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Hauser, US

Adam W. Hauser, Minneapolis, MN US

Patent application numberDescriptionPublished
20120134953ANTI-MICROBIAL COMPOSITION - Anti-microbial compositions including an anti-microbial polymer containing silicon-containing quaternary ammonium groups, polyvinyl alcohol (PVA), at least one short chain alcohol, optional fragrance, and water are provided. The anti-microbial compositions may be used to disinfect both porous and non-porous surfaces. Exemplary compositions may include 0.1-10 wt % of the anti-microbial polymer containing silicon-containing quaternary ammonium groups, 0.1-10 wt % polyvinyl alcohol (PVA), 1.0-20 wt % isopropyl alcohol, optional fragrance, and water.05-31-2012

Alan R. Hauser, Chicago, IL US

Patent application numberDescriptionPublished
20100055702Pathogenecity Islands of Pseudomonas Aeruginosa - Disclosed are 03-04-2010

Bret Hauser, Flower Mound, TX US

Patent application numberDescriptionPublished
20100314200LUBRICATION AND EXHAUST SYSTEM FOR A POWERED SURGICAL INSTRUMENT - A lubrication cartridge includes a cartridge body. A cartridge coupling is located on the cartridge body and defines a first passage and a second passage. A lubricant reservoir is housed in the cartridge body and comprises a pressurized fluid inlet coupled to the first passage and a lubricant outlet coupled to the second passage. A metering insert is located between the lubricant outlet and the second passage and comprises a density that controls lubricant flow between the lubricant reservoir and the second passage.12-16-2010

Carl J. Hauser, Boston, MA US

Patent application numberDescriptionPublished
20120263736METHOD FOR PREDICTING AND TREATING A STERILE INFLAMMATION AND DISCRIMINATING BETWEEN STERILE AND INFECTIVE INFLAMMATION - The invention provides methods for predicting the likelihood that a subject will develop a sterile inflammation or will have an increased propensity to later develop a sterile inflammation, for determining whether a subject with tissue damage should be administered an antimicrobial agent (at full or a reduced dosage) or an anti-inflammatory agent, and for treating a subject with tissue damage. In the methods, an increased ratio of the amount of mitochondrial nucleic acid or peptide to the amount of microbial nucleic acid or peptide indicates a subject that has an increased likelihood of developing a sterile inflammation or an increased propensity to later develop a sterile inflammation, or a subject that should not be administered, or that should be administered at a reduced dosage, an antimicrobial agent or one or more anti-inflammatory agents and not an antimicrobial agent. Kits for detecting mitochondrial and/or microbial nucleic acids or peptides are provided.10-18-2012

Carl J. Hauser, Mountainside, NJ US

Patent application numberDescriptionPublished
20080280866Method of Treating or Sepsis - Provided is a method of treating trauma or sepsis comprising: administering an effective amount of one or both of a SOC channel-selective inhibitor or a SphK inhibitor to an animal at risk of inflammation-mediated organ damage from trauma or sepsis.11-13-2008

Christopher R. Hauser, Pittsburgh, PA US

Patent application numberDescriptionPublished
20100002918System and method for finding regions of interest for microscopic digital montage imaging - A system for determining tissue locations on a slide.01-07-2010
20100060729System for creating microscopic digital montage images - An imaging apparatus. The imaging apparatus may find an area in which a specimen is present, then focus on the specimen and capture images of the specimen during continuous stage motion.03-11-2010

Patent applications by Christopher R. Hauser, Pittsburgh, PA US

Eduardo A. Hauser, Hollywood, FL US

Patent application numberDescriptionPublished
20100250341DIGITAL CONTENT PERSONALIZATION METHOD AND SYSTEM - A system and method for predicting what content a user wants to view based on such user's previous behavior and actions, comprising: receiving a cookie for every content page template in a web site; receiving a request for service of a content page; sending the content requested to a requester; for each content page sent, retrieving the cookie from the user; assigning a unique identifier (ID) to each new requester and storing the ID in the cookie; recording each ID, IP address, referrer, and time of request from the server; and storing the data recorded in a buffer for a period of time before storing it more permanently in a client-specific database. The system can be monetized by receiving fees from end users for presenting the content preferences or by receiving fees form content providers that include advertising related to the content preferences.09-30-2010
20110029858METHOD AND SYSTEM FOR CREATING CUSTOMIZED NEWS DIGESTS - A system is provided for delivering personalized digest documents to multiple users, including a profile module, a content management module, a document creation module, and an interface. The profile module receives a delivery preference of one of the users, and receives at least one of a user attribute and a content preference of the one user. The content management module searches at least one location for content items that match at least one of the user attribute and the content preference. The document creation module receives at least one of the content items that match, and compiles a personalized digest document for the one user that includes the at least one content item that matches. The personalized digest document is in a print-ready format, and the interface delivers the personalized digest document to the one user in accordance with the delivery preference of the one user.02-03-2011

Patent applications by Eduardo A. Hauser, Hollywood, FL US

Edwin W. Hauser, Charlotte, NC US

Patent application numberDescriptionPublished
20120033851SPATIALLY INTEGRATED AERIAL PHOTOGRAPHY FOR BRIDGE, STRUCTURE, AND ENVIRONMENTAL MONITORING - Spatially Integrated Small-Format Aerial Photography (SFAP is one aspect of the present invention. It is a low-cost solution for bridge surface imaging and is proposed as a remote bridge inspection technique to supplement current bridge visual inspection. Providing top-down views, the airplanes flying at about 1000 ft, can allow visualization of sub-inch (large) cracks and joint openings on bridge decks or highway pavements. On board Global Positioning System is used to help geo-reference images collected and allow automated damage detection. A deck condition rating technique based on large crack detection is used to quantify the condition of the existing bridge decks.02-09-2012

