Hendrik Rudolf

Hendrik Rudolf Delwel, Xd Westmaas NL

Patent application number	Description	Published
20100233690	Use of genes identified to be involved in tumor development for the development of anti-cancer drugs and diagnosis of cancer - The invention relates to the use of inhibitors of the expressed proteins of the murine genes and/or their human homologues listed in Table 1 for the preparation of a therapeutical composition for the treatment of cancer, in particular for the treatment of solid tumors of lung, colon, breast, prostate, ovarian, pancreas and leukemia and the use of the genes listed in Table 1 for the diagnosis of cancer. The invention also relates to the therapeutical compositions comprising the inhibitors and to methods for development of the inhibitor compounds.	09-16-2010

Patent application number	Description	Published
20110281270	EFFICIENT DETECTION OF DOUBLE MUTANTS OF THE CEBPA GENE IN ACUTE MYELOID LEUKEMIA - The invention is in the field of molecular diagnostics for cancer, in particular, for acute myeloid leukemia (AML). The invention provides methods for diagnosing AML patients with a favorable prognosis. We have found that not all AML patients carrying a CEBPA mutation may have a more favorable prognosis. We found that only the group with double mutations, i.e., biallelic mutations, have a particularly favorable prognosis. We also found a method that distinguishes mono-allelic CEBPA mutations from bi-allelic mutations.	11-17-2011

Patent application number	Description	Published
20080305965	Classification, Diagnosis and Prognosis of Acute Myeloid Leukemia by Gene Expression Profiling - The present invention relates to method of genetic analysis for the classification, diagnosis and prognosis of acute myeloid leukemia (AML). The invention provides a method for producing a classification scheme for AML comprising the steps of a) providing a plurality of reference samples, said reference samples comprising cell samples from a plurality of reference subjects affected by AML; b) providing reference profiles by establishing a gene expression profile for each of said reference samples individually; c) clustering said individual reference profiles according to similarity; and d) assigning an AML class to each cluster. The invention further relates to a method for classifying the AML of an AML affected subject, to a method for diagnosing AML in a subject, and to a method of determining the prognosis for an AML affected subject.	12-11-2008