Patent application number | Description | Published |
20080234136 | Single molecule arrays for genetic and chemical analysis - Random arrays of single molecules are provided for carrying out large scale analyses, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the invention comprise concatemers of DNA fragments that are randomly disposed on a regular array of discrete spaced apart regions, such that substantially all such regions contain no more than a single concatemer. Preferably, such regions have areas substantially less than 1 μm | 09-25-2008 |
20090137404 | Single molecule arrays for genetic and chemical analysis - Random arrays of single molecules are provided for carrying out large scale analyses, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the invention comprise concatemers of DNA fragments that are randomly disposed on a regular array of discrete spaced apart regions, such that substantially all such regions contain no more than a single concatemer. Preferably, such regions have areas substantially less than 1 μm | 05-28-2009 |
20090137414 | Single molecule arrays for genetic and chemical analysis - Random arrays of single molecules are provided for carrying out large scale analyses, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the invention comprise concatemers of DNA fragments that are randomly disposed on a regular array of discrete spaced apart regions, such that substantially all such regions contain no more than a single concatemer. Preferably, such regions have areas substantially less than 1 μm | 05-28-2009 |
20100081128 | Self-assembled single molecule arrays and uses thereof - The present invention provides methods of making and using self-assembled arrays of single polynucleotide molecules for carrying out a variety of large-scale genetic measurements, such as gene expression analysis, gene copy number assessment, and the like. Random arrays used in the invention are “self-assembled” in the sense that they are formed by deposition of polynucleotide molecules onto a surface where they become fixed at random locations. The polynucleotide molecules fixed on the surface are then identified by direct sequence determination of component nucleic acids, such as incorporated probe sequences, or by other decoding schemes. Such identification converts a random array of determinable polynucleotides, and their respective probes into an addressable array of probe sequences. | 04-01-2010 |
20110071053 | Single Molecule Arrays for Genetic and Chemical Analysis - Random arrays of single molecules are provided for carrying out large scale analyses, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the invention comprise concatemers of DNA fragments that are randomly disposed on a regular array of discrete spaced apart regions, such that substantially all such regions contain no more than a single concatemer. Preferably, such regions have areas substantially less than 1 μm | 03-24-2011 |
20110281738 | SELF-ASSEMBLED SINGLE MOLECULE ARRAYS AND USES THEREOF - The present invention provides methods of making and using self-assembled arrays of single polynucleotide molecules for carrying out a variety of large-scale genetic measurements, such as gene expression analysis, gene copy number assessment, and the like. Random arrays used in the invention are “self-assembled” in the sense that they are formed by deposition of polynucleotide molecules onto a surface where they become fixed at random locations. The polynucleotide molecules fixed on the surface are then identified by direct sequence determination of component nucleic acids, such as incorporated probe sequences, or by other decoding schemes. Such identification converts a random array of determinable polynucleotides, and their respective probes into an addressable array of probe sequences. | 11-17-2011 |
20140073513 | Self-Assembled Single Molecule Arrays and Uses Thereof - The present invention provides methods of making and using self-assembled arrays of single polynucleotide molecules for carrying out a variety of large-scale genetic measurements, such as gene expression analysis, gene copy number assessment, and the like. Random arrays used in the invention are “self-assembled” in the sense that they are formed by deposition of polynucleotide molecules onto a surface where they become fixed at random locations. The polynucleotide molecules fixed on the surface are then identified by direct sequence determination of component nucleic acids, such as incorporated probe sequences, or by other decoding schemes. Such identification converts a random array of determinable polynucleotides, and their respective probes into an addressable array of probe sequences. | 03-13-2014 |
Patent application number | Description | Published |
20090054724 | IMPLANTABLE DEVICE FOR TREATMENT OF VENTRICULAR DILATION - A device and method for reducing ventricular dilation by placing one or more cardiac bridges into vessels extending along a length of the ventricle. Each cardiac bridge preferably includes a pair of anchors and a bridge member secured therebetween. The tension in the bridge member is increased to compress the ventricle and thereby reduce the dilation. In another embodiment, the bridge member is tensioned to reshape the left ventricle for reducing tension on the chordae tendinae in the heart to improve valve function. | 02-26-2009 |
20090076586 | Device and Method for ReShaping Mitral Valve Annulus - Devices and methods for reshaping a mitral valve annulus are provided. One preferred device is configured for deployment in the right atrium and is shaped to apply a force along the atrial septum. The device causes the atrial septum to deform and push the anterior leaflet of the mitral valve in a posterior direction for reducing mitral valve regurgitation. Another preferred device is deployed in the left ventricular outflow tract at a location adjacent the aortic valve. The device is expandable for urging the anterior leaflet toward the posterior leaflet. Another preferred device comprises a tether configured to be attached to opposing regions of the mitral valve annulus. | 03-19-2009 |
