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Hentsch
Bernd Hentsch, Frankfurt Am Main DE
| Patent application number | Description | Published |
|---|---|---|
| 20110092447 | USING INHIBITORS OF HISTONE DEACETYLASES FOR THE SUPPRESSION THERAPY OF INHERITED DISEASE PREDISPOSING CONDITIONS - Compounds can be used to act as inhibitors of enzymes having histone deacetylase activity for the medical therapy of conditions which predispose a person for the development of a disease, such as but not limited to cancer, inflammatory or metabolic diseases. Such conditions are linked to genetically inherited mutations of crucial genes which predispose a person with this condition to develop the disease phenotype. Thus, such compounds can be used for a suppressive therapeutic approach—the SUPPRESSION THERAPY—in order to inhibit or delay the onset or progression of the genetically predisposed disorder. Furthermore, a clinically used medicament can be manufactured for the SUPPRESSION THERAPY of such inherited predisposing conditions. | 04-21-2011 |
Bernd Hentsch, Darmstadt DE
| Patent application number | Description | Published |
|---|---|---|
| 20090104182 | INHIBITION OF TRISTETRAPROLINE FOR PROTECTION OF THE HEART FROM CARDIAC INJURIES - The present invention relates to compounds suitable for the treatment of conditions which may be improved, at least in part, by increasing TNF α production. The invention further relates to assays for the identification of an individual at increased risk for or suffering front such conditions and to methods of screening compounds for their ability to enhance TNF α biosynthesis. | 04-23-2009 |
Bernd Hentsch, Frankfurt/m DE
| Patent application number | Description | Published |
|---|---|---|
| 20080207724 | Use of Inhibitors of Histone Deacteylases in Combination With Compounds Acting as Nsaid for the Therapy of Human Diseases - The present invention relates to the medical use of compounds acting as inhibitors of enzymes having histone deacetylase activity in conditions where their combination with compounds known as NSAID's, Non Steroidal Anti Inflammatory Drugs, causes an enhanced beneficial therapeutic effect. These conditions comprise cancer, cancer predisposing conditions, inflammatory and metabolic diseases. Furthermore, the invention includes the manufacture of clinically used medicaments for the therapy of the diseases mentioned herein, administering the compounds separately in the form of two individual drugs or in an administrative form which contains both drugs in a single application unit. | 08-28-2008 |
Bernd Hentsch, München DE
| Patent application number | Description | Published |
|---|---|---|
| 20090186809 | USE OF VALPROIC ACID FOR THE TOPICAL TREATMENT OF MILD TO MODERATE ACNE VULGARIS - The present invention provides a surprising therapeutic beneficial use for the topical application of valproic acid as a single agent therapy for patients suffering from mild to moderate acne vulgaris. Topically applied VPA has a clinical efficacy comparable to that of the marketed standard medication for this indication, isotretinoin. Furthermore, topically applied VPA is on average well to very well tolerated. The invention relates to the topical medical use of VPA for the treatment of acne vulgaris and comprises the topical application of VPA or of a pharmaceutically acceptable salt thereof. | 07-23-2009 |
Bernd Hentsch, Duisburg DE
| Patent application number | Description | Published |
|---|---|---|
| 20090088478 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS - The present invention relates to compounds as inhibitors of enzymes having histone deacetylase activity, to the processes for the preparation of those compounds, and to their use for the treatment of diseases which are associated with hypoacetylation of histones and/or other molecules, or in which induction of hyperacetylation has a beneficial effect for example by inhibition of proliferation and/or induction of differentiation and/or induction of apoptosis in transformed cells, such as cancer. Furthermore, the compounds are useful for the treatment of other proliferative diseases, for therapy or prophylaxis of conditions associated with abnormal gene expression. | 04-02-2009 |
Bernd Hentsch, München DE
| Patent application number | Description | Published |
|---|---|---|
| 20090186809 | USE OF VALPROIC ACID FOR THE TOPICAL TREATMENT OF MILD TO MODERATE ACNE VULGARIS - The present invention provides a surprising therapeutic beneficial use for the topical application of valproic acid as a single agent therapy for patients suffering from mild to moderate acne vulgaris. Topically applied VPA has a clinical efficacy comparable to that of the marketed standard medication for this indication, isotretinoin. Furthermore, topically applied VPA is on average well to very well tolerated. The invention relates to the topical medical use of VPA for the treatment of acne vulgaris and comprises the topical application of VPA or of a pharmaceutically acceptable salt thereof. | 07-23-2009 |
Edgar Peter Hentsch, Singapore SG
| Patent application number | Description | Published |
|---|---|---|
| 20110172382 | Processes And Apparatus For Polymer Finishing And Packaging - Provided are apparatus and methods relating to the finishing line of a continuous solution polymerization plant. In one aspect, an apparatus includes a pelletizer having cooling liquid, e.g., water or aqueous solution, into which is added a pelletization aid. In another aspect, the apparatus comprises means to remove residual polymer particles from the pelletizer cooling liquid. In a further aspect, the apparatus comprises conduits of at least 50 m in length for carrying propellant cooling liquid from the pelletizer to a drying apparatus. The residence time of the pellets in the cooling liquid may be 10 seconds or more. In a further aspect, a drying apparatus is provided for the pellets which comprises first and second drying zones. In a further aspect, a pneumatic conveyor is provided for carrying pellets to a packaging apparatus. In a further aspect, a packaging apparatus is provided comprising a blender silo. | 07-14-2011 |
Norbert Hentsch, Stuttgart DE
| Patent application number | Description | Published |
|---|---|---|
| 20090128307 | DISPLAY DEVICE AND DISPLAY METHOD FOR A VEHICLE - The invention relates to a display device for a vehicle comprising a display for representing application data to a vehicle user and pivoting means for moving the display between at least two positions. The inventive display device is characterized in that it further comprises checking means for checking whether or not the representation of data of an application selected by the vehicle user is permitted in the actual state of the vehicle; release means in order to release the pivoting means for controlling the display according to the application or any application selected by the vehicle user, in case the checking means emits an affirmative signal. | 05-21-2009 |
Robert Hentsch, Dresden DE
| Patent application number | Description | Published |
|---|---|---|
| 20100045265 | METHOD AND DEVICE FOR FORMING A TEMPORARY ELECTRICAL CONTACT TO A SOLAR CELL - In a method and devices for forming a temporary electrical contact to a solar cell for testing purposes, probes form a contact to the electrode terminals of a solar cell held by a sample holder. The probes are held by a probe holder and exhibit an elastic, electrically conductive contact element and at least one reference sensor. In order to form a contact, the solar cell and the probes are positioned in relation to each other, and then a probe is placed on an electrode terminal of the solar cell. To this end, a feed motion of the probe is carried out until a reference sensor of the probe generates a reference signal upon reaching a predefined distance. Then the feed motion is continued by a predefined path that goes beyond the contact element making contact with the electrode terminal, in order to carry out an overtravel. | 02-25-2010 |
Wolfgang Hentsch, Radebeul DE
| Patent application number | Description | Published |
|---|---|---|
| 20090236311 | Method and Apparatus for Structuring Components Made of a Material Composed of Silicon Oxide - A method and an apparatus for forming a structure on a component made of a material composed of silicon oxide, especially of silicate glass, glass ceramic or quartz, wherein in accordance with the process at least a first surface of the component a partial removal of the material by plasma etching takes place and during the plasma etching at least at the surface to be etched a substrate temperature is established which is substantially greater than 90° C. but less than the softening temperature of the material. The apparatus is equipped for this purpose with a heater for generating the substrate temperature. | 09-24-2009 |