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Helfrich
Barbara A. Helfrich, Lakewood, CO US
| Patent application number | Description | Published |
|---|---|---|
| 20100196366 | Gefitnib Sensitivity-Related Gene Expression and Products and Methods Related Thereto - Disclosed is the identification, provision and use of a panel of biomarkers that predict sensitivity or resistance to EGFR inhibitors, and products and processes related thereto. In one embodiment, a method is described for selecting a cancer patient who is predicted to benefit from therapeutic administration of an EGFR inhibitor, an agonist thereof, or a drug having substantially similar biological activity as EGFR inhibitor. Also described is a method to identify molecules that interact with the EGFR pathway to allow or enhance responsiveness to EGFR inhibitors, as well as a plurality of polynucleotides or antibodies for detection of the expression of genes that are indicative of sensitivity or resistance to EGFR inhibitors, an agonist thereof, or a drug having substantially similar biological activity as EGFR inhibitors. A method to identify a compound with the potential to enhance the efficacy of EGFR inhibitors is also described. | 08-05-2010 |
Evert Alle Helfrich, Groningen NL
| Patent application number | Description | Published |
|---|---|---|
| 20110258792 | SYSTEM FOR AXIAL BRISTLE MOTION IN A TEETH CLEANING MOUTHPIECE - The mouthpiece includes a mouthpiece carrier member ( | 10-27-2011 |
Evert Alle Helfrich, Bellevue, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20110247159 | DENTAL CLEANING MOUTHPIECE WITH REPLACEABLE BRISTLE FIELDS - The dental mouthpiece includes an assembly ( | 10-13-2011 |
Jens Helfrich, Speyer DE
| Patent application number | Description | Published |
|---|---|---|
| 20090009232 | Power Switches - A switching device suitable for operation in temperatures over 150 C comprises first 1 and second 2 transistors, the source | 01-08-2009 |
Jim C. Helfrich, Sun River, MT US
| Patent application number | Description | Published |
|---|---|---|
| 20080211232 | Water current powered motor - A water powered motor for extracting raw energy from a water current and converting it to kinetic energy. The water powered motor is generally rectangular in shape with a generally round water wheel consisting of foldable vanes. The vanes receive raw energy produced by water current transforming that raw energy into usable energy for powering a pump, electric generator or as a general power source to power other equipment such as desalinization machinery. | 09-04-2008 |
Joe Helfrich, Milwaukee, WI US
| Patent application number | Description | Published |
|---|---|---|
| 20120086220 | ENERGY SYSTEM FOR HEAVY EQUIPMENT - An energy system for heavy equipment having an actuator for operating a tool includes a bus, an engine, a generator, an energy storage device, and a controller. The bus is for providing electricity to the actuator as a function of operation of the tool. The engine is for providing a power output and the generator is coupled to the engine and configured to provide electricity to the bus. The energy storage device is configured to receive electricity from the bus for storage of energy, and is further configured to provide electricity to the bus to supplement the electricity provided by the generator. The controller is configured to change the power output of the engine as a function of electrical demand on the bus. In response to a change in the electrical demand, the controller is configured to change the power output of the engine at a rate that is less than a maximum capability of the engine. | 04-12-2012 |
Joseph Helfrich, Milwaikee, WI US
| Patent application number | Description | Published |
|---|---|---|
| 20120089279 | ENERGY MANAGEMENT AND STORAGE SYSTEM - Heavy equipment is designed for operation in a substantially-repetitive work cycle that includes lifting, rotating, and lowering steps. The heavy equipment includes a generator, an electrical bus, an energy storage component, and working components. The generator provides a substantially constant electrical output to the electrical bus, which is communicated to the working components. As such, the working components of the heavy equipment are driven directly or indirectly by the electrical output of the generator. The controller selectively couples the energy storage component to the electrical bus, and the energy storage component is configured to store electricity provided by the generator, and to provide electricity to the working components by way of the electrical bus. The electrical output of the generator is less than the power used by the heavy equipment during a portion of the work cycle, and the controller couples the energy storage component to the electrical bus to supplement the electrical output of the generator during the portion of the work cycle in which the electrical output of the generator is less than the power used by the working components of the heavy equipment. | 04-12-2012 |