20100185210 | Method of Capturing and Macerating Particles in a Blood Vessel - A method of capturing and macerating particles in a blood vessel is provided. A vascular filter device is implanted in the blood vessel at a treatment site. The vascular filter device comprises a filter body and an agitation member disposed within the filter body. Movement of the agitation member acts on particles trapped within the filter body for enhancing the dissolution of the particles, thereby reducing the likelihood of filter occlusion and improving the flow of blood through the vessel. The vascular filter device is preferably collapsible for percutaneous delivery to a treatment site. The agitation member is preferably rotatably coupled to the filter body. A power source is provided for moving the agitation member. In various examples, the power source may take the form of an energy storage device, a drive catheter, or a magnetic field. | 07-22-2010 |
20110015722 | DEVICE AND METHOD FOR RESHAPING MITRAL VALVE ANNULUS - Devices and methods for reshaping a mitral valve annulus are provided. One preferred device is configured for deployment in the right atrium and is shaped to apply a force along the atrial septum. The device causes the atrial septum to deform and push the anterior leaflet of the mitral valve in a posterior direction for reducing mitral valve regurgitation. Another preferred device is deployed in the left ventricular outflow tract at a location adjacent the aortic valve. The device is expandable for urging the anterior leaflet toward the posterior leaflet. Another preferred device comprises a tether configured to be attached to opposing regions of the mitral valve annulus. | 01-20-2011 |
20120123522 | METHOD OF TREATING A DILATED VENTRICLE - A method of reducing ventricular dilation comprises placing one or more cardiac bridges into vessels extending along a length of the ventricle. Each cardiac bridge preferably includes a pair of anchors and a bridge member secured therebetween. The tension in the bridge member compresses the ventricle and thereby reduces the dilation along the ventricle wall. In another embodiment, the bridge member is tensioned to reshape the left ventricle for reducing tension on the chordae tendinae in the heart for improving valve function. | 05-17-2012 |
20120191182 | PROSTHETIC INSERT FOR TREATING A MITRAL VALVE - A prosthetic insert member for improving the function of a mitral valve is disclosed. The insert member is configured for insertion between leaflets of mitral valve. The insert member has an elongated cross-sectional profile for conforming to the opening in the mitral valve. The device also includes an anchoring member for attachment to heart tissue for maintaining the insert member in the mitral valve. In operation, the insert member fills the opening between the leaflets of the mitral valve and reduces regurgitation while preferably allowing the leaflets to function in a substantially normal manner. In one embodiment, the insert member is formed with a valve member disposed in a passageway for allowing blood to pass through the insert member in one direction. | 07-26-2012 |
20120209376 | DEVICE AND METHOD FOR RESHAPING MITRAL VALVE ANNULUS - Methods for treating a defective mitral valve are provided. One preferred method comprises attaching opposing ends of a tether to opposing regions of the mitral valve annulus. The tether is advanced percutaneously into the left atrium by a therapy catheter. Vacuum ports may be provided on the therapy catheter for grasping tissue along the mitral valve annulus. The therapy catheter may also include advanceable needles for passing the tether through the tissue. Alternatively, the ends of the tether may be attached to fastener elements which are secured to the tissue. Tension in the tether pulls the opposing regions of the mitral valve annulus into closer proximity for improving mitral valve function. | 08-16-2012 |
20120310328 | SYSTEM AND METHOD FOR TREATING VALVE INSUFFICIENCY OR VESSEL DILATATION - A medical device for treating aortic insufficiency (and associated aneurysms or defects of any other vessel associated with a valve) includes a support structure, a stent, a prosthetic valve and a deflector. Generally, the support structure is configured to cooperate with the prosthetic valve to pinch the native valve therebetween and provide an anchor for the stent which extends into the aorta and supports the deflector which is positioned to abate blood flow against the aneurysm. | 12-06-2012 |
20130053881 | METHOD OF TREATING OCCULSION IN A BLOOD VESSEL - A method of dissolving a thrombus in a blood vessel for improving blood flow. A filter device includes an expandable filter body fixed to a distal end portion of an outer catheter. The filter device also includes an agitation member disposed along a distal end portion of an inner catheter, wherein the inner catheter is slidably contained within the outer catheter. During treatment, the expandable filter body is expanded within the blood vessel and the inner catheter is advanced relative to the outer catheter such that the agitation member is positioned distal to the filter body. The agitation member is activated for dissolving the thrombus in the blood vessel. After the thrombus is at least partially dissolved, aspiration is applied for pulling resulting particles into the filter body. The filter device is then retracted into a delivery sheath with the particles captured inside the filter body. | 02-28-2013 |
20140012373 | Method for Implanting a Prosthetic Mitral Valve - Embodiments of a method for implanting a prosthetic valve at the native mitral valve region of the heart, the prosthetic valve including a main body that is radially compressible to a radially compressed state and self-expandable from the compressed state to a radially expanded state. The prosthetic apparatus also comprises at least one ventricular anchor coupled to the main body and disposed outside of the main body with a leaflet-receiving space between the anchor and an outer surface of the main body to receive a native valve leaflet. Apparatus for delivering and implanting the prosthetic valve are also described. | 01-09-2014 |
20140135910 | DEVICE AND METHOD FOR RESHAPING TRICUSPID VALVE ANNULUS - A device for reshaping the tricuspid valve comprises a stent that is deployed in the right ventricular outflow tract (RVOT) adjacent to the tricuspid valve and expanded to a size sufficient to reduce the annular diameter or size of the tricuspid valve, thereby improving coaptation of the leaflets and reducing regurgitation. Embodiments of the device are deliverable percutaneously. | 05-15-2014 |
