Hannah
Hannah Benson, Heppenheim DE
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20150104349 | N-Alkyl-N'-Poly(Oxyalkyl)Hexahydropyrimidine-Quaternary Ammonium Salts And The Use Thereof As Corrosion Inhibitors - This invention relates to N-alkyl-N′-poly(oxyalkyl)hexapyrimidine-quaternary ammonium salts of the formulae (Ia)-(Ic) and mixtures thereof | 04-16-2015 |
Hannah Braun-Allen, Manitowoc, WI US
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20100084815 | "Non-wagering Game for Reallocating Collectible and Hobby-Related Items" - A game apparatus where players contribute hobby items to be reallocated. The game apparatus is comprised of a plurality of player game boards, each different from all others and including thereon a combination of randomized words arranged in rows and columns, each randomized word pertaining to a hobby; a plurality of terminology disks, each different from all others and containing one of the randomized words; and a plurality of marker disks in which one terminology disk is selected and the players use a marker disk to cover the corresponding word on his or her player game board. When one of the player game boards is covered by the marker disks in a pre-designated pattern (such as a designated line, shape, or four-corner configuration), that player collects the hobby items contributed by the players. | 04-08-2010 |
Hannah Buerckstuemmer, Darmstadt DE
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20120267579 | MIXTURES FOR PRODUCING PHOTOACTIVE LAYERS FOR ORGANIC SOLAR CELLS AND ORGANIC PHOTODETECTORS - The present invention relates to the use of mixtures which comprise, as components K1), one or more merocyanines selected from the group of the compounds of the general formulae Ia, Ib, Ic, Id, Ie, IIa and IIb, as defined in more detail in the description, as an electron donor or electron acceptor, and, as component K2), one or more compounds which, with respect to component K1), act correspondingly as an electron acceptor or electron donor, for producing photoactive layers for organic solar cells and organic photodetectors, to a process for producing photoactive layers, corresponding solar cells and organic photodetectors, and to mixtures which comprise, as components, one or more compounds of the general formulae Ia, Ib, Ic, Id, Ie, IIa and/or IIb of component K1, as defined in more detail in the description, and one or more compounds of component K2. | 10-25-2012 |
Hannah Calaman, Mahwah, NJ US
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20150141213 | WEIGHTED SLEEVE - The present invention provides a weighted sleeve containing granular weighted material that may be worn on one's hand, wrist, and/or forearm to weight one's hand and limit or curtail hand shaking symptoms and to compress the hand, wrist, and/or forearm as to temporarily alleviate pain and improve blood circulation. | 05-21-2015 |
Hannah Copperman, San Francisco, CA US
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20090138454 | Semi-Automatic Example-Based Induction of Semantic Translation Rules to Support Natural Language Search - Technologies are described herein for generating a semantic translation rule to support natural language search. In one method, a first expression and a second expression are received. A first representation is generated based on the first expression, and a second representation is generated based on the second expression. Aligned pairs of a first term in the first representation and a second term in the second representation are determined. For each aligned pair, the first term and the second term are replaced with a variable associated with the aligned pair. Word facts that occur in both the first representation and the second representation are removed from the first representation and the second representation. The remaining word facts in the first representation are replaced with a broader representation of the word facts. The translation rule including the first representation, an operator, and the second semantic representation is generated. | 05-28-2009 |
Hannah Dewerchin, Merelbeke BE
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20110190273 | METHODS AND COMPOSITIONS IN THE TREATMENT OF CORONAVIRUSES - The invention relates generally to the field of virology, and relates to the identification and characterization of the targets involved in the evasion strategy of viruses and to the use thereof in methods to identify anti-viral compounds. More in particular to identify compounds which are modulators of myosin light chain kinase (MLCK), a target within said entry and immune-evasion strategy. Other aspects of the invention are directed to anti-viral compounds identified using the models and methods of the present invention, as well as to the use thereof in treating viral infections, such as for example caused by the feline infectious peritonitis virus (FIPV), a coronavirus which belongs to an antigenic group which comprises in particular feline enteric coronavirus (FECV), canine coronavirus (CCV), swine transmissible gastroenteritis coronavirus (TGEV), porcine respiratory coronavirus (PRCV) and human coronavirus (HCV), and which induces, in a host-dependent manner, a range of symptoms which range from mild enteritis to the severe debilitating disease, and, in some cases, up to death. In a particular aspect the present invention provides the use of MLCK inhibitors for the treatment of feline infectious peritonitis (FIP). | 08-04-2011 |
