| Patent application number | Description | Published |
|---|
| 20090047322 | Degradable Hydrophilic Block Copolymers with Improved Biocompatibility for Soft Tissue Regeneration - The present application discloses biodegradable polymers, to porous and other materials comprising such polymers, and to various medical uses of such materials, including use as a scaffold for supporting cell adhesion or the in-growth for regeneration of tissue. The polymer is of the formula A—O—(CHR | 02-19-2009 |
| 20090214614 | Method for Cell Implantation - The present invention provides for a method for tissue engineering by cell implantation that involves the use of a scaffold in situ at the site of a defect, where the therapeutic cells are fixed in place into the scaffold only once the scaffold is inserted at the site of the tissue defect, thereby locking not only the cells to the scaffold, but also the scaffold to the tissue defect. The invention also provides a kit of parts suitable for performing the method of the invention. | 08-27-2009 |
| 20090220579 | Gelatin Non-Woven Structures Produced by a Non-Toxic Dry Solvent Spinning Process - The present application discloses an alternative method for the formation of non-woven with fibers in the 1 to 200 μm range. Using an aqueous solution of gelatin (optionally with <30% of low molecular weight alcohol) the fibers are ejected utilizing pressurized air emitted from nozzle and the non-woven formed directly from the emitted thin fibers. | 09-03-2009 |
| 20090280154 | Biodegradable Scaffold with ECM Material - We add discontinuous regions of Extra Cellular Matrix (ECM) to a biodegradable scaffold. Hereby it is possible to combine the range of physical properties the scaffold can offer with the reconstructive properties of the ECM. The optimal amount of discrete ECM material for each application is disclosed and this concentration is equally distributed in the dressing hence avoiding unnecessary high concentrations of ECM. In addition to the effect of the ECM, the porous structure of the base material provides the cells with a structure for in-growth. | 11-12-2009 |
| 20100034868 | SCAFFOLDS FOR THE REGENERATION OF CARTILAGE - The present application discloses that incorporation of dermatan sulfate and/or HA in composite scaffolds of certain polymers gives rise to a chondrogenic effect on chondrocytes resulting in formation of cartilage that resembles the natural ECM. This effect with dermatan sulfate as the primary additive has not previously been seen. The composites are formed by incorporation of dermatan sulfate finely dispersed particles optionally nanoparticles or as molecular dissolutions in a polymer matrix with no bonding between the DS and the matrix, providing the DS to the chondrocytes in an accessible non-crosslinked form. | 02-11-2010 |
| 20100086578 | FISTULA PLUG COMPRISING ECM - The present invention relates to a temporary composite scaffold comprising discrete ECM particles formed as a fistula plug. We demonstrate that when using scaffolds containing ECM material, higher concentrations of ECM surprisingly do not give better cell morphology. Concentrations lower than 60% (w/w) are sufficient to obtain the best cell morphology and distribution. | 04-08-2010 |
| 20100087839 | MESH COMPRISING ECM - The present application discloses that incorporation of dermatan sulfate and/or HA in composite scaffolds of certain polymers gives rise to a chondrogenic effect on chondrocytes resulting in formation of cartilage that resembles the natural ECM. This effect with dermatan sulfate as the primary additive has not previously been seen. The composites are formed by incorporation of dermatan sulfate finely dispersed particles optionally nanoparticles or as molecular dissolutions in a polymer matrix with no bonding between the DS and the matrix, providing the DS to the chondrocytes in an accessible non-crosslinked form. | 04-08-2010 |
| 20100239560 | MULTI COMPONENT NON-WOVEN - The formation of a non-woven, free from organic solvent, formed through parallel formation of fibers on a collection device is disclosed. As the individual fibers are dry prior to contact with other fibers, the different contents of the various fiber types do not interact. However, when wetted, the fibers will start to be dissolved, or swell, and the different contents will be released and then interact. For the example of thrombin and fibrinogen, the interaction will initiate the formation of a fibrin coagulum by the cleavage of fibrinogen through the action of thrombin to form fibrin monomers that spontaneously polymerize to form a three dimensional network of fibrin. | 09-23-2010 |
| 20100322908 | COMPOSITIONS AND METHODS FOR AUGMENTATION AND REGENERATION OF LIVING TISSUE IN A SUBJECT - The present invention provides for a composition, for augmentation and regeneration of living tissue in a subject, comprising a population of porous microparticles of a biodegradable polymer, one or more mammalian cell populations, and optionally, a biocompatible adhesive. | 12-23-2010 |
| 20110014267 | BIOSYNTHETIC CARTILAGINOUS MATRIX AND METHODS FOR THEIR PRODUCTION - An isolated, acellular biosynthetic cartilaginous matrix substantially devoid of synthetic biodegradable scaffold structure is provided. Through a method with the steps of a) contacting in vitro a population of chondrogenic cells with a synthetic biodegradable scaffold; b) culturing in vitro for a period of time said chondrogenic cells within said synthetic biodegradable scaffold so that the chondrogenic cells produce a biosynthetic cartilaginous matrix; c) substantially removing any antigen derived from said chondrogenic cells a matrix suitable of implantation into a living individual mammal, such as a human being is obtained. | 01-20-2011 |