Joseph Helfrich, Milwaukee, WI US
| Patent application number | Description | Published |
|---|---|---|
| 20110056192 | TECHNIQUE FOR CONTROLLING PUMPS IN A HYDRAULIC SYSTEM - A hydraulic system includes a plurality of pumps that provide pressurized fluid to a plurality of hydraulic actuators some of which work more that others. That system is controlled by producing a usage value for each of the plurality of pumps which indicates an amount that the respective pump has worked. One of the pumps is assigned to each hydraulic actuator in response to the usage values. The pumps with lower usage values are assigned to hydraulic actuators which work more, so as to equalize the use of each pump. The assignment of pumps to hydraulic actuators changes with changes in the usage values for the plurality of pumps. When a given one of the plurality of hydraulic actuators is to operate, hydraulic fluid is routed from the assigned pump to that given one of the plurality of hydraulic actuators. | 03-10-2011 |
| 20110056194 | HYDRAULIC SYSTEM FOR HEAVY EQUIPMENT - Heavy equipment includes first and second hydraulic pumps, and first and second hydraulic actuators, where the first hydraulic actuator facilitates a first work function of the heavy equipment and the second hydraulic actuator facilitates a second work function of the heavy equipment. The heavy equipment further includes valving and a computerized controller. The valving is configured to allow the first hydraulic pump to be coupled to the first hydraulic actuator and the second hydraulic actuator, and to allow the second hydraulic pump to be coupled to the first hydraulic actuator and the second hydraulic actuator. The computerized controller is coupled to the valving, and has a logic module. The logic module provides instructions to the computerized controller to operate the valving as a function of inputs from an operator command, a sensor input, and prioritization logic associated with the first and second work functions, so as to optimize performance of the work functions facilitated by the hydraulic actuators with respect to available output of the hydraulic pumps. | 03-10-2011 |
| 20110233931 | ENERGY MANAGEMENT SYSTEM FOR HEAVY EQUIPMENT - Equipment having an energy management system includes an articulated arm, a work implement, an energy management system, and a hydraulic circuit. The articulated arm includes hydraulic actuators designed to maneuver the articulated arm, and the work implement is fastened to the articulated arm. The energy management system is adjustable between a first configuration and a second configuration, and includes a hydraulic rotating machine and an electric rotating machine coupled to the hydraulic rotating machine. When the energy management system is in the first configuration, the hydraulic rotating machine and the electric rotating machine function as an electric motor powering a hydraulic pump. When the energy management system is in the second configuration, the hydraulic rotating machine and the electric rotating machine function as a hydraulic motor powering an electric generator. The hydraulic circuit is designed to supply a hydraulic fluid to drive the hydraulic actuators when the energy management system is in the first configuration, and is further designed to recover the hydraulic fluid from the hydraulic actuators and to generate electrical power when the energy management system is in the second configuration. | 09-29-2011 |
| 20120089280 | ENERGY MANAGEMENT SYSTEM FOR HEAVY EQUIPMENT - Heavy equipment includes a body, an electrical bus, and working components coupled to the body and powered by electricity conveyed via the electrical bus. The heavy equipment further includes a generator set providing an electrical output to the electrical bus, an energy storage element configured to be coupled to the electrical bus, and a computerized controller coupled to the energy storage element. The computerized controller includes a logic module for coupling the energy storage element to the electrical bus in advance of a predicted increase in demand upon the electrical bus, where the increase in demand is anticipated by the computerized controller as forthcoming based upon extrapolation, at least in part, from data related to a previous operation of the heavy equipment. | 04-12-2012 |
