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Hessels
Daphne Hessels, Groesbeek NL
| Patent application number | Description | Published |
|---|---|---|
| 20090233285 | SPECIFIC METHOD OF PROSTATE CANCER DETECTION BASED ON PCA3 GENE, AND KITS THEREFOR - The present invention relates, in general, to prostate cancer. More specifically, the present invention relates to a method to diagnose prostate cancer in a patient by detecting a PCA3 sequence, and more particularly a PCA3 RNA, the PCA3 sequence detected in a sample from the patient being specifically associated with prostate cancer. In a particular embodiment the method and kit enables an amplification of a PCA3 RNA through an exon-exon junction of a spliced PCA3 mRNA. The invention also relates to methods and kits to detect such an amplified PCA3 RNA, using a probe which spans the amplified exon-exon junction. In particular the methods and kits are designed to detect a PCA3 RNA which lacks one intron or more, and in particular case is intron-less. The invention further relates to a method of detecting PCA3 RNA expressed in non-prostate tissue or cells of the urinary tract, that comprises PCA3 intron 3. | 09-17-2009 |
Daphne Hessels, Malden NL
| Patent application number | Description | Published |
|---|---|---|
| 20100021884 | mRNA Ratios in Urinary Sediments and/or Urine as a Prognostic and/or Theranostic Marker for Prostate Cancer - Described herein are methods and kits for prognosis of prostate cancer in a subject. The methods comprises: (a) determining the ratio of PCA3 and PSA expression in a urine sample and (b) correlating the value of the PCA3/PSA ratio with the aggressiveness and mortality risk of prostate cancer in the subject. Kits for prognosing prostate cancer are also described. More particularly, the present invention features a method for prognosing prostate cancer in a biological sample of a patient comprising: assessing the amount of a prostate cancer specific PCA3 mRNA and the amount of PSA in the biological sample; determining a ratio value of this amount of prostate cancer specific PCA3 mRNA over the amount of PSA; comparing the ratio value to at least one predetermined cut-off value, wherein a ratio value above the predetermined cut-off value is indicative of a higher risk of mortality of prostate cancer as compared to a ratio value below the predetermined cut-off value. | 01-28-2010 |
Derwin Scott Hessels, Jerneh SG
| Patent application number | Description | Published |
|---|---|---|
| 20110116765 | METHOD APPARATUS FILM AND SYSTEM FOR FILM VIEWING WITH APPARATUS LOCATION CONTROL - A system for playing a film on a portable media player, the portable media player comprising a central processor, a GPS module to determine a location of the portable media player within a geographic area, and a storage having stored therein film data of the film for playing on the portable media player, as well as location data of a plurality of locations in a geographic area; the film data comprising at least one preliminary scene to be played first, and a plurality of subsequent scenes, each of the subsequent scenes being linked to both the preliminary scene and one of the locations. A corresponding portable media player, film and method are also disclosed. | 05-19-2011 |
Gerda Hessels, Groningen NL
| Patent application number | Description | Published |
|---|---|---|
| 20090186390 | Method for the Production of Modified Steroid Degrading Microorganisms and their Use - A method is described to construct genetically modified strains of steroid degrading micro-organisms wherein the method comprises inactivation of at least one gene involved in methylhexahydroindanedione propionate degradation. Strains with (multiple) inactivated steroid degrading enzyme genes according to the invention can be used in the accumulation of steroid intermediates. Accumulation products are for example 3aα-H-4α(3′-propionic acid)-7aβ-methylhexahydro-1,5-indanedione (HIP), 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione (3-HSA), 1,4-androstadiene-3,17-dione (ADD) and 3aα-H-4α(3′-propionic acid)-5α-hydroxy-7aβ-methylhexahydro-1-indanone-δ-lactone (HIL). | 07-23-2009 |
Hendrik Hessels, Joure NL
| Patent application number | Description | Published |
|---|---|---|
| 20110148133 | PIPE GRIPPING ASSEMBLY - The invention relates to a pipe gripping assembly for handling a pipe comprising at least two gripping members, wherein each gripping member comprises a pipe engaging portion engageable with the outer circumference of a pipe, wherein at least one gripping member is rotatable about a pivot axis, and wherein the pipe gripping assembly further comprises actuation means to rotate the at least one rotatable gripping member such that the pipe gripping assembly is movable between an open position for receiving a pipe and a closed position in which the pipe engaging portions engage with a pipe, wherein each rotatable gripping member further comprises a locking body engaging portion and the pipe gripping assembly further comprises a movable locking body and associated displacement means to move the locking body such that the pipe gripping assembly is lockable in the closed position by moving the locking body to a locking position wherein the locking body is engageable with the locking body engaging portions and thereby limits the rotation of the rotatable gripping members such that movement of the pipe gripping assembly from the closed position to an open position is prevented, thereby preventing disengagement of the pipe. | 06-23-2011 |
Johannes Louis Leonadus Hessels, Eindhoven NL
| Patent application number | Description | Published |
|---|---|---|
| 20110259609 | EXPANDING A TUBULAR ELEMENT IN A WELLBORE - A method is provided of radially expanding a tubular element ( | 10-27-2011 |
Johannes Louis Leonardus Hessels, Mierlo NL
| Patent application number | Description | Published |
|---|---|---|
| 20090123236 | Driver for and method of installing foundation elements and a kit of parts for assembling a driver - The invention pertains to a driver ( | 05-14-2009 |
| 20110123277 | System for and Method of Installing Foundation Elements in a Subsea Ground Formation - The invention relates to a system for installing or removing foundation elements, such as piles, anchors, and conductors, in a subsea ground formation, comprising an impact weight, an hydraulic circuit in turn comprising an hydraulic cylinder for lifting and/or accelerating the impact weight respectively away from and towards the element, the cylinder comprising a piston connected to the impact weight, and wherein a pump for generating an underpressure in the hydraulic cylinder such as to lift and/or accelerate the impact weight by means of this underpressure. | 05-26-2011 |