Elizabeth Hauser, Durham, NC US

Patent application numberDescriptionPublished
20110070583Lsamp gene associated with cardiovascular disease - The LSAMP gene can be used for cardiovascular disease risk assessment, in particular Left Main Disease. The genetic risk attributable to LSAMP adds to known cardiovascular disease risk factors. Assessment of risk attributable to LSAMP permits early initiation of preventive and therapeutic strategies. Given the pronounced clinical risk associated with Left Main Disease, such risk assessment should significantly reduce morbidity and mortality.03-24-2011

Elizabeth R. Hauser, Durham, NC US

Patent application numberDescriptionPublished
20090087844METHODS AND COMPOSITIONS FOR CORRELATING GENETIC MARKERS WITH CARDIOVASCULAR DISEASE - The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: 04-02-2009
20110171630METHODS AND COMPOSITIONS FOR CORRELATING GENETIC MARKERS WITH CARDIOVASCULAR DISEASE - The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.07-14-2011
20110318726PREDICTING CORONARY ARTERY DISEASE AND RISK OF CARDIOVASCULAR EVENTS - Methods of assessing the risk of cardiovascular disease in a subject by detecting the level of at least one metabolite in a sample from the subject are disclosed herein. The level of the metabolite is indicative of the risk of cardiovascular disease in the subject. The metabolites may be acylcarnitines, amino acids, ketones, free fatty acids or hydroxybutyrate. The cardiovascular disease may be risk of a cardiovascular event, presence of coronary artery disease or risk of development of coronary artery disease.12-29-2011
20120065080ACID CERAMIDASE POLYMORPHISMS AND METHODS OF PREDICTING TRAITS USING THE ACID CERAMIDASE POLYMORPHISMS - Provided are methods of predicting a trait in a subject including obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding the acid ceramidase polypeptide, and using the information to predict the expression of the trait in the subject. Further provided are methods of developing a treatment plan for a subject with a disease or condition responsive to exercise. The methods may include obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding the acid ceramidase polypeptide, using the information to predict a trait selected from maintaining an exercise program and physiological responsiveness to an exercise program, and developing a treatment plan for the subject to treat the disease or condition.03-15-2012
20130017962METHODS AND COMPOSITIONS FOR CORRELATING GENETIC MARKERS WITH CARDIOVASCULAR DISEASE - The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.01-17-2013

Patent applications by Elizabeth R. Hauser, Durham, NC US

Ernest Hauser, Pittsburgh, PA US

Patent application numberDescriptionPublished
20100154548Method and apparatus for detecting voids in a pipe - An apparatus for detecting and measuring gas voids in a pipe with a fluid includes a first ultrasonic transducer externally disposed on the pipe. The apparatus includes a second ultrasonic transducer externally disposed on the pipe. The apparatus includes a multiplexer, transmitter, receiver, controller and processor in communication with the first transducer and the second transducer which in combination identify a void in the pipe from ultrasonic measurements of properties of the fluid in the pipe. A method for detecting and measuring gas voids in a pipe with a fluid includes the steps of measuring properties of the fluid internal to the pipe with transmissions of ultrasonic energy from transducers externally disposed on the pipe. There is the step of identifying a void in the pipe from the properties of the fluid internal to the pipe using signals processed by processor.06-24-2010

Hans Hauser, Strongsville, OH US

Patent application numberDescriptionPublished
20080217092VEHICLE CONTROL SYSTEMS AND METHODS - Systems and methods for controlling the speed and direction of vehicles such as tractors.09-11-2008
20090250270Steering and Driving Systems and Related Vehicles - A ZTR vehicle includes true or proper ZTR steering in the forward and reverse directions. The vehicle has independently driven locomotive drives that drive the wheels to provide mobility and steering to the vehicle. A steering wheel is included that pivots one of two steering input members that rotate to independently shift the drive units. A speed and direction pedal is also included, which is communicated to provide direction and magnitude input to the drive units. The steering input and speed and direction inputs coordinate propelling the vehicle such the vehicle turns in the same direction when traveling forward as well as in reverse.10-08-2009
20110193307VEHICLE CONTROL SYSTEMS AND METHODS - Systems and methods for controlling the speed and direction of vehicles such as tractors.08-11-2011
20110248462STEERING SYSTEMS, STEERING AND SPEED COORDINATION SYSTEMS, AND ASSOCIATED VEHICLES - In a broad respect, vehicles that are capable of making a low- to zero-radius turn using the independent rotation of drive wheels and by turning the non-driving steerable structure or structures (such as wheels) with a steering input device (in some embodiments, the driving wheels also may be capable of being turned). This may be accomplished using a steering system, a speed control system and an integration device (together, a control system) that are configured to work together to provide correct steering in forward and reverse, and, in some embodiments, to reduce the speed of the outboard drive wheel of the vehicle when it enters an extreme turn under constant speed input. Different systems configured for use in such vehicles are included.10-13-2011

Patent applications by Hans Hauser, Strongsville, OH US

James Brian Hauser, Clinton, WA US

Patent application numberDescriptionPublished
20120222520MOUNTABLE CORK PULLER - A mountable cork puller including a tray open on one major side thereof adapted to be mounted in a recess in a wall, a hinge pin associated with the tray, and a hinge pivotally carried on the hinge pin, the hinge attached at its free end to a cork puller such that the hinge swings the cork puller between a stowed position in the tray and a deployed use position removed from the tray.09-06-2012
20130076214VEHICLE GALLEY - A modular integrated galley in a passenger vehicle, including a mounting rack in the form of a vertical wall including upper, middle and lower storage areas, at least one storage slot extending laterally between the middle and lower storage areas for storing a work surface therein, and a latch for ejecting the work surface at least partially from the slot into a position for being further extended into a fully deployed position by a user. An elongate hinge that extends vertically along a mounted edge of the doors and is adapted for allowing the door to move 180 degrees of travel between its closed and open positions is also disclosed.03-28-2013

