Patent application number | Description | Published |
20080219929 | Neurofibrillary labels - A method for determining the Braak stage of neurofibrillary degeneration associated with a tauopathy in a subject having neurofibrillary degeneration is disclosed. The method comprises the steps of (i) administering to the subject a conjugated, chelated or detectable chemical group-associated ligand that labels aggregated paired helical filament (PHF) tau protein and is capable of crossing the blood brain barrier; (ii) determining the presence and\or amount of ligand bound to extracellular aggregated PHF tau in the medial temporal lobe of the brain of the subject, and (iii) correlating the result of the determination made in (ii) with the extent of neurofibrillary degeneration in the subject. Preferred ligands include sulphonated-benzothiazole-like compounds and diamonophenothiazines. | 09-11-2008 |
20090075984 | Materials and methods relating to protein aggregation in neurodegenerative disease - The present invention is directed to methods for the treatment or prophylaxis of a tauopathy comprising administering to a patient in need thereof a medicament comprising a phenothiazine. | 03-19-2009 |
20090209526 | INHIBITORS OF PROTEIN AGGREGATION - The invention relates generally to the use of diaminophenothiazine compounds to inhibit or reverse the aggregation of synuclein, and for their use in the manufacture of medicaments for this purpose (e.g. for the treatment of Parkinson's Disease). Also provided are related methods of detecting or labelling of aggregated synuclein. | 08-20-2009 |
20100285605 | Neurofibrillary labels - Disclosed are methods for determining the stage of neurofibrillary degeneration associated with a tauopathy in a subject believed to suffer from the disease, which methods comprise the steps of: (i) introducing into the subject a ligand capable of labelling aggregated paired helical filament (PHF) tau protein, (ii) determining the presence and\or amount of ligand bound to extracellular aggregated PHF tau in the medial temporal lobe of the brain of the subject, (iii) correlating the result of the determination made in (ii) with the extent of neurofibrillary degeneration in the subject. The methods can be used for pre-mortem diagnosis and staging of tauopathies such as Alzheimer's Disease. Preferred ligands include sulphonated-benzothiazole-like compounds and diaminophenothiazines. Novel ligands (e.g. sulphonated-benzothiazole-like compounds) are also provided. The method may also include the use of “blocking ligands” to block competing binding sites. In other aspects the invention provides in vitro methods for identifying ligands capable of labeling aggregated PHF tau protein, the methods comprising the steps of: (i) providing a first agent suspected of being capable of labeling aggregated PHF tau protein, (ii) contacting (a) a tau protein or a derivative thereof containing the tau core fragment bound to a solid phase so as to expose a high affinity tau capture site, with (b) a liquid phase tau protein or derivative thereof capable of binding to the solid phase tau protein or derivative, and (c) said selected first agent and (d) a second agent known to be tau-tau binding inhibitor, (iii) selecting first agent which fully or partially relieves the inhibition of binding of the liquid phase tau protein or derivative of (b) to the solid phase tau protein or derivative of (a) by the inhibitor (d). Ligands may also be tested to confirm that they are not themselves inhibitors. | 11-11-2010 |
20100290986 | THERAPEUTIC USE OF DIAMINOPHENOTHIAZINES - The present invention relates generally to methods and materials for use in the treatment or prophylaxis of diseases, for example cognitive disorders, using diaminophenothiazines. In particular it relates to treatments having optimised pharmacokinetic properties, and dosage forms are intended to improve the relative cognitive or CNS benefits of the diaminophenothiazines, for instance compared to haematological effects. | 11-18-2010 |
20110118242 | 3,7-DIAMINO-10H-PHINOTHIAZINE SALTS AND THEIR USE - This invention pertains generally to the field of phenothiazine compounds, and more particularly to certain stably reduced phenothiazine compounds, specifically, certain 3,7-diamino-10H-phenothiazine (DAPTZ) compounds of the following formula: | 05-19-2011 |
20110300074 | 3,6-DISUBSTITUTED XANTHYLIUM SALTS - This invention pertains generally to processes, uses, methods and materials utilising particular xanthylium compounds, including compounds of formula (I) and (II), as further defined herein. These compounds are useful as drugs, for example, in the treatment of tauopathies, such as Alzheimer's disease. | 12-08-2011 |
20140161731 | 3,6-DISUBSTITUTED XANTHYLIUM SALTS - Described are a compound of formula (II) or (III): | 06-12-2014 |
20140221359 | 3,7-DIAMINO-10H-PHENOTHIAZINE SALTS AND THEIR USE - Described are methods of prepraing reduced 3,7-diamino-10H-phenothiazine (DAPTZ) compounds of formula: | 08-07-2014 |
Patent application number | Description | Published |
20100104763 | Crystalline Resin Sandwich Films - A resin composition that is storable at ambient temperatures. The resin composition forms a cured resin when exposed to a curing agent and heated to a curing temperature that is relatively close to ambient temperature. The resin composition includes a crystalline resin component that is sandwiched between two non-crystalline resin components to provide a zone that is rich in crystalline thermosetting resin. The crystalline thermosetting resin has a melting point that is above ambient temperature, but below the curing temperature. The viscosity of the resin component changes from a high viscosity state to a low viscosity state when the temperature is increased from ambient temperature to the curing temperature. | 04-29-2010 |
