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Hefetz, IL
Meir Hefetz, Oshrat IL
| Patent application number | Description | Published |
|---|---|---|
| 20090012494 | INTRADERMAL DELIVERY OF BIOLOGICAL AGENTS - The present invention relates to methods for intradermally delivering one or more biologically active agents such as vaccines and therapeutic agents into the dermis layer of the skin of a subject to obtain systemic delivery or an immune response using a microneedle drug delivery device containing the agent to be delivered. The methods employ a microneedle device with a row of hollow microneedles. The microneedles penetrate the skin of the subject and assume an anchored state in which the microneedles are anchored in the skin and project laterally from the device. A pivotal motion is then performed with the device so that the skin in which the microneedles are engaged is lifted above the initial plane of the surface of the skin while the biologically active agent is delivered. The methods of the invention elicit increased humoral and/or cellular response as compared to conventional vaccine delivery routes, facilitating dose sparing. | 01-08-2009 |
Meir Hefetz, Mizpeh Harashim IL
| Patent application number | Description | Published |
|---|---|---|
| 20090054842 | Enhanced penetration system and method for sliding microneedles - A microneedle device for transporting fluid through a surface of a biological barrier, the device including a fluid transport configuration, an abutment member and a displacement device. The fluid transport configuration includes a substrate having a substantially planar surface having a plurality of microneedles projecting therefrom. The abutment member has an abutment surface for abutting the biological barrier. The displacement device is configured for generating a relative lateral sliding movement between the surface of the biological barrier and the fluid transport configuration in a sliding direction of the microneedles The microneedles are arranged so that a leading microneedle defines an effective area which is effective void of another microneedle. The effective area is defined as an area marked out by translating the base area of the leading microneedle, by the height of the leading microneedle, in a direction opposite to the sliding direction. | 02-26-2009 |
| 20090069788 | System And Method For Delivering Fluid Into Flexible Biological Barrier - A system and method for delivering fluid into a flexible biological barrier employs a microneedle structure wherein a final position of microneedles ( | 03-12-2009 |
| 20090157094 | DEVICE FOR SUPERFICIAL ABRASIVE TREATMENT OF THE SKIN | 06-18-2009 |
Meir Hefetz, Mizpe Harashim IL
| Patent application number | Description | Published |
|---|---|---|
| 20100106105 | Microneedle Structure And Production Method Therefor - A method for processing a wafer to form a plurality of hollow microneedles projecting from a substrate includes forming, by use of a dry etching process, a number of groups of recessed features, each including at least one slot deployed to form an open shape having an included area and at least one hole located within the included area. The internal surfaces of the holes and the slots are then coated with a protective layer. An anisotropic wet etching process is then performed in such a manner as to remove material from outside the included areas while leaving a projecting feature within each of the included areas. The protective layer is then removed to reveal the microneedles. | 04-29-2010 |
Meir Hefetz, Haifa IL
| Patent application number | Description | Published |
|---|---|---|
| 20090247953 | MICRONEEDLE ADAPTOR FOR DOSED DRUG DELIVERY DEVICES - An adapter for achieving intradermal dosed delivery of a liquid by use of a dosed drug delivery device including a reservoir having a pierceable septum, the adapter having a connector including an attachment configuration for attachment to the dosed drug delivery device and a hollow needle deployed for piercing the septum. A liquid delivery interface, linked to the connector, includes a straight skin contact edge and one or more hollow microneedle adjacent thereto. The microneedle projects away from the skin contact edge. A flow path arrangement interconnects the needle and the at least one hollow microneedle. | 10-01-2009 |
Mier Hefetz, Mizpe Harashim IL
| Patent application number | Description | Published |
|---|---|---|
| 20110073560 | Microneedle Structure And Production Method Therefor - A method for processing a wafer to form a plurality of hollow microneedles projecting from a substrate includes forming, by use of a dry etching process, a number of groups of recessed features, each including at least one slot deployed to form an open shape having an included area and at least one hole located within the included area. The internal surfaces of the holes and the slots are then coated with a protective layer. An anisotropic wet etching process is then performed in such a manner as to remove material from outside the included areas while leaving a projecting feature within each of the included areas. The protective layer is then removed to reveal the microneedles. | 03-31-2011 |
