Patent application number | Description | Published |
20110265194 | THEM5-MODIFIED MODELS OF NON-ALCOHOLIC FATTY LIVER DISEASE - The invention provides a new reproducible genetically-modified mouse model for the study of non-alcoholic fatty liver disease. In particular, the invention concerns the study of non-alcoholic fatty liver disease in an THEM5 knockout mouse model and its use in drug discovery and research. | 10-27-2011 |
20110280886 | TREATING CANCER BY MODULATING MNK - The present invention relates to a method for treating cancer in a subject using a mTOR inhibitor in combination with a therapeutically effective amount of a modulator of a MNK. | 11-17-2011 |
20120213801 | Phosphorylated Twist1 and cancer - The present application relates to methods for treating cancer in a subject by modulating the phosphorylation of the Serine 42 of Twist1 by administering to said subject a therapeutically effective amount of a modulator of said phosphorylation of the Serine 42 of Twist1. Antibodies, uses methods and biomarkers based on the phosphorylation of the Serine 42 of Twist1 are also provided. | 08-23-2012 |
20130089538 | TREATING CANCER BY MODULATING MAMMALIAN STERILE 20-LIKE KINASE 3 - The present invention relates to a method for modulating miRNA, said method being characterized in that a modulator of XRN1 is used. Also provided are uses of said method for therapeutical purposes, reagents therefore, as well as screening methods. | 04-11-2013 |
20130171159 | PHOSPHORYLATED TWIST1 AND METASTASIS - The present application relates to methods for metastasis in a subject by modulating the phosphorylation of the Serine 42 of Twist1 by administering to said subject a therapeutically effective amount of a modulator of said phosphorylation of the Serine 42 of Twist1. Antibodies, uses methods and biomarkers based on the | 07-04-2013 |
Patent application number | Description | Published |
20090320583 | METHOD FOR TESTING PIPETTES - The invention is directed to a method for testing batches of tips for pipettes, the method comprising the steps of calibrating a pipette to be tested with a recommended reference tip, fitting the pipette with a tip to be tested and performing a second calibration and recalibrating the pipette with the reference tip. | 12-31-2009 |
20110179859 | CHARACTERIZATION METHOD AND KIT FOR CARRYING OUT THE METHOD - The present invention relates to evaluating the performance of an automated matrix-format liquid handling system by using receptacles and caps. The invention provides a method comprising the steps of determining a receptacle weight for each receptacle, determining a mean cap weight for the caps, dispensing a volume of liquid in each receptacle by using the liquid handling system, capping each receptacle approximately simultaneously with respect to each other, determining a gross weight for each capped receptacle, and calculating the volume of liquid dispensed in each receptacle from the respective gross weight, the respective receptacle weight, and the mean cap weight. The invention further provides a kit for carrying out the method, the kit comprising a plurality of receptacles, a plurality of caps, a holder device for arranging the receptacles in accordance with liquid dispensing positions in the liquid handling system, and a capping device for capping the receptacles. | 07-28-2011 |
Patent application number | Description | Published |
20120138601 | Method and Apparatus for Microwave Depolymerization of Hydrocarbon Feedstocks - A method and apparatus is provided for the continuous microwave depolymerization of high molecular weight organic feedstock material, such as waste plastics and includes intermittent or continuous feeding of the processing material on the surface or into the bulk of the sensitized hot bed located under microwave irradiation. As a result of the interaction of electromagnetic field with processed materials, sensitizer is heated by microwave energy and feedstock material undergoes the depolymerization reactions. The reaction zone can be localized on the surface of the hot bed or distributed in the bulk of the reaction mass depending on the agitation conditions of the reaction mass, such as stirring, or other agitation means, for example by re-circulated gas. Products of the reactions are vaporized and transported to the collection system, which may include a combination of a scrubber, a condenser and a settler. | 06-07-2012 |
