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He, MA

Chaomei He, Wellesley, MA US

Patent application numberDescriptionPublished
20090130712Compositions and Methods of Producing Hybrid Antigen Binding Molecules and Uses Thereof - This disclosure relates to hybrid antigen binding molecules including at least two polypeptide chains, with at least one polypeptide chain comprises an antigen binding moiety linked to an amino acid sequence of a subunit of a heterodimeric proteinaceous hormone. Also disclosed are methods of making and using such hybrid antigen binding molecules for diagnosis and/or therapy.05-21-2009

Chuang He, Westford, MA US

Patent application numberDescriptionPublished
20090138265Joint Discriminative Training of Multiple Speech Recognizers - Adjusting model parameters is described for a speech recognition system that combines recognition outputs from multiple speech recognition processes. Discriminative adjustments are made to model parameters of at least one acoustic model based on a joint discriminative criterion over multiple complementary acoustic models to lower recognition word error rate in the system.05-28-2009

Chuang He, Woburn, MA US

Patent application numberDescriptionPublished
20090055182Discriminative Training of Hidden Markov Models for Continuous Speech Recognition - Methods are given for improving discriminative training of hidden Markov models for continuous speech recognition. For a mixture component of a hidden Markov model state, a gradient adjustment is calculated of the standard deviation of the mixture component. If the calculated gradient adjustment is greater than a first threshold amount, an adjustment is performed of the standard deviation of the mixture component using the first threshold. If the calculated gradient adjustment is less than a second threshold amount, an adjustment is performed of the standard deviation of the mixture component using the second threshold. Otherwise, an adjustment is performed of the standard deviation of the mixture component using the calculated gradient adjustment.02-26-2009

Ding S. He, Tyngsboro, MA US

Patent application numberDescriptionPublished
20090204113High Density Atrial Fibrillatrion Cycle Length (AFCL) Detection and Mapping System - Systems and methods to assist in locating the focus of an atrial fibrillation include the association of atrial fibrillation cycle length values and statistics relating thereto with temporal locations on an electrogram of a given electrode, and/or the coordination of electrode locations with respective the spectral analyses of electrogram signals and further parameters and statistics relating thereto. Ablation therapy can proceed under guidance of such information.08-13-2009

Ding Sheng He, Tyngsboro, MA US

Patent application numberDescriptionPublished
20080281391Mapping and Ablation Method for the Treatment of Ventricular Tachycardia - An apparatus for mapping and/or ablating tissue includes a braided conductive member that that may be inverted to provide a ring-shaped surface. When a distal tip of the braided conductive member is retracted within the braided conductive member, the lack of a protrusion allows the ring-shaped surface to contact a tissue wall such as a cardiac wall. In an alternative configuration, the braided conductive member may be configured with the distal portion forming a proboscis that can be used to stably position the braided conductive member relative to a blood vessel, such as a ventricular outflow tract. The braided conductive member has a plurality of electronically active sites that may be accessed individually for stable mapping over a broad area for stable mapping or ablation to form broad and deep lesions.11-13-2008
20110066147SYSTEM AND METHOD FOR PREDICTING LESION SIZE SHORTLY AFTER ONSET OF RF ENERGY DELIVERY - Lesion size or volume prediction shortly after the onset of an ablation procedure can inform or control the ablation procedure. The prediction and/or control is made without regard to an actual detected temperature in the vicinity of the ablation electrodes. As a consequence, the system has utility with irrigated catheter constructions and other situations in which local irrigation in the vicinity of an ablation site would otherwise interfere with a prediction or control scheme that solely relies upon temperature measurements.03-17-2011
20120108950BIOIMPEDANCE-ASSISTED PLACEMENT OF A MEDICAL DEVICE - A system and method for guiding a catheter or other medical device to a desired target destination within the vasculature of a patient via bioimpedance measurements is disclosed. The target destination in one embodiment includes placement of the catheter such that a distal tip thereof is disposed proximate the heart, e.g., the junction of the right atrium and superior vena cava. In one embodiment the method for guiding the catheter comprises introducing the catheter into a vessel of the patient, the catheter defining a lumen through which fluids can be infused into the vasculature of the patient. The catheter is advanced toward a target destination within the vasculature. A first impedance value based on intravascular detection of at least one electrical property related to a first tissue surface of the vessel is calculated to enable determination of the proximity of a distal end of the catheter to the target destination.05-03-2012

