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Hemmings

Arthur Brian Hemmings, Bettingen CH

Patent application numberDescriptionPublished
20100260738USES AND METHODS RELATING TO NDR KINASE EXPRESSION AND/OR ACTIVITY - The present invention relates to the diagnosis, prognosis or predisposition of developing cancer, especially lymphoma. The invention also relates to gene therapy and identification of potential new therapeutic agents for treating cancer such as lymphoma.10-14-2010

Brian A. Hemmings, Bettingen CH

Patent application numberDescriptionPublished
20080213240RAC-PK as a therapeutic agent or in diagnostics, screening method for agents and process for activating RAC-PK - The invention concerns RAC-PK and fragments thereof, as well as activators and inhibitors of RAC-PK for use as medicaments, particularly in the treatment of diseases concerned with abnormalities in processes modulated by insulin, such as cellular proliferation, insulin deficiency and/or excess blood sugar levels. Moreover, the invention provides RAC-PK for use in screening potential mimics or modulators thereof. A method for screening for agents capable of affecting the activity of GSK3 is also disclosed. The invention further provides a screening kit comprising the RAC-PK as an active principle, and a method for screening compounds which are candidate mimics or modulators of RAC-PK activity comprising detecting specific interactions between the candidate compounds and RAC-PK. There is also provided a process for activating RAC-PK comprising treatment thereof with a phosphatase inhibitor.09-04-2008

Brian A. Hemmings, Basel CH

Patent application numberDescriptionPublished
20110275102ACTIVATION OF MUTATED RAC-PK - The invention concerns RAC-PK and fragments thereof, as well as activators and inhibitors of RAC-PK for use as medicaments, particularly in the treatment of diseases concerned with abnormalities in processes modulated by insulin, such as cellular proliferation, insulin deficiency and/or excess blood sugar levels. Moreover, the invention provides RAC-PK for use in screening potential mimics or modulators thereof. A method for screening for agents capable of affecting the activity of GSK3 is also disclosed. The invention further provides a screening kit comprising the RAC-PK as an active principle, and a method for screening compounds which are candidate mimics or modulators of RAC-PK activity comprising detecting specific interactions between the candidate compounds and RAC-PK. There is also provided a process for activating RAC-PK comprising treatment thereof with a phosphatase inhibitor.11-10-2011

Brian Arthur Hemmings, Bettingen CH

Patent application numberDescriptionPublished
20110265194THEM5-MODIFIED MODELS OF NON-ALCOHOLIC FATTY LIVER DISEASE - The invention provides a new reproducible genetically-modified mouse model for the study of non-alcoholic fatty liver disease. In particular, the invention concerns the study of non-alcoholic fatty liver disease in an THEM5 knockout mouse model and its use in drug discovery and research.10-27-2011

Chris Hemmings, Hong Kong HK

Patent application numberDescriptionPublished
20080256479Electronic publication and methods and components thereof - An electronic publication and methods and components thereof including a user interface. The electronic publication can be provided by e-mail or similar transmission add contains its own executable file for presentation of the publication without a user requiring a preloaded application software. The electronic publication addresses the processor for calculation and the operating system for increased functionality to minimize the size of the executable file and the publication as a whole. The publication contains a user interface incorporating a page-turn and provides a non-linear travel of the free edge of the tog page across a revealing page so as to imitate a substantially constant rotation of the page. The animation sequence throughout the page-turn is performed on the basis of actual elapsed time since commencement of the animation rather than at predetermined intervals so as to make the individual steps throughout the animation independent of the processor speed. The page-turn also incorporates a 10-16-2008

Patent applications by Chris Hemmings, Hong Kong HK

Ian Hemmings, Derbyshire GB

Patent application numberDescriptionPublished
20090320583METHOD FOR TESTING PIPETTES - The invention is directed to a method for testing batches of tips for pipettes, the method comprising the steps of calibrating a pipette to be tested with a recommended reference tip, fitting the pipette with a tip to be tested and performing a second calibration and recalibrating the pipette with the reference tip.12-31-2009
20110179859CHARACTERIZATION METHOD AND KIT FOR CARRYING OUT THE METHOD - The present invention relates to evaluating the performance of an automated matrix-format liquid handling system by using receptacles and caps. The invention provides a method comprising the steps of determining a receptacle weight for each receptacle, determining a mean cap weight for the caps, dispensing a volume of liquid in each receptacle by using the liquid handling system, capping each receptacle approximately simultaneously with respect to each other, determining a gross weight for each capped receptacle, and calculating the volume of liquid dispensed in each receptacle from the respective gross weight, the respective receptacle weight, and the mean cap weight. The invention further provides a kit for carrying out the method, the kit comprising a plurality of receptacles, a plurality of caps, a holder device for arranging the receptacles in accordance with liquid dispensing positions in the liquid handling system, and a capping device for capping the receptacles.07-28-2011

John William Hemmings, Katy, TX US

Patent application numberDescriptionPublished
20110142722METHOD AND APPARATUS FOR PRODUCING SYNTHESIS GAS - A method and apparatus for reacting a hydrocarbon containing feed stream by steam methane reforming reactions to form a synthesis gas. The hydrocarbon containing feed is reacted within a reactor having stages in which the final stage from which a synthesis gas is discharged incorporates expensive high temperature materials such as oxide dispersed strengthened metals while upstream stages operate at a lower temperature allowing the use of more conventional high temperature alloys. Each of the reactor stages incorporate reactor elements having one or more separation zones to separate oxygen from an oxygen containing feed to support combustion of a fuel within adjacent combustion zones, thereby to generate heat to support the endothermic steam methane reforming reactions.06-16-2011