20130165710 | METHOD AND APPARATUS FOR MICROWAVE DEPOLYMERIZATION OF HYDROCARBON FEEDSTOCKS - A method and apparatus is provided for the continuous microwave depolymerization of high molecular weight organic feedstock material, such as waste plastics and includes intermittent or continuous feeding of the processing material on the surface or into the bulk of the sensitized hot bed located under microwave irradiation. As a result of the interaction of electromagnetic field with processed materials, sensitizer is heated by microwave energy and feedstock material undergoes the depolymerization reactions. The reaction zone can be localized on the surface of the hot bed or distributed in the bulk of the reaction mass depending on the agitation conditions of the reaction mass, such as stirring, or other agitation means, for example by re-circulated gas. Products of the reactions are vaporized and transported to the collection system, which may include a combination of a scrubber, a condenser and a settler. | 06-27-2013 |
20140114097 | Method and Apparatus for Microwave Depolymerization of Hydrocarbon Feedstocks - A method and apparatus is provided for the continuous microwave depolymerization of high molecular weight organic feedstock material, such as waste plastics and includes intermittent or continuous feeding of the processing material on the surface or into the bulk of the sensitized hot bed located under microwave irradiation. As a result of the interaction of electromagnetic field with processed materials, sensitizer is heated by microwave energy and feedstock material undergoes the depolymerization reactions. The reaction zone can be localized on the surface of the hot bed or distributed in the bulk of the reaction mass depending on the agitation conditions of the reaction mass, such as stirring, or other agitation means, for example by re-circulated gas. Products of the reactions are vaporized and transported to the collection system, which may include a combination of a scrubber, a condenser and a settler. | 04-24-2014 |
Patent application number | Description | Published |
20090307980 | PLATFORM SCREEN DOOR SYSTEM - A platform screen door system includes a fixed driving panel and at least one door leaf slidable relative to the fixed driving panel. Further included is a telescopic guide including a fixed guide mounted on the fixed driving panel, a moving guide mounted on the at least one door leaf, and a moving intermediate guide mounted on the fixed guide. Also included is a drive means for slidably moving the at least one door leaf from a closed position to an opened position wherein the at least one door leaf overlaps the fixed driving panel. | 12-17-2009 |
20100295366 | BRAKE SYSTEM - A brake system for a railway vehicle having wheel slide protection includes a main brake pipe fluidly connected to a distributor, and an auxiliary reservoir fluidly connected to the brake distributor, the distributor being fluidly connected to one or more brake cylinders. A further reservoir is provided, compressed air flow to and from the further reservoir being controllable by a valve, operation of the valve being controlled by a control unit adapted to detect wheel slide. The control unit is adapted to switch air supply between air from the auxiliary reservoir and air from the further reservoir in the event that wheel slide is detected. | 11-25-2010 |
20110049399 | PRESSURE EQUALISATION DEVICE - A pressure equalisation device adapted to be operatively connected to an enclosure, the device including an air passage which, when the device is so connected to the enclosure, provides a fluid communication between the interior of the enclosure and atmosphere, the air passage containing a barrier wall comprising an air permeable membrane forming a micro-particulate filter. | 03-03-2011 |
Patent application number | Description | Published |
20090318279 | Low alkali, non-crystalline, vitreous silica fillers - A substantially white powder for use as a filler and/or extender derived from by-products of manufacturing vitreous low alkali, low iron glass fibers, and a method for producing the powder. The filler has very low alkalinity and by virtue of its being essentially free of crystalline silica is non-hazardous to health and therefore safe for consumer-based and industrial-based uses. | 12-24-2009 |
20110020199 | Process for enhanced remediation of contaminated wastewaters, soils and wasteforms - The present invention provides reagents that may be useful for treating wastes such as impure aqueous materials including wastewater to remove a significant proportion of the heavy metals that may be contained therein. The reagents include a calcium aluminosilicate (CAS) source and may include one or more of the following elements as an oxide: calcium oxide, aluminum oxide, silicon oxide, iron oxide, magnesium oxide, sodium oxide, potassium oxide, and sulfate. Further, the reagent comprises lime either as CaO or Ca(OH) | 01-27-2011 |
