| Patent application number | Description | Published |
|---|
| 20090304631 | HEPATITIS C SERINE PROTEASE INHIBITORS AND USES THEREFOR - The invention provides compounds that inhibit a viral protease enzyme of the hepatitis C virus (HCV). The compounds are adapted for treatment of a HCV infection in a patient with the disease. The compounds include analogs of tripeptides and tetrapeptides that resemble the viral protease substrate. The invention also provides pharmaceutical compositions and combinations, methods of preparation of the compounds, and methods of treatment of patients afflicted with HCV using the compounds. | 12-10-2009 |
| 20090325889 | HEPATITIS C SERINE PROTEASE INHIBITORS AND USES THEREFOR - The present invention provides novel compounds which mimic peptides with a C-terminal penultimate proline, such compounds being useful as protease inhibitors, particularly as inhibitors of serine proteases, and more particularly as inhibitors of the NS3 serine protease from hepatitis C. The compounds find utility as antiviral agents directed at hepatitis C. The invention further provides methods of employing such inhibitors, alone or in combination with other therapeutic agents, to treat hepatitis C infection in a subject in need of such treatment. | 12-31-2009 |
| 20100093713 | BETA-CARBOLINES USEFUL FOR TREATING INFLAMMATORY DISEASE - This invention provides beta-carboline compounds of formula | 04-15-2010 |
| 20100120716 | MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS AND USES THEREFOR - Macrocyclic inhibitors of Hepatitis C protease are provided, the inhibitors including a boronic acid or ester group, a macrocyclic ring of about 13 to 25 atoms including at least two amide linkages, a proline-analogous group, and a connecting segment joining moieties on either side of the proline-analogous group. Methods of making the HCV protease-inhibitory compounds, methods of using the compounds, formulations of the compounds, and pharmaceutical combinations including the compounds, are provided. | 05-13-2010 |
| 20100311715 | ALPHA CARBOLINES AND USES THEREOF - This invention provides alpha-carboline compounds of formula I: | 12-09-2010 |
