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Heisel, US

Adam J. Heisel, Garden City, MI US

Patent application numberDescriptionPublished
20110130902METHOD OF SMOOTHING OUTPUT TORQUE - A method of output torque smoothing for a hybrid powertrain having an electric machine and a spark ignition engine with a first cylinder and a second cylinder includes commanding a fuel-cut transition, including consecutively initiating and completing deactivation of the first cylinder and initiating and completing deactivation of the second cylinder. The fuel-cut transition is characterized by an absence of retarding spark to the first cylinder and second cylinder. Fuel is supplied to the first cylinder until the first cylinder completes deactivation and to the second cylinder until the second cylinder completes deactivation. The electric machine captures a first torque from the first cylinder by generating electricity until the first cylinder completes deactivation and captures a second torque from the second cylinder by generating electricity until the second cylinder completes deactivation.06-02-2011
20110130903TORQUE COMMAND STRUCTURE FOR AN ELECTRIC MOTOR - A method controls a motor generator unit (MGU) aboard a vehicle. An event signal is generated using a transmission controller, with the event signal predicting a transient vehicle event, e.g., auto start, transmission shift, fuel cycling, etc. The event signal is received by a motor controller, which determines a predicted level of motor output torque required from the MGU during the transient vehicle. Electromagnetic flux of the MGU is increased to a calibrated threshold level prior to commencement of the transient vehicle event. The MGU may be used for regenerating energy during the transient vehicle event. The MGU is then used to facilitate execution of the transient vehicle event. A vehicle having the MGU uses a controller(s) to automatically increase electromagnetic flux of the MGU prior to the transient vehicle event using the method as noted above.06-02-2011
20110144837HYBRID ACCESSORY POWER MODULE SHEDDING FOR HIGH VOLTAGE BATTERY PROTECTION - A method of controlling a hybrid powertrain of a vehicle includes lowering a target voltage set point of a low voltage battery to a temporary voltage set point to reduce the overall power required by the accessory power module when a requested voltage from a vehicle accessory draws the voltage of the low voltage battery below the target voltage set point. The temporary voltage set point gradually increases over time until equal to the target voltage set point, allowing sufficient time for a high voltage battery to provide the required power for the accessory power module or for an electric motor/generator to generate the current required by the accessory power module.06-16-2011

Jennifer Heisel, Princeton, MN US

Patent application numberDescriptionPublished
20100113351Therapeuting Compositions Comprising an RNAi Agent and a Neurotrophic Factor and Methods of Use Thereof - The invention provides novel combination therapies for treating Huntington's disease which comprise a) BDNF or suitable fragments thereof and b) agents capable of causing inhibition of a gene responsible for the neurodegenerative disease. The invention provides nucleic acid sequences, methods, and systems suitable for applications of these combination therapies.05-06-2010
20100284990Compositions and Methods for Making Therapies Delivered by Viral Vectors Reversible for Safety and Allele-Specificity - The present invention is directed to compositions, methods and kits for regulation of gene therapies for Huntington's Disease, including, without limitation, reversible gene therapies and allele-specific therapies.11-11-2010

Jennifer M. Heisel, Princeton, MN US

Patent application numberDescriptionPublished
20100263066INERT DNA SEQUENCES FOR EFFICIENT VIRAL PACKAGING AND METHODS OF USE - The instant invention provides an inert DNA sequence having a length of between about 0.5 kb and about 5 kb, wherein said isolated inert DNA sequence does not contain an open reading frame and which is suitable for efficient packaging of expression cassettes comprising a nucleic sequence encoding a therapeutic agent into viral vectors, as well as methods of selecting such inert DNA sequences. The invention also provides DNA constructs and medical composition comprising such inert DNA sequences, and kits and medical systems for delivering such DNA constructs and/or compositions.10-14-2010
20100298697METHOD AND DEVICES FOR IMPROVED EFFICIENCY OF RNA DELIVERY TO CELLS - The instant invention provides a method for improving efficiency of RNA delivery to cells. The method comprises applying a low strength electric field to the cells and then after a certain time period, administering the ribonucleic acid sequence to the cells. Devices, kits, and RNA molecules suitable for delivery and devices suitable for practicing the disclosed methods are also provided.11-25-2010
20100298762Methods and Devices for Improved Efficiency of RNA Delivery to Cells - The instant invention provides a method for improving efficiency of RNA delivery to cells. The method comprises applying a low strength electric field to the cells and then after a certain time period, administering the ribonucleic acid sequence to the cells. Devices, kits, and RNA molecules suitable for delivery and devices suitable for practicing the disclosed methods are also provided.11-25-2010

Sara E. Heisel, St. Louis, MO US

Patent application numberDescriptionPublished
20080229456Recombinant DNA constructs and methods for controlling gene expression - The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.09-18-2008
20090070898Plant microRNAs and methods of use thereof - This invention discloses novel microRNAs and their precursors, and recombinant DNA constructs including such novel miRNAs, miRNA precursors, miRNA promoters, and miRNA recognition sites corresponding to the miRNAs. Included are novel miRNA and miRNA precursors that exhibit nutrient-responsive expression. Also disclosed are miRNA decoy sequences. Further provided are non-natural transgenic plant cells, plants, and seeds containing in their genome a recombinant DNA construct of this invention and methods of controlling gene expression using recombinant DNA constructs of this invention.03-12-2009
20100223694Recombinant DNA Constructs and Methods for Controlling Gene Expression - The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.09-02-2010
20110035838Recombinant DNA Constructs and Methods for Controlling Gene Expression - The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.02-10-2011
20110035839Recombinant DNA Constructs and Methods for Controlling Gene Expression - The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.02-10-2011

Patent applications by Sara E. Heisel, St. Louis, MO US

Sara E. Heisel, St.louis, MO US

Patent application numberDescriptionPublished
20090013434Recombinant DNA constructs and methods for controlling gene expression - The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.01-08-2009