Patent applications by Ding Sheng He, Tyngsboro, MA US

Feng He, Cambridge, MA US

Patent application numberDescriptionPublished
20110015232Pyrrolydine Derivatives as IAP Inhibitors - The present invention relates to novel IAP inhibitor compounds of: Formula (I).01-20-2011
20110065726Organic Compounds - The present invention is directed to a compound of the formula:03-17-2011
20110281875Inhibitors of IAP - Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).11-17-2011

Feng He, Arlington, MA US

Patent application numberDescriptionPublished
20080242658Inhibitors of Iap - Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I10-02-2008

Patent applications by Feng He, Arlington, MA US

Guo He, Cambridge, MA US

Patent application numberDescriptionPublished
20100105653PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES - The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.04-29-2010
20110152244PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES - The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.06-23-2011

Guoren He, Franklin, MA US

Patent application numberDescriptionPublished
20100108364FLAME RETARDANT COMPOSITIONS - Flame retardant compositions that are halogen-free or substantially halogen-free are disclosed. In certain examples, the compositions comprise a polyphenylene ether, a halogen-free or substantially halogen-free polyepoxide, and one or more phosphorated compounds. Prepregs, laminates, molded articles and printed circuit boards using the compositions are also disclosed.05-06-2010

Ji C. He, Somerville, MA US

Patent application numberDescriptionPublished
20080309882Method for preventing myopia progression through identification and correction of optical aberrations - A method for at least one of preventing myopia and retarding the progression of myopia is provided. The method includes measuring optical aberrations in a human eye and correcting the optical aberrations. Measuring optical aberrations may include measuring wavefront aberrations of parallel light rays entering the eye.12-18-2008

Jin He, Quincy, MA US

Patent application numberDescriptionPublished
20120111581APPARATUS AND METHOD FOR REDUCING THE RESIDUAL BENDING AND FATIGUE IN COILED TUBING - The subject disclosure provides a reel and a gooseneck which significantly reduce residual bending of the coiled tubing. The subject disclosure discloses a gooseneck that provides reverse bending forces to reduce the residual bending as a result of the reel. Further, the subject disclosure discloses a gooseneck having an adjustable radius during the coiled tubing operations which optimizes the residual bending process. The subject disclosure also discloses a heating and cooling module. The heating and cooling modules are attached to the gooseneck and are used to reduce fatigue of the coiled tubing and elongate the life cycle of the coiled tubing.05-10-2012

Jin-An He, North Chelmsford, MA US

Patent application numberDescriptionPublished
20090256106PATTERNED PHOTOVOLTAIC CELL - Patterned photovoltaic cells, as well as related components and methods, are disclosed.10-15-2009

Patent applications by Jin-An He, North Chelmsford, MA US

Liam Minhai He, Tyngsboro, MA US

Patent application numberDescriptionPublished
20090071989Apparatus and methods for automatic shoe cover stripping - Protective shoe covers have been widely used in health care setting and some industry environment that require clean room condition. To strip off the disposed shoe covers in a hand-free and automated fashion is very desirable to the users, which provide physical convenience, time saving and economic merits. This disclosed invention provides methods and an automatic system for stripping of disposable shoe cover from user's foot/feet that includes the electromechanical complex, a micro control unit and its embedded software programs, control algorithm to guide the execution of the stripping functions in automated and hand-free fashion.03-19-2009

Lijuan He, Bolton, MA US

Patent application numberDescriptionPublished
20100249690Tools And Methods For Programming An Implantable Valve - A two-part tool for reading and adjusting an implantable valve, and methods of use. The tool includes a locator-indicator component that, when placed matingly on the patient's skin over the valve, provides magnetic reading of the valve setting. The tool also includes an adjustor component that couples to the locator-indicator component and is rotatable to change a valve setting.09-30-2010