20110226878 | System and method for compressed bed grinding in a stirred media mill - A system and method are disclosed for the grinding of industrial minerals to fine powders. The system includes a grinding chamber having a generally vertically oriented agitator that is rotated to stir the grinding media intermixed with a feedstock. As the agitator stirs the grinding media and feedstock, there is a retaining plate that is also located within the grinding chamber and positioned atop of the grinding media to prevent the expansion of the grinding media when it is being stirred. The retaining plate has one or more openings to allow the finely ground feedstock to pass upwardly therethrough but to prevent any grinding media from passing through the retaining plate. Introduction of the feedstock may be through one or more hollow support rods that locate the retaining plate in the desired location within the grinding chamber. The support rods are locked into position when the retaining plate is properly located. | 09-22-2011 |
20120118831 | PROCESS FOR ENHANCED REMEDIATION OF CONTAMINATED WASTEWATERS, SOILS AND WASTEFORMS - The present invention provides reagents that may be useful for treating wastes such as impure aqueous materials including wastewater to remove a significant proportion of the heavy metals that may be contained therein. The reagents include a calcium aluminosilicate (CAS) source and may include one or more of the following elements as an oxide: calcium oxide, aluminum oxide, silicon oxide, iron oxide, magnesium oxide, sodium oxide, potassium oxide, and sulfate. Further, the reagent comprises lime either as CaO or Ca(OH) | 05-17-2012 |
20120247766 | GEOTHERMAL GROUT, METHODS OF MAKING GEOTHERMAL GROUT, AND METHODS OF USE - The present disclosure relates to geothermal grout, methods of making geothermal grout, and methods of using geothermal grout. The present disclosure is further directed to an geothermal grout with relative ease of preparation and desirable thermal conductivity while maintaining good sealant properties. | 10-04-2012 |
20130098272 | METHOD AND COMPOSITIONS FOR POZZOLANIC BINDERS DERIVED FROM NON-FERROUS SMELTER SLAGS - The invention encompasses an ultrafine NFS powder wherein the particle size is sufficiently small as to increase the proportion of the reactive glassy silicate phase in the NFS, methods of making the ultrafine NFS powder, and cementitious products which use the ultrafine NFS powder. The invention also encompasses pozzolanic binders produced by fine grinding non-ferrous smelter slags, as well as methods for processing the non-ferrous slags wherein various chemical additives, such as pH increasing additives, are added to the binders to increase the strength of compositions for uses such as mine backfill or grout mixtures. | 04-25-2013 |
20140072368 | PROCESS FOR CONVERSION OF INTRACTABLE OIL-BEARING, DRILL CUTTING WASTES FROM DEEP GAS EXPLORATION WELLS TO ENGINEERING CONSTRUCTION MATERIALS - A process is disclosed which converts intractable, semi-solid drill cuttings into a free-flowing granular, soil-like SDC material, which, after appropriate compaction, can be beneficially used for a variety of engineering construction applications, thereby removing the need for disposal with its associated costs and environmental impact, and as a result improving the overall economics for gas well development, together with improving corporate sustainability and reducing liability. | 03-13-2014 |
Patent application number | Description | Published |
20090182583 | METHODS FOR SELLING INSURANCE USING HYBRID LIFE - An insurer sells a life insurance policy with two distinct coverage periods. Prior to accepting the offer of insurance, the insurer underwrites the insurance contract on a limited basis using information obtainable by querying a remote database. During the first coverage period, full coverage is provided and the premium rates approximate a comprehensively underwritten risk. The value of coverage provided at the end of the first coverage period may be reduced if the insured fails to satisfy various obligations. If before a contractually defined compliance period the insured undergoes medical tests and submits blood, urine, or other tissue samples to an underwriter or approved laboratory, the underwriter comprehensively underwrites the policy. If the comprehensive underwriting is satisfactory, the insurance contract is amended, modified, or replaced with a new contract effectively extending full coverage for a longer, extended coverage period, while maintaining or even reducing the premiums owed. | 07-16-2009 |
