Patent application number | Description | Published |
20140324086 | ENDOSCOPIC CUTTING INSTRUMENTS HAVING IMPROVED EFFICIENCY AND REDUCED MANUFACTURING COSTS - Minimally invasive endoscopic cutting instruments having improved efficiency, access and reduced manufacturing costs are described herein. In particular, the present invention describes means for eliminating or modifying the distal end axial bearing surfaces so as to reduce manufacturing costs as well as the opportunity for galling and metal shedding. The present invention further describes an improved hub attachment method that may further or alternatively reduce overall manufacturing costs. The present invention yet further describes means and methods for improved bendability in the field, which, in turn, enables improved access to remote surgical targets. | 10-30-2014 |
20150065808 | SIMPLIFIED ARTHROSCOPY CANNULA - An arthroscopic sealing cannula having improved efficiency, access and reduced manufacturing costs is described herein. In particular, the present invention describes arthroscopic sealing cannulae in which the conventional thermal and chemical bonding means are eliminated and replaced with a mechanical joining system that utilizes mating fastener pairs integrally molded into the distal and proximal elements of a cannula so as to thereby provide a strong reliable joining of the elements. Such a mechanical system eliminates the need for costly capital equipment and specializing tooling as well as the material and environmental handling problems associated with conventional bonding techniques. Furthermore, in that the join may be readily confirmed through simple visual examination, the present invention also eliminates the need for complex, costly, and time-consuming validation procedures mandated by regulations in place to ensure proper integrity, strength, and reliability of the bond. Accordingly, arthroscopic sealing cannulae constructed in accordance with the principles of this invention are expected to have increased reliability and reduced manufacturing costs. | 03-05-2015 |
20150182233 | PERCUSSIVE SURGICAL DEVICES, SYSTEMS, AND METHODS OF USE THEREOF - In the context of bone surgery and in particular arthroscopic surgery, there is frequently a need for the application of “percussive force” to the distal end component(s) of a surgical device, i.e., repetitive percutient or striking force analogous to that of a hammer driving a nail. Disclosed herein are mechanisms and methods for automating and/or controlling the application of such a percussive force so as to avoid the present need in the art for a “third hand”. The present invention addresses the significant and long felt need by providing a powered percussive driver device that may be controlled directly by the primary surgeon. | 07-02-2015 |
20150245868 | BENDABLE AND REBENDABLE ENDOSCOPIC ELECTROSURGICAL DEVICE - In the context of endoscopic electrosurgery, there is a need for a sufficiently robust, rigid, and preferably aspirating electrosurgical device that may be repeatedly flexed in the field to allow access to a wide array of remote tissues using a single device and, more preferably, during a single minimally invasive procedure. The present invention addresses this significant need by providing the distal portion of the elongate tubular member of an electrosurgical device with a bend region having a non-uniform flexural strength along its length, such that one may bend the tubular member at said bend region not only to an initial small radius bend, but subsequently rebend the distal portion to other angles as needed, with all bends occurring in the same distal region. The flexural strength in the bend region may be reduced by, for example, notching the tube in the bend region, annealing the tube in the bend region, or reducing the wall thickness in the bend region, or any combination of these means. | 09-03-2015 |
20150245901 | IMPLANT PLACEMENT SYSTEMS, DEVICES, AND METHODS - Described herein is a simplified placement system and method for a tissue graft anchor by which a surgeon may introduce one or more sutures into a hole in a boney tissue, apply tension to the sutures to advance a soft tissue graft to a desired location, and then advance the anchor into the bone while maintaining suture tension and without introducing spin to the suture. | 09-03-2015 |
Patent application number | Description | Published |
20110110944 | ANTI-ALK1 ANTIBODIES AND USES THEREOF - The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for AIk1, which plays an integral role in various disorders or conditions, such as cancer and macular degeneration. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of AIk1 in the progression of disorders associated with pathogenic angiogenesis. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use. | 05-12-2011 |