Yaniv Hefetz, Givataim IL
| Patent application number | Description | Published |
|---|---|---|
| 20090160965 | Image sensor having a diffractive optics element - An apparatus for generating a color image that comprises an image sensor having a plurality of light-sensitive elements having a light sensing area, each light-sensitive element is configured for measuring a value corresponding to an intensity of light at the related light sensing area. The apparatus further comprises a diffractive optics element that diffracts impinging light waves. Each one of the impinging light waves is diffracted according to its wavelength toward at least one of the light-sensitive elements. The apparatus further comprises an image processor that generates a color image by arranging the values. | 06-25-2009 |
| 20090180166 | Imaging using diffraction optics elements - An apparatus for manipulating a perceived distance of a display. The apparatus comprises a display having an actual distance from a point of view (POV) and a diffractive optics element for diffracting light waves emitted from the display toward the POV, thereby manipulating a perceived distance of the display for an observer at the POV. The perceived distance is different from the actual distance. | 07-16-2009 |
Yaron Hefetz, Herzlia IL
| Patent application number | Description | Published |
|---|---|---|
| 20090171203 | Cryotherapy Insertion System and Method - Methods and systems for inserting therapeutic probes into a patient are present. Embodiments include an automated probe insertion system and a probe insertion guide comprising a moveable probe guide sleeve; a positioner for positioning said probe guide sleeve; and a controller operable to receive a definition of a locus within a body of a patient and to direct positioning and orienting of said probe guide sleeve so that a probe advanced through said sleeve will advance in direction of said locus. Cryosurgery applications are presented. | 07-02-2009 |
| 20090318804 | Cryotherapy Planning and Control System - The present invention relates to devices and methods for planning and supervising minimally invasive surgery. Included are enhancements to systems for planning, monitoring, and controlling cryosurgery. | 12-24-2009 |
| 20100019918 | Probe Insertion Guide with User-Directing Features - The present invention relates to a probe-insertion guiding apparatus for guiding a user towards correct insertion of therapeutic probes into a patient. The apparatus comprises a template which comprises a plurality of apertures sized to accommodate therapeutic probes and to guide insertion of such probes into a body, a probe command receiver for receiving probe insertion commands specifying template apertures through which probes are to be inserted, and at least one of a) a sensory output device operable to indicate to a user which aperture is to receive a next inserted probe, and b) a probe detection device operable to detect insertion of a probe into an aperture. Preferred embodiments include feedback modules providing feedback to a user indicating whether the user's probe did or did not correspond to a probe insertion specified by a received probe insertion command. | 01-28-2010 |
| 20100168567 | Apparatus for Protecting a Cavity Wall During Ablation of Tissue Near the Cavity - The present invention relates to apparatus and methods for protecting walls of a body cavity during thermal ablation of tissues near that body cavity, while enabling ultrasound monitoring of the ablation process. Heating protective devices and cooling protective devices are provided. Heatable/coolable ultrasound probes and heatable/coolable independent protective devices compatible with ultrasound imaging by moving ultrasound probes are provided. | 07-01-2010 |
Yaron Hefetz, Herzeliya IL
| Patent application number | Description | Published |
|---|---|---|
| 20080304619 | Modular Multi-Hole Collimators Method and System - Embodiments of the present technique relate to a modular multi-hole collimator assembly configured to have an adjustable length. Each of the two or more multi-hole collimator units has a plurality of holes therethrough. Exemplary embodiments also relate to a modular multi-hole collimator assembly that includes a base multi-hole collimator unit and one or more multi-hole collimator extension units. Each of the base multi-hole collimator unit and the one or more multi-hole collimator extension units has a plurality of holes therethrough. At least one of the plurality of holes through the base multi-hole collimator unit and at least one of the holes through the one or more multi-hole collimator extension units are axially aligned. | 12-11-2008 |
