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Henle
Emst S. Henle, Issaquah, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20090141954 | Peak Reassembly - In differential and non-differential analyses, composite images derived from replicates of liquid-chromatography/mass-spectrometry processes can provide scientists with a better signal-to-noise ratio in discovering biological features of interest. Certain distinct peaks in composite images point to distinct biological features but some distinct peaks in composite images may also point to biological features that have common chemical species ancestry. A peak reassembly process is used to indicate whether two adjacent peaks should point to a biological feature using complementation analysis and collision analysis. | 06-04-2009 |
Ernst S. Henle, Issaquah, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20100104153 | ITERATIVE PROCESSING - A regional redefiner redefines a bounding area in sets of chromatographic/mass spectroscopic images. The redefiner defines and localizes peaks in the images which point to a common feature of interest. A redefined bounding area locates other peaks associated with the feature of interest. Peaks can be iteratively identified and extracted using constituent images or a composite image formed as a combination of a set of constituent images. | 04-29-2010 |
| 20100106426 | REGIONS OF INTEREST PROCESSING - After prepared biological samples have been submitted to liquid-chromatography/mass spectrometry equipment, digital images are produced that show variations. Some of these variations may be of interest while others are not of interest. Variations in regions of interest can be correlated and correlation scores produced to classify biological features aid in scientific discovery. Shape properties of variations can also be calculated by geometric scores. A microalignment method aids the correlation calculation without resorting to macroalignment. | 04-29-2010 |
| 20100106460 | NON-CONTIGUOUS REGIONS PROCESSING - Non-contiguous regions of interest as well as contiguous regions of interest are similarly processed. After an isotope peak detector has identified isotope peaks on LC/MS images, a microaligner microaligns bounding areas of identified isotope peaks and redefines the bounding areas to help subsequent scoring process. Forms of isotope peaks influence formation of a peak association matrix and a mass/charge association map which creates association in the mass/charge dimension. A correlation scorer produces reproducibility scores as well as quality scores to help aid scientists to discover biological features of interest. | 04-29-2010 |
| 20100239139 | CENTROID PROCESSING - Hardware and software components are configured to image-process centroid data as if they were profile data to discover biological features. Proper mass/charge bin size are determined to raster centroid data into LC/MS images. To correct for the decrease in precision, the LC/MS images are re-evaluated in view of the original centroid data. Peak detection from the binned image is refined by re-considering the corresponding centroid data through cluster analysis. Additionally, some peaks that were merged through processing may be resolved into individual peaks by identifying more than one significant cluster masked by a peak from the binned image. | 09-23-2010 |
| 20110110569 | DISCOVER BIOLOGICAL FEATURES USING COMPOSITE IMAGES - An image processing system extracts parts or characteristics of interest from prepared biological samples One suitable use of the image processing system is to find biomarkers. But many other suitable uses are possible. Some components of the system include image preprocessing (data interpolation, retention time alignment, image noise filtering, background estimation, and formation of a composite image); image feature extraction (peaks, isotope groups, and charge groups); and computation of feature characteristics and expression statistics, differential expression, and non-differential expression. Outputs of the system include a candidate list of parts or characteristic of interest for aiding further discovery. | 05-12-2011 |
Jörg Henle, Giebelstadt-Allersheim DE
| Patent application number | Description | Published |
|---|---|---|
| 20120054963 | SUPPORT DEVICE WHICH IS ADJUSTABLE BY AN ELECTRIC MOTOR - Support device, which is adjustable by an electric motor, for cushioning of a piece of furniture for sitting and/or lying on has a first support part, and a second support part pivotable about a pivot axis, between which a third support part is provided. Support device has an electric motor drive which has an adjusting element connected in a force-transmitting manner to the second support part by an actuating element for pivoting second support part. Actuating element has a rod-like configuration, by which the adjusting element is guided in a linearly displaceable manner in guide formed on third support part. Actuating element engages with second support part for pivoting the second support part eccentrically relative to pivot axis. | 03-08-2012 |
Roland Henle, Haigerloch-Stetten DE
| Patent application number | Description | Published |
|---|---|---|
| 20110120932 | DIFFUSION AND/OR FILTRATION DEVICE - The present disclosure relates to a diffusion and/or filtration device, such as a dialyser, hemofilter, or ultra-filter, having improved flow characteristics. The invention also relates to an end cap for the device. | 05-26-2011 |
Thomas Henle, Rangendingen DE
| Patent application number | Description | Published |
|---|---|---|
| 20090206816 | CONTROLLER FOR A DOMESTIC APPLIANCE, DOMESTIC APPLIANCE AND ASSOCIATED METHOD - A controller for functionally controlling a domestic appliance, such as a dryer, comprises a monitoring device that monitors the correct functioning of the domestic appliance. The domestic appliance has at least one monitoring connection connected to at least one associated evaluation node within a power circuit of the domestic appliance, and an evaluation device evaluates a signal produced at the at least one monitoring connection, for monitoring the correct functioning of the domestic appliance. | 08-20-2009 |
Thomas Henle, Dresden DE
| Patent application number | Description | Published |
|---|---|---|
| 20110263505 | Whey Protein Hydrolysate Containing Tryptophan Peptide Consisting of Alpha Lactalbumin and the Use Thereof - The invention relates to a whey protein hydrolysate, in particular a hydrolysate consisting of whey protein enriched with α-lactalbumin and α-lactalbumin, and the use thereof for producing pharmaceuticals, anti-hypertensive agents, food supplements, foodstuffs and animal feed, and to pharmaceuticals, anti-hypertensive agents, food supplements, foodstuffs and animal feed produced in this manner. The whey protein hydrolysate according to the invention, which has an ACE inhibiting and anti-hypertensive action, contains a physiologically active quantity of at least one peptide containing tryptophan, preferably at least one of the bio-active dipeptides Ile-Trp and Trp-Leu, and can be obtained by the extensive hydrolysis of whey protein isolates or of pure α-lactalbumin. | 10-27-2011 |