Minsheng He, Watertown, MA US

Patent application numberDescriptionPublished
20110269714Polycyclic Tetracycline Compounds - The present invention is directed to a compound represented by Structural Formula (I):11-03-2011
201201085698-AZA Tetracycline Compounds - The present invention is directed to a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.05-03-2012

Minsheng He, Allston, MA US

Patent application numberDescriptionPublished
20100324131Salvinorin Derivatives and Uses Thereof - The invention features salvinorin compositions that are selective for kappa opioid receptors; methods of treating mania by using a selective kappa receptor agonist; and methods of treating mood disorders, such as depressive disorders and manic disorders, using salvinorin compositions.12-23-2010

Patent applications by Minsheng He, Allston, MA US

Oing He, North Andover, MA US

Patent application numberDescriptionPublished
20100275852PET FOOD DISH - An animal feeding dish having a relatively shallow-food holding bowl that is upraised from the floor by a platform or pedestal so as to minimize whisker contact of an animal eating from the dish. The platform or pedestal can include spaced apart outwardly extending supports that shield interiorly disposed legs carried thereby from food dropped during eating while also preventing tipping of the dish. Such a bowl can be a spherical section having an advantageously large radius of curvature, including relative to bowl width or diameter, which produces a desirably shallow depth bowl that prevents whisker contact. The bottom most portion of the bowl is spaced suitably high relative to overall dish height to more optimally position the mouth of the animal during feeding to further minimize whisker contact.11-04-2010

Qing He, North Andover, MA US

Patent application numberDescriptionPublished
20100300366Pet Fountain - A pet fountain having a housing of snap together construction formed of a base and cover. The base includes a basin in which an integrally formed filter-holding divider is disposed that separates the basin into a return sump and pumping chamber. The cover includes a water holding bowl, an inlet and a drain overlying the return sump that encloses a pump that provides fluid to the bowl via inlet when attached to the base. The cover includes a downwardly extending tube that fluidly registers with a discharge of the pump when attached to the base. In a preferred embodiment, the cover has upper and lower bowls connected by a spillway that conveys overflow from the upper bowl to the lower bowl where it is return via drain to the return sump. The cover can be configured to mate with the housing to enclose the entire basin, pump, and filter.12-02-2010
20110067638Pet Fountain Assembly - A pet drinking fountain assembly having a pump forming part of a fountain mounting arrangement that includes a lift tube coupling a cover to the pump coupled to a lower basin by a mount. The mount and lift tube attenuate pump noise and vibration by providing isolation from the basin and cover and can function as dampeners. In a preferred embodiment the pump is part of a pump module that includes a module housing to which the pump is attached by another noise-attenuating mount. Each mount is formed by one or more suction cups with the cups and lift tube made of vibration dampening material, such as a resilient vibration dampening or isolating material that can be an elastomeric material. The module includes a lift tube coupling discharge that registers in fluid flow communication with a pump outlet and can include a ring or bushing therebetween providing additional noise attenuation.03-24-2011
20110259273Pet Fountain Assembly - A pet fountain having a basin and a cover overlying at least part of the basin and is supported by a sidewall of the basin and a pump disposed therebetween. The basin and cover have sidewall sections that converge to form a V-shaped locator arrangement that positions a coupling tube in communication with drinking bowl inlet of the cover so it is substantially coaxial with an outlet of the pump or pump module to telescopically engage the outlet. The basin can have an upraised shelf that holds a cord conduit providing a cord routing recess underneath. The shelf is disposed adjacent the V-shaped locator arrangement between an apex of the V-shaped locator arrangement and the pump or pump module minimizing the length of the cord run to the pump. In one embodiment, the V-shaped locator arrangement is formed by at least the basin having a raindrop or teardrop shape.10-27-2011
20110266817Sifting Scoop - A sifting scoop for removing pet waste from litter in a litter box having a handle carrying a sifting cup having a mouth wider than a downstream pet waste retaining pocket formed by the cup. The handle overlies the sifting cup providing a waste shield. The handle includes a grip attached by a bridge to the cup that provides a hand guard and scoop hanger with the grip serving as a when the scoop is stood uprightly on a pedestal formed by a cup endwall. The cup has a first sifting portion formed in a litter-engaging surface on the side opposite the handle with the sifting portion formed by a plurality of elongate slots that are wavy or S-shaped extending longitudinally in the direction of scooping. The cup has a second sifting portion having slots in the end wall inline with litter being scooped.11-03-2011
20110277697Animal Mobile Entertainment Device - An animal mobile that includes a mount from which a boom cantilevers carrying an animal plaything with the mobile defining a spring mass system having a plurality of springs and masses that cause the plaything to unpredictably move during animal interaction. The mount is configured for door mounting having a plurality of straps that wrap around respective door knobs. The mount includes a ball and socket boom coupling arrangement that defines a spring and enables adjustable boom attachment. A drive is operated to rotate the mobile in one direction storing potential energy in at least one mobile suspension line defining another spring with the energy being released rotating the mobile in an opposite direction when the drive is caused. System feedback from interaction of the plaything by an animal, e.g., cat, causes the plaything to dance and leap in a manner simulating live prey enticing further animal interaction.11-17-2011
20120025549Sifting Pet Waste Scoop - A pet waste scoop, e.g., cat litter scoop, having a relatively large mouth opening includes body having an open end opposite a closed end and defining an interior therebetween for receiving pet waste for easy disposal thereof. A handle is integrally formed with the body and extends downwardly toward the closed end a predetermined distance such that the user may easily grasp the handle for manipulating the pet waste scoop while maintaining his or her hand a safe distance from the pet waste to be scooped. A plurality of elongate slot-shaped apertures that can be curvilinear are formed within a front surface opposite the handle for sifting the litter scooped with the pet waste scoop. The apertures are defined by a number of rounded elongate sifting bars that also can be of curvilinear construction and configured to prevent pet waste and/or litter build up within the apertures.02-02-2012