20120189644 | ANTI-MESOTHELIN IMMUNOCONJUGATES AND USES THEREFOR - The present invention provides immunoconjugates composed of antibodies, e.g., monoclonal antibodies, or antibody fragments that bind to mesothelin, that are conjugated to cytotoxic agents, e.g., maytansine, or derivatives thereof, and/or co-administered or formulated with one or more additional anti-cancer agents. The immunoconjugates of the invention can be used in the methods of the invention to treat and/or diagnose and/or monitor cancers, e.g. solid tumors. The immunoconjugates comprise antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 40 kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells. | 07-26-2012 |
20130066055 | NEW BINDER-DRUG CONJUGATES (ADCS) AND USE THEREOF - The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures. | 03-14-2013 |
20130122024 | NEW BINDER-DRUG CONJUGATES (ADCS) AND USE THEREOF - The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target mesothelin, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures. | 05-16-2013 |
20140127240 | Novel Binder-Drug Conjugates (ADCs) and Use of Same - The present patent application relates to novel binder-drug conjugates (ADCs) of N,N-dialkylauristatins directed against the target epidermal growth factor receptor (EGFR, gene ID 1956), effective metabolites of these ADCs, methods for producing these ADCs, use of these ADCs for treatment and or prevention of diseases as well as the use of these ADCs to produce pharmaceutical drugs for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic diseases such as cancer, for example. Such treatments may be administered as monotherapy or in combination with other pharmaceutical drugs or other therapeutic measures. | 05-08-2014 |
20150030618 | NOVEL BINDER-DRUG CONJUGATES (ADCS) AND USE THEREOF - The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures. | 01-29-2015 |
20150246136 | NOVEL BINDER-DRUG CONJUGATES (ADCs) AND USE OF SAME - The present patent application relates to novel binder-drug conjugates (ADCs) of N,N-dialkylauristatins directed against the target epidermal growth factor receptor (EGFR, gene ID 1956), effective metabolites of these ADCs, methods for producing these ADCs, use of these ADCs for treatment and or prevention of diseases as well as the use of these ADCs to produce pharmaceutical drugs for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic diseases such as cancer, for example. Such treatments may be administered as monotherapy or in combination with other pharmaceutical drugs or other therapeutic measures. | 09-03-2015 |
20150322160 | ANTI-MESOTHELIN IMMUNOCONJUGATES AND USES THEREFOR - The present invention provides immunoconjugates composed of antibodies, e.g., monoclonal antibodies, or antibody fragments that bind to mesothelin, that are conjugated to cytotoxic agents, e.g., maytansine, or derivatives thereof, and/or co-administered or formulated with one or more additional anti-cancer agents. The immunoconjugates of the invention can be used in the methods of the invention to treat and/or diagnose and/or monitor cancers, e.g. solid tumors. recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 40 kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells | 11-12-2015 |
Patent application number | Description | Published |
20110252724 | Roof Truss Compatible for Solar Panels - A roof truss compatible for solar energy panels, and a method for installing the roof trusses, incorporates a non-structural top chord that may have a removable portion removed and replaced by a solar assembly. The truss is structurally designed to support the solar assembly without the presence of the non-structural top chord. A desired length of the non-structural top chord may be omitted or removed during manufacture of the truss, or may be removed at a future time for installation of solar panel assemblies. A solar assembly for inserting into the solar roof truss may include a panel enclosure which has a channel for holding a solar panel, where the panel is installed approximately flush with the roof line. The panel enclosure may have an air space underneath the solar panel, to allow for cooling air flow and water drainage. | 10-20-2011 |
20130160396 | Roof Truss Compatible for Solar Panels - A roof truss compatible for solar energy panels, and a method for installing the roof trusses, incorporates a non-structural top chord that may have a removable portion removed and replaced by a solar assembly. The truss is structurally designed to support the solar assembly without the presence of the non-structural top chord. A desired length of the non-structural top chord may be omitted or removed during manufacture of the truss, or may be removed at a future time for installation of solar panel assemblies. A solar assembly for inserting into the solar roof truss may include a panel enclosure which has a channel for holding a solar panel, where the panel is installed approximately flush with the roof line. The panel enclosure may have an air space underneath the solar panel, to allow for cooling air flow and water drainage. | 06-27-2013 |
