Hendrik Jan
Hendrik Jan Ankersmit, Wien AT
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20090098104 | Method for Diagnosing Cardiovascular Diseases - Method for diagnosing a cardiovascular disease in an individual comprising the steps of: providing a sample of an individual; determining the amount of cytokeratin-18 (CK-18) or fragments thereof and/or interleukin-1β precursor (IL-1β precursor) in said sample; comparing the amount of CK-18 or fragments thereof and/or IL-1β precursor in said sample to the amount of CK-18 or fragments thereof and/or IL-1β precursor present in a reference control of at least one individual not suffering from a cardiovascular disease; and diagnosing a cardiovascular disease if the amount of CK-18 or fragments thereof in the sample is increased in comparison to the amount of CK-18 or fragments thereof in the reference control and/or the amount of IL-1β precursor in the sample is decreased in comparison to the amount of IL-1β precursor in the reference control. | 04-16-2009 |
Hendrik Jan Ankersmit, Vienna AT
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20110250190 | PHARMACEUTICAL PREPARATION - The present invention relates to a pharmaceutical preparation for treating an inflammatory condition, preferably a condition associated with ischemia comprising: a) a physiological solution comprising peripheral blood mononuclear cells (PBM-Cs) or a subset thereof, or b) a supernatant of the solution a), wherein the solution a) is obtainable by cultivating PBMCs or a subset thereof in a physiological solution free of PBMC-proliferating and PBMC-activating substances for at least 1 h. | 10-13-2011 |
20120045418 | PHARMACEUTICAL PREPARATION COMPRISING SUPERNATANT OF BLOOD MONONUCLEAR CELL CULTURE - The present invention relates to a topical pharmaceutical preparation for treating an inflammatory skin condition, preferably a condition associated with ischemia, comprising a supernatant of a physiological solution obtainable by cultivating peripheral blood mononuclear cells (PBMCs) or a subset thereof in a physiological solution free of PBMC-proliferating and PBMC-activating substances for at least 1 h. | 02-23-2012 |
20130244260 | METHOD FOR DISCRIMINATING BETWEEN EARLY AND ADVANCED STAGE LUNG CARCINOMA - The present invention relates to a method for discriminating between early and advanced stage lung carcinoma in an individual suffering from lung carcinoma comprising the steps of a) providing a sample of an individual suffering from lung carcinoma, b) determining the level of heat shock protein 27 (HSP27) in said sample, c) comparing the determined level of HSP27 in said sample with a reference range of HSP27 measured in samples of control individuals with an early stage lung carcinoma and/or with advanced stage lung carcinoma, d) diagnosing early stage lung carcinoma in said individual when the level of HSP27 in sample a) is below the reference range of HSP27 in samples of control individuals with advanced stage lung carcinoma or within the reference range of control individuals with early stage lung carcinoma and diagnosing advanced stage lung carcinoma when the level of HSP27 in sample a) is above the reference range of HSP27 in samples of control individuals with early stage lung carcinoma or within the reference range of control individuals with advanced stage lung carcinoma. | 09-19-2013 |
Hendrik Jan Bolink, Valencia ES
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20100044682 | CHARGE INJECTION LAYER FOR ELECTRO-OPTICAL DEVICES - The present invention relates to charge injection from metallic conductors to semiconductor or insulation materials based on organic or inorganic molecules and macromolecules with electrical or optical properties, and specifically to a new charge injection layer for electro-optical devices comprising a polymer with conjugated units and a salt mixed with the aforementioned polymer, characterized in that the oxidation state of the polymer is not modified when it is mixed with the salt. Despite the fact that there is no change in the oxidation state of the polymer, the polymer and salt mixture according to the invention makes it possible for a high enough number of charges to reach the optically active layer, such that the efficiency in the charge injection process is increased up to levels exceeding even those provided by the standard PEDOT. | 02-25-2010 |
20100102761 | Organic Radiation-Emitting Device, Use Thereof and a Method of Producing the Device - The invention discloses an organic radiation-emitting device which includes a substrate, and at least one radiation-emitting organic layer, which is arranged on the substrate between a first and a second electrode layer. A first charge carrier transport layer, which includes a first charge carrier transport material and a first salt, is arranged between the first electrode layer and the radiation-emitting organic layer. | 04-29-2010 |