Patent applications by Qing He, North Andover, MA US

Qinggang He, Malden, MA US

Patent application numberDescriptionPublished
20120094199CATALYST FOR ELECTROCHEMICAL APPLICATIONS - The invention relates to a catalyst for electro-chemical applications comprising an alloy of platinum and a transition metal, wherein the transition metal has an absorption edge similar to the absorption edge of the transition metal in oxidic state, measured with x-ray absorption near-edge spectroscopy (XANES) wherein the measurements are performed in concentrated H04-19-2012

Xi He, Jamaica Plain, MA US

Patent application numberDescriptionPublished
20110231942TIKI1 AND TIKI2, WNT INHIBITORS - This invention relates to Tiki1 and Tiki2 proteins and nucleic acids, cells expressing the same, and methods for identifying compounds that modulate Tiki1/2 activity for use in the treatment of osteoporosis or cellular proliferative disorders.09-22-2011

Xiang He, Revere, MA US

Patent application numberDescriptionPublished
20100063783SYSTEMS AND METHODS FOR MODELING OF CRYSTALLIZATION PROCESSES - A computer system and method of modeling a crystallization process includes representing a plurality of crystals in a solution by different subsets of the plurality, tracking increase of the respective characteristic length of each crystal group, and determining a crystal size distribution to output a model to a user. Ech subset forms a respective crystal group characterized by group attributes of (i) a number of crystals and (ii) a characteristic length. Additionally, the system and method track generation of new crystal groups generated by seeding, nucleation and/or breakage.03-11-2010