Hannah Edwards, Salisbury GB
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20160108036 | HETEROCYCLIC DERIVATES - The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein. | 04-21-2016 |
Hannah Fiji, Boyertown, PA US
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20140303143 | BENZOXAZOLINONE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS - Disclosed are compounds of Formula (A) or a salt thereof, wherein “Het”, R | 10-09-2014 |
Hannah Fiji, Fontana, CA US
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20100063114 | INHIBITORS OF PROTEIN PRENYLTRANSFERASES - The present invention is directed to novel compounds. These compounds can be useful in inhibiting the activity of GGTase I. The compounds can also be used as anti-cancer therapeutics including as part of methods for treating cancer, in assays, and in kits. | 03-11-2010 |
20130102639 | INHIBITORS OF PROTEIN PRENYLTRANSFERASES - The present invention is directed to novel compounds. These compounds can be useful in inhibiting the activity of protein prenyltransferases including GGTase I and/or RabGGTase. The compounds can also be used as anti-cancer therapeutics including as part of methods for treating cancer, in assays, and in kits. | 04-25-2013 |
20140341979 | NANODRUG TARGETING PROTEIN GERANYLGERANYLATION - The present invention relates, for example, to a liposome, which can be a basic liposome, a transferrin-conjugated liposome, or a pH-sensitive liposome, which encapsulates a compound that specifically inhibits the activity of a protein prenyltransferase, such as a RabGGTase and/or a GGTase I. The liposomes can be used as anti-cancer therapeutics including as part of methods for treating cancer, in assays, and in kits. | 11-20-2014 |
Hannah Han, Fremont, CA US
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20090197482 | STAMPED BEAM CONNECTOR - An electrical connector includes a first and second array of flexible beams that are overlapped within a hood and that define a substantially cylindrically cavity for receiving a mating connector. Contact areas of each of the flexible beams may be shaped to define multiple contact points, thus increasing the overall area available for current to pass. | 08-06-2009 |
Hannah Johnson US
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20160000166 | IMPROVEMENTS IN OR RELATING TO HAIR ACCESSORIES - A hair accessory which can be inserted directly into a ponytail ( | 01-07-2016 |
Hannah Johnson, Powfoot, Dumfriesshire GB
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20160000166 | IMPROVEMENTS IN OR RELATING TO HAIR ACCESSORIES - A hair accessory which can be inserted directly into a ponytail ( | 01-07-2016 |
Hannah Jörissen, Essen DE
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20130066055 | NEW BINDER-DRUG CONJUGATES (ADCS) AND USE THEREOF - The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures. | 03-14-2013 |
20130122024 | NEW BINDER-DRUG CONJUGATES (ADCS) AND USE THEREOF - The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target mesothelin, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures. | 05-16-2013 |
Hannah Jörißen, Heiligenhaus DE
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20150099298 | Antibodies capable of binding to the coagulation Factor XI and/or its activated form factor XIa and uses thereof - The present invention relates to antibodies capable of binding to the coagulation Factor XI and/or its activated form factor XIa and methods of use thereof, particularly methods of use as agents inhibiting platelet aggregation and by this inhibits thrombus formation. | 04-09-2015 |
20150329613 | FUSION POLYPEPTIDES AND USES THEREOF - The present invention provides Relaxin fusion polypeptides with extended half-life. Thereby, the half-life extending parts are either the Fc moiety of the human IgG2 or of the human IgG4. Furthermore, the invention provides nucleic acid sequences encoding the foregoing fusion polypeptides, vectors containing the same, pharmaceutical compositions and medical use of such fusion polypeptides. | 11-19-2015 |
Hannah Jörißen US
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20130095123 | New binder-drug conjugates (ADCs) and use thereof - The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures. | 04-18-2013 |
Hannah JÖrißen, Essen DE
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20130066055 | NEW BINDER-DRUG CONJUGATES (ADCS) AND USE THEREOF - The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures. | 03-14-2013 |
20130122024 | NEW BINDER-DRUG CONJUGATES (ADCS) AND USE THEREOF - The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target mesothelin, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures. | 05-16-2013 |