20140020308 | Roof Truss Compatible for Solar Panels - A roof truss compatible for solar energy panels, and a method for installing the roof trusses, incorporates a non-structural top chord that may have a removable portion removed and replaced by a solar assembly. The truss is structurally designed to support the solar assembly without the presence of the non-structural top chord. A desired length of the non-structural top chord may be omitted or removed during manufacture of the truss, or may be removed at a future time for installation of solar panel assemblies. A solar assembly for inserting into the solar roof truss may include a panel enclosure which has a channel for holding a solar panel, where the panel is installed approximately flush with the roof line. The panel enclosure may have an air space underneath the solar panel, to allow for cooling air flow and water drainage. | 01-23-2014 |
Patent application number | Description | Published |
20130092153 | Direct Solar Steam Generation - Solar energy generates steam in a “once-through” configuration without recirculation, with closely managed steam quality, to produce wet steam from high-contaminant feed water without scaling or fouling. Feed water is pressurized, preheated, and evaporated in a series of pipes exposed to concentrated solar energy to produce a water-steam mixture for direct distribution to an industrial process such as enhanced oil recovery or desalination. Water flow rates are managed based on measurements of solar energy and steam production to manage variations in the solar energy. Steam generator piping system uses continuous receiver pipe that is illuminated by segmented parabolic mirrors enabled to track the sun. Provisions for steam generator piping recurring maintenance are provided. Thermal energy from hot condensate and/or from low quality steam is recaptured and warms inlet water. | 04-18-2013 |
20130112394 | Oilfield Application of Solar Energy Collection - Solar energy is collected and used for various industrial processes, such as oilfield applications, e.g. generating steam that is injected downhole, enabling enhanced oil recovery. Solar energy is indirectly collected using a heat transfer fluid in a solar collector, delivering heat to a heat exchanger that in turn delivers heat into oilfield feedwater, producing hotter water or steam. Solar energy is directly collected by directly generating steam with solar collectors, and then injecting the steam downhole. Solar energy is collected to preheat water that is then fed into fuel-fired steam generators that in turn produce steam for downhole injection. Solar energy is collected to produce electricity via a Rankine cycle turbine generator, and rejected heat warms feedwater for fuel-fired steam generators. Solar energy is collected (directly or indirectly) to deliver heat to a heater-treater, with optional fuel-fired additional heat generation. | 05-09-2013 |
20130247900 | DIRECT SOLAR STEAM GENERATION - In a “once-through” configuration, feedwater is pressurized, preheated, and evaporated in a series of pipes exposed to concentrated solar energy to produce a water-steam mixture for direct distribution to an industrial process such as enhanced oil recovery or desalination. Active steam quality management, in a preheat mode, vents warm/hot water and low-quality steam to a return vessel where steam is recondensed via contact with water and fed back in as feedwater. In an operating mode, the venting is disabled, and high-quality steam is directed as an outlet stream. Inlet water flowrate and outlet valves are managed to reduce effects of variation in the solar energy. A steam generator continuous piping system uses a single continuous receiver pipe that is illuminated by segmented parabolic mirrors enabled to track the sun to reduce high-temperature fouling. Provisions for steam generator piping recurring maintenance are provided. Low-temperature “overnight” solar field management reduces low-temperature fouling. | 09-26-2013 |
20140216717 | SYSTEMS AND METHODS FOR SELECTIVELY PRODUCING STEAM FROM SOLAR COLLECTORS AND HEATERS FOR PROCESSES INCLUDING ENHANCED OIL RECOVERY - Systems and methods for selectively producing steam from solar collectors and heaters, for processes including enhanced oil recovery, are disclosed herein. A system in accordance with a particular embodiment includes a water source, a solar collector that includes a collector inlet, a collector outlet, and a plurality of solar concentrators positioned to heat water passing from the collector inlet to the collector outlet, a fuel-fired heater, a steam outlet connected to an oil field injection well, and a water flow network coupled among the water source, the solar collector, the heater, and the steam outlet. The system can further include a controller operatively coupled to the water flow network and programmed with instructions that, when executed, direct at least one portion of the flow through the solar collector and the fuel-fired heater in a first sequence, and direct the at least one portion or a different portion of the flow through the solar collector and the fuel-fired heater in a second sequence different than the first sequence. | 08-07-2014 |