Xiang-Dong He, Belmont, MA US

Patent application numberDescriptionPublished
20100037637OIL CIRCULATION OBSERVER FOR HVAC SYSTEMS - An innovative oil observer for estimating oil concentration and oil amount in a refrigerant compressor in a vapor compression cycle is described. The invention ensures the safe operation of the compressor by ensuring that adequate lubricant is present in the compressor. This oil observer is based on oil models for components of air conditioning and refrigeration systems. Oil models for HVAC components estimate oil mass and refrigerant mass in each component. With all component oil models and heat exchanger observers which provide the estimation of inner geometric lengths of two-phase flow heat exchangers, a system-level oil observer is established by integrating all component models. Experimental testing has been conducted to verify the performance of this oil observer for steady state operation and dynamic processes. The invention has direct applications in residential and commercial air conditioning and refrigeration systems.02-18-2010

Patent applications by Xiang-Dong He, Belmont, MA US

Xingbai He, Andover, MA US

Patent application numberDescriptionPublished
20090156936Ultrasound 3D imaging system - The present invention relates to an ultrasound imaging system in which the scan head either includes a beamformer circuit that performs far field subarray beamforming or includes a sparse array selecting circuit that actuates selected elements. When used with second stage beamforming system, three dimensional ultrasound images can be generated.06-18-2009
20120029357ULTRASOUND 3D IMAGING SYSTEM - The present invention relates to an ultrasound imaging system in which the scan head either includes a beamformer circuit that performs far field subarray beamforming or includes a sparse array selecting circuit that actuates selected elements. When used with second stage beamforming system, three dimensional ultrasound images can be generated.02-02-2012

Patent applications by Xingbai He, Andover, MA US

Xingyue He, Cambridge, MA US

Patent application numberDescriptionPublished
20110105583METHODS OF USING MIR34 AS A BIOMARKER FOR TP53 FUNCTIONAL STATUS - In one aspect, the invention generally relates to use of miR-34 as a biomarker to estimate TP53 function in a cell. In another aspect, the invention generally relates to multiple uses of miR-34 and siRNAs functionally and structurally related to miR-34 for the treatment of cancer.05-05-2011

Yangyi He, Quincy, MA US

Patent application numberDescriptionPublished
20120098246REPOSITIONABLE NOTEBOOK ACCESSORIES - Embodiments are directed to repositionable notebook accessories and methods of using such accessories in connection with a notebook. The repositionable notebook accessory comprises a panel and at least one hook feature configured and arranged to couple the panel to a spine of a notebook when the at least one hook feature is at least partially disposed within the spine. The repositionable notebook accessory may comprise, for example, a divider, a folder and/or an adhesive flag holder.04-26-2012

Yie He, Andover, MA US

Patent application numberDescriptionPublished
20080282801Multi-axis Sensor - A method and apparatus for sensing accelerations directed along multiple directions are provided. An embodiment comprises a sensor array comprising two sensor pairs, each of which provides an output signal based on acceleration along two orthogonal directions. The sensor pairs are so that they collectively provide an output signal for each of three mutually orthogonal directions. In some embodiments, the sensor array is augmented to provide three additional signals, each of which is based on rotation about an axis aligned with one of the three orthogonal directions.11-20-2008

Yiyi He, Sunbury, MA US

Patent application numberDescriptionPublished
20100171756DYNAMIC LOCATION-BASED MAPPING SYSTEM AND METHOD - A graphical mapping system configured to display mapping information on a handheld device is disclosed. The system includes an image map database configured to store map data for a plurality of geographic areas, which is useful for generating graphical maps. The system further includes a vector map database configured to store vector map data, which is useful for generating vector “overlays” that correspond to the graphical maps. In response to a mapping request from a handheld device, a set of image mapping data and a corresponding set of vector mapping data, both associated with a given geographic location, are retrievable.07-08-2010

