| Patent application number | Description | Published |
|---|
| 20080233607 | Cell Culture Device - The invention provides cell culture devices comprising a channel, the channel comprising one or more inlets and one or more outlets, and a cell retention chamber defined by an internal surface of the channel and a plurality of projections extending therefrom. The invention further provides methods of use relating to such cell culture devices. | 09-25-2008 |
| 20090023127 | TISSUE SYSTEM AND METHODS OF USE - Apparatus and methods of use of a tissue system for culture and perfusion. The apparatus comprises a needle for injecting a fluid into the tissue. | 01-22-2009 |
| 20090323059 | SHG Quantification of Matrix-Related Tissue Dynamic and Disease - A microscope for optical imaging of high optical scattering coefficient biological tissue, comprising an optical excitation source for irradiating a scan area of the sample and generating optical emissions, wherein the sample has a first face facing away from the source and a second face facing the source. A two dimensional element for scanning the light over the sample; a focusing element having a numerical aperture NAi to focus the light onto the sample; a first optical condenser to collect light from the first face, the collected light comprising source transmitted light and first optical emission generated in the sample, the condenser having a NA2 larger than NAi; an optical filter to block the transmitted source light; an aperture with a size corresponding to the irradiated area of the sample, the aperture at the conjugate image position of the sample generated by the condenser; and an optical detector collecting light from the first face for detecting the first optical emission from the scan area. | 12-31-2009 |
| 20100068691 | TISSUE SYSTEM AND METHODS OF USE - Apparatus and methods of use of a tissue system for culture and perfusion. The apparatus comprises needles for injecting a fluid into the tissue. | 03-18-2010 |
| 20100136649 | Encapsulation of Cells in Biologic Compatible Scaffolds by Coacervation of Charged Polymers - This invention relates to a method for the encapsulation of cells in biologic compatible three dimensional scaffolds and the use of such cells encapsulated in a scaffold. The cells are embedded in a charged polymer that is complex coacervating with an oppositely charged polymer within biologic compatible scaffolds. The polymer complex embedding the cells is forming an ultra thin membrane on the surface of the three dimensional scaffold. | 06-03-2010 |
| 20100208049 | IMAGING CHAMBER WITH WINDOW AND MICRO-NEEDLE PLATFORM MAGNETICALLY BIASED TOWARD EACH OTHER - A device for imaging a tissue culture comprises a chamber for housing a tissue to be cultured and imaged. The chamber comprises a transparent window. The device also includes a platform facing the window. Micro-needles are mounted on the platform and are connected for fluid communication with a fluid source. The platform and the window are magnetically biased toward each other to press the micro-needles into a tissue sandwiched between the window and platform for injecting a fluid into the tissue. One or more spacers are placed between the platform and the window for preventing over-compression of the tissue by the platform and the window. During use, a fluid is supplied to the tissue through the needles from the fluid source and the tissue is imaged through the window of the chamber. | 08-19-2010 |
| 20100216241 | FORMING CELL STRUCTURE WITH TRANSIENT LINKER IN CAGE - In a method of forming a cellular structure, cells and a transient linker are supplied to a volume partially enclosed by a cage. The linker facilitates initial attachment of adjacent cells to form a cell aggregate. The cage defines distributed openings that are sized to retain the cell aggregate. A fluid comprising a cell culture medium is supplied to the volume. The fluid is withdrawn from the volume through the openings. Aggregated cells retained in the volume are cultured to form a cell structure. A cell culturing device is provided which comprises a conduit and a cage in the conduit. A fluid flows in the conduit. The fluid comprises the cells, the transient linker and the cell culture medium. The cage retains aggregated cells formed in the fluid, and defines distributed openings that allow the fluid to flow through. | 08-26-2010 |
| 20110159272 | FORMING POROUS SCAFFOLD FROM CELLULOSE DERIVATIVES - Scaffold comprises a polymer defining macropores and comprising hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, which is crosslinked through the self-crosslinkable group. The macropores have an average pore size larger than 50 microns and are at least partially interconnected. In one method, bicontinuous emulsion comprising a continuous aqueous phase and a continuous polymer phase is formed. The polymer phase comprises hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, and is crosslinked through the self-crosslinkable group to form a polymer defining at least partially interconnected pores. In another method, phase separation is induced in a solution comprising a polymer precursor and water to form a bicontinuous emulsion comprising a continuous polymer phase and a continuous aqueous phase. The polymer precursor comprises a self-crosslinkable group and is crosslinked through the self-crosslinkable group in the emulsion to form a polymer defining at least partially interconnected macropores. | 06-30-2011 |