Janet M. Hauser, Bethesda, MD US

Patent application numberDescriptionPublished
20090247457NEUROTROPHIC COMPONENTS OF THE ADNF I COMPLEX - This invention relates to Activity Dependent Neurotrophic Factor I complex (ADNF I complex) and polypeptides of this complex, which produce their neurotrophic effects through multiple proteases intrinsic to the ADNF I complex. The invention also relates to pharmaceutical compositions comprising ADNF I complex polypeptides, as well as methods for reducing neuronal cell death in vitro and in vivo, methods for treating oxidative stress in a patient, methods for reducing a condition associated with fetal alcohol syndrome in a subject, and methods of enhancing learning and memory both pre- and post-natally, all of which methods use the ADNF I complex polypeptides of the invention.10-01-2009

Joseph A. Hauser, Williamsport, PA US

Patent application numberDescriptionPublished
20130058744Bulk Material Handling System and Carrier Therefor - A system including a receptacle having an inlet for receiving a poke material therethrough and a carrier for supporting a flexible bag with a closable discharge spout, containing a bulk material to be deposited in such receptacle, and means operable upon a bag loaded with bulk material being supported thereon such spout being aligned with such receptacle inlet and such spout being opening for jostling such bag to enhance the discharge of material through such spout into such receptacle, wherein such carrier and such receptacle are provided with cooperating configurations facilitating the positioning of such carrier relative to such receptacle with said bag spout aligned with such receptacle inlet.03-07-2013

Joseph Michael Hauser, Louisville, KY US

Patent application numberDescriptionPublished
20120304676ICE MAKING ASSEMBLY WITH OPTIMIZED HARVESTING AND RELATED REFRIGERATION APPLIANCE - An ice making assembly for a refrigeration appliance includes an ice maker having a mold body defining a plurality of compartments for forming ice cubes therein, a heating element for heating the ice cubes to create a melted portion to assist in removal of the ice cubes from the compartment, and a harvesting assembly including a plurality of elements attached to a rotatable rod. Each element is movable via rotation of the rod through a respective one of the compartments to remove an ice cube from the compartment. Rotation of the rod stopping for a period of time at a stop position in which a removed ice cube can rest atop the harvesting assembly to refreeze the melted portion. Related refrigeration appliances are also disclosed.12-06-2012
20120325827REFRIGERATOR WITH A SLIDE-OUT PAN ASSEMBLY - A refrigeration appliance, such as a refrigerator, includes a food compartment liner having a bottom surface. A pull-out pan is operably disposed within the liner proximate the bottom surface. A slide mechanism is configured between the pull-out pan and the bottom surface of the compartment liner, wherein the pull-out pan is fully supported on and slidable relative to the bottom surface of the compartment liner.12-27-2012

Joseph R. Hauser, Vernon, CT US

Patent application numberDescriptionPublished
20100008764GAS TURBINE ENGINE WITH A VARIABLE EXIT AREA FAN NOZZLE, NACELLE ASSEMBLY OF SUCH A ENGINE, AND CORRESPONDING OPERATING METHOD - A turbofan engine includes a fan variable area nozzle having a multiple of vents through a fan nacelle and a sleeve system movable relative to the vents by an actuator system. The fan variable area nozzle changes the effective area of the fan nozzle exit area to permit efficient operation at predefined pressure ratios. The vents include a grid structure which directs and smoothes the airflow therethrough as well as to reduce noise generation.01-14-2010

Kenneth Clair Hauser, Canton, MI US

Patent application numberDescriptionPublished
20090101465Breakaway Clutch For Controllable Speed Accessory Drive System - An accessory drive system for a hybrid vehicle is provided including a planetary gear set having first, second, and third members. A torque transfer device operatively connects an engine with the first member. A motor/generator is operatively connected to the second member. A plurality of vehicle accessories are operatively connected to the third member. A one-way clutch is operatively connected to either the first member of the planetary gear set or the torque transfer device. The one-way clutch is also selectively connected to a stationary member via a breakaway clutch configured to slip when either the input torque exceeds a threshold value or the direction of rotation is opposite of the driving direction. Engine output is transferable through the planetary gear set to drive the accessories at a selectable rate, and the motor/generator is controllable to run the accessories while the engine is off and while restarting the engine.04-23-2009

Kurt Hauser, Northville, MI US

Patent application numberDescriptionPublished
20100090432STABILIZER BAR WITH DISCONNECTABLE LINK - A disconnectable link may include a first link member having a generally tubular portion, a first ball joint disposed on the first link member and adapted to engage a first suspension member; a second link member slidably receivable within the first link member; a second ball joint disposed on the second link member and adapted to engage a second suspension member; a lock shaft engaged with the second link member; and a lock element disposed within an aperture in the second link member. Movement of the lock shaft into a first position may cause the lock element to engage the first link member to prevent relative axial movement between the first and second link members, and movement of the lock shaft into a second position may cause the lock element to disengage the first link member to allow relative axial movement between the first and second link members.04-15-2010

Lawrence Hauser, Auburn, WA US

Patent application numberDescriptionPublished
20110219959CITRUS JUICE AND MEASURE - A juicer and measurer includes a lower container having a circumference that is preferably small enough to be grasped and held by a single hand. An upper rim region supports a reamer atop a funnel that flares outwardly to collect juice and funnel it into the container. In an exemplary version, the flared upper rim includes at least one region that is configured to serve as a spout so that the juice can be poured from the container more readily.09-15-2011