Juliana Helfrich, Glauchau DE
| Patent application number | Description | Published |
|---|---|---|
| 20080220527 | MODULAR TRANSFECTION SYSTEMS - The present invention relates to a method for transfection of cells using at least one protein capable of forming nucleoprotein filaments, wherein the protein is initially modified with at least one functional component which influences one or more steps of the transfection, the nucleic acid to be transfected is then loaded with the modified protein, whereby the nucleic acid and the protein form a filament-like complex, and this complex is finally added to the cells to be transfected. The invention further relates to a transfection agent consisting of nucleoprotein filaments (NPF), with at least one nucleoprotein filament-forming protein being modified with at least one functional component for the transfection. Furthermore, the present invention relates to the use of the transfection agent according to the invention for producing a drug for gene therapeutic treatment of humans and animals. The present inventions also includes corresponding pharmaceutical preparations, especially for use in gene therapy as well as the use of such transfection agents as component in kits. | 09-11-2008 |
| 20090023131 | CIRCUIT ARRANGEMENT FOR INJECTING NUCLEIC ACIDS AND OTHER BIOLOGICALLY ACTIVE MOLECULES INTO THE NUCLEUS OF HIGHER EUCARYONTIC CELLS USING ELECTRICAL CURRENT - The invention relates to a novel circuit arrangement for electrotransfection or electrofusion, which enables the transportation of DNA and/or other biologically active molecules to the nucleus of higher eukaryotic cells or the fusion of cells, independent of cell division and with reduced cell mortality. | 01-22-2009 |
Juliana Helfrich, Cologne DE
| Patent application number | Description | Published |
|---|---|---|
| 20110117654 | BUFFER SOLUTION FOR ELECTROPORATION AND A METHOD COMPRISING THE USE OF THE SAME - A method for introducing biologically active molecules into animal or human cells using an electric current includes suspending the cells and dissolving the biologically active molecules in a buffer solution including HEPES and at least 10 mmol×1 | 05-19-2011 |
Kenneth Helfrich, Duluth, GA US
| Patent application number | Description | Published |
|---|---|---|
| 20110276734 | USB Dedicated Charger Identification Circuit - In an embodiment, set forth by way of example and not limitation, a USB dedicated charger identification circuit includes a USB D+ port, a USB D− port, a first circuit conforming to a first identification protocol, a second circuit conforming to a second identification protocol, and logic selectively coupling one of the first circuit and the second circuit to the USB D+ port and the USB D− port. In an alternate embodiment set forth by way of example and not limitation, a method to provide USB charger identification includes providing a first USB charger identification at a USB D+ port and a D− port. Next, it is detected if the first USB charger identification was inappropriate. Then, if the first USB charger identification was inappropriate, a second USB charger identification is provided at the USB D+ port and the D− port. | 11-10-2011 |
Kenneth Jay Helfrich, Duluth, GA US
| Patent application number | Description | Published |
|---|---|---|
| 20120082166 | ANALOG FRONT END PROTOCOL CONVERTER/ADAPTER FOR SLPI PROTOCOL - In an embodiment, an analog front end (AFE) bridge for a SLPI PHY includes: an AFE LINK-side circuit having at least one pair of differential LINK-side nodes which does not conform to SLPI PHY specifications; an AFE PHY-side circuit having a pair of differential PHY-side nodes conforming to SLPI PHY specifications, wherein the AFE PHY-side circuit is coupled to the AFE LINK-side circuit; and a termination control circuit coupled to the AFE PHY-side circuit. A method of bridging a legacy LINK circuit to a SLPI PHY circuit includes: communicating with a legacy LINK circuit with a legacy LINK protocol; communicating with a SLPI PHY circuit with a SLPY PHY protocol over a differential pair; converting outputs of the legacy LINK circuit into inputs of the SLPI PHY circuit; converting outputs of the SLPI PHY circuit into inputs of the legacy LINK circuit; controlling a termination of the differential pair. | 04-05-2012 |
