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Heiner, US

Cheryl Heiner, San Mateo, CA US

Patent application numberDescriptionPublished
20090105094Error-free amplification of DNA for clonal sequencing - Methods of preparing nucleic acid templates and providing the nucleic acid templates to low copy number reaction volumes are provided. Related compositions of nucleic acid templates are also provided.04-23-2009
20090280538Methods and compositions for nucleic acid sample preparation - Provided are methods and compositions for the production of linear single-stranded nucleic acids, which can be used as templates in high-throughput sequencing systems. Also provided are methods and compositions for the production of closed single-stranded nucleic acid loops, which can be used as templates in high-throughput sequencing systems.11-12-2009
20090298075COMPOSITIONS AND METHODS FOR NUCLEIC ACID SEQUENCING - Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant sequence determination through one or both of sequencing sense and antisense strands, and iteratively sequencing the entire construct multiple times. Additional sequence components are also optionally included within such template constructs. Methods are also provided for the use and preparation of these constructs as well as sequencing compositions for their application.12-03-2009

Cheryl Heiner, La Honda, CA US

Patent application numberDescriptionPublished
20090325184Compositions and Methods for Clonal Amplification and Analysis of Polynucleotides - Compositions and methods of use are disclosed for clonally amplifying and analyzing one or more polynucleotides.12-31-2009
20100206730Internal Calibration Standards for Electrophoretic Analyses - The present teachings relate, among other things, to polynucleotide sequencing, fragment analysis and sample/lane tracking, and to polynucleotide sequencers and analyzers that employ optical detection techniques. Embodiments of the present teachings are described which include, for example, the addition of a calibration standard to a sequencing reaction. Information such as peak spacing and peak shape can be extracted from the standard.08-19-2010

Patent applications by Cheryl Heiner, La Honda, CA US

David Heiner, San Diego, CA US

Patent application numberDescriptionPublished
20100187115ELECTROOSMOTIC PUMP WITH IMPROVED GAS MANAGEMENT - An electroosmotic (EO) pump is provided that includes a housing having a pump cavity, a porous core medium and electrodes. The porous core medium is positioned within the pump cavity to form an exterior reservoir that extends at least partially about an exterior surface of the porous core medium. The porous core medium has an open inner chamber provided therein. The inner chamber represents an interior reservoir. The electrodes are positioned in the inner chamber and are positioned proximate the exterior surface. The electrodes induce flow of a fluid through the porous core medium between the interior and exterior reservoirs, wherein a gas is generated when the electrodes induce flow of the fluid. The housing has a fluid inlet to convey the fluid to one of the interior reservoir and the exterior reservoir. The housing has a fluid outlet to discharge the fluid from another of the interior reservoir and the exterior reservoir. The housing has a gas removal device to remove the gas from the pump cavity.07-29-2010

David A. Heiner, Pittsburgh, PA US

Patent application numberDescriptionPublished
20090106918Retractable Ramp - A ramp assembly includes an elongated frame sized and shaped to extend between a first door and a second door aligned opposite each other on opposed sides of a vehicle; a first sectional ramp section having a first end and a second end; and a second sectional ramp having a first end and a second end. The first sectional ramp is slidably moveable along the frame from a stored position to a deployed position on either of the opposed sides of the vehicle. The second sectional ramp is positioned adjacent the first sectional ramp and is slidably moveable along the frame from a stored position to a deployed position on either of the opposed sides of the vehicle. The ramp assembly also includes a first locking mechanism coupled to the first end of each of the first sectional ramp and the second sectional ramp; and a second locking mechanism coupled to the second end of each of the first sectional ramp and the second sectional ramp. The first locking mechanism is placed in a locked position and the second locking mechanism is placed in an unlocked position to allow the first and second sectional ramps to be coupled together and moved from the stored position to the deployed position through the first door. The second locking mechanism is placed in a locked position and the first locking mechanism is placed in an unlocked position to allow the first and second sectional ramps to be coupled together and moved from the stored position to the deployed position through the second door.04-30-2009

David Louis Heiner, San Diego, CA US

Patent application numberDescriptionPublished
20110136684CHEMICAL REACTION MONITOR - Disclosed herein are systems for monitoring chemical reactions. The systems can comprise a lighting device, a camera device for obtaining an image of the chemical reaction mixtures and an analyzer program to process data obtained from the image. Also disclosed are methods of monitoring the progress of chemical reactions using these systems.06-09-2011

Jeffrey N. Heiner, Los Altos, CA US

Patent application numberDescriptionPublished
20090307326MANAGING ELECTRONIC MESSAGES - A recipient computer system may receive one or more electronic messages. The recipient computer system may send one, two, or more challenge messages to the sender of the electronic messages in determining whether to deliver the electronic message. The recipient computer system may accept or reject an electronic message based on the response, or lack of response, to the challenge messages. The recipient computer system may send two or more challenge messages at intervals. A sender computer system may record activity of the sender computer system for a recipient computer system to use in determining whether to deliver an electronic message. A sender computer system may provide a summary of that activity with an electronic message. A sender computer system may provide an authorization key for a recipient computer system to use in determining whether to deliver an electronic message. The authorization key may be generated by a third party.12-10-2009

William Heiner, O'Fallon, MO US

Patent application numberDescriptionPublished
20090088032Open face electrical connector - An open-face electrical wire connector for forming an electrical connection to a wire connector lug wherein the wire connector lug, which is free of any sealant can be brought into engagement with another portion of a housing, which carries a sealant, to cause the sealant to flow around the wire connector lug and the electrical connection therein for on-the-go formation of a sealant covered electrical connection.04-02-2009