Lawrence M. Hauser, Auburn, WA US

Patent application numberDescriptionPublished
20090246311BURGER PRESS - A burger press includes a base having upward extending sidewalls, a lifter sized and shaped to fit within the base, and a plunger having a handle attached to a first side of a generally planar plate that is sized and shaped to fit within the base. At least one of a second side of the plunger plate and the lifter are shaped to include a surface feature selected from a plurality of ribs and a raised portion, the plurality of ribs and the raised portion being structured to press into a burger as the burger is formed in the burger press by compressing the burger between the plunger and the lifter.10-01-2009
20090249965PIT REMOVER - The preferred example of the pit remover and slicer includes a frame having a central hub and one or more blades extending radially from the central hub to the frame. In some versions, the pit remover may include a frame defining an interior region, with one or more blades extending across the interior space, either with or without a defined central hub.10-08-2009
20100101372SUCTION JAR OPENER - A suction jar opener includes a suction cup or other vacuum-creating mechanism secured to a handle. The suction cup forms a grip between a lid of a jar and the suction cup, allowing the handle to be rotated to remove the lid. The handle is preferably pivotable between a position that releases the suction and a position that causes a suction and is radially extending away from the jar.04-29-2010
20110094111FOOD PROCESSING TOOL - A food processing tool particularly suited for processing garlic and the like generally includes a main body having a tray configured to allow garlic to be passed back and forth across the tray for processing as desired. The main body optionally includes a pair of opposing guides positioned on opposing lateral sides of the tray and a plurality of ribs provided along either a portion or the entirety of the tray to reduce friction and improve the sliding ability of the garlic along the ribs and therefore the tray. A main slicing blade and one or more pluralities of blades are provided to slice, mince, or julienne cut the garlic. A pusher and cap is configured to selectively allow or restrict rotational movement of the cap and garlic for different orientations when cutting.04-28-2011
20110192290VEGETABLE CUTTER - A container includes an internal plate having slicing blade supported by a lower container and covered by a lid. A threaded axle is connected to a hand crank extending from the top of the lid and urges a pusher downward toward the blade as the crank is turned. A food item carried on the pusher is thereby forced downward and rotated against the blade and cut in accordance with the size of the threads on the axle. Additional interchangeable plates are provided, including cheese grating and juice reaming plates.08-11-2011
20120102760APPLE WEDGER - An apple wedger for cutting fruits or vegetables into wedges or other desired shapes includes a slicer and a pusher, in which the slicer has a peripheral frame and internal cutting blades. The pusher is configured to be used to push at least partially sliced food items through the gaps between cutting blades. In some versions, the pusher is pivotally attached to the slicer.05-03-2012
20120131800Slicing Device - A slicing device for cutting fruits or vegetables into wedges, cubes, or other desired shapes includes a slicing frame and a pusher, in which the frame includes a grid of internal cutting blades. The pusher is configured to be used to push at least partially sliced food items through the gaps between cutting blades. In some versions, the pusher is pivotally attached to the slicer and includes a removable container.05-31-2012

Patent applications by Lawrence M. Hauser, Auburn, WA US

Lawrence Michael Hauser, Federal Way, WA US

Patent application numberDescriptionPublished
20090056561Combination Breading Tongs And Dipping Tool - A kitchen utensil includes a handle having a dipping utensil at one end and a gripping surface at a second end thereof. The dipping utensil includes a frame member defining an opening. A tong member is engaged to the handle and is rotatable with respect to the handle between open and closed positions. The tong includes an actuation lever at one end and a gripping surface on a second end, whereby the gripping surfaces of the handle and tong may cooperate to hold an item placed therebetween.03-05-2009

Michael Hauser, Durham, NC US

Patent application numberDescriptionPublished
20090263801Phenotype-Genotype Relationship in Age-Related Macular Degeneration - Age-Related Macular Degeneration (AMD) cases possessing the LOC387715 (rs10490924) variant have a higher risk of neovascular AMD. Individuals with AMD who are homozygous for both variants might be at greater risk for earlier onset of neovascular AMD. Determining the presence of this variant indicates which path the disease may take and which nutritional, supplement, or medicaments are appropriate.10-22-2009
20100145223Peripheral Reticular Pigmentary Change and Age-Related Macular Degeneration - Examination of 956 age-related macular degeneration cases showed that the complement factor H variant (Y402H, C allele at rs1061170) increases risk for the development of peripheral reticular pigmentary change. AMD phenotypes of 796 carriers of the CFH Y402H variant were compared to the AMD phenotypes of 160 non-carriers. Of 34 phenotypic features analyzed, only peripheral reticular pigmentary change (PRPC) was associated with this CFH variant (P-value 0.0006). The proportion of AMD cases with PRPC correlated with the number of CFH risk C alleles in a dose-response fashion. The association of CFH Y402H polymorphism with PRPC suggests that AMD changes are not limited to the macula. Current AMD grading methods assess only the macula; peripheral retinal changes should also be included in grading methods. PRPC may be used as a surrogate of a high-risk genotype and may be used for diagnostic, therapeutic, and research purposes.06-10-2010
20110183340Phenotype-Genotype Relationship in Age-Related Macular Degeneration - Age-Related Macular Degeneration (AMD) cases possessing the LOC387715 (rs 10490924) variant have a higher risk of neovascular AMD. Individuals with AMD who are homozygous for both variants might be at greater risk for earlier onset of neovascular AMD. Determining the presence of this variant indicates which path the disease may take and which nutritional, supplement, or medicaments are appropriate.07-28-2011
20130059366Integrated Droplet Actuator for Gel; Electrophoresis and Molecular Analysis - The invention is directed to a droplet actuator device and methods for integrating gel electrophoresis analysis with pre or post-analytical sample handling as well as other molecular analysis processes. Using digital microfluidics technology, the droplet actuator device and methods of the invention provide the ability to perform gel electrophoresis and liquid handling operations on a single integrated device. The integrated liquid handling operations may be used to prepare and deliver samples to the electrophoresis gel, capture and subsequently process products of the electrophoresis gel or perform additional assays on the same sample materials which are analyzed by gel electrophoresis. In one embodiment, one or more molecular assays, such as nucleic acid (e.g., DNA) quantification by real-time PCR, and one or more sample processing operations such as sample dilution is performed on a droplet actuator integrated with an electrophoresis gel. In one embodiment, an electrophoresis gel may be integrated on the top substrate of the droplet actuator.03-07-2013

