduces surface tension and therefore can covalently bond more quickly. A method of treating a substrate, and the treated substrate so formed, by contacting the substrate with the improved formulation for a period of time sufficient for treatment of the substrate are disclosed. | 09-10-2009 |
| 20100167613 | Organosilane-Nonionic Water Stable Quaternary Ammonium Compositions and Methods - Methods of applications of organosilanes optionally having a nonhydrolyzable organic group, but having one or more hydrolyzable groups, with a polyol containing at least three hydroxy groups, where any two of the hydroxy groups are separated by at least three intervening atoms by aerosolization of droplets between 0.5-8 microns are disclosed and an improved formulation comprising adding a nonionic wetting agent are disclosed. An improved aerosolization application technique and the improved formulation provide for smaller droplet size and better coverage of substrates to which the organosilanes are applied. The improved formulation has increased affinity, reduces surface tension and therefore can covalently bond more quickly. A method of treating a substrate, and the treated substrate so formed, by contacting the substrate with the improved formulation for a period of time sufficient for treatment of the substrate are disclosed. | 07-01-2010 |
