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Harnish, US
Douglas Harnish, Pennsburg, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20080300235 | FXR Agonists for Reducing LOX-1 Expression - Provided are certain methods of treating at least one disease state characterized by elevated expression of the Lectin-like Oxidized Low-density Lipoprotein Receptor 1 (LOX-1) in a patient with farnesoid X receptor agonists. Also provided are certain methods of reducing expression of LOX-1 in a cell with farnesoid X receptor agonists. | 12-04-2008 |
| 20090163474 | FXR Agonists for the Treatment of Nonalcoholic Fatty Liver and Cholesterol Gallstone Diseases - Provided are certain methods of treating nonalcoholic fatty liver disease with farnesoid X receptor agonists. Also provided are certain methods of modulating levels of keratinocyte-derived chemokine (KC), alanine aminotransferase (ALT), aspartate aminotransferase (AST), cytokeratin 18 (CK-18), matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase-14 (MMP-14), tissue inhibitor of metalloproteinase 1 (TIMP-1), and Cytochrome P450 2E1 (CYP2E1); certain methods of identifying FXR modulators; and certain methods of treating patients with existing cholesterol gallstone disease. | 06-25-2009 |
| 20090215748 | FXR agonists for treating vitamin D associated diseases - Provided are certain methods of treating at least one condition that can be treated by elevating the vitamin D receptor (VDR) activity level in a patient with at least one farnesoid X receptor (FXR) agonist. Also provided are certain methods of modulating levels of Cytochrome P450, family 27, subfamily B, polypeptide 1 (CYP27B1) and 1α,25-dihydroxyvitamin D | 08-27-2009 |
Douglas Carl Harnish, Pennsburg, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090311271 | Methods and Compositions for Selective Inhibition of Ligand Binding to the Lectin-Like Receptor for Oxidized Low Density Lipoprotein (LOX-1) - The present invention provides methods of selectively inhibiting the binding of one ligand for LOX-1, but not one other ligand for LOX-1. Moreover, the invention relates to the identification of binding partners that act in a selective manner to inhibit the binding of one ligand to LOX-1, but not one other ligand for LOX-1, and methods of identifying such binding partners. Pharmaceutical compositions comprising the binding partners for LOX-1, in particular, anti-LOX-1 antibodies or fragments thereof, are also provided in the present invention. | 12-17-2009 |
Justin Harnish, Boise, ID US
| Patent application number | Description | Published |
|---|---|---|
| 20090239366 | Method Of Forming A Transistor Gate Of A Recessed Access Device, Method Of Forming A Recessed Transistor Gate And A Non-Recessed Transistor Gate, And Method Of Fabricating An Integrated Circuit - Methods and structures are provided for full silicidation of recessed silicon. Silicon is provided within a trench. A mixture of metals is provided over the silicon in which one of the metals diffuses more readily in silicon than silicon does in the metal, and another of the metals diffuses less readily in silicon than silicon does in the metal. An exemplary mixture includes 80% nickel and 20% cobalt. The silicon within the trench is allowed to fully silicide without void formation, despite a relatively high aspect ratio for the trench. Among other devices, recessed access devices (RADs) can be formed by the method for memory arrays. | 09-24-2009 |
Marshall W. Harnish, Mercer Island, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20090138385 | Crate Tool - A computer implemented method, apparatus, and computer program product for processing aircraft software parts. A crate containing an aircraft software part is received from a source. Signatures are validated for the crate and the aircraft software part. If the signatures are valid, the crate is unpacked. The contents of the incoming crate are displayed. The aircraft software part is unpacked. Responsive to a request to upload the stored part to a library in the aircraft software part management apparatus, a determination is made as to whether the stored part meets a policy. If the stored part meets the policy, the part is signed. The signed part is placed in a crate and is signed to form a signed crate wherein signatures for the signed aircraft software part and the signed crate are different from the set of signatures in the incoming crate. The signed crate is sent to the library. | 05-28-2009 |
Michelle Harnish, Sparta, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20120114735 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF THROAT DISCOMFORT - The physiological cooling agent N-ethyl-2,2-diisopropylbutanamide exhibits a surprising selectivity for throat cooling over mouth cooling, especially when consumed in the form of a confection. Methods of treating throat discomfort using N-ethyl-2,2-diisopropylbutanamide are described. Also described are various confections that incorporate N-ethyl-2,2-diisopropylbutanamide, including hard candy confections, soft candy confections, and center-filled confections. | 05-10-2012 |
Scott David Harnish, Lancaster, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100261367 | PLUG ASSEMBLY - A protective plug assembly for use with a USB connector. The plug assembly may be installed over a terminated USB connector and provides additional shielding for the USB connector, thereby allowing the USB connector to be used in military, aerospace, industrial or other applications in which signal degradation is a concern. The plug assembly is easily installed in the field, as the plug adapter assembly may be preassembled during manufacture. The plug assembly also provides sealing for the USB connector which allows the USB connector to be used in environmental conditions which are not conducive to the longevity of an unprotected connector. | 10-14-2010 |
| 20120045924 | FLEXIBLE BREAKAWAY CONNECTOR - A connector which has a flexible portion which allows the connector to bend in response to non-axial forces applied thereto. When off-axis forces are applied to the connector or a mating connector, the off-axis forces do not cause oblique loading on the connector or mating connector. | 02-23-2012 |
Stephen Wayne Harnish, Wharton, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20080200496 | SUBSTITUTED 1H-PYRROLO[3,2-b, 3,2-c, and 2,3-c]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE Ie - The present invention discloses and claims compounds of formula (I) | 08-21-2008 |