Patent applications by Michael Hauser, Durham, NC US

Michael A. Hauser, Durham, NC US

Patent application numberDescriptionPublished
20090098557IDENTIFICATION OF GENETIC MARKERS ASSOCIATED WITH PARKINSON DISEASE - The present invention provides methods and compositions for screening a subject for Parkinson disease, for increased risk of developing Parkinson disease and/or for an earlier or later age of developing Parkinson disease, comprising detecting the presence of a genetic marker associated with Parkinson disease.04-16-2009
20100190264Genetic Variants Increase the Risk of Age-Related Macular Degeneration - Age-related macular degeneration (AMD) is a leading cause of visual impairment and blindness in the elderly whose etiology remains largely unknown. Previous studies identified chromosome 1q32 as harboring a susceptibility locus for AMD, but it was not identified. We identified a strongly associated haplotype in two independent data sets. DNA sequencing of the complement factor II gene (CHI) within this haplotype revealed a coding variant, Y402II, that significantly increases the risk for AMD with odds ratios between 2.45 and 5.57. This identifies Complement factor II as involved in pathogenesis of AMD. This single variant alone is so common that it likely explains 43 percent of AMD in older adults. In addition, we have replicated and refined previous reports implicating a coding change in LOC387715 as the second major AMD susceptibility allele. The effect of rs10490924 appears to be completely independent of the Y402II variant in the CFH gene. The joint effect of these two susceptibility genes is consistent with a multiplicative model, and together, they may explain as much as 65% of the PAR of AMD. In contrast, the effect of rs10490924 appears to be strongly modified by cigarette smoking. Smoking and LOC387715 together may explain as much as 34% of AMD. Our data indicate that variant genotypes at rs10490924 confer a substantially larger AMD risk to cigarette smokers than non-smokers. This observation is supported by traditional case-control modeling, by ordered subset linkage analysis (OSA) incorporating pack-years of cigarette smoking as a covariate, and by family-based association analysis using a more homogeneous set of families as defined by OSA.07-29-2010

Patent applications by Michael A. Hauser, Durham, NC US

Michael J. Hauser, Bolton, VT US

Patent application numberDescriptionPublished
20090250622DESIGN STRUCTURE FOR ALPHA PARTICLE SENSOR IN SOI TECHNOLOGY AND STRUCTURE THEREOF - The invention relates to a design structure, and more particularly, to a design structure for an alpha particle sensor in SOI technology and a circuit thereof. The structure is a silicon-on-insulator radiation detector which includes: a charge collection node; a precharge transistor that has a source from the charge collection node, a drain at Vdd, and a gate controlled by a precharge signal; an access transistor that has a source from the charge collection node, a drain connecting to a readout node, and a gate controlled by a read-out signal; and a detector pulldown transistor having a drain from the charge collection node, a source to ground, and a grounded gate.10-08-2009
20100096536ON DEMAND CIRCUIT FUNCTION EXECUTION EMPLOYING OPTICAL SENSING - Disclosed is a method of executing an electrical function, such as a fusing operation, by activation through a chip embedded photodiode through spectrally selected external light activation, and corresponding structure and circuit. The present invention is based on having incident light with specific intensity/wave length characteristics, in conjunction with additional circuit elements to an integrated circuit, perform the implementation of repairs, i.e., replacing failing circuit elements with redundant ones for yield and/or reliability. Also to perform disconnection of ESD protection device from input pad one the packaged chip is placed in system. No additional pins on the package are necessary.04-22-2010
20100230772ARRAY OF ALPHA PARTICLE SENSORS - An array of radiation sensors or detectors is integrated within a three-dimensional semiconductor IC. The sensor array is located relatively close to the device layer of a circuit (e.g., a microprocessor) to be protected from the adverse effects of the ionizing radiation particles. As such, the location where the radiation particles intersect the device layer can be calculated with coarse precision (e.g., to within 10 s of microns).09-16-2010
20120122260ARRAY OF ALPHA PARTICLE SENSORS - An array of radiation sensors or detectors is integrated within a three-dimensional semiconductor IC. The sensor array is located relatively close to the device layer of a circuit (e.g., a microprocessor) to be protected from the adverse effects of the ionizing radiation particles. As such, the location where the radiation particles intersect the device layer can be calculated with coarse precision (e.g., to within 05-17-2012

Patent applications by Michael J. Hauser, Bolton, VT US

Oded Hauser, Matawan, NJ US

Patent application numberDescriptionPublished
20120179630METHODS FOR MEASURING HEDGING VALUE-AT-RISK AND PROFITABILITY - Methods for measuring value-at-risk and profitability of hedging in relation to BMA debt obligations are provided using rigorous, statistical solutions that address problems associated with municipalities involved in swap hedging face. Various embodiments permit users to quantify POL hedging basis risk through a VAR-style loss measurement and statistics measuring the profitability of a hedge, those statistics including gain durability and gain/loss ratio. Various aspects introduce significant innovation to risk management practices, particularly for tax-exempt issuers of debt. Certain embodiments of this disclosure facilitate better management of hedging risk, analysis of hedges using POL vs. BMA and provide guidance for analyzing the risk existing in an existing portfolio of POL swap hedges to better inform decision-making regarding use of hedging risk for profit or to lay off risk.07-12-2012

