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Handley, US
David W. Handley, Waterford, WI US
Dean A. Handley, Shrewsbury, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080293823 | Methods and Compositions For Treating Sleep-Related Breathing Disorders - Provided herein are methods of treating a sleep-related breathing disorder, such as obstructive sleep apnea, comprising the administration of O-desmethylvenlafaxine or duloxetine. | 11-27-2008 |
Harold H. Handley, Encinitas, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110009796 | METHOD AND APPARATUS FOR INCREASING CONTAMINANT CLEARANCE RATES DURING EXTRACORPOREAL FLUID TREATMENT - An extracorporeal fluid treatment apparatus includes a separator comprising a cartridge surrounding a porous separation membrane. The membrane separates a main flow path of a cellular component of the blood from a plasma flow path. An affinity medium is disposed within the plasma flow path to bind contaminants such as viral pathogens or toxins contained within the plasma. A pump pumps the plasma through the affinity medium at an assisted flow rate preferably between 10% and 40% of the whole blood flow rate. The assisted flow rate is selected to reduce a T90% of the apparatus by at least 50% as compared to a T90% of the apparatus without the plasma pump. A method of treating blood containing contaminants includes supplying infected blood to a separator and pumping the plasma component through an affinity medium at an assisted flow rate to increase contaminant clearance. | 01-13-2011 |
| 20120037564 | METHODS AND SYSTEMS FOR REDUCING VIRAL LOAD OF HEPATITIS C VIRUS IN HEMODIALYSIS PATIENTS - The present technology relates to methods and systems for the removal of pathogens and fragments thereof in hemodialysis patients. In particular, methods and systems are described where lectins can be used to remove the Hepatitis C virus and fragments thereof in hemodialysis patients, and to provide a sustained reduction in viral load. | 02-16-2012 |
Harold H. Handley, Encintas, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110284463 | DEVICE AND METHOD FOR PURIFYING VIRALLY INFECTED BLOOD - The present invention relates to a method for using lectins that bind to pathogens having surface glycoproteins or fragments thereof which contain glycoproteins, to remove them from infected blood or plasma or other fluids in an extracorporeal setting. Accordingly, the present invention provides a methods and devices for reducing viral load or plaque forming units in blood or plasma from one or more infected individuals. A preferred embodiment of the method comprises passing the blood or plasma through a porous hollow fiber membrane wherein lectin molecules are disposed proximate to the membrane, collecting pass-through blood or plasma and optionally reinfusing the pass-through blood or plasma into the individual. Additionally, the present invention provides a methods and devices for the reduction of plaque forming units, cleared more rapidly and more efficiently than overall viral load. | 11-24-2011 |
Ian Handley, Mountain View, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110093006 | BIOCOMPATIBLE PHASE INVERTIBLE PROTEINACEOUS COMPOSITIONS AND METHODS FOR MAKING AND USING THE SAME - Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. The subject phase invertible compositions are prepared by combining a crosslinker and a proteinaceous substrate. The proteinaceous substrate includes one or more proteins and a polyamine, where the polyamine and a proteinaceous substrate are present in synergistic viscosity enhancing amounts, and may also include one or more of: a carbohydrate, a tackifying agent, a plasticizer, or other modification agent. In certain embodiments, the crosslinker is a heat-treated dialdehyde, e.g., heat-treated glutaraldehyde. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications. | 04-21-2011 |
Ian J. Handley, Mountain View, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090143500 | BIOCOMPATIBLE PHASE INVERTIBLE PROTEINACEOUS COMPOSITIONS AND METHODS FOR MAKING AND USING THE SAME - Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. Phase invertible compositions in accordance with the invention are prepared by combining a liquid proteinaceous substrate and a liquid crosslinking composition, where the liquid crosslinking composition includes a macromolecular crosslinking agent. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications. | 06-04-2009 |
James Richard Handley, East Amherst, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20120125044 | FEED COMPRESSION METHOD AND APPARATUS FOR AIR SEPARATION PROCESS - A method and apparatus for separating air to produce a gaseous oxygen product in which the air is separated in an air separation plant to conduct a cryogenic rectification process that utilizes higher and lower pressure compressed air streams. The higher and lower pressure compressed air streams are generated in two multistage compressors linked together so that the lower pressure compressed air stream is produced from intermediate stages and the higher pressure compressed air stream is produced from higher pressure compression stages. During turn-down operational conditions, one of the two multistage compressors can be shut down to decrease the flow of air and therefore, the production of the oxygen product. | 05-24-2012 |
John Handley, Chicago, IL US
| Patent application number | Description | Published |
|---|---|---|
| 20100138334 | EXCHANGE ORDER PRIORITY RETENTION FOR ELECTRONIC TRADING USING AUTOMATIC BOOK UPDATES - The present invention involves providing a computer based platform for allowing a user to establish a target trading book; evaluating the user's unmatched exchange trades to determine an actual trading book at a point in time; determining a differential between the target trading book and the actual trading book; and identifying at least one exchange trade action to transition from the actual trading book to the target trading book, wherein the exchange trade action is based on preserving at least one unmatched order with the oldest possible entry time stamp. | 06-03-2010 |
John Handley, Duluth, MN US