20130190290 | Substituted phenylimidazopyrazoles and their use - The present application relates to novel 1-phenyl-1H-imidazo[1,2-b]pyrazole derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular angiogenic disorders and hyperproliferative disorders, where neovascularization plays a role, such as, for example, neoplastic disorders and tumour disorders. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures. | 07-25-2013 |
20140127240 | Novel Binder-Drug Conjugates (ADCs) and Use of Same - The present patent application relates to novel binder-drug conjugates (ADCs) of N,N-dialkylauristatins directed against the target epidermal growth factor receptor (EGFR, gene ID 1956), effective metabolites of these ADCs, methods for producing these ADCs, use of these ADCs for treatment and or prevention of diseases as well as the use of these ADCs to produce pharmaceutical drugs for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic diseases such as cancer, for example. Such treatments may be administered as monotherapy or in combination with other pharmaceutical drugs or other therapeutic measures. | 05-08-2014 |
20150030618 | NOVEL BINDER-DRUG CONJUGATES (ADCS) AND USE THEREOF - The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures. | 01-29-2015 |
20150246136 | NOVEL BINDER-DRUG CONJUGATES (ADCs) AND USE OF SAME - The present patent application relates to novel binder-drug conjugates (ADCs) of N,N-dialkylauristatins directed against the target epidermal growth factor receptor (EGFR, gene ID 1956), effective metabolites of these ADCs, methods for producing these ADCs, use of these ADCs for treatment and or prevention of diseases as well as the use of these ADCs to produce pharmaceutical drugs for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic diseases such as cancer, for example. Such treatments may be administered as monotherapy or in combination with other pharmaceutical drugs or other therapeutic measures. | 09-03-2015 |
Hannah Monyer, Heidelberg DE
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20100297102 | SEROTONIN 5-HT3A RECEPTORS IN TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS - Methods are provided for modulating post-natal migration of neurons. Activation of the 5-HT3A receptor increases migration, while pharmacological blockade of the 5-HT3A receptor disrupts neuroblast migration into the cortex and hippocampus. These neuroblasts mature into GABAergic interneurons, and thus are relevant to conditions associated with disturbances in 5-HT levels and GABAergic inhibition. | 11-25-2010 |
Hannah Murnen, Lagrange, IL US
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20100090440 | SYSTEM AND METHOD FOR PROVIDING GYROSCOPIC STABILIZATION TO A WHEELED VEHICLE - This invention provides a stabilizing system and method for two-wheeled vehicles that affords the rider no restriction on the full range of movements (banks, leans, etc.) common to bicycles, but that provides greater stability during turns and other maneuvers so that an unintentional bank or tilt (potentially causing a fall) is less likely, even at relatively slow speeds and startup. A rotating mass of predetermined mass-value and radial mass-distribution is provided coaxially with the front axle. The mass is supported on bearings so as to freewheel with respect to the rotation of the front wheel. As such it can be induced to spin significantly faster than the front wheel thereby generating a gyroscopic effect at the front wheel about the axle. This gyroscopic effect influences the steering of the wheel by the rider. Due to precession, the wheel tends to follow any excessive bank by the vehicle, ensuring that the rider can “steer-out-of” an unintended tilt or bank. Likewise, the gyroscopic effect limits the rider's ability to execute excessive steering, thereby preventing jackknife movements. The mass can be an electric-motor-driven flywheel within a shell housing that includes a battery, control system and drive motor. The drive motor engages a surface of the flywheel with a drive tire in a resilient manner to reduce potential damage to the motor. | 04-15-2010 |
Hannah Murnen, Berkeley, CA US
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20120319456 | SYSTEM AND METHOD FOR PROVIDING GYROSCOPIC STABILIZATION TO A WHEELED VEHICLE - This invention provides a stabilizing system and method for two-wheeled vehicles that affords the rider no restriction on the full range of movements (banks, leans, etc.), while providing greater stability during turns and other maneuvers so that an unintentional bank or tilt (potentially causing a fall) is less likely, even at slow speeds and startup. A rotating mass of predetermined mass-value and radial mass-distribution is provided coaxially with the front axle. The mass is supported on bearings and freewheels with respect to the rotation of the front wheel. It can be induced to spin significantly faster than the front wheel thereby generating a gyroscopic effect at the front wheel about the axle. The gyroscopic effect limits the rider's ability to execute excessive steering, thereby preventing jackknife movements. The mass can be an electric-motor-driven flywheel within a shell housing that includes a drive tire battery, control system and drive motor. | 12-20-2012 |