20090182584 | METHODS FOR SELLING INSURANCE USING RAPID DECISION TERM - An insurer sells a life insurance policy having a coverage period equal in length to the term of the policy. The consideration paid by the insured is relatively high compared to conditional receipt coverage, but is generally lower than that charged for standard simplified issue policies. The policy is only underwritten on a limited basis, preferably using information available in remote databases. During a predetermined time period, the insured has the option of providing medical test results or other material sufficient to enable comprehensive medical underwriting. Upon receipt of the information and material, an underwriter comprehensively underwrites the policy. If the results of the underwriting are satisfactory, the premiums are reduced significantly for the remainder of the term of the insurance policy and/or the benefit amount is increased. If the insured does not provide any additional information or materials, or if the materials provided result in unsatisfactory underwriting, the premiums remain unchanged. | 07-16-2009 |
20090182585 | METHODS FOR SELLING INSURANCE USING RAPID DECISION TERM - An insurance company sells a life insurance policy having a coverage period. The policy provides a total benefit amount which includes an all-cause benefit amount and an accidental death only benefit amount. The policy is initially underwritten on a limited basis and the ratio of the all-cause benefit to the accidental death benefit is low. The insured has the option of providing material to enable comprehensive underwriting and to enable risk classification. If the risk classification improves the policy benefits, the mix of coverage is adjusted to include a higher ratio of the all-cause benefit amount to the accidental death only benefit amount. If the insured does not provide any additional information or materials, or if the materials provided do not result in an underwritten risk classification that enables the policy provisions to be improved, the mix of coverage remains unchanged. | 07-16-2009 |
20120084104 | SYSTEM AND METHOD FOR SELLING INSURANCE USING RAPID DECISION TERM - An insurance company sells a life insurance policy having a coverage period. The policy provides a total benefit amount which includes an all-cause benefit amount and an accidental death only benefit amount. The policy is initially underwritten on a limited basis and the ratio of the all-cause benefit to the accidental death benefit is low. The insured has the option of providing material to enable comprehensive underwriting and to enable risk classification. If the risk classification improves the policy benefits, the mix of coverage is adjusted to include a higher ratio of the all-cause benefit amount to the accidental death only benefit amount. If the insured does not provide any additional information or materials, or if the materials provided do not result in an underwritten risk classification that enables the policy provisions to be improved, the mix of coverage remains unchanged. | 04-05-2012 |
20120239438 | SYSTEM AND METHOD FOR PROVIDING IMMEDIATE, SHORT-TERM LIFE INSURANCE COVERAGE AND FACILITATING OFFERS OF LONGER-TERM INSURANCE - The computerized system disclosed herein implements an improved online marketplace for facilitating sales of insurance products from a plurality of insurance providers to customers of insurance. The system enables the customers to apply for insurance products from each of the carriers in a single step using a single, common application. Thereafter, the system performs an immediate, preliminary underwriting, and if appropriate offers the individual the option for immediate short-term coverage. The system then performs more comprehensive underwriting on behalf of a plurality of carriers, and if the underwriting is successful, provides the customer with an offer for long-term coverage to replace the short-term coverage. The customer can accept any provided offer to receive coverage. The system also enables carriers to define filters so that if customers enter the system with an affiliation with a particular character, they remain affiliated with the carrier until the filter is no longer satisfied. | 09-20-2012 |
20130080193 | SYSTEM AND METHOD FOR SELLING INSURANCE USING RAPID DECISION TERM - An insurance company sells a life insurance policy having a coverage period. The policy provides a total benefit amount which includes an all-cause benefit amount and an accidental death only benefit amount. The policy is initially underwritten on a limited basis and the ratio of the all-cause benefit to the accidental death benefit is low. The insured has the option of providing material to enable comprehensive underwriting and to enable risk classification. If the risk classification improves the policy benefits, the mix of coverage is adjusted to include a higher ratio of the all-cause benefit amount to the accidental death only benefit amount. If the insured does not provide any additional information or materials, or if the materials provided do not result in an underwritten risk classification that enables the policy provisions to be improved, the mix of coverage remains unchanged. | 03-28-2013 |