20150208482 | Organic Electroluminescent Device and a Method of Operating an Organic Electroluminescent Device - An organic electroluminescent device includes a substrate, a first electrode arranged on the substrate, and a functional organic layer arranged on the first electrode. The functional organic layer emits electromagnetic radiation. A second electrode is arranged on the functional organic layer. The functional organic layer includes at least one ionic component and one emitter material having a band gap. The emitter material is selected from the group of ionic transition metal complex, neutral transition metal complex, polymer emitter and combinations thereof. The organic electro-luminescent device is adapted to work in two modes, wherein a pre-biasing mode comprises applying a first voltage being a constant or pulsed value less than and/or equal to the band gap to the first and the second electrode. | 07-23-2015 |
20150303394 | Organic Electroluminescent Device and a Method of Producing an Organic Electroluminescent Device - An organic electroluminescent device includes a substrate, a first electrode arranged on the substrate, and a functional organic layer arranged on the first electrode. The functional organic layer is adapted to emit electromagnetic radiation A second electrode is arranged on the functional organic layer. The functional organic layer includes a matrix material and an emitter material. The emitter material is neutral or ionically charged. The emitter material is selected from the group of ionic transition metal complex, neutral transition metal complex, polymer emitter and combinations thereof, wherein the matrix material comprises at least one ionic charge carrier transporting material, wherein the ionic charge carrier transporting material is selected from the group of electron-transporting material, hole-transporting material, ambipolar-transporting material and combinations thereof, and wherein the at least one ionic charge carrier transporting material is ionically charged. | 10-22-2015 |
Hendrik Jan Bouwmeester, Renkum NL
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20090031455 | TERPENE HYDROXYLATION - The present invention provides a novel cytochrome P450 enzyme, as well as vectors and recombinant host cells comprising the gene encoding the enzyme. Provided are recombinant plant with enhanced disease and/or pest resistance, modified favour and/or fragrance and methods for hydroxy lifting terpene substrates. | 01-29-2009 |
20090178158 | RESISTANCE AGAINST PARASITIC WEEDS - The seeds of parasitic plants of the genera | 07-09-2009 |
20100144893 | ISOPRENOID SYNTHASES - The invention relates to the field of genetic engineering of flavor, fragrance and biocontrol agent development. More specifically it relates to a process for production of natural flavors, fragrances or bio-control agents by the control of one or more genes implicated in that process. The invention provides an isolated or recombinant nucleic acid or functional fragment thereof encoding a proteinaceous molecule essentially capable of flavor, fragrance and/or bio-control agent synthesis when provided with a suitable substrate under appropriate reaction conditions. The invention further provides a nucleic acid or functional fragment thereof encoding a proteinaceous molecule essentially capable of synthesizing at least a monoterpene alcohol linalool when contacted with geranyl diphosphate (GPP) and/or at least a sesquiterpene alcohol nerolidol when contacted with farnesyl diphosphate (FPP) under appropriate reaction conditions. | 06-10-2010 |
Hendrik Jan Bujkema, Groningen NL
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20090029005 | Anti-Hypertensive Functional Food Products - The present invention provides novel protein hydrolysates with anti-hypertensive properties, as well as food products and food supplements comprising these. | 01-29-2009 |
Hendrik Jan De Jong, Jr., Den Haag NL
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20120043438 | SUBSTRATE SUPPORT STRUCTURE, CLAMP PREPARATION UNIT, AND LITHOGRAPHY SYSTEM - A substrate support structure for clamping a substrate on a surface by means of a capillary layer of a liquid. The surface has an outer edge and includes one or more substrate supporting elements for receiving the substrate to be clamped, wherein the one or more substrate supporting elements are arranged to provide support for the substrate at a plurality of support locations. The substrate support structure further includes a sealing structure circumscribing the surface and having a top surface or edge forming a sealing rim. A distance between the outer edge of the surface and an outermost of the support locations is greater than a distance between the outer edge and the sealing rim. | 02-23-2012 |
Hendrik Jan Guchelaar, Ab Gouda NL
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20080288177 | PHARACOGENETIC METHOD FOR PREDICTION OF THE EFFICACY OF METHOTREXATE MONOTHERAPY IN RECENT-ONSET ARTHRITIS - Pharmacogenetic methods for determining a predicting responsiveness to antifolate therapy for subjects that present with recent-onset undifferentiated arthritis. The methods are based on the determination of a set of clinical parameter values and determining a predicted responsiveness to antifolate therapy by correlating the parameter values with predefined responsiveness values associated with ranges of parameter values. Parameters values that are decisive for responsiveness to antifolate therapy may include polymorphisms in the methylenetetrahydrofolate dehydrogenase (MTHFD1) gene as well as in three genes involved in the adenosine release pathway, the presence or absence of Rheumatoid factors, gender, pre- or postmenopausal status and/or smoking status. | 11-20-2008 |
