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Herbert L.
Herbert L. Bonkovsky, Charlotte, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20100086519 | Treatment of Hepatitis C Infection With Metalloporphyrins - The present invention is directed to the treatment of hepatitis C infection with a metalloporphyrin. In particular, the present invention is based on the discovery that the NS5A protein plays a key role in HCV RNA replication by participating in polyprotein cleavage, interferon response and cellular signaling pathways. It has been found that metalloporphyrins, such as zinc porphyrins, induce post-translational down-regulation of HCV NS5A protein in an ubquitin-proteasome degradation pathway. That is, metalloporphyrins can be used to activate the ubiquitin-proteasomal pathway of NS5A protein catabolism. As a result, metalloporphyrins can be used to significantly suppress HCV viral replication in HCV infected cells. | 04-08-2010 |
| 20110117181 | TREATING HEPATITIS C VIRUS INFECTION WITH OVER-EXPRESSION OF MICRORNA-196 - The present invention is directed to methods of treating cells infected with HCV and mammals suffering from HCV infection by transfecting the infected cells with miRNA-196 mimic. miRNA-196 mimic significantly down-regulates Bach1 protein and HCV gene expression, while also up-regulating HMOX1 gene expression. miRNA-196 binds with the 3′-UTR of Bach1 mRNA to reduce the expression of Bach1. As such, miRNA-196 can play an important role in the regulation of HCV replication and HMOX1/Bach1 expression in hepatocytes. The present invention also provides a formulation for the treatment of cells expressing HCV comprising a therapeutically effective amount of miRNA-196 such that Bach1 and HCV gene expression are down-regulated while HMOX1 expression is increased. The formulations are adapted to enable the transfection of miRNA-196 mimic into hepatocytes expressing HCV proteins. | 05-19-2011 |
Herbert L. Ley, Iii, Salt Lake City, UT US
| Patent application number | Description | Published |
|---|---|---|
| 20090048111 | RNA INTERFERENCE USING A UNIVERSAL TARGET - The present invention provides novel methods for manipulating levels of expression of gene products using RNA interference (RNAi). The methods disclosed can be used to investigate gene function, to create disease-resistant organisms, and to treat disease. | 02-19-2009 |
Herbert L. Meiselman, Rockport, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100185564 | METHOD AND QUESTIONNAIRE FOR MEASURING CONSUMER EMOTIONS ASSOCIATED WITH PRODUCTS - A method of measuring consumer emotions associated with a product comprises producing a list of emotional terms and validating emotional terms from the list that consumers use with the product. The method also includes developing a questionnaire, using the validated emotional terms, that asks the consumers to describe their feelings associated with the product and analyzing data from the completed questionnaire. The questionnaire includes a plurality of validated emotional terms associated with the product and a scale next to each of the validated emotional terms for the consumer to indicate the applicability of the emotional terms associated with the product. | 07-22-2010 |
Herbert L. Roitblat US
| Patent application number | Description | Published |
|---|---|---|
| 20110295856 | IDENTIFYING RELATED OBJECTS USING QUANTUM CLUSTERING - Techniques for grouping related objects such as documents and files using quantum clustering are disclosed. A method may include constructing a feature-object database of multiple objects. The feature-object database may have quantized selected features as keys. A connected objects database maybe built. Clusters of connected objects may be identified in the connected objects database. The clusters of identified objects may be evaluated to determine groups of related objects. The method may be implemented on a computing device. | 12-01-2011 |