20140288480 | DEVICE AND METHOD FOR INCREASING FLOW THROUGH THE LEFT ATRIAL APPENDAGE - Methods and devices for increasing flow in the left atrial appendage (LAA) include a conduit directing blood flow from a pulmonary artery into the LAA and/or a conduit drawing blood from the LAA by a Bernoulli effect. In one embodiment, a method comprises implanting a conduit in a pulmonary vein, expanding an inlet portion such that the conduit becomes anchored within the vein and directs blood through an outlet portion of the conduit into or toward the left atrial appendage. | 09-25-2014 |
20140336702 | EXPANDABLE CLIP FOR TISSUE REPAIR - An apparatus, system, and method for repairing openings such as septal defects includes advancing a catheter to the site of the defect, grasping opposing edges of the defect, passing one or more suture lines through the opposing edges, tightening the suture lines, and deploying and expanding a fastener to secure the suture lines and close the defect. The fastener can include tissue-growth-inducing materials to encourage tissue growth onto or into the fastener and/or suture. The fastener includes a locking clip portion and a plug portion, which may be an expandable portion and/or tissue-growth-inducing portion. | 11-13-2014 |
Patent application number | Description | Published |
20140028579 | Touch Gesture Offset - In one embodiment, logic embodied in a computer-readable non-transitory storage medium of a device determines a location of a touch gesture by a user within a touch-sensitive area of the device. The logic selects for the touch gesture based on its location within the touch-sensitive area one of a plurality of pre-determined offsets, the pre-determined offsets being specific to the device, the pre-determined offsets being derived from device-specific empirical data on usage of the device by a plurality of users, and the pre-determined offsets being pre-loaded onto the device. The logic applies the pre-determined offset to the location of the touch gesture to determine a touch input intended by the user. | 01-30-2014 |
20140095419 | Enhanced Predictive Input Utilizing a Typeahead Process - Particular embodiments may retrieve information associated with one or more nodes of a social graph from one or more data stores. A node may comprise a user node or a concept node. Each node may be connected by edges to other nodes of a social graph. A first user may be associated with a first user node of the social graph. Particular embodiments may detect that the first user is entering an input term. Predictive typeahead results may be provided as the first user enters the input term. The predictive typeahead results may be based on the input term. Each predictive typeahead result may include at least one image. Each predictive typeahead result may correspond to at least one node of the social graph. | 04-03-2014 |
20140096059 | Systems and Methods for a User-Adaptive Keyboard - In one embodiment, a method includes detecting one or more user interactions, associated with a user of a computing device, each interaction occurring at a region associated with an input value, and determining, for at least one user interaction, that the at least one user intended to provide a different input value. Adaptation information is generated for the at least one user based on the at least one user interaction. The adaptation information is stored for the at least one user. A user interaction is detected at a region. The user's intended input value is determined based on the user interaction and the adaptation information. | 04-03-2014 |
20140143665 | Generating a Social Glossary - Particular embodiments determine that a textual term is not associated with a known meaning. The textual term may be related to one or more users of the social-networking system. A determination is made as to whether the textual term should be added to a glossary. If so, then the textual term is added to the glossary. Information related to one or more textual terms in the glossary is provided to enhance auto-correction, provide predictive text input suggestions, or augment social graph data. Particular embodiments discover new textual terms by mining information, wherein the information was received from one or more users of the social-networking system, was generated for one or more users of the social-networking system, is marked as being associated with one or more users of the social-networking system, or includes an identifier for each of one or more users of the social-networking system. | 05-22-2014 |
20140149921 | Using Clamping to Modify Scrolling - In one embodiment, a method includes receiving user input to scroll within a GUI on a touch screen. The user input includes a touch gesture having a path that includes a starting point and one or more other points on the touch screen. The computing device determines regions of the touch screen defined with respect to the starting point. A first one of the regions corresponds to a first scrolling axis, and a second one of the regions corresponds to a second scrolling axis perpendicular to the first scrolling axis. If the path corresponds to the first region, then the computing device scrolls within the GUI according to the user input linearly and parallel to the first scrolling axis. If the path corresponds to the second region, then the computing device scrolls within the GUI according to the user input linearly and parallel to the second scrolling axis. | 05-29-2014 |
20140149922 | Infinite Bi-Directional Scrolling - In one embodiment, a method includes providing for display to a user content including multiple content objects that each have a boundary defining a two-dimensional area. A two-dimensional scroll region for user scrolling within the content is determined. The two-dimensional scroll region is independent of the two-dimensional areas of the content objects. User input to scroll within the content in one or both of the two dimensions across one or more of the boundaries is received. The method includes scrolling within the content according to the user input, the scrolling being continuous across the boundaries. | 05-29-2014 |