| Patent application number | Description | Published |
|---|---|---|
| 20110046315 | Method for Preparing Conjugates Using Polymer Maleimides - Methods for preparing conjugates using polymeric reagents bearing a maleimide are provided. Also provided are compositions comprising the conjugates. | 02-24-2011 |
| 20120022220 | Method for Preparing Polymer Maleimides - Methods for preparing polymeric reagents bearing a maleimide are provided. Also provided are related compositions. | 01-26-2012 |
Joshua Handley, Silver Spring, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110202856 | Systems and methods for interfacing with a virtual object in a haptic virtual environment - A user of a modeling application modifies an initial virtual object using a sketch drawn on one or more construction planes. Typically, construction planes are connected by an axis that intersects the virtual object. The user can draw a sketch on each construction plane, and the modeling application interpolates a shape along the axis between the sketches to determine what material in the virtual object is to be removed from it. In this manner, material may be removed to create a recess or hole in the virtual object or otherwise to slice away material from the object. A user can use two or more axes and construction planes to produce complex shapes from the initial virtual object. A user can also select a portion of a virtual object and mirror the selected portion. Modifications that the user makes in the selected portion are made correspondingly in the mirrored portion. | 08-18-2011 |
Joshua Handley, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090027411 | APPARATUS AND METHODS FOR STENCILING AN IMAGE - The invention provides methods of protecting selected regions of an image from subsequent modification during the operation of a graphics application. The methods allow a user to select a region of an image to protect, and to assign a level of protection to the selected region. Subsequent brush strokes in the region are then attenuated according to the assigned level of protection and blended into the image without artifacts caused by overlapping strokes. The invention also provides a method of blending individual strokes into a texture without segmentation artifacts. | 01-29-2009 |
| 20090033660 | APPARATUS AND METHODS FOR TEXTURE MAPPING - The invention provides texture mapping techniques that facilitate interactive painting of a three-dimensional virtual surface by a user in object space, without requiring global parameterization. The texture mapping techniques feature rendering texture for a given virtual object using a plurality of composite textures, each formed by blending collapsible texture layers. Texture coordinates in texture space are derived using information determined at the time of surface mesh generation. The invention features dynamic texture allocation and deallocation, allowing a user to interactively modify the shape of a painted, three-dimensional model. Finally, the invention features an architecture for combined graphical rendering and haptic rendering of a virtual object, allowing a user to experience force feedback during the painting of the object in object space. | 02-05-2009 |
Joyce A. Handley, Atlanta, GA US
| Patent application number | Description | Published |
|---|---|---|
| 20100000019 | MATTRESS WITH REMOVABLE TOP - A mattress is constructed from a mattress body having an upper and a lower deck, which is preferably pervious to moisture and air. A removable panel, which includes a top layer of breathable fabric, a bottom layer of a fabric that forms a moisture barrier, and a batting layer, is placed on at least the upper deck of the mattress body. The removable panel is removably attached along the perimeter of the deck or decks by a fastener, such as a zipper. The panel can be removed from the deck for cleaning and folded and secured by the fastener in an inverted configuration, with the top layer facing outward. | 01-07-2010 |
Maynard Handley, Cupertino, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080232475 | VIDEO ENCODING AND DECODING - A method for encoding video with a two-dimensional (2D) transform separable to two one-dimensional ( | 09-25-2008 |
| 20080240600 | ADAPTIVELY POST FILTERING ENCODED VIDEO - Some embodiments of the invention provide a method of decoding an encoded video signal that includes a plurality of successive encoded images. The method initially receives an encoded image of the video signal. It then decodes the encoded image. The method next examines the decoded image to determine whether the decoded image satisfies at least one criterion for performing a post-filter operation on the decoded image. Only if the decoded image satisfies the criterion, the method performs the post-filter operation on the decoded image. The criterion in some embodiments is whether the amount of time for applying the post-filter operation exceeds the remaining amount of time that the method has to process the received image. Some embodiments of the invention provide a method of post-filtering a current image that was decoded from an encoded video signal, which includes a plurality of successive encoded images. The current image has several sub-sections. The method selects a sub-section of the current image. It then determines whether the selected sub-section satisfies at least one condition for performing a post-filter operation on the selected sub-section. The method next performs the post-filter operation on the selected sub-section only if the selected sub-section satisfies the criterion. | 10-02-2008 |
Michael Handley, Farmington, MN US
| Patent application number | Description | Published |
|---|---|---|
| 20110067368 | FILTER ARRANGEMENT AND METHODS - A filter element includes a single seamless media pack having first and second opposite ends and first and second lateral sides extending between the first and second ends. The media pack also has pleats extending between the first and second ends and a first cross-section defined between the first and second lateral sides. The first cross-section having at least one outward projection that defines an internal radius of at least ¼ inch wherein a plurality of pleats of the media pack are fanned around the internal radius. A first end cap is secured to the first end of the media pack while a second end cap secured to the second end of the media pack. Additionally, a frame member is secured to the first end cap, second end cap, the first lateral side, and the second lateral side. A pre-filter is usable with described filter arrangements. | 03-24-2011 |