20100124863 | Gelator Stabilized Crystalline Resins - A resin composition that is storable at ambient temperatures. The resin composition forms a cured resin when exposed to a curing agent and heated to a curing temperature that is relatively close to ambient temperature. The resin composition includes a resin component that is composed of a liquid part that is made up of one or more liquid thermosetting resins and a solid part that includes particles of one or more solid thermosetting resins. The liquid part further includes a gelation agent that is present in a sufficient amount to maintain the particles in suspension within the liquid part at ambient temperatures. The viscosity of the resin component changes from a high viscosity state to a low viscosity state when the temperature is increased from ambient temperature to the curing temperature. The high viscosity state is substantially more viscous than the low viscosity state. | 05-20-2010 |
20100219612 | FIBER REINFORCED RESIN ASSEMBLY - An uncured fiber reinforced assembly that includes a reinforcement layer containing a fibrous material and at least one highly reactive curing agent. A matrix film layer is applied to the reinforcement layer so that it does not substantially impregnate the reinforcement layer. The matrix film layer includes at least one uncured epoxy resin and at least one latent epoxy curing agent. The assembly is designed for use in making snowboards and skis. | 09-02-2010 |
20110070447 | Crystalline Resin Sandwich Films - A resin composition that is storable at ambient temperatures. The resin composition forms a cured resin when exposed to a curing agent and heated to a curing temperature that is relatively close to ambient temperature. The resin composition includes a crystalline resin component that is sandwiched between two non-crystalline resin components to provide a zone that is rich in crystalline thermosetting resin. The crystalline thermosetting resin has a melting point that is above ambient temperature, but below the curing temperature. The viscosity of the resin component changes from a high viscosity state to a low viscosity state when the temperature is increased from ambient temperature to the curing temperature. | 03-24-2011 |
Patent application number | Description | Published |
20130138333 | SYSTEM AND METHOD FOR CONTROLLING OPERATION OF AN AIRLINE - An airline operations control system for an airline having multiple aircraft and multiple routes formed by one or more flights where the airline operations control system includes a computer searchable database a query module configured to query the database and a display module and a method of controlling operation of the airline having the multiple aircraft and the multiple routes. | 05-30-2013 |
20140279802 | METHODS AND SYSTEMS FOR PROPAGATING INFORMATION IN COLLABORATIVE DECISION-MAKING - A computer includes a processor and a memory device. The computer is configured to a) receive decision-making criteria from at least one of at least a portion of a plurality of agents associated with a plurality of agent devices, the memory device, and a user, b) generate valid decision combinations using at least a portion of received decision-making criteria, c) transmit, to the plurality of agents, valid decision combinations, d) receive, from a deciding agent, a decision, and e) constrain, using the received decision, valid decision combinations. The computer is configured to f) return to c) until determining that no more decisions can be received. The computer is configured to g) transmit a final decision set to the plurality of agents upon determining that no more decisions can be received. The final decision set represents a complete combination of decisions including at least a portion of received decisions. | 09-18-2014 |
20140281712 | SYSTEM AND METHOD FOR ESTIMATING MAINTENANCE TASK DURATIONS - A computer-implemented method for estimating maintenance task durations is provided. The method is implemented by at least one computing system including at least one processor and at least one memory device coupled to the processor. The method includes receiving a query including a first query maintenance task and a plurality of query factors, and identifying an initial baseline task duration based at least in part on the first query maintenance task. The initial baseline task duration includes a plurality of baseline task factors. The method further includes identifying at least one adjustment factor based at least in part on the differences between the plurality of query factors and the plurality of baseline task factors, calculating a maintenance task duration estimate based at least in part on the initial baseline task duration and the adjustment factors, and planning execution of the first query maintenance task based on maintenance task duration estimate. | 09-18-2014 |
20150019065 | SYSTEM, METHOD, AND APPARATUS FOR SCHEDULING AIRCRAFT MAINTENANCE EVENTS - Systems, methods, and apparatuses for scheduling aircraft maintenance events. One system includes a user interface and at least one processor. The system is configured to receive an indication that an unscheduled maintenance event for an aircraft is to be scheduled, and to determine, using the at least one processor, a maintenance schedule for completing the unscheduled maintenance event on the aircraft, a modified flight schedule for the aircraft, and a modified aircraft schedule for the aircraft based on the unscheduled maintenance event, an initial flight schedule, an initial aircraft schedule, and at least one selectable parameter indicative of user preferences to reduce a total cost of operating the at least one aircraft. The system is configured to provide at least one of the maintenance schedule, the modified flight schedule, and the modified aircraft schedule to the user interface. | 01-15-2015 |