20130196313 | Pharmacogenetic Method for Prediction of the Efficacy of Methotrexate Monotherapy in Recent-Onset Arthritis - Pharmacogenetic methods for determining a predicting responsiveness to antifolate therapy for subjects that present with recent-onset undifferentiated arthritis. The methods are based on the determination of a set of clinical parameter values and determining a predicted responsiveness to antifolate therapy by correlating the parameter values with predefined responsiveness values associated with ranges of parameter values. Parameters values that are decisive for responsiveness to antifolate therapy may include polymorphisms in the methylenetetrahydrofolate dehydrogenase (MTHFD1) gene as well as in three genes involved in the adenosine release pathway, the presence or absence of Rheumatoid factors, gender, pre- or postmenopausal status and/or smoking status. | 08-01-2013 |
Hendrik Jan Guchelaar, Gouda NL
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20090029379 | GENETIC MARKERS FOR PROGNOSIS OF ANTIFOLATE TREATMENT EFFICACY - Methods and kits for predicting the efficacy of antifolate (e.g., methotrexate) treatment of rheumatoid arthritis by detecting polymorphisms, particularly single nucleotide polymorphisms, in adenosine pathway genes. | 01-29-2009 |
20100240541 | GENETIC MARKERS FOR PROGNOSIS OF ANTIFOLATE TREATMENT EFFICACY - Methods and kits for predicting the efficacy of antifolate (e.g., methotrexate) treatment of rheumatoid arthritis by detecting polymorphisms, particularly single nucleotide polymorphisms, in adenosine pathway genes. | 09-23-2010 |
Hendrik Jan Hanskamp, Zelhem NL
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20110239943 | MILKING DEVICE FOR THE MILKING OF MILKING ANIMALS - The invention relates to a milking device for milking animals, the required vacuum being, for example, generated by generating compressed air using a compressor and passing said compressed air through the system, the compressed air creating a vacuum at all required locations by means of the Venturi system. Because this vacuum differs at the various locations, the reduced pressure can be regulated precisely and adapted as required. | 10-06-2011 |
Hendrik Jan Kettelarij, Eindhoven NL
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20110164237 | SPECTRAL PURITY FILTER, LITHOGRAPHIC APPARATUS, AND METHOD FOR MANUFACTURING A SPECTRAL PURITY FILTER - A transmissive spectral purity filter is configured to transmit extreme ultraviolet radiation. The spectral purity filter includes a filter part having a plurality of apertures configured to transmit extreme ultraviolet radiation and to suppress transmission of a second type of radiation. Each aperture has been manufactured by an anisotropic etching process. | 07-07-2011 |
Hendrik Jan Righolt, Oosterhout NL
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20130045294 | 3D-FOOD PRODUCT FORMING APPARATUS AND PROCESS - The present invention is related to a food forming apparatus to produce patties with a form member which comprises moulds in which the patties are formed, whereas the form member is located adjacent to a pressure member and is at least partially made from a porous material. | 02-21-2013 |
20130337128 | FOOD FORMING DRUM - The present invention relates to a food forming drum comprising a multitude of rows of cavities. The present invention further relates to the process of manufacturing the inventive drum. | 12-19-2013 |
20140199423 | FOOD FORMING APPARATUS WITH A FOOD FEED MEMBER - The present invention relates to a food-form-apparatus with: a rotating drum ( | 07-17-2014 |
Hendrik Jan Righolt, Oosterhour NL
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20130164403 | PATTY MAKING MACHINE - The present invention is related to a patty forming apparatus with a mould plate ( | 06-27-2013 |
Hendrik Jan Van Ooijen, Eindhoven NL
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20160110494 | MEDICAL PROGNOSIS AND PREDICTION OF TREATMENT RESPONSE USING MULTIPLE CELLULAR SIGNALLING PATHWAY ACTIVITIES - The present application relates to a method for determining a risk score that indicates a risk that a clinical event will occur within a certain period of time. The risk score is based at least in part on a combination of inferred activities of two or more cellular signaling pathways in a tissue and/or cells and/or a body fluid of a subject. The cellular signaling pathways comprise a Wnt pathway, an ER pathway, an HH pathway, and/or an AR pathway. The risk score is defined such that the indicated risk that the clinical event will occur within the certain period of time decreases with an increasing P | 04-21-2016 |
Hendrik Jan Van Ooijen, Wijk En Aalburg NL
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20140156200 | ASSESSMENT OF CELLULAR SIGNALING PATHWAY ACTIVITY USING PROBABILISTIC MODELING OF TARGET GENE EXPRESSION - The present application mainly relates to specific methods for inferring activity of one or more cellular signaling pathway(s) in tissue of a medical subject based at least on the expression level(s) of one or more target gene(s) of the cellular signaling pathway(s) measured in an extracted sample of the tissue of the medical subject, an apparatus comprising a digital compressor configured to perform such methods and a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such methods. | 06-05-2014 |