Peter Edmund Heinrich Hauser, Kirkland, WA US

Patent application numberDescriptionPublished
20110255454METHOD AND SYSTEM FOR REPACKAGING WIRELESS DATA - The present disclosure may include a method for repackaging data in a communications system. The method may include receiving low-power RF data at a wireless relay device from one or more low power wireless devices and translating the low-power RF data at the wireless relay device into one or more translated packets. The method may further include synchronizing the translated low-power RF data with one or more wireless links and transmitting the synchronized low-power RF data to a host device. The method may further include receiving wireless communications from a host device, translating the parsing the wireless packets, synchronizing the translated packets with one or more low-power RF connections, and transmitting the synchronized packets to one ore more low-power RF devices. The method may further include managing the network topology of the communications system via commands to the wireless relay device.10-20-2011

Peter E.h. Hauser, Kirkland, WA US

Patent application numberDescriptionPublished
20110059720WIRELESS SECURITY DEVICE AND METHOD - A wireless security device and method includes implementing, by a wireless security device, one or more Bluetooth wireless protocol profiles for connecting to one or more Bluetooth enabled devices. A Bluetooth enabled telephony device may be paired with the wireless security device using one or more Bluetooth wireless protocol profiles. The wireless security device may send a command to the telephony device over the wirelessly paired Bluetooth connection, to the telephony device. The command may cause the telephony device to place a telephone call to an emergency telephone number. Once the telephone call is placed, a prerecorded emergency message may be sent from the wireless security device to the telephony device, causing the telephony device to play the prerecorded emergency message.03-10-2011

Peter E. H. Hauser, Kirkland, WA US

Patent application numberDescriptionPublished
20130122853WIRELESS SECURITY DEVICE AND METHOD TO PLACE EMERGENCY CALLS - A wireless security device and method includes implementing, by a wireless security device, one or more Bluetooth™ wireless protocol profiles for connecting to one or more Bluetooth™ enabled devices. A Bluetooth™ enabled telephony device may be paired with the wireless security device using one or more Bluetooth™ wireless protocol profiles. The wireless security device may send a command to the telephony device over the wirelessly paired Bluetooth™ connection, to the telephony device. The command may cause the telephony device to place a telephone call to an emergency telephone number. Once the telephone call is placed, a prerecorded emergency message may be sent from the wireless security device to the telephony device, causing the telephony device to play the prerecorded emergency message.05-16-2013

Peter L. Hauser, Lakeville, MN US

Patent application numberDescriptionPublished
20090204448BENEFIT MANAGEMENT - Methods, devices and systems are provided for benefit management. One system includes a server including an application interface and access to a data store having one or more client files. A client file can include a definable set of business rules for managing and administering benefits and can include fund use rules for accessing and applying funds to claims from one or more accounts. The system includes a program operable on the server to apply the definable set of business rules in connection with processing a claim.08-13-2009

Rachel E. Hauser, Jacksonville, FL US

Patent application numberDescriptionPublished
20100230837Release aids for releasing silicone hydrogel ophthalmic lenses - This invention includes methods and systems for processing hydrogel biomedical devices, such as ophthalmic lenses using polyethylene glycol to facilitate release of the devices from a mold part.09-16-2010

Raymond Hauser, Sullivan, IL US

Patent application numberDescriptionPublished
20080277188Front Steering Module For A Zero Turn Radius Vehicle - A front steering module adapted for integration with the subframe of a zero-turn radius vehicle incorporating an electronic steering apparatus. The module provides both front wheel steering and corresponding control inputs for the electronic steering apparatus. The module has a frame member having a pair of steered wheel assemblies mounted thereto and a mounting member for attachment to the vehicle. The module further comprises a steering mechanism and a steering position sensor for providing input to the electronic steering apparatus.11-13-2008
20090201650Controller Assemblies For Electric Drive Utility Vehicles - Controller assemblies and packaging for electronic control systems of electric motors utilized in utility vehicles or other power equipment. Features of the controller assemblies and packaging described herein allow for, among other things, modularity, scalability, and improved heat transfer.08-13-2009
20120265390Controller Assemblies For Electric Drive Utility Vehicles - Controller assemblies and packaging for electronic control systems of electric motors utilized in utility vehicles or other power equipment are disclosed. The controller assemblies are packaged for robust design and heat dissipation, while collectively housing the controllers, switches and sensors needed to operate multiple motors performing different functions, or the same function in serial.10-18-2012

Patent applications by Raymond Hauser, Sullivan, IL US

Rob Hauser, Richmond, VA US

Patent application numberDescriptionPublished
20110131059PHARMACY BENEFITS MANAGEMENT METHOD AND APPARATUS - A pharmacy benefits management system and method. A processor server has claim information relating to pharmacy benefits claims, and information relating to a claims processing formularly stored therein. A provider server has pharmacy benefits plan structure information stored therein. A management server has price information relating drugs in various classes and a processing module for correlating the claim information with the benefits plan structure information and the formularly information to identify drugs dispensed to patients, expenses associated with the drugs in accordance with the pharmacy benefits plan structure information, alternative drugs in the same class as the drugs and expenses associated with the alternative drugs.06-02-2011
20130013335PHARMACY BENEFITS MANAGEMENT METHOD AND APPARATUS - A pharmacy benefits management system and method. A processor server has claim information relating to pharmacy benefits claims, and information relating to a claims processing formularly stored therein. A provider server has pharmacy benefits plan structure information stored therein. A management server has price information relating drugs in various classes and a processing module for correlating the claim information with the benefits plan structure information and the formularly information to identify drugs dispensed to patients, expenses associated with the drugs in accordance with the pharmacy benefits plan structure information, alternative drugs in the same class as the drugs and expenses associated with the alternative drugs.01-10-2013