Michael Helfrich, Leutenbach DE
| Patent application number | Description | Published |
|---|---|---|
| 20100248888 | TANDEM AXLE HAVING TWO DRIVABLE AXLES AND A DRIVETRAIN WHICH CAN BE PARTIALLY DISCONNECTED - A tandem axle having two drivable axles, each axle including a differential gearing with a drive input gearwheel, drivable by a shaft, as a differential gearing input and with two drive input semi-axles driving the wheels of the axle using axle shaft wheels. The wheels of the first axle are permanently positively coupled to the drive input gearwheel of the axle. An activatable distributor wheel is seated on a drive input shaft of the drive input gearwheel of the first axle. The distributor wheel meshes with a through drive shaft wheel which is arranged in a rotationally rigid fashion on a through drive shaft. The output of the through drive shaft is coupled to the input-side drive input gearwheel of the second axle by means of intermediate members. Switchable clutches are arranged in the second axle between the axle shaft wheels and their adjacent wheels. | 09-30-2010 |
Michael Helfrich, München DE
| Patent application number | Description | Published |
|---|---|---|
| 20090162420 | Matrix-Controlled Transdermal System Comprising Salts of ACE Inhibitor Dicarboxylic Acids - The invention relates to a salt of an ACE inhibitor dicarboxylic acid with an organic amine and/or an alkali compound, a transdermal therapeutic system comprising the salt, and a method of producing the transdermal therapeutic system. | 06-25-2009 |
Michael Helfrich, München DE
| Patent application number | Description | Published |
|---|---|---|
| 20090162420 | Matrix-Controlled Transdermal System Comprising Salts of ACE Inhibitor Dicarboxylic Acids - The invention relates to a salt of an ACE inhibitor dicarboxylic acid with an organic amine and/or an alkali compound, a transdermal therapeutic system comprising the salt, and a method of producing the transdermal therapeutic system. | 06-25-2009 |
Patrick Helfrich, Monroe, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20100298775 | ACCESS SHEATH WITH CENTRAL SEAL - An access apparatus for use during a surgical procedure to provide access to the interior of the body includes an access member defining a longitudinal axis and having a proximal end for being disposed at an exterior side of the body and a distal end for extending into the interior of the body. The access member has a bore therethrough dimensioned to permit passage of an object. A seal is disposed within the longitudinal bore substantially at the rotational center of the access member. The seal has inner seal portions adapted to establish a substantial seal about a surgical instrument introduced within the longitudinal bore of the access member. An access housing may be mounted to the proximal end of the access member. A zero closure valve may be mounted to the access housing. The zero-closure valve may be adapted to close in the absence of the instrument. The seal may be generally disc shaped. The seal may define an aperture for reception of the surgical instrument. The seal may comprise a fabric material, an elastomeric material or a gel material. | 11-25-2010 |
Wijnand Helfrich, Groningen NL
| Patent application number | Description | Published |
|---|---|---|
| 20080234177 | Targeting-enhanced activation of galectins - Lectin-binding proteins and their therapeutic use. In particular, described are the targeting and targeting-enhanced multimerization and activation of galectins. Provided is a galectin-conjugate including at least one galectin molecule conjugated to a non-galectin cell targeting means. Exemplary targeting means include targeting means able to bind EGP2, a pancarcinoma-associated cell surface target antigen, CD antigen, such as CD7 or CD38, or a TNF family member, such as TRAIL-R. The targeting means may comprise an antibody or a functional fragment thereof, such as a single chain variable antibody fragment (scFv). Also provided is the use of a galectin-conjugate for treating a disease, like cancer or an immune disorder, such as auto-immune disease, allergic disorder, auto-immune encephalomyelitis, arthritis, colitis, hepatitis, asthma, multiple sclerosis, transplant rejection, Graft-versus-host disease (GVHD) and/or inflammatory bowel disease. | 09-25-2008 |