Patent application number | Description | Published |
20080274971 | Use of ACRP30 Globular Head to Promote Increases in Muscle Mass and Muscle Differentiation - The present invention relates to the field of muscle research, in particular to the discovery of a compound effective for increasing muscle mass, muscle cell differentiation, and oxidation of free fatty acids in muscle, useful in methods of treating muscle-related diseases and disorders as well as for augmenting muscle mass in general. The muscle-related diseases or disorders envisaged to be treated by the methods of the invention include, but are not limited to, muscular dystrophy, and other conditions resulting in muscle atrophy or muscle wasting. | 11-06-2008 |
20110117061 | Ex Vivo Expansion of Human Hematopoietic Stem Cells - Methods and kits for expanding the number of hematopoietic stem cells are provided. The methods comprise incubating cells in medium comprising isolated IGFBP-2 and an angiopoietin-like protein (Angptl). Expanded HSCs are provided as well as culture media and kits for the expansion of human HSCs in a defined medium. Methods of administering expanded human HSCs to and individual are provided as well as methods of treating an individual by administering certain growth factors and cytokines. | 05-19-2011 |
20110136230 | Cultured Hematopoietic Stem Cells and Method for Expansion and Analysis Thereof - Hematopoietic stem cells and methods for ex vivo expansion of hematopoietic stem cells are provided. The methods comprise culturing the cells in a media containing an effective amount insulin-like growth factor(IGF), fibroblast growth factor (FGF), thrombopoietin (TPO), and stem cell factor (SCF), under conditions sufficient for expansion of said cells. Methods for identifying expanded hematopoeitc stem cells and kits for ex vivo expansion of hematopoietic stem cells are also provided. | 06-09-2011 |
20120196924 | METHODS AND PRODUCTS FOR EXPRESSION OF MICRO RNAs - The invention relates to microRNAs, methods of producing microRNAs and methods for using microRNAs. | 08-02-2012 |
20140187613 | METHODS AND PRODUCTS FOR EXPRESSION OF MICRO RNAs - The invention relates to microRNAs, methods of producing microRNAs and methods for using microRNAs. | 07-03-2014 |
20140234266 | Cultured Hematopoietic Stem Cells and Method for Expansion and Analysis Thereof - Hematopoietic stem cells and methods for ex vivo expansion of hematopoietic stem cells are provided. The methods comprise culturing the cells in a media containing an effective amount insulin-like growth factor (IGF), fibroblast growth factor (FGF), thrombopoietin (TPO), and stem cell factor (SCF), under conditions sufficient for expansion of said cells. Methods for identifying expanded hematopoeitic stem cells and kits for ex vivo expansion of hematopoietic stem cells are also provided. | 08-21-2014 |
20140308747 | Ex Vivo Expansion of Human Hematopoietic Stem Cells - Methods and kits for expanding the number of hematopoietic stem cells are provided. The methods comprise incubating cells in medium comprising isolated IGFBP-2 and an angiopoietin-like protein (Angptl). Expanded HSCs are provided as well as culture media and kits for the expansion of human HSCs in a defined medium. Methods of administering expanded human HSCs to and individual are provided as well as methods of treating an individual by administering certain growth factors and cytokines. | 10-16-2014 |
20160082046 | IN VITRO PRODUCTION OF RED BLOOD CELLS WITH SORTAGGABLE PROTEINS - Methods for the in vitro production of enucleated red blood cells and the enucleated red blood cells thus prepared are provided. Such enucleated red blood cells may express a sortaggable surface protein, which allows for surface modification in the presence of a sortase. Also described herein are surface modified enucleated red blood cells, e.g., conjugated with an agent of interest such as a peptide, a detectable label, or a chemotherapeutic agent, and uses thereof in delivering the agent to a subject. | 03-24-2016 |