| Patent application number | Description | Published |
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| 20080262878 | SYSTEMS, METHODS, AND COMPUTER PROGRAM PRODUCTS FOR GENERATING AND UPDATING A CACHE OF PRICE AND AVAILABILITY INFORMATION FOR TRAVEL PACKAGES AND COMPONENTS - Systems, methods, and computer program products are provided for generating, updating, and managing a cache of price and availability information for a plurality of travel packages and components. The cache of price and availability information may then be searched by an online travel planning service to provide customers with a list of available travel products. More particularly, embodiments of the present invention provide a cascading cache system including a cache of price and availability data related to travel components and a cache of price and availability data related to travel packages. Changes made to the component cache can affect information stored in the package cache, and changes made to the package cache can affect information stored in the component cache. Furthermore, the cache system updates the package and component caches based on information received from a purchase of a package or component, as well as by proactively polling one or more travel reservation systems. | 10-23-2008 |
| 20110054997 | METHOD AND SYSTEM FOR ELECTRONIC ADVERTISING - A method of delivering advertising in an online environment includes determining an intent of a user interacting with an e-commerce website, and determining a hurdle rate that is based at least on the user intent and which identifies a threshold amount to be bid by an advertiser in order to display an advertisement to the user. The method further includes selecting, from a plurality of advertisements, an optimal advertisement having an advertiser bid that exceeds the hurdle rate, and displaying the optimal advertisement to the user in an interface of a client computer system. | 03-03-2011 |
| 20110054998 | METHOD AND SYSTEM FOR ELECTRONIC ADVERTISING - A method of delivering advertising in an online environment includes determining an intent of a user interacting with an e-commerce website and determining a hurdle rate, based at least on the intent of the user, that identifies a threshold amount to be bid by an advertiser in order to display an advertisement to the user interacting with the e-commerce website. The method may further include selecting, from a plurality of advertisements, one or more optimal advertisements having a combined advertiser bid that exceeds the determined hurdle rate. The method may further include providing one or more controls in a user interface of a client computer system, each of the controls being associated with a respective advertisement of the one or more optimal advertisements and adapted to enable the user to select one or more of the controls, and providing an element, responsive to an input of the user, that is adapted to display, to the user, the respective advertisements selected by the user. | 03-03-2011 |
| 20110055008 | METHOD AND SYSTEM FOR ELECTRONIC ADVERTISING - A method of delivering advertising in an online environment includes determining a context of a user operating a client computer to interact with an e-commerce website, where the determined context representing an intent of the user to locate a product for purchase, defining a relation between one or more of a plurality of advertisements and the product based on at least one of a plurality of relevance types, and displaying, to the user, at least one of the advertisements having the relation to the product. | 03-03-2011 |
| Patent application number | Description | Published |
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| 20080286780 | Novel compositions and methods for the identification, assessment, prevention and therapy of human cancers - The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent. The invention also features marker sets that can predict patients that are likely to respond or not to respond to an agent. | 11-20-2008 |
| 20090136961 | Novel compositions and methods for identification, assessment, prevention, and therapy of ovarian cancer - The present invention is directed to the identification of markers that can be used to determine whether ovarian cancer is sensitive or resistant to a therapeutic agent. In particular, the present invention is directed to the use of certain combinations of markers, wherein the expression of the markers correlates with sensitivity or resistance to a therapeutic agent. Thus, by examining the expression of the individual markers of a marker set, also referred to as the expression profile of the marker set, it is possible to determine whether a therapeutic agent, or combination of agents, will be most likely to reduce the growth rate of the ovarian cancer. | 05-28-2009 |
| 20110104306 | NOVEL COMPOSITIONS AND METHODS FOR THE IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY OF HUMAN CANCERS - The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent. The invention also features marker sets that can predict patients that are likely to respond or not to respond to an agent. | 05-05-2011 |
