Hauer-Jensen
Martin Hauer-Jensen, Little Rock, AR US
Patent application number | Description | Published |
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20110144024 | PREVENTION AND TREATMENT OF RADIATION INJURY - The invention relates to the field of radiation injury. More particularly, this invention relates to the protection against/prevention of and treatment of diseases caused by ionizing radiation by the use of thrombomodulin. | 06-16-2011 |
20130158106 | TOCOPHEROL DERIVATIVES AND METHODS OF USE - Tocol derivative compounds, compositions comprising these tocol derivatives and methods of using the tocol derivatives are provided herein. Specifically the tocol derivatives have a partially unsaturated hydrocarbon tail and are thus distinct from the tocopherols. The hydrocarbon tails do not have a trans carbon-carbon double bond in the second isoprene unit of the hydrocarbon tail and are distinct from the tocotrienols. The compounds are expected to allow improved interaction with the α-tocopherol transfer protein receptor than the tocotrienols and better bioactivity than the tocopherols. | 06-20-2013 |
20150087033 | METHODS FOR MAKING TOCOFLEXOLS AND ANALOGUES THEREOF - Methods for the synthesis of tocoflexols of Formula (I) and (II) and a number of related tocol analogues are provided herein. The methods are economical and amenable to large scale production and can be performed using either pure of partially purified tocotrienols as the starting material. | 03-26-2015 |
Martin K. Hauer-Jensen, Little Rock, AR US
Patent application number | Description | Published |
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20100204254 | Use of statins in the prevention and treatment of radiation injury and other disorders associated with reduced endothelial thrombomodulin - The present invention discloses statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) consistently and significantly increased endothelial cell thrombomodulin protein and functional activity. Statins also abrogated the downregulation of thrombomodulin that occurs in response to radiation injury. These results indicate that preserving or restoring endothelial thrombomodulin expression and function by statins may be useful in a variety of disorders associated with widespread endothelial dysfunction such as sepsis, adult respiratory distress syndrome, and normal tissue radiation injury. | 08-12-2010 |
Martin Kristian Hauer-Jensen, Little Rock, AR US
Patent application number | Description | Published |
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20150353912 | METHODS FOR TREATING AND PREVENTING RADIATION INJURY USING ACTIVATED PROTEIN C POLYPEPTIDES - Methods of treating and preventing radiation injury are provided by the present invention. In particular, provided herein are methods comprising administering to a subject an Activated Protein C (APC), Plasma Zymogen Protein C (PC), or a variant thereof to treat or prevent radiation injury and to reduce chemical toxicity in subjects receiving myelosuppressive therapy. | 12-10-2015 |