20150278470 | COMBINED USE OF CLINICAL RISK FACTORS AND MOLECULAR MARKERS FRO THROMBOSIS FOR CLINICAL DECISION SUPPORT - The present invention relates to an apparatus and method for clinical decision support to identify patients at high risk of thrombosis based on a combination of clinical risk factors and molecular markers, e.g., protein concentrations. These clinical risk factors and molecular markers are combined in a machine learning based algorithm which returns an output value, relating to an estimated risk of a thrombosis event in the future. | 10-01-2015 |
Hendrik Jan Van Ooijen, Wijken Aalburg NL
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20150347672 | ASSESSMENT OF CELLULAR SIGNALING PATHWAY ACTIVITY USING LINEAR COMBINATION(S) OF TARGET GENE EXPRESSIONS - The present application mainly relates to specific methods for inferring activity of a cellular signaling pathway in tissue and/or cells of a medical subject based at least on expression levels of one or more target gene(s) of the cellular signaling pathway measured in an extracted sample of the tissue and/or cells of the medical subject, an apparatus comprising a digital compressor configured to perform such methods and a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such methods. | 12-03-2015 |
Hendrik Jan Van Oojen, Wijk En Aalburg NL
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20140128707 | METHOD OF PREDICTING A BLOOD DILUTION RISK VALUE - The present invention provides for a clinical decision support system which makes use of a numerical model which dynamically describes a blood dilution of a blood circulation. Based on measured coagulation data and maybe other patient information, loss of hemostatic balance is predicted based on calculations of certain protein concentrations. Additionally, a calculation arrangement translates at least some of the calculated values of concentrations of human blood proteins into a risk value which risk value describes a risk of clotting and/or embolism and/or bleeding. A time development of that risk value is displayed to the user. | 05-08-2014 |
Hendrik Jan Zwerver, Eindhoven NL
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20090115381 | AUTOMATIC FREQUENCY CONTROL FOR SERIES RESONANT SWITCHED MODE POWER SUPPLY - A switched mode power supply comprises a half bridge circuit or a full bridge circuit. A resonant circuit is connected to the bridge circuit and comprises an inductive element ( | 05-07-2009 |
20090244930 | ELECTRICAL DC-DC POWER CONVERTER WITH MAGNETICALLY COUPLED SWITCH CONTROL CIRCUIT - Power converter with a controllable first switch and a diode and a controllable second switch and a second diode, a transformer with a primary winding and a secondary winding, of which the secondary winding forms at least part of a control circuit for the first switch. As a result of an alternating voltage across the primary winding, a synchronously alternating voltage is induced in the secondary winding, which can be used to control the first switch essentially synchronously with the second switch. | 10-01-2009 |
20100327759 | ELECTRONIC BALLAST FOR A FLUORESCENT LAMP - An electronic ballast for supplying a lamp load is described. The electronic ballast comprises an inverter arranged in a half-bridge configuration for providing an AC voltage and at least one lamp load circuit. The inverter comprises an upper switch, connected to a DC terminal for receiving a DC supply voltage, and a first lower switch arranged in a half-bridge configuration for generating an AC voltage at an inverter terminal of the inverter. A first diode and a second lower switch are connected in series. This series arrangement is connected in parallel with the first lower switch. A lamp load circuit for supplying the lamp load is connected to a node between the first diode and the second lower switch. When the inverter supplies a fluorescent lamp, and the lamp load circuit comprises a heating circuit for heating an electrode of the fluorescent lamp, the heating circuit includes a heating transformer and a second lower switch connected in parallel with the primary winding of the transformer. By doing so, the heating circuit can be operated and controlled independent of the current supplied to the fluorescent lamp, or operating conditions of the fluorescent lamp. | 12-30-2010 |
20120242253 | METHOD AND DEVICE FOR DRIVING A FLUORESCENT LAMP - A method is described for driving a fluorescent lamp (L) with variable light output within a dimming range between a low dimming level and a high dimming level. The lamp power and the lamp current are monitored. At high dimming level the lamp control is based on current control; at low dimming level, the lamp control is based on power control; at intermediary levels the lamp control is based on both current and power control. A first measuring signal (Ilamp) indicating lamp current and a second measuring signal (Plamp) indicating lamp power are obtained. An error signal (Serr) is calculated as a function of the said two measuring signals and as a function of dim level. With increasing dim level, the contribution of the first measuring signal (Il-amp) to the error signal (Serr) increases while the contribution of the second measuring signal (Plamp) to the error signal (Serr) decreases. | 09-27-2012 |