| Patent application number | Description | Published |
|---|
| 20080204742 | Method and System for Optimizing Surface Enhanced Raman Scattering - A substrate for enhanced electromagnetic spectroscopy of an analyte comprises a solid support and a plurality of individual nanoparticles affixed thereto, wherein the nanoparticles are designed to have an increased electromagnetic field strength and/or plasmon resonance frequency that is between the frequency of an incident electromagnetic radiation and the frequency of the Raman response from the analyte and wherein the Raman response is enhanced by the individual nanoparticles. The nanoparticles may comprise a shell surrounding a core and the thicknesses of the core and the shell are selected to produce a plasmon resonance frequency. The wavelength of the incident radiation may be between 200 nm and 20 microns. A method for carrying out spectroscopy comprises providing a light source having a frequency different from that of the analyte, selecting a nanoshell configuration, providing a plurality of nanoshells with that configuration, and affixing the nanoparticles to a support. | 08-28-2008 |
| 20100022020 | Compositions for surface enhanced infrared absorption spectra and methods of using same - A composition comprising a substrate and at least one adsorbate associated with the substrate wherein the composition has an enhanced infrared absorption spectra. A method comprising tuning a nanoparticle to display a plasmon resonance in the infrared, associating an adsorbate with the nanoparticle to form an adsorbate associated nanoparticle, and aggregating the adsorbate associated nanoparticle. A method of preparing a SERS-SEIRA composition comprising fabricating a nanoparticle substrate, functionalizing the nanoparticle substrate to form a functionalized substrate, dispersing the functionalized substrate in solution to form a dispersed functionalized substrate, and associating the dispersed functionalized substrate with a medium. | 01-28-2010 |
| 20100028680 | Nonconcentric nanoshells and methods of making and using same - A nanoparticle comprising a shell surrounding a core material with a lower conductivity than the shell material, wherein the core center is offset in relation to the shell center. A method comprising providing a nanoparticle comprising a nonconductive core and a conductive shell, and asymmetrically depositing additional conductive material on the conductive shell. A method comprising providing a concentric nanoshell having a core and a shell, immobilizing the concentric nanoshell onto a support, and asymmetrically depositing a conductive material onto the shell to produce a nanoegg. | 02-04-2010 |
| 20100040549 | Composition for Targeted Drug Delivery and Controlled Release - Disclosed herein are novel targeted drug delivery and controlled release methods and compositions where optically absorbing nanoparticles, such as nanoshells, are functionalized on their surfaces with thermolabile molecules that bind the drug molecules to be delivered. The linkage between the thermolabile moiety on the nanoparticles and the drug is deliberately designed or selected to be temperature sensitive, so that upon illumination of the nanoparticle at a wavelength of light, the drug molecules on the nanoparticles will be released. Targeting molecules, such as antibodies, aptamers or other molecules like folic acid, can be concurrently bound to the nanoparticle surface to deliver the nanoparticle to specifically targeted cells or tissues prior to the photothermally induced drug release. In this way the nanoparticles can be advantageously concentrated on the target prior to illumination, which makes the disclosed compositions both a targeted delivery and a controllable drug release vehicle. | 02-18-2010 |
| 20110065946 | FLUORINATED NANODIAMOND AS A PRECURSOR FOR SOLID SUBSTRATE SURFACE COATING USING WET CHEMISTRY - The present invention is directed to nanodiamond (ND) surface coatings and methods of making same. Such coatings are formed by a covalent linkage of ND crystals to a particular surface via linker species. The methods described herein overcome many of the limitations of the prior art in that they can be performed with standard wet chemistry (i.e., solution-based) methods, thereby permitting low temperature processing. Additionally, such coatings can potentially be applied on a large scale and for coating large areas of a variety of different substrates. | 03-17-2011 |
| 20110158915 | NANOSHELLS WITH TARGETED ENHANCEMENT OF MAGNETIC AND OPTICAL IMAGING AND PHOTOTHERMAL THERAPEUTIC RESPONSE - A particle and a method of manufacturing a particle that includes a complex, a paramagnetic entity, and a silica layer that encapsulates the paramagnetic entity and the complex. The dielectric layer of the particle encapsulates the complex and the paramagnetic entity such that at least a portion of an outer surface of the complex is covered by the paramagnetic entity. In addition, the particle may or may not include a fluorescent entity encapsulated within the dielectric layer. Also, the particle may or may not include a targeting entity covalently bonded to the silica layer. | 06-30-2011 |
