| Patent application number | Description | Published |
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| 20090062297 | Hydroxyalkylarylamide Derivatives - The present invention relates to a novel class of hydroxyalkylarylamide derivatives. The instant compounds can be used to treat cancer. The fluorinated arylamide derivatives can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo. | 03-05-2009 |
| 20090209566 | Spirocyclic Compounds - The present invention relates to a novel class of substituted spirocyclic compounds, represented by the following structural Formula: I Wherein A, B and D are independently selected from CR | 08-20-2009 |
| 20090291965 | Histone Deacetylase Inhibitors With Aryl-Pyrazolyl-Motifs - The present invention relates to a novel class of histone deacetylase inhibitors with aryl-pyrazolyl motifs. The compounds of this invention can be used to treat cancer. The compounds of this invention are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The present invention further provides pharmaceutical compositions comprising the compounds of this invention and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the compounds of this invention in vivo. | 11-26-2009 |
| 20110039925 | CYCLOBUTYL SULFONES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS - The invention encompasses a novel class of cyclobutyl sulfone derivatives which inhibit the processing of APP by the putative γ-secretase while sparing Notch signaling pathway, and thus are useful in the treatment or prevention of Alzheimer's disease without the development of Notch inhibition mediated gastrointestinal issues. Pharmaceutical compositions and methods of use are also included. | 02-17-2011 |
| Patent application number | Description | Published |
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| 20100079386 | HUMAN-MACHINE INTERFACE HAVING MULTIPLE TOUCH COMBINATORIAL INPUT - A Human-Machine Interface (HMI) system comprises a user interface, a processing system, and a machine interface. The user interface displays a multi-state enable option graphic selectable by a first touch from a user, that, when the first touch is maintained, enables a multi-state mode of a state option graphic having a plurality of modes comprising a single-state mode and the multi-state mode, displays the state option graphic selectable by a second touch from the user, and receives the second touch from the user selecting the state option graphic. If the state option graphic is in the multi-state mode when selected, the processing system processes the second touch to select a state option from a plurality of state options corresponding to a plurality of operation states of a machine. If the state option graphic is in the single-state mode when selected, the processing system processes the second touch to select the state option from a single state option corresponding to a single operation state of the machine. The machine interface transfers a control instruction to operate the machine in an operation state corresponding to the state option. | 04-01-2010 |
| 20100079499 | HUMAN-MACHINE INTERFACE HAVING MULTIPLE TOUCH TREND MANIPULATION CAPABILITIES - A Human-Machine Interface (HMI) system comprises a machine interface, a processing system, and a user interface. The machine interface receives operational data associated with an operation of a machine. The processing system processes the operational data associated with the operation of the machine to determine a trend in the operational data. The user interface displays a graphical representation of the trend, and receives a first user input and a second user input simultaneously on a surface of the user interface. The processing system processes the first user input and the second user input to determine a change in the trend. The user interface displays a graphical representation of the change in the trend. | 04-01-2010 |
| 20100083110 | HUMAN-MACHINE INTERFACE HAVING MULTIPLE TOUCH DISPLAY NAVIGATION CAPABILITIES - A Human-Machine Interface (HMI) system comprises a user interface and a processing system. The user interface displays a plurality of machine systems in an automation environment having a plurality of automation information, displays an information menu indicating a plurality of information types associated with the plurality of machine systems, receives a first touch on a surface of the user interface selecting an information type from the plurality of information types, and, while receiving the first touch, receives a second touch on the surface of the user interface selecting a machine system from the plurality of machine systems. The processing system processes the first touch and the second touch to select from the plurality of automation information an automation information associated with the selected information type and the selected machine system. The user interface displays the selected automation information. | 04-01-2010 |