Robert Hauser, Columbia, MD US

Patent application numberDescriptionPublished
20100069292INSULIN WITH A BASAL RELEASE PROFILE - A clear basal insulin formulation composed of insulin (preferably human recombinant insulin), buffering agents, precipitating agents, and/or stabilizing agents for subcutaneous, intradermal or intramuscular administration. The formulation is designed to form a precipitate of insulin following injection, creating a slow releasing “basal insulin” over a period of 12 to 24 hours, which can be varied by compositional changes to tailor the release profile to the needs of the individual diabetic patient03-18-2010
20100227795INSULIN FORMULATIONS FOR RAPID UPTAKE - Injectable insulin formulations with improved stability and rapid onset of action are described herein. The formulations may be for subcutaneous, intradermal or intramuscular administration. In the preferred embodiment, the formulations are administered via subcutaneous injection. The formulations contain insulin in combination with a chelator and dissolution agent, and optionally additional excipients. In the preferred embodiment, the formulation contains human insulin, a zinc chelator such as EDTA and a dissolution agent such as citric acid or sodium citrate. These formulations are rapidly absorbed into the blood stream when administered by subcutaneous injection. In the preferred embodiment, the insulin is provided as a clear liquid, neutral pH, in a multi-use sterile vial. In an alternative embodiment, the insulin is provided as a powder in a sterile vial. This is mixed with a diluent containing a pharmaceutically acceptable carrier, such as water, a zinc chelator such as EDTA and a dissolution agent such as citric acid shortly before or at the time of administration. In another embodiment, the insulin is stored as a frozen mixture, ready for use upon thawing.09-09-2010
20110097386STABILIZED GLUCAGON SOLUTIONS - A formulation composed of a sugar such as glucose and a surfactant such as myristoyl lysophosphocholine (LMPC) has been designed to stabilize both hydrophilic and hydrophobic portions of the glucagon molecule, under prolonged physiological conditions, in a formulation that is sufficiently similar to the pH and osmolarity of plasma so as not to induce or to minimize site irritation. The combination of a simple sugar and an surfactant stabilizes the glucagon molecule in an aqueous solution for seven days at 37° C.04-28-2011
20110237510STABILIZED GLUCAGON SOLUTIONS - A formulation composed of a sugar such as glucose and a surfactant such as myristoyl lysophosphocholine (LMPC) has been designed to stabilize both hydrophilic and hydrophobic portions of the glucagon molecule, under prolonged physiological conditions, in a formulation that is sufficiently similar to the pH and osmolarity of plasma so as not to induce or to minimize site irritation. The combination of a simple sugar and an surfactant stabilizes the glucagon molecule in an aqueous solution for seven days at 37° C.09-29-2011
20110281790INSULIN WITH A STABLE BASAL RELEASE PROFILE - A basal insulin formulation composed of insulin, preferably insulin glargine, injectable zinc and injectable iron compounds as precipitating and/or stabilizing agents has been developed for subcutaneous, intradermal or intramuscular administration. The formulation is designed to form a precipitate of insulin following injection, creating a slow releasing “basal insulin” over a period of 12 to 24 hours.11-17-2011
20120178675Compositions And Methods For Modulating The Pharmacokinetics and Pharmacodynamics of Insulin - Compositions and methods for modulating the pharmacokinetics and pharmacodynamics of rapid acting injectable insulin formulations are described herein. In the preferred embodiment, the formulations are administered via subcutaneous injection. The formulations contain insulin in combination with a zinc chelator such as ethylenediaminetetraacetic acid (“EDTA”) and a dissolution/stabilization agent, and optionally additional excipients. Calcium disodium EDTA is less likely to remove calcium from the body, and typically has less pain on injection in the subcutaneous tissue. Modulating the type and quantity of EDTA can change the insulin absorption profile. Increasing the quantity of citrate can further enhance absorption and chemically stabilize the formulation. In the preferred embodiment, the formulation contains human insulin, calcium disodium EDTA and a dissolution/stabilization agent such as citric acid or sodium citrate. These formulations are rapidly absorbed into the blood stream when administered by subcutaneous injection.07-12-2012

Patent applications by Robert Hauser, Columbia, MD US

Robert G. Hauser, Long Lake, MN US

Patent application numberDescriptionPublished
20120283773BARRIER DEVICE FOR OSTIUM OF LEFT ATRIAL APPENDAGE - A membrane applied to the ostium of an atrial appendage for blocking blood from entering the atrial appendage which can form blood clots therein is disclosed. The membrane also prevents blood clots in the atrial appendage from escaping therefrom and entering the blood stream which can result in a blocked blood vessel, leading to strokes and heart attacks. The membranes are percutaneously installed in patients experiencing atrial fibrillations and other heart conditions where thrombosis may form in the atrial appendages.11-08-2012