Michael Handley, Greenbrae, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20120065185 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE - Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. | 03-15-2012 |
Michael W. Handley, Farmington, MN US
| Patent application number | Description | Published |
|---|---|---|
| 20090064860 | Z-filter media with reverse-flow cleaning systems and methods - A method for cleaning a filter having Z-media includes providing a filter having Z-media and cleaning the media construction by directing a pulse of compressed gas into the media construction through the downstream flow face. Filter elements useable with such methods include elements made of Z-media. An example system utilizing the method includes a gas turbine air intake system. | 03-12-2009 |
| 20110048228 | FILTER CONSTRUCTION FOR USE WITH AIR IN-TAKE FOR GAS TURBINE AND METHODS - The filter of the invention is a cartridge filter comprising a structure that can maintain a filter medium in an air stream to filter particulates to protect a gas turbine power system. The filter combines a mechanically adequate filter structure and an effective filter medium for to obtain a useful system. | 03-03-2011 |
Richard A. Handley, Loon Lake, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20090053785 | METHODS AND COMPOSITIONS FOR OPTIMIZING FERMENTATION - Embodiments described include methods for maintaining the pH and alkalinity during industrial fermentation processes are described that foster optimal microorganism activities throughout the duration of the fermentation process. Magnesium based buffering agents having sufficient buffering capacity and applied at sufficient concentration levels required to neutralize the acidic content of fermentation fluids during the fermentation process cycle are detailed. These magnesium based buffering agents control fermenter processes without causing extreme pH swings to maximize the production of desired fermentation products. | 02-26-2009 |
| 20110024360 | COMPOSITIONS AND METHODS FOR WASTEWATER TREATMENT - Methods and compositions utilizing aluminum, magnesium, and calcium-based additives for the treatment and neutralization of wastewater are described for removing contaminants from wastewater, including reducing phosphorous-containing compounds, total suspended solids (TSS), biological oxygen demand (BOD), fats, oils, and greases (FOG), and total Kjedahl nitrogen (TKN) are described. Methods and compositions to control pH, sulfur and sodium loads present in wastewater and precipitatable solids are described. Concentrations of aluminum, magnesium, and calcium-based additives are maintained at mass action concentrations to the wastewater component levels present in the wastewater and bracketed approximately +/−0.5 pH units about the pK value of the soluble, buffering species. | 02-03-2011 |
Richard S. Handley, Canton, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20080261318 | Signalling Compounds For Use In Methods Of Detecting Hydrogen Peroxide - Methods and compound useful for detecting a source of hydrogen peroxide are disclosed wherein a signalling compound of the formula: | 10-23-2008 |
| 20100055800 | Compositions for Chemiluminescent Detection of Hydrogen Peroxide - Methods and compound useful for detecting a source of hydrogen peroxide are disclosed wherein a signalling compound of the formula: | 03-04-2010 |
Sheryll H. Handley, Fort Worth, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20080305514 | METHOD FOR DETECTING MICROBES - The present invention relates to methods for detecting microbes in a sample comprising filtering the sample through a fluid-permeable surface, contacting the surface with a viability stain, scanning the surface for viability stain to form a first scan, contacting the surface with a nucleic acid stain, scanning the surface for nucleic acid stain to form a second scan, and comparing said first scan and said second scan. | 12-11-2008 |
Simon Handley, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080249876 | METHOD AND SYSTEM USING DISTRIBUTIONS FOR MAKING AND OPTIMIZING OFFER SELECTIONS - A method and system for making and optimizing offer selections targeted to particular recipients or groups improves selection quality by combining and aggregating quantitative and qualitative data to capture recipient needs and provider expectations and intentions. Offer descriptions are first received. Distribution variables for application to offer descriptions and recipients are then selected. Distributions are then assigned to offer descriptions, and distributions appropriate to the recipient are determined and assigned to the recipient. Distributions can incorporate demographic, psychographic and behavioral variables. Offer description distributions and recipient distributions are combined for each offer description, resulting in a ranking for each offer description. Offer descriptions are automatically selected based on the rankings, using, for example, simple ordering or roulette wheel selection. Offer descriptions are instantiated as offers, and finally offers are output to the recipient. | 10-09-2008 |
William Handley, Chandler, AZ US
| Patent application number | Description | Published |
|---|---|---|
| 20080217764 | Piezoelectric cooling of a semiconductor package - In one embodiment, the present invention includes a semiconductor package having a plurality of fan blades embedded within a first surface of the package, where a first group of the fan blades extend from a first side of the package and a second group of the fan blades extend from a second side of semiconductor package. The fan blades may be powered by piezoelectric devices to cause motion of the fan blades. Other embodiments are described and claimed. | 09-11-2008 |