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| 20080263563 | METHOD AND APPARATUS FOR ONLINE SAMPLE INTERVAL DETERMINATION - In one embodiment, functional system elements are added to an autonomic manager to enable automatic online sample interval selection. In another embodiment, a method for determining the sample interval by continually characterizing the system workload behavior includes monitoring the system data and analyzing the degree to which the workload is stationary. This makes the online optimization method less sensitive to system noise and capable of being adapted to handle different workloads. The effectiveness of the autonomic optimizer is thereby improved, making it easier to manage a wide range of systems. | 10-23-2008 |
| 20080313160 | Resource Optimizations in Computing Utilities - Techniques are provided for use in accordance with relates to computing utilities. For example, in one aspect of the invention, a method for use in a computing utility, wherein the computing utility comprises a plurality of application service provider systems and a utility controller, and each application service provider system comprising an application controller, comprises the following steps. An application request to one of the plurality of application service provider systems is obtained. Then, in response to the application request, at least one of: (i) the application controller of the application service provider system to which the application request is directed computes a value of a business metric associated with a resource action; and (ii) the utility controller computes a value of a business metric associated with a resource action. | 12-18-2008 |
| 20090019447 | Adaptive Throttling System for Data Processing Systems - An adaptive throttling system for minimizing the impact of non-production work on production work in a computer system is provided. The adaptive throttling system throttles production work and non-production work to optimize production. The adaptive throttling system allows system administrators to specify a quantified limit on the performance impact of non-production or utility work on production work. The throttling rate of the utility is then automatically determined by a supervisory agent, so that the utilities' impact is kept within the specified limit. The adaptive throttling system adapts dynamically to changes in workloads so as to ensure that valuable system resources are well utilized and utility work is not delayed unnecessarily. | 01-15-2009 |
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| 20090041661 | MEASUREMENT OF BIOSYNTHESIS AND BREAKDOWN RATES OF BIOLOGICAL MOLECULES THAT ARE INACCESSIBLE OR NOT EASILY ACCESSIBLE TO DIRECT SAMPLING, NON-INVASIVELY, BY LABEL INCORPORATION INTO METABOLIC DERIVATIVES AND CATABOLITIC PRODUCTS - Methods of determining rate of biosynthesis or breakdown of biological molecules from metabolic derivatives and catabolic products are disclosed herein. In particular, methods of measuring the rates of biosynthesis and breakdown of biological molecules inaccessible or not easily accessible to direct sampling by sampling metabolic derivatives and catabolic products in accessible biological samples are disclosed herein. | 02-12-2009 |
| 20100041082 | METHODS FOR DETERMINING THE METABOLISM OF SUGARS AND FATS IN AN INDIVIDUAL - Provided herein are methods for determining the metabolism of one or more sugars and/or fatty acids, and applications thereof. Such applications include determining the rate of glycogen synthesis and glycolysis, which are believed to be early markers for predicting elevated risk of diabetes and cardiovascular disease. Other applications include methods for screening drugs that effect sugar and/or fatty acid metabolism. The methods are useful for at least partially characterizing drugs for desirable or undesirable (toxic) characteristics. Drugs that are at least partially characterized using the methods of the invention can then be further developed in pre-clinical testing and clinical trials. Such drugs may be found to be useful in treating obesity, diabetes, cardiovascular disease, and other disorders of metabolism. | 02-18-2010 |
| 20110076236 | COMPOSITIONS AND METHODS OF TREATMENT USING MODULATORS OF MOTONEURON DISEASES - The invention disclosed herein describes a novel therapeutic target for motoneuron diseases (altered dynamics of microtubules in neurons); methods for measuring the state of activity of this therapeutic target in subjects with established, incipient, or potential motoneuron disease; the discovery of drug agents that modulate neuronal microtubule dynamics in living subjects with motoneuron diseases; the discovery that administration of such agents, alone or in combinations, can improve MT-mediated transport of “synaptic vesicle cargo” molecules along and through axons; the discovery that such modulation of altered microtubule dynamics and improvement in MT-transport of molecules along axons can provide marked neuroprotective therapy for living subjects with motoneuron diseases, including delay in symptoms and prolongation of survival; and the discovery that monitoring of neuronal microtubule dynamics in response to therapeutic interventions in subjects with motoneuron diseases, allows diagnostic monitoring, to optimize therapeutic regimens and treatment strategies in individual subjects or in drug trials. The monitoring involves measuring isotope enrichment in secreted synaptic vesicle cargo molecules. | 03-31-2011 |
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| 20090155179 | KINETIC BIOMARKER FOR QUANTIFICATION OF LYMPHOPROLIFERATION, CLONAL EXPANSION, RECRUITMENT AND TRAFFICKING IN LYMPHOID TISSUES AND OF THE IN VIVO ACTIONS OF ANTIGENS AND MODULATING THEREON - The methods of the present invention allow for the measurement of proliferation, clonal expansion trafficking and/or recruitment of lymphocytes into lymphoid tissue in an in vivo setting. Proliferation, clonal expansion, recruitment and/or trafficking of lymphocytes are measured by using stable isotopes to label newly synthesized DNA, isolating the newly-labeled DNA, and quantifying enrichment of the isolated DNA with mass spectrometry or other appropriate techniques. Such methods are useful in screening candidate drugs for stimulatory or inhibitory effects on proliferation, clonal expansion, recruitment and/or trafficking of lymphocytes. The methods also allow for the discovery of therapeutic agents in disorders of immune regulation such as HIV infection and for optimizing vaccine efficacy. | 06-18-2009 |
| 20090197279 | MICROTUBULE SYNTHESIS AS A BIOMARKER - Stable isotope labeling was used to measure dynamics of tubulin incorporation into microtubule subpopulations representing different neuronal compartments in the murine hippocampus. Neuronal microtubules were largely static. Basal turnover was highest in tau-associated (axona) and growth cone), lower in MAP2-associated (somatodendritic), and lowest in cold stable (axonal shaft) subpopulations. Intracerebroventricular glutamate injection stimulated label incorporation into axonal shaft and somatodendritic microtubules, the latter dependent on cAMP-PKA. Hippocampus-dependent memory formation after contextual fear conditioning was accompanied by increased assembly of MAP2- and cold stable-microtubules. Both microtubule assembly and memory formation were inhibited by the microtubule depolymerizing drug, nocodazole. This approach allows for correlation with behavioral measures of learning and memory and for the screening of candidate agents for stimulatory activities on learning memory. | 08-06-2009 |
| 20100172834 | METHOD FOR AUTOMATED, LARGE-SCALE MEASUREMENT OF THE MOLECULAR FLUX RATES OF THE PROTEOME OR THE ORGANEOME USING MASS SPECTROMETRY - Disclosed here is a method for measuring the kinetics (i.e., the molecular flux rates—synthesis and breakdown or removal rates) of a plurality of proteins or organic metabolites inn living systems. The methods may be accomplished in a high-throughput, large-scale automated manner, by using existing mass spectrometric profiling techniques and art well known in the fields of static proteomics and static organeomics, without the need for additional biochemical preparative steps or analytic/instrumental devices. | 07-08-2010 |