20140345599 | OILFIELD APPLICATION OF SOLAR ENERGY COLLECTION - Solar energy is collected and used for various industrial processes, such as oilfield applications, e.g. generating steam that is injected downhole, enabling enhanced oil recovery. Solar energy is indirectly collected using a heat transfer fluid in a solar collector, delivering heat to a heat exchanger that in turn delivers heat into oilfield feedwater, producing hotter water or steam. Solar energy is directly collected by directly generating steam with solar collectors, and then injecting the steam downhole. Solar energy is collected to preheat water that is then fed into fuel-fired steam generators that in turn produce steam for downhole injection. Solar energy is collected to produce electricity via a Rankine cycle turbine generator, and rejected heat warms feedwater for fuel-fired steam generators. Solar energy is collected (directly or indirectly) to deliver heat to a heater-treater, with optional fuel-fired additional heat generation. | 11-27-2014 |
20150285048 | SYSTEMS AND METHODS FOR SELECTIVELY PRODUCING STEAM FROM SOLAR COLLECTORS AND HEATERS FOR PROCESSES INCLUDING ENHANCED OIL RECOVERY - Systems and methods for selectively producing steam from solar collectors and heaters, for processes including enhanced oil recovery, are disclosed herein. A system in accordance with a particular embodiment includes a water source, a solar collector that includes a collector inlet, a collector outlet, and a plurality of solar concentrators positioned to heat water passing from the collector inlet to the collector outlet, a fuel-fired heater, a steam outlet connected to an oil field injection well, and a water flow network coupled among the water source, the solar collector, the heater, and the steam outlet. The system can further include a controller operatively coupled to the water flow network and programmed with instructions that, when executed, direct at least one portion of the flow through the solar collector and the fuel-fired heater in a first sequence, and direct the at least one portion or a different portion of the flow through the solar collector and the fuel-fired heater in a second sequence different than the first sequence. | 10-08-2015 |
20150285490 | SYSTEMS AND METHODS FOR SELECTIVELY PRODUCING STEAM FROM SOLAR COLLECTORS AND HEATERS FOR PROCESSES INCLUDING ENHANCED OIL RECOVERY - Systems and methods for selectively producing steam from solar collectors and heaters, for processes including enhanced oil recovery, are disclosed herein. A system in accordance with a particular embodiment includes a water source, a solar collector that includes a collector inlet, a collector outlet, and a plurality of solar concentrators positioned to heat water passing from the collector inlet to the collector outlet, a fuel-fired heater, a steam outlet connected to an oil field injection well, and a water flow network coupled among the water source, the solar collector, the heater, and the steam outlet. The system can further include a controller operatively coupled to the water flow network and programmed with instructions that, when executed, direct at least one portion of the flow through the solar collector and the fuel-fired heater in a first sequence, and direct the at least one portion or a different portion of the flow through the solar collector and the fuel-fired heater in a second sequence different than the first sequence. | 10-08-2015 |
20150295158 | SYSTEMS AND METHODS FOR SELECTIVELY PRODUCING STEAM FROM SOLAR COLLECTORS AND HEATERS FOR PROCESSES INCLUDING ENHANCED OIL RECOVERY - Systems and methods for selectively producing steam from solar collectors and heaters, for processes including enhanced oil recovery, are disclosed herein. A system in accordance with a particular embodiment includes a water source, a solar collector that includes a collector inlet, a collector outlet, and a plurality of solar concentrators positioned to heat water passing from the collector inlet to the collector outlet, a fuel-fired heater, a steam outlet connected to an oil field injection well, and a water flow network coupled among the water source, the solar collector, the heater, and the steam outlet. The system can further include a controller operatively coupled to the water flow network and programmed with instructions that, when executed, direct at least one portion of the flow through the solar collector and the fuel-fired heater in a first sequence, and direct the at least one portion or a different portion of the flow through the solar collector and the fuel-fired heater in a second sequence different than the first sequence. | 10-15-2015 |