Yunsheng He, Waltham, MA US

Patent application numberDescriptionPublished
20090281090BIOMARKERS FOR THE PREDICTION OF RESPONSIVENESS TO CLOZAPINE TREATMENT - This invention provides methods to predict the likelihood of suicidal or self-destructive behaviour in a patient during treatment. The method employs the detection of a VNTR polymorphism in the 3′-UTR of the dopamine transporter gene (SLC6A3). Patients with nine or fewer repeats are considered poor responders to clozapine. Nine or fewer repeats in the SLC6A3 gene have been correlated with poor expression of the SLC6A3 gene. Also provided are methods of treatment based on the presence or absence of this polymorphism or surrogate markers thereof. Also provided are kits to use in the methods of the invention.11-12-2009
20100035251BioMarkers for the Progression of Alzheimer's Disease - The genetic polymorphism LRRK2 (leucine-rich repeat kinase 2)-T1602S is significantly associated with conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD), with the patients with TT genotype being at greater risk to progress to Alzheimer's disease. The LRRK2-T2352 also showed a trend for conversion to Alzheimer's disease, with the patients with CC genotype tending to progress to Alzheimer's disease. Similar to the APOE-E4 allele, in the presence of a BuChE-K variant, LRRK2-T1602S and LRRK2-T2352 showed a greater association with the rate of conversion from mild cognitive impairment to Alzheimer's disease. In another study with placebo-treated Alzheimer's disease patients, LRRK2-T1602S and LRRK2-T2352 showed a same trend of association. The Alzheimer's disease patients with TT genotype of LRRK2-T1602S or CC genotype of LRRK2-T2352 tended to decline faster on cognitive performance over 6 months, especially in the presence of a BuChE-K variant. The association between the two common LRRK2 polymorphisms and Alzheimer's disease progression shows that LRRK2 may play a role in Alzheimer's disease pathogenesis, especially disease progression, and that polymorphisms of LRRK2 can be used as biomrkers of this progression.02-11-2010

Zhigang He, Boston, MA US

Patent application numberDescriptionPublished
20090148494EGFR INHIBITORS PROMOTE AXON REGENERATION - Compositions and methods for promoting neural regeneration in a patient determined to have a lesion in a mature CNS neuron are disclosed. The method comprises the step of contacting the neuron with an EGFR inhibitor sufficient to promote regeneration of the neuron.06-11-2009
20090181420Inhibiting Smad signaling promotes neuron regeneration - Regeneration of a lesioned CNS axon of a mature neuron, determined to be subject to regeneration inhibition by Smad2/3 signaling, is promoted by contacting the neuron with an inhibitor of Smad2/3 signaling sufficient to promote regeneration of the axon.07-16-2009
20090220570Axon Regeneration with PKC Inhibitors - Regenerative growth of an adult mammalian central nervous system neuron axon subject to growth inhibition by endogenous, myelin growth repulsion factors is promoted by delivering to the axon a therapeutically effective amount of a specific inhibitor of protein kinase C, whereby regenerative growth of the axon is promoted and a resultant promotion of the regenerative growth of the axon is detected.09-03-2009
20090305333Promoting Axon Regeneration in the Adult CNS through Control of Protein Translation - Survival of, or axon regeneration in a lesioned mature central nervous system (CNS) neuron is promoted by (a) contacting the neuron with a therapeutically effective amount of an exogenous activator of protein translation; and (b) detecting the resultant promotion of the survival of, or axon regeneration in the neuron.12-10-2009
20110124706SOCS3 Inhibition Promotes CNS Neuron Regeneration - Regeneration of injured CNS neurons in a mammal in need thereof is promoted by delivering directly to the body of the injured CNS neurons, such as with an intracerebral or intraretinal cannula, an effective amount of a specific inhibitor of SOCS3.05-26-2011

Patent applications by Zhigang He, Boston, MA US

Zhihua He, Reading, MA US

Patent application numberDescriptionPublished
20110069315METHOD AND APPARATUS FOR WIDE-BAND IMAGING BASED ON NARROW-BAND IMAGE DATA - In one embodiment, an imaging method may include receiving an intensity value of a first spectral channel associated with a pixel location. The intensity value of the first spectral channel may be based on electromagnetic radiation reflected from an object after being emitted from a narrow-band electromagnetic radiation source. The method may further include defining an intensity value of a second spectral channel based on the intensity value of the first spectral channel. The second spectral channel may be associated with a spectral region of electromagnetic radiation different from a spectral region of electromagnetic radiation associated with the first spectral channel. The method may also include associating the intensity value of the second spectral channel with the pixel location.03-24-2011