Stephen A. Hauser, Carlisle, MA US

Patent application numberDescriptionPublished
20090109619METHOD APPARATUS FOR COOLING SYSTEM HAVING AN S-SHAPED AIR FLOW PATH FOR USE IN A CHASSIS - A method and apparatus cooling a chassis. The apparatus includes a telecommunication shelf structure or chassis (04-30-2009
20100216389System and Method For Restricting Airflow Through A Portion Of An Electronics Enclosure - An apparatus is disclosed for restricting air flow through an electronics enclosure. The apparatus may include a panel having at least one edge adapted to be secured to a surface of the electronics enclosure to thus place the panel in a path of a cooling air flow flowing through a cardcage portion of the enclosure. The panel may have a footprint that at least substantially fills an opening through which said cooling air flow flows through said cardcage portion of the enclosure. The panel may have a plurality of openings so that the panel reduces a volume of a cooling air flow flowing through the panel by a predetermined desired degree, and thus reduces a volume of the air flow through the cardcage to a desired volume.08-26-2010
20100216390Apparatus and Method for Restricting Air Flow Within an Electronic Equipment Enclosure - An air flow restrictor panel adapted for use in an electronics equipment enclosure to block a gap existing between a midplane and an electronics module positioned adjacent the midplane. The air flow restrictor panel may incorporate a main panel portion and a plurality of flanges extending from the main panel portion. The main panel portion may have a footprint sufficiently large in area to block the gap.08-26-2010
20100218920System And Method For Airflow Dividers For Use With Cooling Systems For An Equipment Enclosure - A cooling system that has a fan having a plurality of fan blades disposed in a housing, with the fan having an input side and an exhaust side. A flow divider component may be disposed parallel to an axial center of the fan and positioned adjacent to the housing of the fan, and adjacent to one of the input side or the exhaust side. The flow divider may further project away from the fan blades for channeling an air flow created by the fan blades.09-02-2010
20100220432System And Method For Supplying Power To Electronics Enclosures Utilizing Distributed DC Power Architectures - A power entry module (PEM) that is used with an electronics equipment enclosure. The PEM has a housing adapted to be coupled to a shelf of the electronics equipment enclosure. The housing has at least one pair of power cable lugs accessible from an exterior of the housing for coupling the PEM to a pair of power cables associated with a power feed. The PEM also has a backplane connector for coupling the PEM to a blackplane of the electronics enclosure. A distribution network is disposed within the PEM housing and forms at least a pair of electrically isolated power distribution buses for coupling electrical power provided from the power cables to each of the power distribution branches. Each power distribution branch independently provides electrical power to at least one blade supported within the electronics equipment enclosure.09-02-2010
20100220456System And Method For Blocking Lateral Airflow Paths Between Modules In An Electronic Equipment Enclosure - A gap filler member apparatus for blocking air flow through a gap existing between an edge of a first electronics board and a surface of a second electronics board that is disposed generally perpendicular to the first electronics board, where the first and second electronics boards are coupled by at least one pair of connectors and disposed within an electronics equipment enclosure, to block air flow through the gap. The apparatus has at least one rib extending therefrom, with the base portion being secureable to the surface of the second electronics board. A rib extends away from the base portion and has a height approximately equal to a height of the gap, and a length at least as long as a length of the gap so that the rib at least substantially blocks air flow through the gap.09-02-2010

Terry Hauser, Winston-Salem, NC US

Patent application numberDescriptionPublished
20110059947ALPHA 7 NICOTINIC AGONISTS AND ANTIPSYCHOTICS - The present invention relates to a synergistic combination of an alpha7 (α7) nicotinic agonist and an antipsychotic agent.03-10-2011
20110257224PREPARATION AND THERAPEUTIC APPLICATIONS OF (2S,3R)-N-2-((3-PYRIDINYL)METHYL)-1-AZABICYCLO[2.2.2]OCT-3-YL)-3,5-DIFLUO- ROBENZAMIDE - The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetyl-choline receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).10-20-2011
20110262407TREATMENT WITH ALPHA7 SELECTIVE LIGANDS - The present invention includes methods, uses, and selective alpha7 nAChR ligands for treating or preventing disease and disorders in which stimulation of neurogenesis is ameliorative; namely, wherein the recruitment of neurogenesis is therapeutic.10-27-2011

Timothy Glenn Hauser, Fort Wayne, IN US

Patent application numberDescriptionPublished
20100210147CONNECTORS TO CONNECT ELECTRONIC DEVICES - A connector for electrically connecting an electronic device to another device includes an outer shell with a front surface that terminates at a front side of the connector, an inner core at least partially disposed within the outer shell and including a front surface that is recessed within the outer shell, and a plurality of electrical connecting elements at least partially disposed within the inner core and extending from the front surface of the inner core. The plurality of electrical connecting elements includes a first set of electrical connecting elements and a second set of at least one electrical connecting element, and the first set of electrical connecting elements includes five connecting elements that are arranged in a pentagon pattern. The connector facilitates the transmission of audio signals between devices and also additional analog or digital signals or the transmission of a power supply between the devices.08-19-2010

Todd Hauser, Seattle, WA US

Patent application numberDescriptionPublished
20110159586COMPOSITIONS AND METHODS FOR MODULATING GENE EXPRESSION USING ASYMMETRICALLY-ACTIVE PRECURSOR POLYNUCLEOTIDES - The present invention is directed to novel nucleic acid molecules which include a region complementary to a target gene and one or more self-complementary regions, and the use of such nucleic acid molecules and compositions comprising the same to modulate gene expression and treat a variety of diseases and infections.06-30-2011

Todd M. Hauser, Seattle, WA US

Patent application numberDescriptionPublished
20120184598POLYNUCLEOTIDES FOR MULTIVALENT RNA INTERFERENCE, COMPOSITIONS AND METHODS OF USE THEREOF - The present invention includes bivalent or multivalent nucleic acid molecules or complexes of nucleic acid molecules having two or more target-specific regions, in which the target-specific regions are complementary to a single target gene at more than one distinct nucleotide site, and/or in which the target regions are complementary to more than one target gene or target sequence. Also included are compositions comprising such nucleic acid molecules and methods of using the same for multivalent RNA interference and the treatment of a variety of diseases and infections.07-19-2012

Todd M. Hauser, Sammamish, WA US

Patent application numberDescriptionPublished
20090005332Compositions and Methods for Modulating Gene Expression Using Self-Protected Oligonucleotides - The present invention is directed to novel nucleic acid molecules which include a region complementary to a target gene and one or more self-complementary regions, and the use of such nucleic acid molecules and compositions comprising the same to modulate gene expression and treat a variety of diseases and infections.01-01-2009

Wendy Hauser, Lehighton, PA US

Patent application numberDescriptionPublished
20110061663Infant Sleep System - The invention provides an infant sleep system that can deter, reduce or eliminate several risk factors affecting infants while sleeping, including, but not limited to SIDS (Sudden Infant Death Syndrome), skull flattening, toxic gas theory, acid reflux or Gastro-Esophageal Reflux (GER), colic, and injuries resulting from falls.03-17-2011