| 20100193697 | APPARATUS AND METHODS FOR EVALUATING OPERATION OF PIXELATED DETECTORS - An apparatus and methods for evaluating the operation of pixelated detectors are provided. The method includes obtaining data values for each of a plurality of pixels of a pixelated detector and determining a data consistency metric for each of the plurality of detector pixels. The method further includes identifying, using the determined data consistency metric, any detector pixels that exceed an acceptance criterion as noisy pixels. | 08-05-2010 |
Yaron Hefetz, Kibbutz Alonim IL
| Patent application number | Description | Published |
|---|---|---|
| 20110110486 | APPARATUS AND METHODS FOR COMPUTED TOMOGRAPHY IMAGING - Apparatus and methods for computed tomography (CT) imaging are provided. One method includes providing a patient table to move along an examination axis of a rotating gantry of a CT imaging system having at least one imaging detector. The imaging detector includes a pixelated detector array. The method further includes configuring the CT imaging system to perform an overlapping helical CT scan by controlling a speed of the moving patient table along the examination axis through a field of view (FOV) of the at least one imaging detector of the rotating gantry. | 05-12-2011 |
| 20110147574 | CALIBRATION SOURCE AND METHODS FOR CALIBRATING A NUCLEAR MEDICINE IMAGING SYSTEM - Systems and methods for calibrating a nuclear medicine (NM) imaging system are provided that include an NM calibration source. The NM calibration source includes an isotope source having an energy spectrum with at least one energy peak and a fluorescence layer adjacent the isotope source creating at least one additional energy peak in the energy spectrum. | 06-23-2011 |
| 20110155900 | SYSTEMS AND METHODS FOR GENERATING CALIBRATION MAPS FOR NON-PIXELATED GAMMA DETECTORS - A method for calibrating a non-pixelated gamma camera is provided, wherein the method includes determining a linearity map and a uniformity map of a reference isotope; and determining a linearity map and uniformity map of another isotope. Delta maps are calculated based on the maps of the reference isotope and the maps of the other isotope. During recalibration, new maps of the reference isotope are determined, thereby enabling new maps of the other isotope to be created based on the delta maps. | 06-30-2011 |
| 20110155918 | SYSTEMS AND METHODS FOR PROVIDING A SHARED CHARGE IN PIXELATED IMAGE DETECTORS - Systems and methods for providing a shared charge in pixelated image detectors are provided. One method includes providing a plurality of pixels for a pixelated solid state photon detector in a configuration such that a charge distribution is detected by at least two pixels and obtaining charge information from the at least two pixels. The method further includes determining a position of an interaction of the charge distribution with the plurality of pixels based on the obtained charge information. | 06-30-2011 |
| 20110268339 | SYSTEMS AND METHODS FOR DETERMINING A LOCATION OF A LESION IN A BREAST - A system and method for determining an existence, uptake, size and location of a lesion within a breast is provided. The system includes a first detector and a second detector. The breast is positioned between the first detector and the second detector. The first detector acquires a first image data set of the lesion and the second detector acquires a second image data set of the lesion. The system also includes a existence, uptake, size and location determining program that uses the first image data set and the second image data set to calculate existence, uptake, size and location information for the lesion and determines a existence, uptake, size and location of the lesion within the breast based on the calculated existence, uptake, size and location information. | 11-03-2011 |
Yaron Hefetz, Herzliya IL
| Patent application number | Description | Published |
|---|---|---|
| 20120085942 | COLLIMATORS AND METHODS FOR MANUFACTURING COLLIMATORS FOR NUCLEAR MEDICINE IMAGING SYSTEMS - Collimators and methods for manufacturing collimators for nuclear medicine (NM) imaging systems are provided. One method includes forming a plurality of collimator segments from powdered tungsten, wherein the plurality of collimator segments have opposing faces with edges therebetween. The method also includes sintering the powdered tungsten segments and joining the plurality of sintered powdered tungsten segments at least at one or more of the edges to form the collimator for the NM imaging system. | 04-12-2012 |