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Higginbottom, GB
Adrian Higginbottom, Yorkshire GB
| Patent application number | Description | Published |
|---|---|---|
| 20110251230 | THERAPEUTICS FOR NEUROLOGICAL DISORDERS - The present invention relates to therapeutic compounds that are Nrf2-ARE pathway activators suitable for the treatment of diseases known to be mediated by oxidative stress such as motor neurone disease. The invention also includes compounds identified by methods of the invention for treatment of neurogenerative diseases. | 10-13-2011 |
David Higginbottom, Rothley GB
| Patent application number | Description | Published |
|---|---|---|
| 20090320710 | Projectile for simulating multiple ballistic impacts - A projectile is provided for simulating multiple sequential ballistic impacts. The projectile has a plurality of relatively dense loading layers spaced along the firing direction of the projectile. Each pair of nearest-neighbour loading layers is separated by a less dense support element which maintains the spacing of the loading layers. The projectile may be suitable for simulating bird slurry impacts on stator vanes of an aero gas turbine engine. | 12-31-2009 |
Michael Higginbottom, Cambridge GB
| Patent application number | Description | Published |
|---|---|---|
| 20110059969 | PIPERAZINES AS ANTI-OBESITY AGENTS - The present invention relates to new compounds of formula (I), to pharmaceutical compositions comprising these compounds, to processes for their preparation, and to the use of these compounds as leptin receptor modulator mimetics in the preparation of medicaments against conditions associated with weight gain, type 2 diabetes and dyslipidemias. | 03-10-2011 |
Michael Higginbottom, Cambridgeshire GB
| Patent application number | Description | Published |
|---|---|---|
| 20090176798 | New compounds III - The present application relates to new compounds of formula (I), | 07-09-2009 |
| 20090181967 | New compounds I - The present application relates to new compounds of formula (I), | 07-16-2009 |
| 20090203695 | Compounds IV - The present application relates to new compounds of formula (I), | 08-13-2009 |
| 20090281087 | Compounds II - The present application relates to new compounds of formula (I), | 11-12-2009 |
| 20110046135 | NEW COMPOUNDS I - The present application relates to new compounds of formula (I), | 02-24-2011 |
| 20110207746 | NEW COMPOUNDS I - The present invention relates to compounds of formula (I), | 08-25-2011 |
Simon Higginbottom, Manchester GB
| Patent application number | Description | Published |
|---|---|---|
| 20090181430 | PROTEIN FOLDING - The present invention concerns a method for folding a Transforming Growth Factor Beta, or a functional analogue thereof, into a dimeric, biologically active form. The method involves adding solubilized, unfolded monomeric growth factor to a solution containing 2-(cyclohexylamino)-ethanesulfonic acid (CHES) or a functional analogue thereof and a low molecular weight sulfhydryl/disulfide redox system. The solution is then incubated under conditions suitable for generating dimeric biologically active Transforming Growth Factor Beta. | 07-16-2009 |