Mark Hemmings, Wiltshire GB

Patent application numberDescriptionPublished
20090307980PLATFORM SCREEN DOOR SYSTEM - A platform screen door system includes a fixed driving panel and at least one door leaf slidable relative to the fixed driving panel. Further included is a telescopic guide including a fixed guide mounted on the fixed driving panel, a moving guide mounted on the at least one door leaf, and a moving intermediate guide mounted on the fixed guide. Also included is a drive means for slidably moving the at least one door leaf from a closed position to an opened position wherein the at least one door leaf overlaps the fixed driving panel.12-17-2009
20100295366BRAKE SYSTEM - A brake system for a railway vehicle having wheel slide protection includes a main brake pipe fluidly connected to a distributor, and an auxiliary reservoir fluidly connected to the brake distributor, the distributor being fluidly connected to one or more brake cylinders. A further reservoir is provided, compressed air flow to and from the further reservoir being controllable by a valve, operation of the valve being controlled by a control unit adapted to detect wheel slide. The control unit is adapted to switch air supply between air from the auxiliary reservoir and air from the further reservoir in the event that wheel slide is detected.11-25-2010
20110049399PRESSURE EQUALISATION DEVICE - A pressure equalisation device adapted to be operatively connected to an enclosure, the device including an air passage which, when the device is so connected to the enclosure, provides a fluid communication between the interior of the enclosure and atmosphere, the air passage containing a barrier wall comprising an air permeable membrane forming a micro-particulate filter.03-03-2011

Patent applications by Mark Hemmings, Wiltshire GB

Raymond T. Hemmings, Kennesaw, GA US

Patent application numberDescriptionPublished
20090318279Low alkali, non-crystalline, vitreous silica fillers - A substantially white powder for use as a filler and/or extender derived from by-products of manufacturing vitreous low alkali, low iron glass fibers, and a method for producing the powder. The filler has very low alkalinity and by virtue of its being essentially free of crystalline silica is non-hazardous to health and therefore safe for consumer-based and industrial-based uses.12-24-2009
20110020199Process for enhanced remediation of contaminated wastewaters, soils and wasteforms - The present invention provides reagents that may be useful for treating wastes such as impure aqueous materials including wastewater to remove a significant proportion of the heavy metals that may be contained therein. The reagents include a calcium aluminosilicate (CAS) source and may include one or more of the following elements as an oxide: calcium oxide, aluminum oxide, silicon oxide, iron oxide, magnesium oxide, sodium oxide, potassium oxide, and sulfate. Further, the reagent comprises lime either as CaO or Ca(OH)01-27-2011
20110226878System and method for compressed bed grinding in a stirred media mill - A system and method are disclosed for the grinding of industrial minerals to fine powders. The system includes a grinding chamber having a generally vertically oriented agitator that is rotated to stir the grinding media intermixed with a feedstock. As the agitator stirs the grinding media and feedstock, there is a retaining plate that is also located within the grinding chamber and positioned atop of the grinding media to prevent the expansion of the grinding media when it is being stirred. The retaining plate has one or more openings to allow the finely ground feedstock to pass upwardly therethrough but to prevent any grinding media from passing through the retaining plate. Introduction of the feedstock may be through one or more hollow support rods that locate the retaining plate in the desired location within the grinding chamber. The support rods are locked into position when the retaining plate is properly located.09-22-2011

Patent applications by Raymond T. Hemmings, Kennesaw, GA US

Richard A. Hemmings, Glenview, IL US

Patent application numberDescriptionPublished
20090182583METHODS FOR SELLING INSURANCE USING HYBRID LIFE - An insurer sells a life insurance policy with two distinct coverage periods. Prior to accepting the offer of insurance, the insurer underwrites the insurance contract on a limited basis using information obtainable by querying a remote database. During the first coverage period, full coverage is provided and the premium rates approximate a comprehensively underwritten risk. The value of coverage provided at the end of the first coverage period may be reduced if the insured fails to satisfy various obligations. If before a contractually defined compliance period the insured undergoes medical tests and submits blood, urine, or other tissue samples to an underwriter or approved laboratory, the underwriter comprehensively underwrites the policy. If the comprehensive underwriting is satisfactory, the insurance contract is amended, modified, or replaced with a new contract effectively extending full coverage for a longer, extended coverage period, while maintaining or even reducing the premiums owed.07-16-2009
20090182584METHODS FOR SELLING INSURANCE USING RAPID DECISION TERM - An insurer sells a life insurance policy having a coverage period equal in length to the term of the policy. The consideration paid by the insured is relatively high compared to conditional receipt coverage, but is generally lower than that charged for standard simplified issue policies. The policy is only underwritten on a limited basis, preferably using information available in remote databases. During a predetermined time period, the insured has the option of providing medical test results or other material sufficient to enable comprehensive medical underwriting. Upon receipt of the information and material, an underwriter comprehensively underwrites the policy. If the results of the underwriting are satisfactory, the premiums are reduced significantly for the remainder of the term of the insurance policy and/or the benefit amount is increased. If the insured does not provide any additional information or materials, or if the materials provided result in unsatisfactory underwriting, the premiums remain unchanged.07-16-2009
20090182585METHODS FOR SELLING INSURANCE USING RAPID DECISION TERM - An insurance company sells a life insurance policy having a coverage period. The policy provides a total benefit amount which includes an all-cause benefit amount and an accidental death only benefit amount. The policy is initially underwritten on a limited basis and the ratio of the all-cause benefit to the accidental death benefit is low. The insured has the option of providing material to enable comprehensive underwriting and to enable risk classification. If the risk classification improves the policy benefits, the mix of coverage is adjusted to include a higher ratio of the all-cause benefit amount to the accidental death only benefit amount. If the insured does not provide any additional information or materials, or if the materials provided do not result in an underwritten risk classification that enables the policy provisions to be improved, the mix of coverage remains unchanged.07-16-2009