Hannah Pezzi, New Berlin, WI US
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20160038132 | System and Method for Percutaneous Spine Fusion - The present disclosure provides a retractor including an enclosure extending from a first open end to a second open end to form a lumen extending along an axis therebetween and that is accessible from the first open end and the second open end. The retractor further includes a first aperture formed at first angular position in the enclosure, and a second aperture formed at second angular position in the enclosure and opposing the first aperture to form a passage extending transverse to the axis from the first aperture, through the lumen, and to the second aperture. The first aperture and the second aperture are located proximate to the first open end and sized to arrange the passage along a spine of a patient to receive a trocar for delivering a graft material to the spine. | 02-11-2016 |
Hannah Storrie, Chapel Hill, NC US
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20130177536 | Enhancement Of Skeletal Muscle Stem Cell Engraftment By Dual Delivery Of VEGF And IGF-1 - An improved device and method for extended repair and regeneration of muscle tissue. An exemplary device comprises (a) a scaffold comprising an ECM component; (b) a combination of growth factors such as VEGF and IGF; and (c) a population of myogenic cells. Implantation of the device leads to muscle regeneration and repair over an extended period of time. | 07-11-2013 |
Hannah Thölking, Stuttgart DE
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20130319392 | Hand-operated implement comprising a cutting chain for cutting mineral and metal materials - A hand-operated implement has a guide bar on which is fitted a cutting chain for cutting mineral and metal materials. The cutting chain is driven around the guide bar by a chain sprocket. The chain sprocket is arranged in a chain sprocket chamber which is delimited by a chain sprocket cover. A cutting element has an outer side facing a sidewall of the chain sprocket cover which lies in a first notional plane. The distance between the sidewall and the first notional plane measured perpendicular to the first notional plane and centrally between the top of the cutting element and the peripheral wall is less than approximately 0.8 cm over at least 30% of the section between a second notional plane containing the central axis of a fixing bolt on the guide bar and the exit opening at which the cutting chain leaves the chain sprocket chamber. | 12-05-2013 |
Hannah Tipple, Hull GB
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20090098060 | Aerosol Compositions - An aerosol composition comprising: 0.01 wt % to 1.00 wt % sodium borate; 0.01 wt % to 1.50 wt % polyglycerol ester surfactant; <30 wt % propellant; and 67.5 wt % to 85.0 wt % water. Methods of manufacture of an aerosol air freshener are also described wherein the aerosol composition further comprises a fragrance. | 04-16-2009 |
Hannah Valantine, Stanford, CA US
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20120295810 | Non-Invasive Diagnosis of Graft Rejection in Organ Transplant Patients - The disclosure provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant. The methods comprise determining the presence or absence of one or more nucleic acids from a donor transplant, wherein said one or more nucleic acids from said donor are identified based on a predetermined marker profile, and diagnosing or predicting transplant status or outcome based on the presence or absence of said one or more nucleic acids. | 11-22-2012 |
20150133391 | CELL-FREE NUCLEIC ACIDS FOR THE ANALYSIS OF THE HUMAN MICROBIOME AND COMPONENTS THEREOF - Methods, devices, compositions and kits are provided for analysis of the microbiome or individual components thereof in an individual. The methods find use in a determination of infection, in analysis of the microbiome structure, in determining the immunocompetence of an individual, and the like. In some embodiments of the invention, the individual is treated with a therapeutic regimen, e.g. drugs, diet, radiation therapy, and the like. | 05-14-2015 |
20150337361 | Non-Invasive Diagnosis of Graft Rejection in Organ Transplant Patients - The invention provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant. | 11-26-2015 |
Hannah Venit, Cheltenham, PA US
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20110306062 | Babesia microti genomic clones containing novel antigens useful in the diagnosis of babesios - Disclosed are the cloning and expression of novel antigens in | 12-15-2011 |
20120202227 | Babesia microti Genomic Clones Containing Novel Antigens Useful in the Diagnosis of Babesiosis - Disclosed are the cloning and expression of novel antigens in | 08-09-2012 |
20130177941 | BABESIA MICROTI GENOMIC CLONES CONTAINING NOVEL ANTIGENS USEFUL IN THE DIAGNOSIS OF BABESIOSIS - Disclosed are the cloning and expression of novel antigens in | 07-11-2013 |