Hanger
Ann-Christin Malmborg Hanger, Helsingborg SE
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20150368318 | MUTANTS OF INTERLEUKIN-1 RECEPTOR ANTAGONIST AND USES THEREOF - The invention provides an isolated polypeptide comprising a variant amino acid sequence of SEQ ID NO: 1, or a fusion or derivative of said polypeptide, or a fusion of a said derivative thereof, wherein the polypeptide, fusion or derivative retains a biological activity of wild type IL-IRa. In one embodiment, the isolated polypeptide, fusion or derivative is or comprises a polypeptide variant of amino acid sequence SEQ ID NO: 1 comprising or consisting of substitutions at one or more of the following amino acid mutations of SEQ ID NO: 1: Q29K, P38Y, P38R, L42W, D47N, E52R, H54R, E90Y, Q129L, Q129N, M136N, M136D and Q149K. Also provided are pharmaceutical compositions of the above polypeptide, fusion or derivative, as well as uses of the same for treating a disease or condition capable of being treated by an agent which inhibits the function of IL-1 receptors. | 12-24-2015 |
Cecilia Ann-Christin Malmborg Hanger, Helsingborg SE
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20130129672 | MUTANTS OF INTERLEUKIN- 1 RECEPTOR ANTAGONIST AND USES THEREOF - The invention provides an isolated polypeptide comprising a variant amino acid sequence of SEQ ID NO: 1, or a fusion or derivative of said polypeptide, or a fusion of a said derivative thereof, wherein the polypeptide, fusion or derivative retains a biological activity of wild type IL-IRa. In one embodiment, the isolated polypeptide, fusion or derivative is or comprises a polypeptide variant of amino acid sequence SEQ ID NO: 1 comprising or consisting of substitutions at one or more of the following amino acid mutations of SEQ ID NO: 1: Q29K, P38Y, P38R, L42W, D47N, E52R, H54R, E90Y, Q129L, Q129N, M136N, M136D and Q149K. Also provided are pharmaceutical compositions of the above polypeptide, fusion or derivative, as well as uses of the same for treating a disease or condition capable of being treated by an agent which inhibits the function of IL-1 receptors. | 05-23-2013 |
Diane Hanger, London GB
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20150051097 | Methods for Screening Inhibitors of Tau Phosphorylation By Casein Kinase I - Methods of screening for candidate compounds capable of inhibiting activity of fyn in phosphorylating tau protein at Y394 or binding to fyn to inhibit interaction with tau protein at Y394, including determining whether, and optionally the extent, the candidate compounds have these capabilities under conditions where fyn has these capabilities in the absence of the candidate compound. Methods of screening for substances capable of promoting dephosphorylation of tau protein by a phosphatase at a site of tau protein including contacting a candidate substance, the tau protein and a phosphatase capable of dephosphorylating the tau protein under conditions where the phosphatase is capable of dephosphorylating the site in absence of the candidate substance, where the kinase is fyn; determining whether, and optionally the extent, the candidate substance promotes dephosphorylation of the tau protein at the site; and selecting the candidate substance which promotes dephosphorylation of the tau protein the sites. | 02-19-2015 |
Gregory Hanger, Carmel, IN US
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20150087518 | CONTROL OF AAD DICOT VOLUNTEERS IN MONOCOT CROPS - The subject invention relates in part to the control of AAD-12 and/or AAD-13 dicot volunteers in fields planted with monocot crops such as corn. The dicots can include soybeans and cotton. | 03-26-2015 |
Gregory A. Hanger, Carmel, IN US
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20120220460 | CONTROL OF AAD-1 MONOCOT VOLUNTEERS IN FIELDS OF DICOT CROPS - The subject invention relates in part to the control of AAD-1 monocot volunteers in fields planted with dicot crops such as soybeans or cotton. According to some embodiments of the subject invention, cyclohexanedione herbicides are selected as being an effective tool for controlling AAD-1 volunteers, as AAD genes do not impart tolerance to this class of graminicide chemistry. In addition, imidazolinone-class herbicides can be used in some preferred embodiments for selective control of conventional or herbicide-tolerant varieties of volunteer corn. AAD-1 corn comprising Event DAS-40278-9 is used in some particularly preferred embodiments. | 08-30-2012 |
20130296170 | CONTROL OF AAD DICOT VOLUNTEERS IN MONOCOT CROPS - The subject invention relates in part to the control of AAD-12 and/or AAD-13 dicot volunteers in fields planted with monocot crops such as corn. The dicots can include soybeans and cotton. | 11-07-2013 |
Mccarthy Hanger, La Jolla, CA US
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20100297297 | ENERGY BEVERAGES AND METHODS FOR FABRICATION THEREOF - Powder composition for preparing an energy beverage are provided, the powder compositions including at least one vitamin of group B, chromium picolinate, and calcium carbonate, and optionally also including other vitamins, minerals, or nutrient, such as vitamins A, C, and/or E. The beverage is designed as means of providing additional energy to persons suffering from diabetes. Methods for preparing such a powdered composition and energy beverage are also provided. | 11-25-2010 |